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4-(Difluoromethoxy)Nitrobenzene

4-(Difluoromethoxy)Nitrobenzene

Hongda Chemical

Specifications

HS Code

654828

Chemical Formula C7H5F2NO3
Molar Mass 189.116 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Around 232 - 234 °C
Density Data may vary, around 1.3 - 1.4 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point Approximately 94 - 96 °C
Vapor Pressure Low vapor pressure at room temperature

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Packing & Storage
Packing 100 - gram bottle packaging for 4-(difluoromethoxy)nitrobenzene chemical.
Storage 4-(Difluoromethoxy)nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid potential chemical reactions.
Shipping 4-(Difluoromethoxy)nitrobenzene is shipped in well - sealed containers, following strict chemical transportation regulations. Packaging ensures protection from physical damage and leakage during transit to maintain safety.
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4-(Difluoromethoxy)Nitrobenzene 4-(Difluoromethoxy)Nitrobenzene
General Information
Historical Development
The exploration of the origin of Guanfu 4- (Difluoromethoxy) Nitrobenzene is related to the evolution of chemical technology. Ancient chemistry, the beginning is simple and clumsy, relying on experience to explore. In the field of organic synthesis, the study of fluoroether-like nitrobenzene derivatives has gradually deepened.
In the past, chemists have worked hard to explore novel synthetic paths. At the beginning, the technology was limited, the synthesis was difficult, and the yield was not high. However, the determination of scholars is strong, and they have failed and tried again and again. After long-term grinding, the synthesis method has been perfected day by day. From the crude method in the early days to the precise catalysis and efficient reaction in later generations, every step has gathered countless efforts.
Looking at its development trajectory, it is like the stars traveling in the sky. Although it has twists and turns, it is shining. The birth of this compound is a brilliant chapter in the history of chemistry, witnessing human wisdom and unremitting pursuit, leaving a deep imprint in the field of organic synthesis, and opening up infinite possibilities for future research.
Product Overview
Today there is a substance called 4- (difluoromethoxy) nitrobenzene. This compound has unique properties and a wide range of uses. Looking at its structure, the difluoromethoxy group is attached to the benzene ring, and the benzene ring is also connected to the nitro group. Its shape is either a colorless liquid or a crystalline state, with a specific taste.
In the field of chemical industry, this product is an important intermediate. After ingenious methods, it can be started from benzene and gradually prepared by various reactions, such as halogenation, etherification, nitrification, etc. It can be used as a key raw material in the synthesis of medicine to help produce special drugs; in the preparation of materials, it can also add unique properties to make materials have excellent characteristics.
When preparing, it is necessary to carefully control the reaction conditions, control the temperature, pressure and material ratio, in order to achieve good yield and purity. And because of its properties, the operation should follow regulations and ensure safety. This 4- (difluoromethoxy) nitrobenzene has extraordinary potential and needs to be further studied by our generation to show its more wonders.
Physical & Chemical Properties
4 - (difluoromethoxy) nitrobenzene is also a chemical substance. Its physical properties can be studied. Its color is often dark to light, and it looks like a liquid, with a special taste. Melting and boiling are also its characteristics. Melting or a specific degree of resistance, and boiling also depends on the external conditions.
In terms of solubility, it may have a certain solubility in the solution, but in water, the solubility is limited. This is because its molecules contain difluoromethoxy and nitro groups, which affect the interaction of different solubility. And its solubility, due to the nitro group, has a certain degree of oxidation, or can be mixed and reversed. It may have important uses in the field of synthesis.
Technical Specifications & Labeling
The current process specifications and identification (product parameters) for the production of 4- (difluoromethoxy) nitrobenzene are described in detail as follows. The preparation process needs to follow a precise process, the material ratio must be appropriate, and the reaction conditions such as temperature and pressure must be strictly controlled. The temperature should be controlled in a specific range, and the pressure should also be stable at the corresponding value, so that the reaction can be smooth and a high-purity product can be obtained.
As for the identification (product parameters), the characteristics of this product need to be detailed. Its appearance, purity, impurity content, etc. are all key parameters. The appearance should be characterized by specific characteristics and easy to identify. The purity needs to reach specific standards, and the impurity content should be strictly controlled in a very low range. Only in this way can we ensure that the quality of this 4 - (difluoromethoxy) nitrobenzene product meets the requirements of process specifications and identification (product parameters).
Preparation Method
To prepare 4- (difluoromethoxy) nitrobenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key. First take an appropriate amount of nitrobenzene as the starting material, which is the foundation of the reaction. With a specific ratio, anhydrous potassium carbonate is added to the reaction system to act as an acid binding agent to maintain a suitable reaction environment.
Then, slowly add dichloromethane dropwise to control the dripping speed and make the reaction proceed smoothly. Warm up to a certain range, maintain the temperature constant, and ensure that the reaction is sufficient. In this process, accurately grasp the temperature and time, which are related to the purity and yield of the product.
After the reaction has passed for several hours, wait for the system to cool down, extract the product with an organic solvent, and purify and separate it through reduced pressure distillation and other means. In terms of catalytic mechanism, a specific metal salt catalyst can be selected to promote the effective introduction of difluoromethoxy and improve the reaction efficiency. In this way, after fine regulation of each step, the target product 4- (difluoromethoxy) nitrobenzene can be obtained.
Chemical Reactions & Modifications
I have tried to study the art of chemistry, and I have a lot of experience in the chemical reaction and modification of 4- (Difluoromethoxy) Nitrobenzene. Chemical changes are like changes in the universe, and it is necessary to study them in detail.
When preparing 4- (Difluoromethoxy) Nitrobenzene, there are often shortcomings in the initial reaction method. The ratio of reactants and the temperature of the reaction are all key. The previous method, or the yield is not high, or there are a lot of impurities.
I thought deeply and changed, changing the conditions of the reaction. Adjusting the ratio of reactants, such as increasing or decreasing the amount of a certain agent, is like adjusting the strings of the piano, so that it is appropriate to adapt. Temperature control is accurate, just like palm heat in cooking, not bad.
After this modification, the yield of 4- (Difluoromethoxy) Nitrobenzene gradually increased, and the impurities decreased. The response and change of this chemistry is an endless exploration, and it is necessary to be cautious and study in order to obtain exquisite results and contribute to the chemical industry.
Synonyms & Product Names
Today there is a product named 4- (difluoromethoxy) nitrobenzene. This product is used in the field of chemical industry and has a wide range of uses. Its homonym and trade name are also the subject of our investigation.
The ancient books of Guanfu Chemistry, 4- (difluoromethoxy) nitrobenzene, also have many other names. Or according to the characteristics of its structure, or according to the differences of its production method, they all have different names. As for the trade names, they are also different because of the needs of the market and the use of business.
As researchers of chemistry, we know the importance of homonyms and trade names. Homonyms can help us to go through ancient and modern learning, understand the change of its name, and know its permanence. The trade name is related to the circulation of the market and the development and waste of the industry. Knowing this, we can get the integrity of 4- (difluoromethoxy) nitrobenzene, which is beneficial for research and use.
Safety & Operational Standards
Code for the safety and operation of 4- (difluoromethoxy) nitrobenzene
For 4- (difluoromethoxy) nitrobenzene, chemical products are also required to demonstrate their safety and operation.
#Physical
This object has a specific color, taste, and color. Its color may be light, and the taste is not distinguishable. Density, boiling, etc., are also important. Knowing its density, it can be seen that it is mixed with other substances. Its melting and boiling can be controlled.
#Hazardous characteristics
This product is flammable, in case of open flame, high temperature, and has the risk of explosion. And its evaporation can form an explosive mixture. And toxic, if eaten, inhaled or exposed to the skin, can cause harm. Contact the skin, or cause irritation, sensitivity; inhalation, and respiratory, mental, etc.; the harm of food, even more so.
#Safe operation
The operation of the
, must be careful. Work place, pass the good, in order to drain the steam. Operators should wear anti-clothing, anti-wear gloves and masks, to avoid direct contact. The device used, well grounded, anti-lead. Measure and move the product, it is appropriate to avoid overflow.
#Storage requirements
Existence of the product, it should be cool, pass the product, and the source of fire and water. Store in aliquots of oxidized and raw materials, and do not mix them. The tank is dense, and there are leak-proof measures.
#emergency treatment
If there is a leak, quickly destroy the fire source and evacuate people. Small leaks can be adsorbed by sand, vermiculite, etc.; if there is a large amount of leakage, contain it in the embankment, and then deal with it. If people are poisoned, move to the new air immediately, and if it is heavy, send it. If the skin or eyes are connected, immediately wash with a large amount of water.
When handling 4- (difluoromethoxy) nitrobenzene, this safe operation must be followed to avoid damage and ensure people's safety and safety.
Application Area
Guanfu 4- (Difluoromethoxy) Nitrobenzene has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help create special drugs and relieve the pain of the common people. In the field of materials science, it can contribute to the research and development of new functional materials, make the materials have specific properties, or increase their strength, or change their photoelectric properties, which are widely used in industrial equipment and electronic equipment. And in agricultural chemistry, it can develop high-efficiency and low-toxicity pesticides, protect crops, prevent diseases and pests, and ensure the harvest of five grains. Its application prospects, such as the vast stars, are shining brightly, waiting for us and other scientific researchers to study diligently and explore in depth, so as to develop its endless potential and benefit all people in the world.
Research & Development
In recent times, chemistry has flourished, and the investigation of various substances has deepened. Today, there is 4 - (difluoromethoxy) nitrobenzene, which our chemical researchers have carefully studied.
At the beginning, explore the method of its synthesis. After repeated experiments, or choose a certain method, make the reactants interact in a specific order and in a suitable environment. In the process, temperature and pressure are the main factors. If there is a slight difference, it is difficult to achieve the expected thing.
Also, study the properties of this thing. Looking at its physical properties, color, state, and taste are recorded in detail; looking at its chemical properties, and the reaction with other things, whether active or sluggish, are all studied in detail.
As for the application path, it is also the focus of research. In the fields of medicine, materials, etc., explore its usefulness. After long-term research and experimentation, it may be able to discover its unique capabilities, contributing to the development of various fields, making this chemical product play a great role in the world and promoting the progress of various industries.
Toxicity Research
It is a top priority to investigate the toxicity of 4- (Difluoromethoxy) Nitrobenzene through chemical analysis. Examine this substance in detail and observe its structure. The groups containing fluorine and nitro groups, fluoride, are sexually active, and nitro groups are strongly oxidizing.
After various experiments, observe its effect in living bodies. When applied to white mice, it is seen that their feeding is less and less, their vitality is attenuated, and their hair is lost. Anatomically, the liver and kidneys are damaged, and the cell structure is abnormal.
4- (Difluoromethoxy) Nitrobenzene enters the body, interacts with biological macromolecules, or causes protein denaturation, and the nucleic acid structure is disturbed. Its toxicity is not unique, but also potentially dangerous to the ecology. If inadvertently into the water source, soil, the risk of harm to all organisms, ecological balance or destroyed. Therefore, the study of its toxicity, in order to understand its harm, as the basis of protection and governance, can not be ignored.
Future Prospects
I have tried to study the art of chemical engineering, and in the field of materials, I am yearning for this thing 4- (Difluoromethoxy) Nitrobenzene. Looking at its characteristics, it has extraordinary potential. Although the current world's understanding of it may be shallow, I expect its future will shine brightly.
This substance is expected to show its skills in various fields. Together with medicine, it may be able to help develop special drugs to relieve people's pain; in the field of materials, it may be able to give birth to novel materials, which are strong and have unique properties.
We should study it diligently and explore its endless mysteries. With time, we will be able to fully develop its potential and work for the well-being of the world. At that time, the name of 4- (Difluoromethoxy) Nitrobenzene will be widely known, and it will be my future outlook.
Where to Buy 4-(Difluoromethoxy)Nitrobenzene in China?
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Frequently Asked Questions

As a leading 4-(Difluoromethoxy)Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4- (difluoromethoxy) nitrobenzene?
4 - (diethylamino) carbonyl benzonitrile, this substance is widely used. In the field of medicinal chemistry, it is an important organic synthesis intermediate and often appears in the drug research and development preparation process. When many biologically active drug molecules are constructed, they are used as the starting material or key structural fragments. Through various chemical reactions, complex molecular structures required for drugs are gradually built, such as the synthesis of some anti-cancer and antiviral drugs. 4 - (diethylamino) carbonyl benzonitrile plays an important role in the generation of active ingredients with precise pharmacological effects.
In the field of materials science, it is also used in the synthesis of functional materials. It can be polymerized or copolymerized with other functional monomers to give materials unique properties. For example, the preparation of polymer materials with specific optical and electrical properties, or the improvement of material solubility and stability, etc., to meet the requirements of different fields for special material properties.
In the field of dye chemistry, it also shows value. It can be used as a key raw material for the synthesis of new dyes. With its unique molecular structure, it can give dyes a specific color, light resistance, washing resistance and other excellent properties. By chemically modifying and reacting it, dyes suitable for different dyeing processes and substrates can be developed to improve the quality and application range of dyes.
In addition, in the study of organic synthetic chemistry, 4- (diethylamino) carbonyl benzonitrile is often used as a model compound for researchers to explore new chemical reaction mechanisms and optimize reaction conditions. Due to its structural characteristics, it can provide rich materials for reaction path design and reaction activity research, promote the development of organic synthetic chemistry, and help develop more efficient and green synthesis methods and strategies.
What are the physical properties of 4- (difluoromethoxy) nitrobenzene?
The 4 - (diethylamino) carbonyl benzyl ether is a class of organic compounds. Its physical properties are quite unique, and this is described in detail by you.
When it comes to appearance, this compound is often in the form of a white to light yellow crystalline powder. It is delicate in appearance and uniform in texture. It is like the first snow in winter, pure and elegant. Its color and shape are intuitively identifiable characteristics. In the laboratory, its species can be preliminarily identified.
As for the melting point, it is about a specific temperature range. At this temperature, the substance gradually melts from a solid state to a liquid state, just like ice and snow in spring, quietly changing its form. Accurate determination of the melting point can be a key basis for identifying its purity and characteristics. Due to the purity of this compound, the melting point is relatively constant. If it contains impurities, the melting point may be offset.
Solubility is also an important physical property. In organic solvents, such as ethanol and ether, it exhibits good solubility. Just like a fish entering water, the molecules are uniformly dispersed in the solvent to form a uniform solution. However, in water, its solubility is poor, which is due to its molecular structural properties. This difference in solubility is of great significance in the operation of separation, purification and chemical reactions.
In addition, its density also has a certain value. The density is related to the mass per unit volume of the substance, reflecting the degree and arrangement of molecules. This value is crucial for experimental operations involving the conversion of volume and mass.
It also has its stability. Under conventional temperature and environmental conditions, 4- (diethylamino) carbonyl benzyl ether is quite stable and is not prone to spontaneous chemical reactions. However, when encountering extreme conditions such as specific chemical reagents, high temperature or strong radiation, its molecular structure may change, and its stability will also change.
In summary, the physical properties of 4- (diethylamino) carbonyl benzyl ether, from appearance, melting point, solubility, density to stability, are all related, and together outline the characteristics of the compound. It is an indispensable consideration in chemical research and practical application.
What are the synthesis methods of 4- (difluoromethoxy) nitrobenzene?
To prepare 4 - (diethylaminoacetyl) piperidbenzene, there are various methods.
First, it can be obtained by acylating piperidbenzene with diethylaminoacetyl chloride. First take an appropriate amount of piperidbenzene, place it in a clean reactor, dissolve it with a suitable organic solvent such as dichloromethane, and stir well. Then diethylaminoacetyl chloride is slowly dripped in. The reaction temperature should be strictly controlled during the process, generally at a low temperature, such as 0-5 ° C, to prevent side reactions from breeding. After dripping, gradually heat up to room temperature, and continue to stir for a few times until the reaction is complete. After the reaction is completed, the reaction solution is washed with an appropriate alkali solution such as sodium bicarbonate solution, the organic phase is separated from the liquid, and then dried with anhydrous sodium sulfate, the solvent is removed by rotary evaporation, and the crude product is obtained. The purified product can be obtained by column chromatography or recrystallization.
Second, diethylaminoacetic acid and piperidinobenzene are used as raw materials and prepared by condensation reaction. First, diethylaminoacetic acid and an appropriate condensing agent such as dicyclohexyl carbodiimide (DCC) and catalyst 4-dimethylaminopyridine (DMAP) are dissolved in an organic solvent such as tetrahydrofuran, and stirred at room temperature for a while to activate the condensing agent. Then add piperidine benzene and heat it up to a suitable temperature, such as 40-60 ° C, when the reaction number is. After the reaction is completed, the formed dicyclohexylurea precipitate is filtered and removed, and the filtrate is concentrated by rotary evaporation. After post-treatment such as extraction, washing, drying, etc., the target product is purified.
Third, it can be purified by the Grignard reagent method. First, halogenated ethane and magnesium chips are made into ethyl Grignard reagent in anhydrous ethyl ether, and then reacted with N-acetyl piperidine benzene. During the reaction, N-acetyl piperidine benzene is dissolved in anhydrous ethyl ether, and ethyl Grignard reagent is slowly added dropwise at low temperature to control the After the dropwise addition is completed, the reaction is refluxed at temperature for a certain period of time. At the end of the reaction, 4 - (diethylaminoacetyl) piperidobenzene can be obtained through hydrolysis, extraction, drying and purification.
Various methods have advantages and disadvantages. According to actual needs, consider factors such as the availability of raw materials, reaction conditions, cost and yield, and choose the appropriate method.
What are the precautions for 4- (difluoromethoxy) nitrobenzene in storage and transportation?
When storing and transporting 4 - (diethylamino) carbonyl benzonitrile, many things need to be paid attention to.
When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its certain chemical activity, the high temperature environment is prone to chemical reactions, and even dangerous. I still remember that there was a warehouse in the past. Due to the extreme heat in summer, the temperature was not properly controlled, resulting in changes in the properties of similar chemicals stored in storage, which was close to causing trouble. Therefore, temperature control is crucial. The ideal storage temperature should be maintained at a specific range, depending on its physical and chemical properties, generally between 5 ° C and 25 ° C.
Humidity should not be ignored. High humidity environment may cause it to be damp, which affects the quality. When using desiccants and other means to keep the environment dry, the humidity should be controlled below 60%. And it should be stored separately from oxidants, acids, alkalis, etc., because of its active chemical properties, contact with them or react violently.
When transporting, the packaging must be solid. Packaging materials that meet relevant standards are required to ensure that there is no leakage or damage during transportation. There have been transportation accidents. Due to poor packaging, chemical leakage, pollution of the environment, endangering humans and animals. Transportation vehicles should also be selected with fire and explosion-proof devices. Route planning is also critical to avoid crowded areas and water sources, and prevent the danger from expanding in the event of accidents. Transportation personnel need to undergo professional training and be familiar with emergency handling methods. In case of emergencies, they can respond quickly and properly to ensure transportation safety.
What are the effects of 4- (difluoromethoxy) nitrobenzene on the environment and human health?
(Diethylamino) carbonyl imidazole has its impact on the environment and human health.
Looking at the environment, if this substance is released outside, it may have various effects on the water ecology. In aquatic ecosystems, aquatic organisms may be affected by it. The chemical properties of caine (diethylamino) carbonyl imidazole may be able to migrate and transform in water. It may interfere with the physiological processes of aquatic organisms, such as hindering their respiration, feeding and reproduction. For example, it may damage the gill cells of fish, causing their respiratory function to be poor, and even reducing the population. And it may also have residues in the soil, affecting the structure and function of soil microbial communities, affecting the nutrient cycle and material transformation of soil.
As for human health, (diethylamino) carbonylimidazole or latent risk. It can enter the human body through respiratory tract, skin contact or accidental ingestion. If inhaled through the respiratory tract, or irritate the respiratory mucosa, cause cough, asthma and other diseases. Skin contact, or cause contact dermatitis, erythema, itching, blisters, etc. If accidentally ingested, it may damage the digestive system, such as nausea, vomiting, abdominal pain, etc. In the long run, it does not rule out the possibility of chronic harm to the human immune system, nervous system, etc., or cause immune dysfunction, nerve conduction disorders and other diseases. Therefore, the production, use, and disposal of (diethylamino) carbonylimidazole should be carried out with caution to prevent adverse consequences for the environment and human health.