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4-Difluoromethoxybenzenesulfonyl Chloride

4-Difluoromethoxybenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

794967

Chemical Formula C7H5ClF2O3S
Molecular Weight 244.63
Appearance Typically a colorless to light - yellow liquid
Physical State Liquid at room temperature
Boiling Point Approximately [specific value] °C (under specific pressure conditions)
Melting Point Approximately [specific value] °C
Density [specific value] g/cm³
Solubility Soluble in some organic solvents like dichloromethane, less soluble in water
Flash Point Approximately [specific value] °C
Stability Stable under normal conditions, but may react with strong bases and reducing agents
Hazard Class Corrosive, harmful if swallowed, in contact with skin or if inhaled
Packing & Storage
Packing 1 kg of 4 - difluoromethoxybenzenesulfonyl chloride in sealed, corrosion - resistant containers.
Storage 4 - difluoromethoxybenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent contact with moisture, as it can react with water. Store it separately from incompatible substances like bases, reducing agents, and reactive metals to avoid potential chemical reactions.
Shipping 4 - difluoromethoxybenzenesulfonyl chloride is a chemical. For shipping, it must be in appropriate, tightly - sealed containers. It should be transported as a hazardous chemical following strict regulations to prevent spills and ensure safety during transit.
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4-Difluoromethoxybenzenesulfonyl Chloride 4-Difluoromethoxybenzenesulfonyl Chloride
General Information
Historical Development
The historical development of 4-difluoromethoxybenzenesulfonyl chloride is worth exploring. In the past, chemists studied the way of organic synthesis. At first, the understanding of this object was still shallow and only theoretical speculation. Later, after countless difficult experiments, scholars repeatedly considered the reaction conditions and raw material proportions. Gradually, the synthesis method was slightly promising, but the purity and yield did not reach the ideal state. The public is reluctant to study, or improve the catalyst, or optimize the reaction process. With the passage of time, with the advance of science and technology, the analytical methods have become more refined, and the understanding of its structure and properties has become more and more thorough. The synthesis process has also been greatly improved, from the initial crude attempt to the current precise control, 4-difluoromethoxybenzenesulfonyl chloride has been widely used in the chemical field, and its historical development is a vivid chapter of chemical exploration.
Product Overview
4-Difluoromethoxybenzenesulfonyl chloride is also a chemical product that I have studied. This product has unique characteristics. Its shape may be colorless to slightly yellow liquid, and it smells pungent.
In the chemical industry, it has a wide range of uses. It can be used as a key intermediate in organic synthesis and participates in the preparation of a variety of complex compounds. Its reactivity is quite high, and it can react with many reagents such as substitution and condensation, providing an opportunity for the synthesis of organic compounds with novel structures.
Preparation of this product requires strict follow of specific process procedures. It is extremely important to control the reaction conditions, such as temperature, pressure, and the ratio of reactants, etc., with slight deviations, or changes in yield and purity.
However, it is dangerous, so be careful when operating, and strictly follow safety procedures to prevent accidents and ensure the safety of the experimenter and the tranquility of the environment.
Physical & Chemical Properties
4-Difluoromethoxy benzene sulfonyl chloride, its physical and chemical properties are related to many aspects. The appearance of this compound is often in a specific state, or it is a colorless to light yellow liquid, and it looks quite shiny. Its smell may be irritating to a certain extent, so you need to be cautious when smelling it.
In terms of physical properties, the boiling point and melting point have their own numbers. The boiling point can reach a certain value at a specific pressure, and the melting point is also within the corresponding range. In terms of solubility, it is soluble in some organic solvents, and shows a specific solubility in water.
In terms of chemical properties, it is active and reactive. Sulfonyl chloride groups are prone to substitution reactions with nucleophiles, and can react with alcohols, amines, etc. to form corresponding sulfonates or sulfonamides. Its chemical stability can be maintained under certain conditions, but it will also change when encountering specific substances or conditions. These are all important physicochemical properties of 4-difluoromethoxybenzenesulfonyl chloride.
Technical Specifications & Labeling
4-Difluoromethoxybenzenesulfonyl chloride is a chemical that we have studied with great care. Its process specifications and identification (product parameters) are crucial.
In terms of process specifications, the synthesis of this product needs to follow a precise process. The ratio of raw materials must be accurate, and the reaction temperature and duration must also be strictly controlled. For example, in a specific reactor, with a suitable catalyst, the temperature should be controlled in a certain range, and the reaction can be fully completed after several hours.
In terms of identification, the name, chemical formula, content and other parameters should be clearly marked on the product packaging. And a warning label must be attached to indicate its chemical properties to prevent misuse. Only in this way can the quality and safety of 4-difluoromethoxybenzenesulfonyl chloride be ensured, and its due effectiveness can be exerted in the chemical industry.
Preparation Method
To prepare 4-difluoromethoxy benzenesulfonyl chloride, the method is as follows: First take the raw materials, and obtain difluoromethanol, benzenesulfonic acid, etc. Slowly add difluoromethanol to the pretreated benzenesulfonic acid in an appropriate amount to control the temperature and rate. This is the first step in the reaction. When reacting, pay attention to observe the reaction phenomenon to make the two fully react.
After the reaction is completed, the obtained product is moved to a special container and purified by a specific process. When purifying, several processes are required to remove its impurities and improve its purity. After multiple treatments, a relatively pure 4-difluoromethoxy benzenesulfonyl chloride can be obtained. The whole preparation process is complicated, and each step needs to be strictly controlled in order to obtain satisfactory products.
Chemical Reactions & Modifications
There is now a substance named 4-difluoromethoxybenzenesulfonyl chloride. In the field of chemistry, its reaction and modification are quite important.
Looking at its chemical reaction, it can meet with various reagents to produce different products. Or nucleophilic substitution, or addition, etc., all change according to the conditions and the nature of the reagent. The beauty of this reaction lies in manipulating the conditions, such as temperature and solvent, to guide the reaction direction to obtain the desired thing.
As for modification, it is to optimize its properties. Either adjust its chemical activity, or increase its stable state, or change its physical properties, such as the degree of melting and boiling, the ability to dissolve. By modifying its structure, adding or subtracting atoms or groups, to achieve the purpose of modification. In this way, 4-difluoromethoxybenzenesulfonyl chloride can be used in chemical, pharmaceutical and other industries to develop more capabilities, and to meet diverse needs, to contribute to the progress of chemical research and industry, and to promote its progress.
Synonyms & Product Names
Today there is a thing called 4-difluoromethoxybenzenesulfonyl chloride. This thing has a wide range of uses in the field of chemistry. Its nickname and trade name are also important for academic research.
Or it has another name, due to chemical naming rules and different application scenarios. In experiments, scholars have different names according to its structure and characteristics, which are all synonymous names. The determination of the trade name is related to the market, use and promotion. The name given by each merchant may vary depending on the product positioning.
Like the ancient medicinal stone, the same type is called differently in various places, but its essence is the same thing. The synonyms and trade names of 4-difluoromethoxybenzenesulfonyl chloride are the same. Although the names are different, they are all important materials for chemical research and industrial applications.
Safety & Operational Standards
4-Difluoromethoxybenzenesulfonyl chloride is also a chemical product. Regarding its safety and operating standards, it cannot be ignored.
This product has certain risks. Its nature may be strong, and it may change under improper circumstances. When handling, be sure to follow specific regulations.
First protection. The operator must wear appropriate protective gear, such as corrosion-resistant clothing, gloves, and goggles to prevent it from splashing on the body and eyes. And in the place of handling, it should be ventilated to make the air smooth and avoid gas accumulation and risk.
Secondly, there are rules for handling. When taking it, it should be slow and careful to avoid its sudden tilting and splashing. When mixing other substances, you should proceed in sequence and observe the changes in detail. If there is a reaction, predict the process and fruit, and prepare corresponding strategies.
Furthermore, storage is also necessary. It is advisable to keep it in a cool and dry place, avoid fire and heat, and keep it away from flammable and fried objects. Labels are clear, indicating its name, sex, and risk, so that people can easily identify it.
If it is accidentally dyed, dispose of it as soon as possible. When it touches the skin, rinse it with water urgently, and then apply it with appropriate medicine; when it enters the eye, rinse it with water for a long time, and seek medical treatment.
In short, the handling of 4-difluoromethoxybenzenesulfonyl chloride must be based on safety and follow the operating regulations to avoid disasters and protect the safety of the body and the goods.
Application Area
4-Difluoromethoxybenzenesulfonyl chloride has a wide range of application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize drugs with special curative effects, and by precisely manipulating its chemical structure, it can achieve the purpose of treating specific diseases. In the field of pesticide creation, it also has significant effects, which can help develop efficient and low-toxicity pesticides, protect crops from pests, and improve crop yield and quality. In the field of materials science, or participate in the preparation of special materials, endow materials with unique chemical and physical properties, such as enhancing material stability and corrosion resistance. In many practical fields, these products are of great value and provide an important material basis for the development of related industries.
Research & Development
I have dedicated myself to the study of 4 - Difluoromethoxybenzenesulfonyl Chloride. At the beginning, I observed its physical properties, the color was pure and the state was stable, but the preparation was difficult, just like the difficulty of Shu Dao. I have exhausted all kinds of techniques, tried and failed repeatedly, and my heart is burning. Fortunately, I have been inspired by ancient books, changed the order of materials, and regulated the temperature and time, and finally achieved success.
Not only have this product been obtained, but also its application has been researched. In the field of organic synthesis, add it to the reaction, such as a skilled craftsman adding materials, the reaction is smooth, and the quality of the product is also excellent. Looking at its effect in pharmaceutical research and development, it can adjust the properties of molecules, and is expected to become the foundation of good medicine.
At present, although the research of 4 - Difluoromethoxybenzenesulfonyl Chloride has made progress, the road ahead is still long. I should continue to study, hope to expand its use, for the prosperity of chemical industry and medicine, do my best to promote its long-term development, and live up to the mission of our generation of scientific research.
Toxicity Research
Since modern times, chemical refinement, new things come out. Today there is a thing, named 4 - Difluoromethoxybenzenesulfonyl Chloride, which may be useful in various karma. However, we should study its toxicity for the sake of learning.
The toxicity of this thing is related to the safety of living beings and the tranquility of the environment. Or try it on insects, birds and beasts, observe the change of its form and spirit, and the difference in physiology. Observe the path of its entry into the body, through the skin, through the mouth, or by breathing, and study its transmission in the body, and the involved viscera and meridians.
And think about it in the environment, in contact with water, light, and temperature changes, the new quality produced increases and decreases in toxicity. If it is accidentally leaked, it will cause trouble in water, soil and air. Our chemical researchers should investigate deeply and make sure to clarify the details of its toxicity, so as to be a lesson for the world and ensure the safety of all things.
Future Prospects
4-Difluoromethoxybenzenesulfonyl chloride, this chemical substance, has great hope for future development in our chemical research. Its structure is exquisite, its properties are unique, and it seems to hold endless possibilities.
Looking at the prosperity of today's chemical industry, the research of many new materials and new drugs depends on such fine chemicals. 4-Difluoromethoxybenzenesulfonyl chloride may emerge in the field of new drug synthesis, with its unique chemical activity, or it can create special drugs to cure various diseases.
In the field of material science, it is also expected to give birth to novel materials. It may be able to modify polymers and make materials have better properties, such as weather resistance, wear resistance, corrosion resistance, etc., creating a new situation for the construction, electronics and other industries.
We should dedicate ourselves to exploring its mysteries, looking forward to the future, and use its power to promote the progress of chemistry, benefit all people, and show endless brilliance on the road of science.
Frequently Asked Questions
What are the chemical properties of 4-difluoromethoxybenzenesulfonyl chloride?
4-Diethylaminoethoxyhexanoic acid ethyl ester (DEAE-dextran) is a kind of substance with special chemical properties. It dissolves in water and exhibits cationic properties, which gives it the ability to dissociate cations in water due to the diethylamino group contained in the molecule.
Looking at its chemical structure, the ethoxy chain and the ethyl hexanoate part give it a certain lipophilicity, while the diethylamino group enhances its water solubility and causes it to have a certain amphiphilicity.
Because of its cationic properties, it can interact with negatively charged substances such as nucleic acids, proteins, etc. by electrostatic attractive forces. This property is widely used in the field of biological experiments. For example, in transfection experiments, it can bind to nucleic acids to assist nucleic acids in crossing cell membranes and entering cells, promoting the introduction of foreign genes.
And because of the chemical activity of some groups in its structure, under appropriate conditions, it can participate in chemical reactions and realize the modification of its structure to meet the needs of different experiments or applications. However, its stability is also affected by environmental factors, such as temperature, pH value, etc. Under extreme pH conditions, the protonation state of diethylamino may change, which in turn affects its charge characteristics and chemical properties. When the temperature is too high, its chemical bonds may be broken, affecting its structure and function. In conclusion, ethyl 4-diethylaminoethoxyhexanoate has unique chemical properties and has played an important role in many fields.
What are the main uses of 4-difluoromethoxybenzenesulfonyl chloride?
Ethyl 4-diethylaminoethoxyhexanoate, commonly known as tetracaine, is a local anesthetic and has many important uses. The details are as follows:
First, it is used for surface anesthesia. The practitioner drops tetracaine solution on the mucosal surfaces of the eyes, nose, and throat. The drug can penetrate the mucosa, block nerve impulse transmission, and temporarily disappear local pain. Ophthalmic surgeries such as corneal foreign body removal, superficial mass excision of the eye, or ENT surgeries such as nasal polyps removal and laryngoscopy are often used as surface anesthesia to make patients feel pain during surgery.
Second, conduction anesthesia is feasible. Injecting tetracaine near the nerve trunk can block nerve conduction and cause anesthesia in the area it innervates. If you need to anesthetize the brachial plexus nerve for upper limb surgery, or if you want to anesthetize the sciatic nerve for lower limb surgery, you can use conduction anesthesia to make the surgical site painless, which is convenient for doctors to operate and reduce the pain of patients.
Third, it is used for subarachnoid anesthesia. That is, lumbar anesthesia, tetracaine is injected into the subarachnoid space, and the drug acts on the spinal nerve root to produce anesthesia in the corresponding area. This anesthesia method is often used in lower abdominal and lower limb surgeries, such as cesarean section, lower limb fracture incision, reduction and internal fixation, etc., which can provide good surgical conditions and ensure the smooth progress of the operation.
Fourth, epidural anesthesia can be implemented. Tetracaine is injected into the epidural space, and the drug acts This method of anesthesia is widely used, abdominal surgery, waist surgery, lower limb surgery and many other surgeries can be applied, not only can effectively relieve pain, but also can adjust the anesthesia range and time according to the needs of surgery.
What is the preparation method of 4-difluoromethoxybenzenesulfonyl chloride?
To prepare 4-diethylaminoethoxybenzaldehyde oxime hydrochloride, the method is as follows:
First take an appropriate amount of 4-diethylaminoethoxybenzaldehyde and place it in a clean reaction vessel. This aldehyde is the starting material for the reaction, and its purity and quality need to be ensured before the subsequent reaction can be smooth.
Next, add an appropriate amount of hydroxylamine hydrochloride. Hydroxylamine hydrochloride is a key reagent in this reaction, and a specific chemical reaction occurs with benzaldehyde. When adding, it should be added slowly, and stirred moderately at the same time, so that the two are fully mixed to promote the uniform progress of the reaction.
During the reaction process, temperature control is crucial. It is usually necessary to maintain the reaction system at a suitable temperature range, which may be within a specific range depending on the specific reaction conditions. If the temperature is too high or too low, it may adversely affect the reaction rate and product formation. If the temperature is too high or the side reactions increase, the product will be impure; if the temperature is too low, the reaction will be slow and take a long time.
The reaction lasts for a period of time, during which close attention should be paid to the process of the reaction. The degree of the reaction can be monitored by various analytical methods, such as thin-layer chromatography. When the reaction reaches the expected level, that is, the raw materials are exhausted or the amount of product generated becomes stable, follow-up treatment is carried out.
After the reaction is completed, the product is separated and purified. Methods such as extraction and crystallization can be used. At the time of extraction, select a suitable extractant, extract the product from the reaction mixture, and separate it from impurities. After that, perform crystallization operations to adjust the temperature and concentration of the solution to make the product crystallize and precipitate. After multiple crystallization and washing, a pure 4-diethylaminoethoxybenzaldehyde oxime hydrochloride product can be obtained.
The whole preparation process requires fine operation in each step, and strict control of the reaction conditions and reagent dosage can produce high-quality target products.
What are the precautions for storing and transporting 4-difluoromethoxybenzenesulfonyl chloride?
Sodium 4-diethylaminoethoxyethanaphthalene sulfonate, this agent has many things to pay attention to when storing and transporting.
When storing, the first choice of environment. Be sure to store in a cool, dry and well-ventilated place. The cover can avoid changes in its properties due to excessive temperature in a cool environment, and the dry state can prevent it from moisture and deterioration. Well-ventilated can prevent the accumulation of harmful gases from affecting it. If placed in a place with high temperature, humidity or no air circulation, the agent may decompose and agglomerate, resulting in damage to its quality and weakened efficacy.
Furthermore, it must be stored separately from oxidizing agents and acids. The oxidizing agent is highly oxidizing, and the acid is chemically active. Both of them are easy to chemically react with sodium 4-diethylaminoethoxyethanaphthalene sulfonate, causing dangerous accidents such as combustion and explosion. At the same time, it is necessary to make a good mark, indicating the name, characteristics, hazards and emergency treatment methods of the agent, so as to access and manage it. The storage place should be equipped with suitable materials for containing and handling leaks, so as to prevent accidental leakage, so as not to pollute the environment and damage the safety of personnel.
When transporting, it should not be slack. The packaging must be tight and stable to ensure that there is no risk of leakage of the agent during the transportation turbulence. The selected means of transportation should be clean, dry, and free of other residues that may react with it. During transportation, it is necessary to strictly control the temperature and avoid direct sunlight and rain. Direct sunlight and rain will damage the quality of the medicine.
In addition, transportation personnel should be familiar with the characteristics of the medicine and emergency treatment measures. In the event of an emergency such as leakage or fire, they can quickly act according to the established plan to reduce losses and hazards. And the transportation process must follow relevant regulations and standards to ensure safe and orderly transportation.
What is the market price range of 4-difluoromethoxybenzenesulfonyl chloride?
At present, the price of 4-diethylaminoethoxybenzaldehyde bromide in the city varies according to quality, supply and demand. High-quality products, with pure quality, less miscellaneous, and fine craftsmanship, may be expensive. However, ordinary products, the price is slightly lower.
In the bustling city of Kyoto, among the pharmacies, if there are many people in need of this material, but there are few suppliers, the price must go up. Because merchants are all chasing profits, rare is expensive. I heard that there was a market in the past, and the price of this product was doubled due to natural disasters.
Roughly speaking, the price per catty is as low as tens of dollars, and if the quality is high, it may reach hundreds of dollars. In the market, bargaining is also a common thing. Those who are good merchants can buy at a good price by observing the current situation and observing supply and demand. There are also merchants who come from afar, bringing things into the market, and their prices may be different from those in the local area. Due to their travel fees, taxes, etc., they are all included in the price.
And what is produced in various places has different quality and different prices. What comes from the north is heard for its high quality, and the price is often higher than elsewhere. For those in the south, or because of water, soil, and craftsmanship, the quality is slightly inferior, and the price is also lower. However, the change in price is not solely due to quality, supply and demand, but also involves decrees and fortunes. Those who are good merchants must carefully observe it, so that they can profit.