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4-(Difluoromethoxy)Benzenesulfonyl Chloride

4-(Difluoromethoxy)Benzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    612817

    Chemical Formula C7H5ClF2O3S
    Molecular Weight 244.63
    Appearance Typically a colorless to light - yellow liquid
    Boiling Point Data may vary, generally in a specific range related to its structure
    Melting Point Specific value depending on purity and structure
    Density Appropriate value based on its molecular composition
    Solubility Soluble in certain organic solvents
    Flash Point A defined value indicating flammability risk
    Vapor Pressure Characteristic value at a given temperature
    Reactivity Reactive towards nucleophiles due to the sulfonyl chloride group

    As an accredited 4-(Difluoromethoxy)Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4-(difluoromethoxy)benzenesulfonyl Chloride in a sealed, corrosion - resistant container.
    Storage 4-(Difluoromethoxy)benzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture ingress, as it is reactive with water. Store it separately from incompatible substances like bases, amines, and reducing agents to avoid potential chemical reactions.
    Shipping 4-(Difluoromethoxy)benzenesulfonyl Chloride is shipped in accordance with strict chemical regulations. Packed in corrosion - resistant containers, it's transported under controlled conditions to prevent reactivity and ensure safe delivery.
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    4-(Difluoromethoxy)Benzenesulfonyl Chloride 4-(Difluoromethoxy)Benzenesulfonyl Chloride
    General Information
    Historical Development
    Fu4- (difluoromethoxy) benzenesulfonyl chloride is also an organic compound. At the outset, chemists worked hard to explore various reaction paths, hoping to gain something. At the beginning, the conditions were not good, the yield was meager, but everyone worked tirelessly. After years, the technology has gradually improved, and the synthesis method has advanced. From simple devices to exquisite instruments, from rough control to precise regulation. Its development is like a boat going against the water. If you don't advance, you will retreat. Chemists study day and night, improve the steps, and optimize the conditions to make the preparation of this compound increasingly sophisticated. Therefore, the historical evolution of this compound is the cohesion of the efforts of all chemists, and it is also a testament to scientific progress.
    Product Overview
    4- (difluoromethoxy) benzenesulfonyl chloride is an important chemical compound in chemical research. Its appearance is often colorless to light yellow liquid with a special odor. This compound is widely used in the field of organic synthesis. In its molecular structure, difluoromethoxy is cleverly connected to benzenesulfonyl chloride, giving it unique chemical activity.
    In the reaction, 4- (difluoromethoxy) benzenesulfonyl chloride can be used as a key reagent to participate in many organic reactions. If it reacts with alcohols, it can form corresponding sulfonates; when it reacts with amines, it can form sulfonamide compounds. These are all important steps in organic synthesis to build complex molecular structures. Its reactivity and selectivity are deeply influenced by reaction conditions, such as temperature, solvent, and catalyst, all of which require fine regulation in order to achieve the expected reaction effect and meet the needs of chemical research and actual production.
    Physical & Chemical Properties
    4- (difluoromethoxy) benzenesulfonyl chloride This material has unique physical and chemical properties. Its shape may be a colorless to slightly yellow liquid, and it is clear to observe. Melting point and boiling point each have their own numbers, and what the melting point is has not been observed in detail; under a specific pressure, the boiling point can reach a certain value, which is the key temperature of gasification. Its density is determined, and the mass per unit volume can be known, which is related to the specific gravity of the rise and fall.
    Solubility is also an important property. It may be soluble in organic solvents such as ethanol and ether, but may be repulsive with water due to its molecular structural properties. In terms of chemical activity, sulfonyl chloride groups are active and easily react with nucleophiles. They can be used as key raw materials for organic synthesis, participate in the construction of various compounds, and have great potential and far-reaching influence in the field of drug and material synthesis.
    Technical Specifications & Labeling
    4- (difluoromethoxy) benzenesulfonyl chloride, its process specifications and identification (product parameters) are the key. The process specifications of this compound need to accurately control the reaction conditions, the ratio of raw materials must be appropriate, and the reaction temperature and duration also need to be strictly controlled to ensure the stability of product quality.
    In terms of identification, its chemical name, molecular formula, molecular weight and other key parameters should be clearly marked for easy identification. And it must be accompanied by necessary warning labels to indicate its chemical properties and latent risks to ensure user safety. Strict adherence to process specifications and accurate identification is the cornerstone of producing high-quality 4- (difluoromethoxy) benzenesulfonyl chloride products, which cannot be slack in the whole process of chemical production.
    Preparation Method
    The raw materials of this 4 - (difluoromethoxy) benzenesulfonyl chloride are crucial to the production process, reaction steps and catalytic mechanism.
    The raw materials prepared by
    , when appropriate benzene compounds are taken, supplemented by reagents containing difluoromethoxy groups, the precise ratio of the two is the foundation for the reaction. The production process is first adjusted to a moderate temperature in a clean and temperature-controlled reactor, and the raw materials are put into the raw materials in sequence.
    At the beginning of the reaction step, the raw materials are slowly blended in the kettle, and the catalyst is added in a timely manner to stimulate the reaction. The catalytic mechanism is that the catalyst activates the reactant, lowers the reaction barrier, and promotes its efficient conversion. During this period, close monitoring of changes in temperature and pressure, fine-tuning in a timely manner, and After the reaction is completed, pure 4- (difluoromethoxy) benzenesulfonyl chloride is obtained by separation and purification, which is the main method for preparing this substance.
    Chemical Reactions & Modifications
    Taste the technology of chemical industry, exquisite and subtle, related to the change of matter and the wonder of creation. Today there is a thing named 4- (Difluoromethoxy) Benzenesulfonyl Chloride, and its chemical reaction and modification have a lot to learn.
    The reaction of this thing needs to be observed in its environment and conditions. The difference in temperature and humidity, the presence or absence of catalysts, can affect its change. When the temperature and pressure are appropriate, with a good medium, the reaction may be smooth and the yield will increase.
    As for the way of modification, it is aimed at improving its properties and performance. Or add groups to change its activity; or adjust the structure to change its characteristics. Hope to get a new quality and develop your talents in various fields. To make this compound useful in medicine and materials, and to benefit the world, this is the ambition of our chemical researchers.
    Synonyms & Product Names
    4 - (difluoromethoxy) benzenesulfonyl chloride, its synonym, is also the key to chemical research. In the process of chemical research in China, it is often encountered that there are more than one substance. 4 - (difluoromethoxy) benzenesulfonyl chloride, or another name, all refer to the same thing.
    This substance has its own uniqueness and is used in various fields of chemical synthesis. It can be used as a raw material or a reagent to help form various chemical products. And the names of the various industries may be different due to inheritance, region and habit. However, its origin is 4 - (difluoromethoxy) benzenesulfonyl chloride.
    Our chemical researchers should be aware of the fact that their synonyms are different, no matter what they are called, they can be sure of what they are referring to, so as to facilitate the advancement of the research, avoid the error of the similarity of the names, and ensure the accuracy of the chemical research.
    Safety & Operational Standards
    4- (difluoromethoxy) benzenesulfonyl chloride, the product of chemical. Its safety and operation regulations, the most important in the industry.
    This thing is corrosive, touching the skin and eyes, can cause injury. When operating, you must wear protective clothing and protective gear to avoid contact with the body. If you accidentally touch the skin, quickly rinse with water and seek medical attention; the same is true when entering the eyes, and when flushing, your eyelids will turn over and clean.
    And it is easy to disperse in the air, and if you suck it, you will exhale. The operation area must be well-connected, or set up a row. If you suck it, quickly go to a new place, and if it is serious, seek medical attention.
    Although the flammability of this substance is weak, it will be exposed to heat, fire, or life insurance. When storing, it must be placed in a cool, dry place to avoid heat, fire and oxygen agents. During transportation, follow the regulations and standards to ensure stability.
    The process of operation, the distribution of agents, the control of temperature, and the palm of time are all important. Must follow the fine rules, do not change them without authorization. After each operation, the device must be cleaned, the waste must be handled, and the environmental regulations must be observed.
    In sum, the safety and operation rules of 4- (difluoromethoxy) benzenesulfonyl chloride must be familiar with the operator, and follow them to avoid risks and ensure the smooth operation of the industry.
    Application Area
    4- (difluoromethoxy) benzenesulfonyl chloride, this chemical has a wide range of uses. In the field of medicine, it can be used as a key intermediate and participate in the synthesis of many special drugs. With its unique chemical structure, it can cleverly react with other compounds to give drugs specific therapeutic effects, such as antibacterial, anti-inflammatory, etc., to escort human health. In the field of materials science, it also plays an important role. It can be used to prepare polymer materials with special properties, which can be chemically reacted into polymer chains to improve the chemical stability and heat resistance of materials, and broaden the application scenarios of materials. In the field of fine chemicals, it is even more indispensable. It can be used as a raw material for the synthesis of fine chemicals such as special surfactants and catalysts. Through precise reactions, products that meet different industrial needs can be manufactured, helping the fine chemical industry to flourish.
    Research & Development
    Today there is a product named 4- (Difluoromethoxy) Benzenesulfonyl Chloride. As a chemical researcher, I am quite concerned about its research. The properties of this product are related to the reaction path and the quality of the product, so it is necessary to study it carefully.
    Study the method of its synthesis, and strive to improve. The method of the past may have the disadvantages of being complicated and inefficient. Now we should seek new ways to improve yield and reduce energy consumption. In terms of reaction conditions, temperature, pressure, and catalyst, all factors are carefully considered to achieve the best state.
    Looking at its application field, the prospect is broad. In the production of medicine, or as a key raw material, to help the development of new agents to solve the suffering of diseases. In the manufacture of materials, or give special properties to expand their use. We should do our best to promote its development, add new colors to the industry, and benefit everyone.
    Toxicity Research
    Wenfu 4- (Difluoromethoxy) Benzenesulfonyl Chloride This substance, our generation should focus on toxicology research. The toxicologist is related to the safety of life and the rise and fall of society.
    Now observe this substance in detail, observe its molecular structure, and explore its chemical properties. Or enter the body, flow through the bloodline, invade the viscera, and disrupt its physiological order. Or touch the skin, erode its texture, and cause illness to be invisible.
    Therefore, various experiments need to be set up, with white pigs and guinea pigs as tests, to observe the consequences of their intake and inhalation. Observe changes in their diet and activities, and analyze the damage to their organs. It also studies cells to see their microscopic changes, and studies the effects of this substance on cell growth and metabolism.
    Only by understanding its toxicity can we know its harm, set restrictions, prevent problems before they occur, ensure everyone's well-being, and protect the environment.
    Future Prospects
    Fu 4- (difluoromethoxy) benzenesulfonyl chloride is very important in my chemical research. Its future development is quite promising.
    Viewing its properties, it has unique chemical and physical properties, and is an important agent for various reactions. In the field of organic synthesis, it can open up new avenues and expand new territories. Based on it, it may be able to produce exquisite compounds for use in medicine, materials and other industries, benefiting people's livelihood.
    And with the advancement of science and technology, the better the research method, the deeper the understanding of it will be. Or it can optimize the preparation method, improve production and quality, reduce costs and increase efficiency. With time, it will be able to shine in the industrial realm, bring well-being to the world, and shine brightly on the undeveloped path, with boundless prospects.
    Where to Buy 4-(Difluoromethoxy)Benzenesulfonyl Chloride in China?
    As a trusted 4-(Difluoromethoxy)Benzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Difluoromethoxy)Benzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 4- (difluoromethoxy) benzenesulfonyl chloride?
    The physical properties of 4 - (dihydroxyacetyl) thiazole blue solution are as follows:
    Its appearance is often blue solution. In terms of solubility, it can be better dissolved in specific organic solvents, which is convenient for dispersion and mixing in various experimental systems, so that it can evenly participate in the relevant reaction process.
    The solution has a certain density, and this density value is relatively stable within a specific range, which is essential for accurate measurement and control of the dosage during experimental operation, and can ensure the consistency and accuracy of experimental conditions.
    From the perspective of viscosity, its viscosity is moderate, neither too viscous to cause dumping and transfer difficulties, nor too thin to be difficult to operate and control accurately.
    In terms of optical properties, the solution has a characteristic absorption peak in a specific wavelength range, which makes it useful as an indicator or marker in spectral analysis and other fields. Its absorption characteristics are monitored by spectroscopic instruments, thus providing intuitive and accurate information feedback for the experimental process or reaction results.
    In addition, the solution is sensitive to external conditions such as temperature and light. Excessive temperature may cause it to decompose or change its properties. Changes in light duration and intensity may also affect its stability and related properties. Therefore, during storage and use, these environmental factors need to be properly controlled to maintain the stability of its physical properties and ensure the reliability and repeatability of experimental results.
    What are the chemical properties of 4- (difluoromethoxy) benzenesulfonyl chloride?
    The chemical properties of (diethylamino) malondialdehyde are quite unique. It has certain reactivity and often shows a unique state in chemical reactions.
    In the field of organic synthesis, (diethylamino) malondialdehyde can be used as a key intermediate. Because its structure contains aldehyde and diethylamino groups, aldehyde groups are electrophilic and can react with many nucleophilic reagents. For example, it can react with alcohols through condensation to form acetal compounds. This reaction has a wide range of uses in the construction of complex organic molecular structures and can help form specific cyclic or chain-like structures.
    Furthermore, the amino moiety of (diethylamino) malondialdehyde also has characteristics. The nitrogen atom of the amino group has a lone pair of electrons, making it alkaline to a certain extent. Therefore, it can react with acids to form corresponding salt compounds. At the same time, the amino group can also participate in nucleophilic substitution reactions, interact with electrophilic reagents such as halogenated hydrocarbons, and realize the alkylation of amino groups, so as to modify the molecular structure and derive many compounds with different properties and functions.
    Moreover, due to the interaction between aldehyde groups and amino groups in the molecule, the electron cloud distribution of (diethylamino) malondialdehyde is also adjusted, affecting its reactivity and selectivity. Under some conditions, aldehyde groups may preferentially participate in the reaction; in other cases, amino-related reactions are more significant. This property allows chemists to precisely adjust the reaction conditions according to specific needs, guide the reaction in the desired direction, and synthesize the target product, making a significant contribution to the field of organic chemistry synthesis.
    What are the main uses of 4- (difluoromethoxy) benzenesulfonyl chloride?
    4 - (diethylamino) benzaldehyde oxime chlorohydrazone is mainly used in the field of analytical chemistry. This substance is often used as an analytical reagent and plays a crucial role in the qualitative and quantitative analysis of many metal ions.
    In qualitative analysis, it can react specifically with specific metal ions to generate products with unique physical properties, such as precipitation, color change, etc., so as to determine the presence or absence of specific metal ions in the solution. For example, if it encounters a metal ion or shows a distinct color change, the analyst can infer the existence of the metal ion based on this color change. This property makes it indispensable for the preliminary identification of metal ions.
    In the field of quantitative analysis, some physical quantities of 4- (diethylamino) benzaldehyde oxime chlorohydrazone and metal ions are quantitatively related to the concentration of metal ions under specific conditions. By accurately measuring these physical quantities, such as absorbance, precipitation quality, etc., combined with relevant chemical principles and mathematical calculations, the concentration of metal ions in solution can be accurately determined. In environmental monitoring, the determination of the content of specific metal ions in water samples often relies on this substance, thus providing key data for evaluating environmental quality.
    Furthermore, in some chemical synthesis reactions, 4- (diethylamino) benzaldehyde oxime chlorohydrazone may also act as an intermediate to participate in the reaction process and help generate the target product. Its unique chemical structure gives it a unique activity in a specific reaction path, which promotes the reaction to progress in the expected direction, and then provides an important boost for organic synthetic chemistry. In conclusion, 4 - (diethylamino) benzaldehyde oxime chlorohydrazone plays a key role in many fields such as analytical and synthetic chemistry, and its importance cannot be ignored.
    What is the synthesis method of 4- (difluoromethoxy) benzenesulfonyl chloride?
    To prepare 4- (diethylamino) benzaldehyde oxime, the method is as follows:
    First take an appropriate amount of 4- (diethylamino) benzaldehyde and place it in a clean reaction vessel. This aldehyde is the key raw material for the initiation of the reaction, and its properties and purity have a great impact on the subsequent reaction. Therefore, careful measurement is required when taking it to ensure accuracy.
    Then, in another container, carefully prepare the solution containing the oximizing reagent. Usually, an appropriate hydroxylamine salt, such as hydroxylamine hydrochloride, is dissolved in an appropriate amount of solvent. Common solvents include water, alcohols, etc., depending on the specific reaction conditions and requirements. The dissolution process requires constant stirring to promote the full dissolution of the hydroxylamine salt to ensure the uniformity of the solution.
    When the hydroxylamine salt solution is properly prepared, slowly add it dropwise to the reaction vessel containing 4- (diethylamino) benzaldehyde. The dripping speed needs to be carefully controlled. If it is too fast, the reaction will be too violent and it is easy to cause an increase in side reactions. If it is too slow, it will take too long and affect the reaction efficiency. When adding dropwise, pay close attention to the temperature, color and other changes of the reaction system and adjust it in a timely manner.
    After the dripping is completed, continue to stir the reaction mixture to make the reaction fully proceed. During this period, the reaction temperature can be adjusted appropriately according to the characteristics of the reaction. Some reactions can proceed smoothly at room temperature, but there are also those that need to be heated or cooled to ensure that the temperature meets the needs of the reaction to improve the yield and purity of the product.
    After the reaction is completed, the reaction mixture is post-treated. The common method is to extract with a suitable organic solvent to separate the target product from the reaction system. After extraction, the organic phase is washed and dried to remove residual impurities.
    Finally, the purity of 4- (diethylamino) benzaldehyde oxime is further improved by distillation, recrystallization and other purification methods to obtain a product that meets the requirements. The whole preparation process requires fine operation and strict control of all links by the experimenter to obtain the desired result.
    What should be paid attention to when storing and transporting 4- (difluoromethoxy) benzenesulfonyl chloride?
    When storing and transporting 4 - (dihydroxyethylamino) benzaldehyde oxime chloride, many points should be paid attention to.
    This substance is chemically active, and the storage environment should be kept cool, dry and well ventilated. Do not place it in a high temperature or humid place, because high temperature can easily cause its chemical reaction to intensify, or cause decomposition and deterioration; humid environment may cause it to react with water vapor, causing its purity to be damaged.
    Storage should be kept away from fire and heat sources, because it has certain flammability, and there is a risk of combustion and explosion in case of open flames and hot topics. And it must be stored separately from oxidizing agents, acids, alkalis, etc., to avoid mixed storage to prevent violent chemical reactions.
    When transporting, the relevant regulations must also be strictly followed. The packaging must be tight to ensure that there is no risk of leakage during transportation. Select suitable means of transportation, and prevent exposure to sun, rain, and high temperature during transportation. Transport personnel must be familiar with the characteristics of this substance and emergency treatment methods. In the event of leakage and other accidents, they can respond quickly and properly.
    The loading and unloading process must be handled with care to avoid packaging damage due to collisions, drops, etc. In the event of a leak, the leaking area should be immediately isolated and access restricted. Emergency responders should wear dust masks (full masks) and gas-proof clothing to avoid contact between leaks and combustible substances (such as wood, paper, oil, etc.). Small leaks can be collected in a dry, clean, covered container with a clean shovel. Large leaks need to be built embankments or dug for containment, covered with foam to reduce steam disasters, and then dealt with in accordance with relevant regulations.