4-Chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide is useful in many fields.
In the field of pharmaceutical research and development, it is often a key intermediate. By organic synthesis, this compound can build a special molecular structure, and the construction of many new drug molecules depends on it as a starting material or a participant in the key reaction process. For specific disease targets, it can be converted into substances with unique pharmacological activities through clever chemical modification and reaction, laying the foundation for the creation of innovative drugs.
In the field of pesticides, it also plays an important role. Due to its special chemical structure, it can endow pesticides with unique biological activities. It can either have an efficient toxic effect on certain pests, or inhibit the growth and reproduction of specific pathogens, thereby assisting agricultural production, ensuring the healthy growth of crops, and improving the yield and quality of agricultural products.
Furthermore, in the field of materials science, it also has potential value. Due to the special atoms such as fluorine and chlorine, it can endow materials with special physical and chemical properties. If used in the preparation of special polymer materials, it can improve the chemical resistance and heat resistance of materials, and expand the application range of materials in special environments.
In conclusion, 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide, with its unique structure, has shown a wide range of application prospects in the fields of medicine, pesticides, materials, etc., and has been relied on by many scientific research and practical production.

The physical properties of 4-chloro-N - (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide are crucial for many applications.
Looking at its appearance, it is mostly solid at room temperature and pressure. The color is usually white to off-white, and this color is pure, reflecting its high purity. When used in specific chemical and pharmaceutical fields, this characteristic can ensure that the appearance indicators such as product color meet standards.
Its melting point is also of great significance. After experimental determination, the melting point is about a specific temperature range, and the stability of the melting point is an important indicator to measure the purity and stability of the substance. The fixed melting point indicates that its molecular structure is regular and the internal force is balanced. When heated or applied in different temperature environments, its physical state can be controlled according to the melting point characteristics to achieve the expected reaction or application effect.
In terms of solubility, the substance exhibits a certain solubility in organic solvents. In organic solvents such as dichloromethane and chloroform, it can be moderately dissolved. This solubility provides convenience for its synthesis, purification and preparation processes. By selecting a suitable organic solvent, operations such as dissolution, separation and mixing of the substance can be realized, which can help prepare high-purity products or specific dosage forms.
Density is also the main point of its physical properties. Under specific conditions, the substance has a corresponding density value. The characteristics of density are indispensable in the process of material measurement, mixing ratio control, etc. Accurate density data helps to accurately prepare materials according to volume or quality, ensure the accuracy of the reaction system or formulation, and then ensure the stability of product quality and performance. The physical properties of 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide, from its appearance, melting point, solubility to density, have a profound impact on its research, production and application in chemical and pharmaceutical fields. Only by carefully grasping these properties can we make good use of this substance.

This is related to the stability of the chemical properties of 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide. This compound is composed of many special groups, and the chlorine atom, nitro group, trifluoromethyl group and benzenesulfonamide group all have a great influence on its properties.
Let's talk about the chlorine atom first, which has electron-absorbing properties, which can reduce the electron cloud density of the benzene ring, and can cause the reaction activity to change during the electrophilic substitution reaction. The coexistence of two chlorine atoms further enhances the electron-absorbing effect and affects the stability of the compound.
Nitro is a strong electron-absorbing group, which not only reduces the electron cloud density on the benzene ring, but also reduces the electron cloud density of the adjacent para-site even more. Interacting with 2-chlorine atoms, the electron cloud distribution of the benzene ring is significantly changed, the polarity of the whole molecule is enhanced, the intermolecular force is affected, and the stability is affected.
Trifluoromethyl is also a strong electron-absorbing group. Because of its high electronegativity, it will attract electrons, which further reduces the electron cloud density of the benzene ring. At the same time, its steric resistance is large, which affects the molecular spatial structure and the interaction of surrounding groups, and then affects the stability. In the benzenesulfonamide group, the sulfonyl group has strong electron-withdrawing properties, and the amide group can form hydrogen bonds, which not only affects the intermolecular forces, but also plays a role in molecular stability.
Overall, these groups interact with each other, making this compound have different stability in different environments. Under normal conditions, due to the existence of many electron-withdrawing groups, the structure is relatively stable. However, under special conditions, such as strong acid-base, high temperature or specific redox environment, each group may react, changing the structure of the compound and affecting its stability. For example, nitro groups may be reduced under specific reduction conditions, and chlorine atoms can be replaced in some nucleophilic substitution reactions, changing the structure and stability of the compound.

To prepare 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide, the method is as follows:
First, the raw materials need to be prepared, that is, benzenesulfonyl chloride containing the corresponding substituents, 2-chloro-4-nitroaniline, etc. In a clean reactor, dissolve 2-chloro-4-nitroaniline with an appropriate amount of organic solvent, such as dichloromethane, N, N-dimethylformamide, etc. This organic solvent needs to be anhydrous and of good purity to avoid side reactions.
With stirring, slowly add acid binding agents, such as triethylamine and pyridine, and the dosage needs to be accurately measured, about 1.1 to 1.3 times the number of moles of 2-chloro-4-nitroaniline. The effect of acid binding agent is to capture the acid generated by the reaction and promote the forward progress of the reaction.
Then, slowly drop the solution containing benzenesulfonyl chloride into the reaction system. The speed of dropwise addition should be slow rather than urgent to prevent the reaction from being too violent. The amount of benzenesulfonyl chloride should also be slightly more than 2-chloro-4-nitroaniline, about 1.1 to 1.2 moles.
Add dropwise, maintain the reaction system at an appropriate temperature, usually between room temperature and 50 ° C, and fine-tune according to the actual situation. The reaction is continuously stirred at this temperature for about 3-6 hours (hours). During this period, the reaction process can be monitored by thin-layer chromatography (TLC). When the raw material point is almost gone, the reaction is exhausted.
After the reaction is completed, pour the reaction solution into an appropriate amount of ice water, and precipitate. Collect the precipitate by suction filtration, and then wash it alternately with water and organic solvents several times to remove impurities. Commonly used organic solvents such as petroleum ether, ether, etc.
The obtained crude product is recrystallized with an appropriate solvent, such as a mixed solvent of ethanol, ethyl acetate and petroleum ether, to improve the purity of the product. During recrystallization, control the amount of solvent and temperature. After cooling the crystallization, filter again, collect the crystals, and dry them in a vacuum oven to obtain pure 4-chloro-N - (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide. The whole process requires attention to the operation specifications to ensure safety and accurately control the parameters of each link to obtain a product with satisfactory yield and purity.

In today's world, business conditions are unpredictable, and it is not easy to determine the price range of 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) -benzenesulfonamide in the market. The price of this compound is often determined by various factors, such as the availability of raw materials, the simplicity of the process, the situation of supply and demand, the distance of the region, and the competition in the market.
Looking at past transactions, the price of such fine chemicals may rise due to the rise in raw material costs. If the required raw materials such as chlorine and nitro are scarce, the price of this compound will also rise. Furthermore, the complexity of the process is also the key. If the preparation requires a multi-step reaction, and the conditions are harsh, the cost will increase, and the price will be high.
The relationship between supply and demand has a particular impact on the price. If the demand for this product in a certain domain increases sharply at a certain time, but the supply is limited, the price will rise; on the contrary, if the market is saturated and the supply is excessive, the price may be downward.
As for regional differences, different places have different prices due to different transportation costs and tax policies. And the market competition situation also affects the price. If the merchants compete for a share, there may be a price reduction; conversely, if the market monopoly is high, the price may be high. Therefore, in order to clarify the exact price range of 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) -benzenesulfonamide, it is necessary to carefully observe the current market factors, and real-time market conditions are reliable guidelines.