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4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene

4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene

Hongda Chemical

    Specifications

    HS Code

    215758

    Chemical Formula C8H8ClFO
    Molecular Weight 174.599
    Appearance Typically a liquid (specific color may vary based on purity)
    Boiling Point Data may vary, around [X] °C (experimental determination needed for exact value)
    Melting Point Data may vary, around [Y] °C (experimental determination needed for exact value)
    Density Data may vary, around [Z] g/cm³ (experimental determination needed for exact value)
    Solubility Solubility in common organic solvents like ethanol, acetone; solubility in water is likely low
    Flash Point Data may vary, around [W] °C (experimental determination needed for exact value)
    Vapor Pressure Data may vary depending on temperature, experimental determination needed for exact value
    Refractive Index Data may vary, around [U] (experimental determination needed for exact value)

    As an accredited 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4-(chloromethyl)-1-fluoro-2-methoxybenzene packaged in a sealed glass bottle.
    Storage 4-(Chloromethyl)-1 -fluoro-2-methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and vapor release. It is best stored in a dedicated chemical storage cabinet, following safety regulations to avoid potential fire, explosion, or harmful exposure risks.
    Shipping 4-(Chloromethyl)-1-fluoro-2-methoxybenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict chemical shipping regulations to ensure safe transportation due to its potentially hazardous nature.
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    4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene
    General Information
    Historical Development
    4- (chloromethyl) -1-fluoro-2-methoxybenzene, the rise of this substance has gone through years. In the past, all the sages worked hard in the field of organic synthesis. At the beginning, only a little knowledge of its characteristics, it was difficult to make this substance. However, scholars are determined to study ancient methods and introduce new ones. After repeated trials, in the reaction conditions and raw material ratio, there have been gains. As a result, the preparation method has gradually matured, and the yield has steadily increased. From the difficult exploration at the beginning to the stable output today, the development of this substance has witnessed the process of chemical inquiry of our generation, and it has also paved the way for the subsequent great cause of organic synthesis, creating a new situation.
    Product Overview
    Today, there is a compound named 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene. This is an organic compound with a unique structure, containing chloromethyl, fluorine atoms and methoxy groups on the benzene ring.
    Chloromethyl groups are active and can initiate many substitution reactions, which is a key check point for the construction of new chemical bonds. Fluorine atoms have strong electronegativity, which can significantly change the physical and chemical properties of compounds, such as enhancing fat solubility and affecting intermolecular forces. Methoxy groups have a electron supply effect, which affects the electron cloud density distribution of the benzene ring, which is related to reactivity and selectivity.
    This substance is widely used in the field of organic synthesis, or can be used as an intermediate to create medicines, pesticides and materials. The carefully designed reaction path, with its active groups, can react with a variety of reagents to build complex and functional molecular structures, providing an important material foundation for the development of related industries.
    Physical & Chemical Properties
    4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene is an organic compound. Its physical and chemical properties are particularly important. This substance is volatile at room temperature or in a liquid state. Looking at its chemical structure, the presence of chloromethyl, fluorine atoms and methoxy groups endows it with unique reactivity.
    In terms of physical properties, it should have a specific boiling point and melting point, or it varies due to intermolecular forces. In terms of solubility, according to the principle of similar phase dissolution, it may have a certain solubility in organic solvents.
    In terms of its chemical properties, chloromethyl is active and can undergo nucleophilic substitution reactions. It is an important intermediate in organic synthesis. The electronegativity of fluorine atoms affects the distribution of electron clouds, and the electron density of benzene rings changes, which affects the selectivity of reaction check points. The methoxy group can stabilize the charge of the benzene ring, and also has an effect on the reactivity and selectivity. The physicochemical properties of this compound are of great significance in the fields of organic synthesis.
    Technical Specifications & Labeling
    4- (chloromethyl) -1-fluoro-2-methoxybenzene, its process specifications and identification (product parameters) are the key. Looking at this compound, the arrangement of chloromethyl, fluorine and methoxy groups determines its unique chemical properties.
    In terms of process specifications, the synthesis requires precise temperature control, pressure regulation, and the selection of suitable solvents and catalysts. The reaction time also needs to be carefully weighed, which is related to the purity and yield of the product. If a specific halogenation reaction is started, follow the established process to avoid side reactions. On the
    label, from the physical and chemical properties, such as melting point, boiling point, density, to the express indication of dangerous properties, such as flammability and toxicity, are all indispensable. The product parameters cover the content index and must meet the corresponding purity standards to meet the needs of market application. This is the essence of ensuring the effective application of this product in the chemical field.
    Preparation Method
    To make 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene, the raw materials and production process are very critical. The raw materials should be selected from pure products to ensure the quality of the product. In the production process, the reaction steps need to be carefully controlled.
    First take an appropriate amount of specific starting materials and mix them according to the exact ratio. In the reactor, control the appropriate temperature and pressure to slowly initiate the reaction. This process requires close attention to the reaction process and fine-tune the conditions according to its changes.
    After the reaction is completed, impurities are removed through the purification step. Purification can be carried out by distillation, extraction and other methods to achieve the requirements of high purity of the product.
    Furthermore, the catalytic mechanism is also important. Choose a high-efficiency catalyst to accelerate the reaction and improve the yield. And in the whole reaction process, strictly follow the specifications to ensure safe production, so as to become a high-quality 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene.
    Chemical Reactions & Modifications
    There is a compound called 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene. In the field of chemistry, its reaction and modification are the focus of our research.
    Looking at this compound, its structure is unique, chloromethyl, fluorine atoms and methoxy groups coexist in a benzene ring. This structure makes it specific in chemical reactions. Its chloromethyl group is active, and it is easy to involve nucleophilic substitution. It can be used as a path for introducing new groups, so that it can be derived from new compounds and has unique characteristics.
    Although fluorine atoms are small, they affect the distribution of molecular electron clouds, change their polarity and stability, and cause reactivity and direction to change. Methoxy groups, with their power supply, left and right electron densities of benzene rings, increasing the activity of benzene ring ortho-para-sites, which is conducive to specific reactions.
    In order to modify this substance, nucleophilic substitution can be selected to change chloromethyl; or benzene ring modification can be used to adjust its overall properties. Studying the reaction and modification of this 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene is of great benefit to chemical creation.
    Synonyms & Product Names
    4- (chloromethyl) -1-fluoro-2-methoxybenzene, the alias and trade name of this substance, is an important item of my chemical research. Its alias, or according to its structural characteristics, or from the name of past research heritage. As for the trade name, it is the logo used in market circulation, which is the key to distinguish congeneric products.
    In my research process, I often encounter many chemical substances, all of which have aliases and trade names. 4- (chloromethyl) -1-fluoro-2-methoxybenzene, its alias may show the unique chemical structure, or be named for a specific research stage. The trade name needs to meet the needs of marketing activities and product positioning. We chemical researchers need to clarify the aliases and trade names of this object in order to be accurate and not confused when researching and applying it. In this way, we can promote the progress of chemical research and help the rational application and market circulation of related products.
    Safety & Operational Standards
    4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is also a chemical product. The safety and operation regulations of the product must be detailed before it can be safe.
    This product has its properties, chloromethyl, fluorine and methoxy groups are concentrated in the benzene ring. The activity of chloromethyl is easy to cause nucleophilic substitution during the reaction. This requires the operator to be careful to avoid encountering nucleophilic strong agents, resulting in violent reactions.
    When operating, the first priority is the cleanliness and transparency of the environment. This product may be used in the air. If it is concentrated and high, it may explode in case of open flame or hot topic. Therefore, the operation should be well-maintained, and fireworks are prohibited.
    In addition, the operator must be protected. Wear special anti-chemical clothing, goggles and gloves. Because of the production of skin contact, eyes, or injury; inhalation of the body, but also harmful to health.
    When storing, it should be cool, dry, and open, protected from direct light. And stored in parts with oxygen agents and alkalis, do not mix.
    When used, dose control should be accurate. The reaction strip also needs to be strictly controlled, temperature, time, agent ratio, etc., are all related to the quality and safety of the product.
    In short, 4 - (chloromethyl) - 1 - fluoro - 2 - methoxybenzene safety and handling regulations, is the production and use of. Operators must be familiar with, follow, to ensure that everything goes smoothly, no safety.
    Application Area
    Today there is a thing named 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene, which is available in various fields. In the genus of medicine, it can be used as a raw material for making good medicines, helping to heal various diseases and enabling the recovery of the sick. In the field of chemical industry, it can be used as the foundation for synthesizing other substances, so as to form various exquisite materials, which are used in utensils, fabrics, etc. In the process of scientific research, it is the key to exploring the chemical mechanism, helping students to clarify the mystery of reactions, and opening up new frontiers of knowledge. It has a wide range of uses, such as the stars are in the sky, and it can emit light and heat in all fields, contributing to the life and academic development of the world, and the benefits are endless.
    Research & Development
    Today, there is a thing named 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene, which is of great importance to our chemical researchers. The research and development of this compound is what we love.
    We scrutinize its properties, study its structure, and explore its reaction rules. After repeated trials, we know how it changes under different conditions. Or combine with other things, or change itself, are recorded in detail and analyzed in detail.
    In the way of development, strive to improve. Think about how to improve its yield and quality. Or find a new way, or change the old method, hoping that the product can be made to a higher level. In this way, we can live up to our research and make this product more widely used in various fields, so as to advance the development of chemical research.
    Toxicity Research
    Since modern times, chemical refinement, all kinds of new substances have emerged. Today there are 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene this substance, and the study of its toxicity is crucial.
    The study of toxicity requires a detailed investigation of its properties. This substance has a unique structure. Chloromethyl, fluorine and methoxyl are combined in the benzene ring. Chloromethyl has strong activity, or leads to chemical reactions in organisms, messing with the order of its biochemistry. Although fluorine atoms are small, they change the physicochemical properties of molecules and have a huge impact. Methoxy or electron cloud distribution affects its reactivity and biological activity.
    After various experiments, observe its effect on biological cells. Observe the changes in cell morphology, measure the changes in metabolic function, and test the path of its toxicity. Either enter the cell, disturb the combination of nucleic acid and protein; or break the structure and function of the membrane, disrupt the cell homeostasis. Only by understanding its toxic mechanism can it be the basis for protective application, keep the health of the people, and promote the good progress of chemistry.
    Future Prospects
    I have tried to study chemical products, and today I say 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene this product. Looking at this product, it is unique and has a wide range of uses. In the future development, it can be used for the research of new medicines, adding new paths to cure diseases and diseases; or it can be used for the production of exquisite materials to make the properties of materials better. Although the research is not complete at present, it looks to the future, and its potential is endless. With time and careful research, it will be able to expand its use, shine in the fields of medicine and materials, add brilliance to human well-being, become an unfinished cause, and fulfill the beauty of the future.
    Where to Buy 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene in China?
    As a trusted 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene?
    4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to participate in the synthesis of various drugs. For example, in the preparation of some compounds with specific physiological activities, it can introduce functional groups such as chloromethyl, fluorine atoms and methoxy groups by virtue of its unique chemical structure, which affects the activity, solubility and stability of drug molecules, and then lays the foundation for the development of new specific drugs.
    In the field of organic synthesis chemistry, it is an important starting material for the construction of complex organic molecules. Due to the differences in the reactivity of different functional groups in the structure, carbon-carbon bonds or carbon-heteroatom bonds can be constructed through various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., to realize the construction of complex organic frameworks, and to assist in the synthesis of organic materials with special structures and properties.
    In addition, in the field of materials science, materials synthesized based on this compound may have unique optical, electrical or thermal properties. For example, synthetic polymer materials may exhibit specific fluorescence properties or good electrical insulation due to the functional groups introduced by the compound, which can be applied to optical sensors or electronic device insulation layers.
    What are the physical properties of 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene
    4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is a kind of organic compound. Its physical properties are particularly important for its application in various fields.
    Looking at its properties, under room temperature and pressure, this substance may be a colorless to pale yellow liquid with a clear texture. The characteristics of this color state may be related to the arrangement of atoms in the molecular structure and the distribution of electron clouds.
    When it comes to the boiling point, due to the existence of van der Waals forces between molecules and the interaction between specific functional groups, its boiling point is within a certain range. However, the exact value needs to be determined by professional experiments. In general, the presence of halogen atoms and methoxy groups increases the force between molecules, and the boiling point also increases.
    In terms of melting point, it is also determined by the molecular structure and force. Molecular regularity and functional group properties all affect the melting point. In this compound, the synergistic action of chloromethyl, fluorine atoms and methoxy groups causes its melting point to have a unique value.
    In terms of solubility, since it is an organic compound, it may have good solubility in common organic solvents such as ethanol, ether, dichloromethane, etc. Due to the principle of "similar miscibility", the organic properties of its molecular structure are similar to those of organic solvents. However, in water, due to its limited molecular polarity, solubility or poor.
    Density is also an important physical property. Its density is related to the molecular weight and the degree of intermolecular accumulation. The introduction of halogen atoms increases the molecular weight, or the density is higher than that of ordinary benzene compounds.
    In addition, the volatility of this compound may be volatile to a certain extent due to boiling point and intermolecular forces. In an open environment, it may evaporate slowly into the air.
    In summary, the physical properties of 4- (chloromethyl) -1-fluoro-2-methoxy benzene, such as color state, melting boiling point, solubility, density and volatility, are determined by its unique molecular structure, and are of great significance for applications in organic synthesis, materials science and other fields.
    What are the synthesis methods of 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene
    The synthesis method of 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene has been around for a long time. In the past, many wise men worked hard in the field of organic synthesis, and many achievements were made. Today, there are several methods available for everyone to study.
    First, the corresponding phenolic compound can be started. First, the phenol is methoxylated to introduce methoxy groups. In this step, reagents such as dimethyl sulfate or iodomethane can be used, catalyzed by bases, such as potassium carbonate, sodium hydroxide, etc., in suitable solvents, such as N, N -dimethylformamide (DMF), acetone, and heated to obtain methoxylation products. Then, the benzene ring is halogenated. For the introduction of fluorine atoms, nucleophilic fluorination reagents can be selected, such as potassium fluoride and phase transfer catalyst, such as tetrabutylammonium bromide, which can be reacted at high temperature to fluorinate specific positions in the benzene ring. For the introduction of chloromethyl, chloromethylation reagents can be used, such as chloromethyl ether or triformaldehyde and hydrogen chloride gas, under the catalysis of Lewis acid catalyst, such as anhydrous zinc chloride, to achieve the access of chloromethyl, and then obtain the target product 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene.
    Second, halogenated aromatics can also be used as starting materials. First, halogenated aromatics are reacted with metallic magnesium to form Grignard reagents. After that, it reacts with methoxy-substituted halogenated hydrocarbons to form methoxylated products. Then, after halogenation, fluorine atoms and chloromethyl groups are introduced successively. The specific reaction reagents and conditions are similar to those in the previous halogenation step.
    Both of these are feasible paths for the preparation of 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene. However, in actual operation, it is necessary to consider in detail according to specific conditions and needs and choose the best one.
    4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene what to pay attention to when storing and transporting
    4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is an organic compound, and many matters need to be paid attention to during storage and transportation.
    When storing, the first environment. It should be placed in a cool and well-ventilated place, away from fire and heat sources. Cover this kind of compound is flammable, and it is easy to cause combustion in case of open flame and hot topic. If the storage environment temperature is too high, or its volatilization intensifies, and the concentration accumulates in the air, it also increases the risk of fire and explosion.
    Furthermore, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. Due to its active chemical properties, it encounters with oxidants or causes severe oxidation reactions; contact with acids and bases may also cause chemical reactions, cause compounds to deteriorate, and even produce dangerous products.
    Packaging must be sealed to prevent moisture. Moisture may affect its chemical stability, or cause reactions such as hydrolysis, changing its chemical structure and properties.
    When transporting, also be cautious. Transportation vehicles must be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall, or damage. During driving, keep away from densely populated areas and avoid transporting during high temperatures. When loading and unloading, the operation should be handled lightly to prevent damage to the packaging and containers, so as to avoid the leakage of the compound and pose a threat to the environment and personal safety.
    In short, the storage and transportation of 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is related to safety and quality, and it needs to be operated in strict accordance with the regulations.
    What is the effect of 4- (Chloromethyl) -1-Fluoro-2-Methoxybenzene on the environment?
    4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, the influence of this substance on the environment is quite important and cannot be ignored.
    This compound contains chloromethyl, and the chlorine atom is active, and it may be prone to chemical reactions in the environment. If it enters natural water bodies, or reacts with substances in water, or causes changes in water quality, it affects aquatic organisms. Aquatic organisms are sensitive to chlorine, and trace amounts of chlorine-containing compounds may cause physiological abnormalities, resulting in stunted growth and reproduction.
    In addition, fluorine atoms are electronegative, and the molecular structure is stable. However, because of its stability, it is difficult to degrade in the environment, or it persists for a long time, accumulating in environmental media such as soil and water bodies. If this compound accumulates in the soil, it may affect the soil microbial community, destroy the soil ecological balance, cause soil fertility to decline, and affect plant growth.
    Although methoxy is relatively stable, it is transformed in complex environments, or due to microbial action, light, pH changes, etc. Its transformation products are also difficult to measure on the environment, or have more toxicity, or change the environmental chemical properties.
    And if 4- (chloromethyl) -1-fluoro-2-methoxybenzene volatilizes into the atmosphere, or participates in photochemical reactions, it affects atmospheric quality. Complex photochemical reactions in the atmosphere may produce new pollutants, endangering human health and the ecological environment.
    In conclusion, this compound has potential effects on all aspects of the environment and requires careful treatment and in-depth study of its environmental behavior to reduce its harm to the ecological environment.