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4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene

4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    900421

    Chemical Formula C8H5ClF4
    Molecular Weight 214.57
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Data may vary, around a certain temperature range (specific value needs literature check)
    Melting Point Data may vary, around a certain temperature range (specific value needs literature check)
    Density Value depends on conditions, needs literature check
    Solubility In Water Low solubility in water
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Vapor Pressure Value depends on temperature, needs literature check
    Flash Point Data may vary, around a certain temperature range (specific value needs literature check)

    As an accredited 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 - gram vial packaging for 4-(chloromethyl)-1-fluoro-2-(trifluoromethyl)benzene.
    Storage 4-(Chloromethyl)-1-fluoro-2-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources, open flames, and oxidizing agents. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances to prevent reactions. Ensure proper labeling for easy identification and handling.
    Shipping 4-(Chloromethyl)-1-fluoro-2-(trifluoromethyl)benzene is shipped in accordance with chemical regulations. It's carefully packaged in suitable containers to prevent leakage during transit, ensuring safe delivery.
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    4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    The chemical industry is changing with each passing day, and various compounds have come into being. Today there are 4- (chloromethyl) -1-fluoro-2 - (trifluoromethyl) benzene compounds, which originated from the research of scholars in the past.
    At the beginning, everyone explored the field of organic synthesis, hoping to obtain novel structures. After years of experiments, the sages prepared formulas, changed conditions, and worked tirelessly. The basic chemical raw materials were used at the beginning, and after many reactions, the embryonic form of this compound was gradually obtained.
    Years passed, and the technology became more and more exquisite. Later scholars optimized the process and improved the yield and purity on the foundation of predecessors. Its application has also become increasingly widespread, emerging in the fields of medicine and materials, becoming an indispensable part of the development of the chemical industry, and driving this field forward to achieve today's grand scene.
    Product Overview
    Description of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene
    There is currently a product named 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene. Its shape may be a colorless liquid with a special odor.
    This product is widely used in the field of organic synthesis. It can be used as a key intermediate, involved in the preparation of medical drugs and pesticides. In the creation of medicine, or as the basis for the synthesis of special drugs, to assist in the treatment of diseases. In the development of pesticides, or to create efficient pesticides, to protect the growth of plants and prevent the invasion of diseases and pests.
    The preparation method requires fine study of chemical principles, control of reaction conditions, selection of appropriate raw materials and reagents, and obtained through multi-step reactions. However, when preparing, be careful about safety and environmental protection, because it contains fluorine, chlorine elements, or has potential effects on the environment and human body.
    In summary, 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene is of great significance in the development of the chemical industry, and it should be used with caution.
    Physical & Chemical Properties
    4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene, the physical and chemical properties of this substance are important to our research. Its appearance may be a colorless to light yellow liquid with a special odor. In terms of boiling point, it has been accurately measured to be within a certain temperature range, which reflects the critical conditions for its transition from liquid to gaseous state.
    When it comes to solubility, it may exhibit good solubility in organic solvents, while solubility in water needs to be investigated in detail. Density is also a key property, which can help us to determine the stratification of it when mixed with other substances.
    Its chemical activity cannot be ignored, because it contains functional groups such as chloromethyl, fluorine and trifluoromethyl, or can participate in a variety of chemical reactions, such as nucleophilic substitution, addition, etc., providing many possibilities for subsequent chemical synthesis research.
    Technical Specifications & Labeling
    There is a product today, named 4- (Chloromethyl) -1-Fluoro-2- (Trifluoromethyl) Benzene. To make this product, the process specification and identification (product parameters) are the key. The process specification requires clear material ratio, reaction conditions, such as temperature, pressure, and reaction time, so that the steps are clear and orderly, so that a pure product can be obtained.
    As for the identification (product parameters), the properties of this product should be listed in detail, such as color, odor, and morphology; its physical and chemical properties, melting point, boiling point, solubility, etc. are also required. The process specification is the standard of the product, and the identification (product parameters) is the evidence for the identification of the product, which complement each other. It is indispensable for the development of 4- (Chloromethyl) -1-Fluoro-2- (Trifluoromethyl) Benzene.
    Preparation Method
    In order to prepare 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene, the raw materials and production process, reaction steps and catalytic mechanism are crucial.
    First take an appropriate amount of fluoroaromatic hydrocarbons as the starting material, which is the foundation. Supplemented by specific halogenating reagents, the halogenation reaction is initiated at a suitable temperature and catalyst. The temperature needs to be precisely controlled. If it is too high, side reactions will breed, and if it is too low, the reaction will be delayed. The activity and selectivity of the catalyst used need to be adapted to make the reaction smooth.
    In the reaction step, the first step of halogenation generates a key intermediate, and the structural characteristics of this intermediate have a profound impact on the subsequent process. Then, the intermediate is converted into a specific functional group and chloromethyl is introduced. In this step, it is necessary to pay attention to the mildness of the reaction conditions to prevent damage to the existing fluorine and trifluoromethyl groups.
    In terms of catalytic mechanism, the catalyst used needs to be able to effectively reduce the activation energy of the reaction and promote the efficient progress of the reaction. At the same time, it has a guiding effect on the reaction path to ensure that the selectivity of the product is as expected. In this way, through various steps, 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene can be prepared.
    Chemical Reactions & Modifications
    Guanfu 4- (Chloromethyl) -1-Fluoro-2- (Trifluoromethyl) Benzene, in the field of chemistry, its reaction and modification are very important. To clarify its details, it is necessary to study all kinds of reaction mechanisms.
    Its chloromethyl, fluorine and trifluoromethyl structures endow unique chemical properties. Chloromethyl is active and is often the target of nucleophilic substitution reactions, which can lead to different groups and change their properties. Fluorine atoms have high electronegativity, which can change the distribution of molecular electron clouds and affect the reaction activity and selectivity. Trifluoromethyl has strong electron absorption and also affects the reaction process.
    By chemical modification, or adjusting its physical properties, such as melting point, boiling point, or changing its chemical activity, it has great potential in the fields of drug and material synthesis. Scholars should study its reaction path in detail, control conditions, and seek optimal modification to expand its use and contribute to chemistry.
    Synonyms & Product Names
    4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene, this substance is very important in chemical research. There are many aliases. From the perspective of academic inquiry, chemists may give aliases to professional terms according to their structural properties. However, in the commercial field, merchants will also give unique trade names for the convenience of promotion.
    The ancients said: "The famous person is the real guest." The aliases and trade names of this chemical revolve around its essential characteristics and uses. In the laboratory, scholars communicate or use academic aliases to show accuracy; in market transactions, trade names are easier to spread.
    Looking at this 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene, its alias reflects the delicate structure, and the trade name contains commercial considerations. The alias helps researchers to express accurately, and the trade name attracts users' attention. Although the two names are different, they both refer to this key chemical, and in the field of chemistry, they each develop their own capabilities and complement each other.
    Safety & Operational Standards
    4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene safety and operating specifications
    Fu 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene is a chemical research often involved in the substance. Its unique nature, related to experimental safety and accurate operation, cannot be ignored.
    On the safety side, this substance is potentially harmful. The structure of chloromethyl, fluorine and trifluoromethyl may cause chemical activity to highlight. The skin that touches, or irritates, causes redness, swelling and pain. In the eye, it is particularly harmful and may damage the vision. If inhaled inadvertently, or damage the respiratory tract, causing cough, asthma, and even life-threatening. Therefore, the experimenter must take strict protective measures.
    The way of protection, the first heavy equipment. The experimenter is wearing protective clothing, which is dense and tough, and can resist the erosion of this substance. Wear protective gloves, and the material is suitable to ensure that the hands are complete. Goggles are also indispensable, clear and visible, and can prevent the risk of splashing.
    When operating, the specification comes first. The laboratory must be well ventilated, and an effective ventilation system must be set up to allow the rapid discharge of harmful gases. To take this substance, it is appropriate to use precise equipment, and the amount must meet the needs of the experiment. The operating table is always kept clean. If there is a leak, remove it immediately. In addition, according to its nature, choose the appropriate reagent to neutralize or absorb it to prevent its diffusion.
    Furthermore, there are regulations for storage. It should be stored in a cool, dry place, protected from heat and open flames. Separate from other substances, prevent chemical action. Label clearly, remember its name, sex and hazards for inspection.
    In general, the safety and operation specifications of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene are a compulsory course for experimenters. If you follow them, the experiment will go well and protect your body; otherwise, the disaster will come, and it will be too late to regret.
    Application Area
    Today there is a product named 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene. This product has a wide range of uses in the field of chemical industry.
    It can be used as a key intermediate in the synthesis of medicine. With its unique structure, it can participate in many reactions, help to form special drugs, and cure various diseases. For example, through subtle reactions, specific groups can be introduced to make anti-disease medicines, which can cure diseases for patients.
    In the field of materials science, it also has potential. It may be able to optimize the properties of materials to make them more stable and weather-resistant. Such as adding polymers to enhance the material's resistance to external erosion, used in construction, electronics and many other fields to increase its utility and lifespan.
    Furthermore, in fine chemical products, it can be used as an additive. Make the product have special properties, such as improving the leveling of coatings, enhancing the adhesion of inks, etc., to achieve the quality of fine chemical products.
    Research & Development
    In recent years, I have been studying chemical substances, focusing on the compound 4- (Chloromethyl) -1-Fluoro-2- (Trifluoromethyl) Benzene. At first, explore its properties, observe its response to other substances, and record its changes in detail. Also study the method of its preparation, seek a better path, hope to improve its production and reduce its consumption.
    In the process of research, I have encountered difficulties. If the reaction is difficult to control, the removal of impurities is not easy. However, I have not been discouraged, I have tried to change it again and again, and with new technologies and new machines, I have gradually overcome difficulties. Now there are methods that can be obtained, and the production has also improved.
    I think this research is not limited to this, but should be expanded. Hope to explore together with Tonghao, promote the application of this compound in the fields of medicine and materials, promote its development, and benefit the world.
    Toxicity Research
    Taste the harm of poisons in the world, even more than tigers. Today, among chemical substances, there are 4- (Chloromethyl) -1-Fluoro-2- (Trifluoromethyl) Benzene, and the study of its toxicity is particularly important.
    This chemical may exist in industrial processes, and its nature is unknown. We who are scholars should study its toxicity with caution. Or through animal tests, observe its physiological changes, observe the damage of organs; or study its molecular structure, and understand its response to biomolecules.
    The study of toxicity concerns the safety of everyone. If this product is toxic and accidentally leaked into the wild, the mountains, rivers, plants, birds, beasts, insects and fish will all suffer from it; if it enters the water source, the people will drink it, and it will also suffer from it. Therefore, the study of toxicity must be diligent and meticulous, so as to avoid disasters and ensure the safety of life in the world.
    Future Prospects
    In the future, for 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene, it contains high performance. This compound is not special, and its properties are not special. In the field of synthesis, it can be used in the field of synthesis, to explore new synthetic pathways, and to give birth to many advanced materials. In the research and development, it may be able to create its special and special effects to overcome the problem. In terms of materials science, it is expected to produce high-performance functional materials, which can be used in the frontiers of electronics, aviation, etc. And if the synthesis method is refined again, the efficiency will be improved and the cost will be reduced, and it will be widely used. On the way of technological progress, it will be able to expand the color and promote the development of many fields.
    Where to Buy 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene in China?
    As a trusted 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
    4- (cyanomethyl) -1 -cyanomethyl-2- (tricyanomethyl) benzene is a chemical substance with special uses in the field of organic synthesis. Its main use is as an intermediary in organic synthesis. In the field of fine chemical synthesis, it is often used to build the structural skeleton of complex organic molecules. Because its molecular structure is rich in cyanide groups, cyanide groups have high reactivity and can participate in many types of chemical reactions, such as nucleophilic substitution, addition reactions, etc., which can realize the synthesis and transformation of various organic compounds.
    Furthermore, in the field of materials science, 4- (cyanomethyl) -1-cyanomethyl-2- (tricyanomethyl) benzene also plays an important role. It can be introduced into the structure of polymer materials through a specific reaction path, thereby improving the properties of polymer materials. For example, it can improve the physical properties such as heat resistance and mechanical strength of materials, making the materials more suitable for application needs in special environments, such as aerospace, electronics and other fields that require strict material properties.
    In addition, in pharmaceutical chemistry research, this compound can be used as a structural unit of the lead compound due to its unique molecular structure. Through structural modification and modification, it is expected to develop new drugs with specific biological activities, and open up new avenues and directions for pharmaceutical research and development. In short, 4- (cyanomethyl) -1-cyano-2- (tricyanomethyl) benzene has shown important application value in many fields such as organic synthesis, materials science, and medicinal chemistry due to its special structure and reactivity.
    What are the physical properties of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
    (4- (Methoxy) -1-ene-2- (trimethylsilyl) benzene, this material is very different. Its color is clear, like the first condensation of morning dew, pure and free of impurities. At room temperature, it is in a flowing state, like a river gurgling, very smart.)
    Its boiling point is unique, about a certain temperature range, just like a specific star in the sky, shining a unique light in the sky. This number of boiling points is its unique sign in the field of heat, so that it follows this established rule when it is heated and changed. The melting point of
    is also fixed, just like the boundary point where the earth sleeps in winter. When the temperature drops to this point, it is like a sleeping beast, gradually solidifying from the state of flow, showing the stability of the solid state.
    Solubility is also one of its characteristics. In some organic solvents, it is like a stream that merges into the sea, blending with it, showing good solubility, just like confidants meeting and accepting each other. In other solvents, it is difficult to integrate like a stone, maintaining its own independence and characteristics.
    In terms of density, it has a specific value, which seems to give itself a unique sense of weight and occupy a unique position on the balance of matter. This density allows it to follow specific laws in the mixing and separation of various substances, and deduce its own material legend. All kinds of physical properties are unique imprints carved in the material world, making it unique on the stage of chemistry.
    What are the chemical properties of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
    (Hydromethyl) -1 -Hydrogen-2 - (trihydromethyl) naphthalene has unique chemical properties. In this compound, the position of the naphthalene ring attached to (hydromethyl) and (trihydromethyl) has a great influence on its properties.
    In terms of its physical properties, the naphthalene ring has a certain planar structure due to its conjugated system, which makes the compound have a certain rigidity. And the existence of carbon-hydrogen bonds in (hydromethyl) and (trihydromethyl) makes it have a certain polarity, but the overall polarity is weakened by the non-polar conjugated structure of the naphthalene ring. Therefore, in organic solvents, its solubility may change compared with the naphthalene itself, and in polar organic solvents, its solubility may be slightly better than that of naphthalene.
    According to the chemical properties, the electron cloud distribution of the naphthalene ring is affected by (hydromethyl) and (trihydromethyl). (hydromethyl) and (trihydromethyl) as power supply groups can increase the electron cloud density of the naphthalene ring, especially the adjacent and para-site electron clouds connected to the substituents. This makes the electrophilic substitution activity of the compound higher than that of naphthalene. Electrophilic reagents are easy to attack the parts with high electron cloud density of the naphthalene ring. When halogenation, nitrification, sulfonation, etc., the reaction rate is accelerated, and the substituents are easy to enter the adjacent and para-sites.
    At the same time, the activity of carbon-hydrogen bonds in the compound also changes. ( Hydrogen methyl) and (trihydromethyl) in α-hydrogen are affected by the naphthalene ring and substituents, and have a certain acidity. Under the action of appropriate bases, deprotonation reactions may occur, which can lead to subsequent reactions, such as substitution reactions with electrophilic reagents to construct new carbon-carbon bonds or carbon-hetero bonds, which have potential application value in the field of organic synthesis.
    What are the synthesis methods of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
    To prepare 4- (methoxy) -1 -methyl-2- (trifluoromethoxy) benzene, there are many methods, and now there are one or two of them.
    First, the corresponding halogenated aromatic hydrocarbons can be started. First, take halogenated benzene, such as bromobenzene, and methoxylation reagents, such as sodium methoxide, under suitable reaction conditions, carry out nucleophilic substitution reaction to introduce methoxy groups. This process requires attention to the reaction temperature and the choice of solvent. Commonly used solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc., can improve the solubility and reactivity of the reagents. The temperature depends on the activity of the specific reagent and the substrate. Usually at a moderate temperature, such as 50-100 ° C, the reaction can proceed smoothly.
    After the methoxy group is successfully introduced, another position on the benzene ring is modified. Introduce trifluoromethoxy in a specific method. At this time, reagents containing trifluoromethoxy groups can be selected, such as trifluoromethoxylation reagents in combination with suitable catalysts. For example, the introduction of trifluoromethoxy can be achieved by using a copper salt as a catalyst and reacting with the corresponding trifluoromethoxylation reagents. This step requires strict control of the reaction conditions, because the selectivity and activity of the trifluoromethoxylation reaction need to be precisely regulated. The amount of catalyst, reaction time and other factors all have a great influence on the yield and purity of the product.
    Second, benzene can also be used as the starting material to construct the target molecule through multi-step reaction. First, benzene and halogenated methane are carried out under the catalysis of Lewis acid catalysts such as aluminum trichloride, and Fu-gram alkylation is carried out, and methyl is introduced. This reaction is carried out under anhydrous conditions, and the reaction temperature needs to be carefully controlled to prevent the occurrence of polyalkylation side reactions.
    Subsequently, the benzene ring is methoxylated and trifluoromethoxylated. This process is similar to the corresponding steps in the above-mentioned halogenated aromatics method, but attention should be paid to the order of reaction and the optimization of conditions in each step. After each step of the reaction, the product needs to be separated and purified. Commonly used methods include column chromatography, recrystallization, etc., to ensure the smooth progress of the reaction and the purity of the product, and finally 4 - (methoxy) -1 - methyl - 2 - (trifluoromethoxy) benzene.
    What should be paid attention to when storing and transporting 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
    When storing and transporting 4- (methoxy) -1-pentyl-2- (trifluoromethoxy) benzene, pay attention to the following things.
    The first thing to pay attention to is its physical properties. The chemical structure of this substance contains specific functional groups, or has unique physical and chemical properties. For example, it may have specific boiling point, melting point, solubility, etc. Before storage, it is necessary to know its physical properties in detail, so that the appropriate storage conditions can be selected according to its characteristics. If its boiling point is low and volatile, it should be placed in a closed container to prevent escape.
    Its chemical stability is checked for the second time. The structure of methoxy group and trifluoromethoxy group, or the tendency of chemical reaction under specific conditions. In case of acid, alkali, oxidizing agent, reducing agent, etc., or react. Therefore, when storing and transporting, avoid contact with it. If it cannot be stored and transported with strong acid and alkali, it will avoid dangerous reactions.
    Furthermore, safety is paramount. Or toxic, irritating and other hazards. The place of storage should be well ventilated and have appropriate protective measures. When transporting, it is also necessary to use suitable packaging materials and warning labels in accordance with relevant regulations to ensure the safety of transporters and the environment.
    Repeat, environmental factors need to be considered. Temperature and humidity may have an impact on it. High temperature or cause its decomposition, evaporation to accelerate; high humidity environment, or cause its hydrolysis and other reactions. Therefore, the temperature of the storage place should be moderate, and the humidity should be controlled within a certain range.
    At the end of the rule, the records and labels should not be ignored. When storing, remember the name, specifications, quantity, date of storage and other information in detail. The packaging for transportation should also be clearly marked with ingredients, hazards, emergency treatment methods, etc., in order to deal with emergencies. In this way, the substance must be properly stored and transported to ensure its quality and safety.