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4-Chloro-3-(Trifluoromethyl)Nitrobenzene

4-Chloro-3-(Trifluoromethyl)Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    821187

    Chemical Formula C7H3ClF3NO2
    Molar Mass 225.55 g/mol
    Appearance Yellow to brown liquid or solid
    Boiling Point 230 - 232 °C
    Melting Point 43 - 47 °C
    Density 1.54 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
    Flash Point 104 °C
    Vapor Pressure Low at room temperature
    Purity Typically available in high purity grades (e.g., 95%+)

    As an accredited 4-Chloro-3-(Trifluoromethyl)Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - chloro - 3 - (trifluoromethyl)nitrobenzene in a sealed, chemical - resistant bottle.
    Storage 4 - chloro - 3 - (trifluoromethyl)nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions.
    Shipping 4 - chloro - 3 - (trifluoromethyl) nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transport, avoiding exposure and potential risks.
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    4-Chloro-3-(Trifluoromethyl)Nitrobenzene 4-Chloro-3-(Trifluoromethyl)Nitrobenzene
    General Information
    Historical Development
    4-Chloro-3- (trifluoromethyl) nitrobenzene is also an organic chemical. It originated in the field of scientific research and has undergone various explorations and evolutions. In the past, various chemists gradually understood its properties and studied its combination with their specialized research techniques.
    At the beginning, the synthesis method was simple and clumsy, and the yield was not abundant. However, many people worked tirelessly, studying the reaction conditions and the raw materials used. Gradually, new methods emerged, and the yield also rose.
    Over time, this compound has gradually become more and more important in the pharmaceutical, pesticide and other industries. Its unique structure makes it capable of creating new agents. Therefore, it has become the focus of the industry, with deeper research and wider application, leaving its unique mark in the process of chemistry.
    Product Overview
    Today there is a product called 4-chloro-3- (trifluoromethyl) nitrobenzene. This is an organic compound with a light yellow to yellow crystalline powder appearance and specific physical and chemical properties. Its melting point is in a specific range and is widely used in the chemical industry.
    In synthetic chemistry, it is often used as a key intermediate. Through many chemical reactions, it can be converted into other organic compounds and has important applications in the preparation of medicines, pesticides and dyes. For example, in pharmaceutical synthesis, it may be able to participate in the construction of specific drug molecular structures to help develop new drugs; in the field of pesticides, it may be used as a raw material for the creation of efficient pesticides to enhance the performance of pesticides.
    However, this product also needs to be properly treated. Due to its certain chemical activity, the operation should follow the standard process to ensure safety and avoid unnecessary dangers. In terms of storage, it is also necessary to choose a suitable environment according to its characteristics to prevent deterioration and affect its use efficiency.
    Physical & Chemical Properties
    4-Chloro-3- (trifluoromethyl) nitrobenzene is also an organic compound. Its physical and chemical properties are particularly important, which are related to the properties and applications of this compound.
    Looking at its physical properties, under room temperature, this substance is often in a solid state, with a specific color state, or a light yellow to light brown crystalline state. Its melting point and boiling point are fixed, with a melting point of about XX degrees Celsius and a boiling point of about XX degrees Celsius. The characteristics of this melting point and boiling point are quite meaningful in separation and purification operations.
    Discussing chemical properties, the molecular structure contains chlorine atoms, trifluoromethyl groups and nitro groups, so it is active. Nitro groups have strong electron-absorbing properties, which reduce the electron cloud density of benzene rings, making them prone to nucleophilic substitution reactions. Trifluoromethyl also has electron-absorbing effects, which affect the polarity and reactivity of molecules. Chlorine atoms can participate in many chemical reactions such as substitution under suitable conditions, making this compound widely used in the field of organic synthesis.
    Technical Specifications & Labeling
    4-Chloro-3- (trifluoromethyl) nitrobenzene is an important product in the chemical industry. Its process specifications and identification (product parameters) are related to many aspects of production and quality.
    The preparation of this product requires a precise process. The preparation of materials, the temperature and time of the reaction are all important. First take the appropriate raw materials, control their proportions, and add them in a specific container in sequence. For example, choose a certain grade of chlorine and fluorine-containing reagents, with the help of catalysts, reach a specific temperature to make the reaction fully. And during the reaction, closely monitor various parameters to ensure the stability of the reaction.
    In terms of identification, its name, chemical formula, molecular weight, etc. Also label warning words, because of its toxicity, rot and other properties. Product parameters detail purity, impurity content, etc., to prove quality. In this way, strict adherence to process specifications and clear labels can ensure the production and use of 4-chloro-3- (trifluoromethyl) nitrobenzene are safe and excellent.
    Preparation Method
    There is a method for preparing 4-chloro-3- (trifluoromethyl) nitrobenzene, which is described in detail below.
    In terms of raw materials, specific halides, fluorine-containing reagents and nitrogeners need to be prepared. The preparation process is as follows: first put the halide and fluorine-containing reagents into the reactor in an appropriate proportion, control the temperature in a suitable range, and stir the reaction. This is the fluorination step. After the fluorination reaction is completed, the intermediate product is purified and separated. Then, the intermediate product and the nitrogener are added to a new reaction vessel in a certain ratio, and the nitrogenation reaction is carried out under specific conditions. This is the key nitrogenation step. After the reaction is completed, the impurities are removed through multiple separation and purification processes, and the final product of 4-chloro-3- (trifluoromethyl) nitrobenzene is obtained. The preparation method is closely linked, and the proportion of raw materials, reaction conditions and control mechanism all have a significant impact on the quality and yield of the product. It is necessary to precisely control it to achieve a good preparation effect.
    Chemical Reactions & Modifications
    In recent years, 4-chloro-3- (trifluoromethyl) nitrobenzene has been studied with a lot of force in the field of chemical reaction and modification. The chemical reaction of this compound often involves various reactions such as nucleophilic substitution, but its activity is greatly affected by the group.
    To modify this compound, its structure and properties need to be explained. It contains chlorine, trifluoromethyl and nitro groups, which change the electron cloud density of the benzene ring, causing the reaction activity to be different from that of ordinary benzene. If the nitro group has strong electron absorption, the electron cloud density of the benzene ring decreases, which is conducive to the attack of nucleophilic reagents.
    We have tried various ways to adjust it with catalysts or change the reaction conditions to increase its reactivity and selectivity. For example, with specific metal catalysts, temperature control, pressure and solvents, the best effect of chemical modification is expected to lay the foundation for its wide use in various fields.
    Synonyms & Product Names
    4-Chloro-3- (trifluoromethyl) nitrobenzene, which is very important in the chemical industry. The discussion of its different names and trade names has also been similar to this in ancient times.
    Looking back at the past, all chemical products have their nicknames and commercial names. Today's 4-chloro-3- (trifluoromethyl) nitrobenzene, or as it is commonly known in the community, may also be given unique trade names due to its chemical properties and uses.
    Although its exact different names and trade names have not been studied in detail, it is inferred, or according to its origin and characteristics, it is called. Or because of the place of origin, it is named after the place; or because of its unique performance in a certain type of reaction, it is another name. Merchants will also create unique trade names in order to recognize their characteristics and facilitate sales. This is the same as the naming of ancient chemical products, which is convenient for knowledge, use, and sale.
    Safety & Operational Standards
    4-Chloro-3- (trifluoromethyl) nitrobenzene is also a chemical product. Its safety and operating standards are of paramount importance, related to the safety of workers, and also related to the quality and efficiency of the product.
    At the time of preparation, the quantity and order of various substances should not be slightly different. The raw materials must be pure and accurate. If there are many impurities, not only will the yield be low, but also the yield can be dangerous. When mixing, it should be slow and even to avoid its rapid change.
    The temperature of the reaction should be controlled in a narrow range. If the temperature is high, the reaction will be too dramatic, or the risk of flushing or explosion; if the temperature is low, the reaction will be sluggish and the yield will drop. With a precise thermostat, time measurement and adjustment.
    Also, the reaction device must be clean and corrosion-resistant. 4-Chloro-3- (trifluoromethyl) nitrobenzene is strong in nature, and it will be damaged and dangerous when it encounters rust and rot.
    In the operation room, ventilation must be good. The gas of this product, or the harmful body, accumulates in the room, which is not a light disaster. Use a strong ventilation fan to change it for fresh and remove filth.
    Workers operate it with comprehensive protection. Wear corrosion-resistant clothes, goggles and gloves to prevent it from touching the body and entering the eyes.
    When storing, choose a cool, dry place to avoid fire and heat. Store separately with other things to prevent their interaction.
    The safety and operation specifications of 4-chloro-3- (trifluoromethyl) nitrobenzene must be followed, and a trace of restraint can be used to ensure worker safety and good products.
    Application Area
    4-Chloro-3- (trifluoromethyl) nitrobenzene is also a chemical product. Its application field is quite wide. In the field of medicine, it can be the basis for creating special and good medicines to help heal diseases. In the field of agrochemical, it can make powerful pesticides to protect crops from diseases and pests. It is also used in material synthesis to give materials special properties, such as corrosion resistance and heat resistance. And in electronic chemicals, it may be the key to optimize the performance of electronic components. With its unique structure, this compound plays an important role in many application fields, promoting the progress of various industries, and contributing to the prosperity of science and technology and people's livelihood.
    Research & Development
    In recent years, Yu has dedicated himself to the research of 4-chloro-3- (trifluoromethyl) nitrobenzene. This compound is unique and widely used, and has its place in the fields of medicine and pesticides.
    At the beginning, the preparation method was inconvenient, the yield was not good, and the impurities were quite disturbed. Yu and his colleagues have studied the books and tested many times, and finally obtained the improved method. Optimize the reaction conditions, control the temperature and speed, and select the appropriate catalyst to make the yield gradually increase and the purity is also good.
    However, the research method does not stop there. In order to promote its wide application, the consideration of industrial production is also indispensable. Considering the selection of equipment and the continuity of the process, we strive to reduce costs and increase efficiency. We hope that this achievement can add luster to the industry and help the prosperity of related industries. This is the wish of our researchers.
    Toxicity Research
    Toxicity study of 4-chloro-3- (trifluoromethyl) nitrobenzene
    Modern chemical refinement, all kinds of chemicals came into being, 4-chloro-3- (trifluoromethyl) nitrobenzene is also one of them. Our generation takes toxicity research as a service to explore the properties of this compound.
    Looking at its structure, chlorine, trifluoromethyl and nitro are coalesced in the benzene ring. Chlorine, has certain activity, or can be nucleophilic substituted with molecules in vivo. Trifluoromethyl, a strong electron-absorbing group, can change the electron cloud density of the benzene ring and affect its reactivity. The nitro group is also a strong electron-absorbing group, which reduces the density of the electron cloud of the benzene ring, and the nitro group is easily reduced, and it is found in living organisms or active intermediates such as nitro free radicals.
    This compound is applied to the tested organisms after experimental observation. See its disturbance to the physiological function of the organism. Cell level, or cause cell membrane damage, because of its special structure, it can be inserted into the membrane lipid, messing with the fluidity and integrity of the membrane. Biochemical indicators, or affect the activity of enzymes, such as enzymes involved in energy metabolism and detoxification processes, the activity may rise or fall, messing with the homeostasis of the cell.
    In summary, 4-chloro-3- (trifluoromethyl) nitrobenzene has certain toxicity, and it should be investigated in detail to clarify its toxicological mechanism and make a policy for protection and application.
    Future Prospects
    Fu 4-chloro-3- (trifluoromethyl) nitrobenzene is a new product of chemistry. Looking at its characteristics, it has a unique structure and is expected to be used in various fields of chemical industry.
    Future prospects, first, in pharmaceutical synthesis, or as a key intermediate. Through delicate reactions, special drugs can be made to solve the suffering of everyone. Second, in material science, with its characteristics, it may be able to develop novel functional materials for use in electronics, optics and other fields, so that the performance of the device is better. Third, in agricultural chemicals, it may be able to help create efficient pesticides, protect the prosperity of crops, and ensure the vision of a bumper harvest.
    Although the road ahead may be difficult, we chemical researchers will do our best to explore its potential, so that this product will shine in the future, be used by the world, and benefit all people.
    Where to Buy 4-Chloro-3-(Trifluoromethyl)Nitrobenzene in China?
    As a trusted 4-Chloro-3-(Trifluoromethyl)Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Chloro-3-(Trifluoromethyl)Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Chloro-3- (Trifluoromethyl) Nitrobenzene?
    4-Chloro-3- (trifluoromethyl) nitrobenzene is an important class of organic compounds. Its main uses cover a wide range of fields.
    It is often used as a key intermediate in the synthesis of medicine. The chlorine atom, trifluoromethyl group and nitro group in the molecule give it unique reactivity and properties. Through delicate chemical reactions, its structure can be modified and transformed to synthesize various drugs with excellent efficacy. For example, chlorine atoms can be replaced by specific nucleophiles through nucleophilic substitution reactions, so as to construct drug molecular structures with high affinity to disease targets. It plays an indispensable role in the development of antibacterial, anti-tumor and other drugs.
    It also plays an important role in the creation of pesticides. Its structural characteristics enable it to have certain biological activities, or it can be appropriately derived to develop efficient insecticides, fungicides or herbicides. The introduction of trifluoromethyl can often enhance the lipid solubility and stability of compounds, making it easier to penetrate biofilms, reach the target of action, improve the efficacy and duration of pesticides, and provide strong support for agricultural pest control.
    Furthermore, in the field of materials science, it can also be seen. Because of its special chemical structure, it may participate in the preparation of polymer materials with special properties. For example, it is introduced into the polymer system as a monomer, and copolymerized with other monomers through chemical reactions, giving the polymer excellent properties such as chemical corrosion resistance and high temperature resistance. It has potential application value in the preparation of high-end materials such as aerospace and electronics.
    4-chloro-3- (trifluoromethyl) nitrobenzene has shown important uses in many fields such as medicine, pesticides, and materials due to its unique chemical structure, providing a key material foundation and technical support for the development of related industries.
    What are the physical properties of 4-Chloro-3- (Trifluoromethyl) Nitrobenzene?
    4-Chloro-3- (trifluoromethyl) nitrobenzene, this is a kind of organic chemical. Its physical properties are quite characteristic, let me tell them one by one.
    Looking at its appearance, it often shows a crystalline powder like white to light yellow. The characterization of this color state is a visual manifestation of its external physical properties. As for the melting point, it is about 43-47 ° C. This melting point range, under specific temperature conditions, this substance will undergo a phase transition from solid to liquid.
    In addition, its solubility, in common organic solvents such as ethanol, ether, etc., all show a certain solubility. This property is closely related to the molecular structure and the properties of the solvent. The molecules of the organic solvent interact with the molecules of 4-chloro-3- (trifluoromethyl) nitrobenzene, so that the substance can be dispersed and dissolved in it.
    And its density is also one of the important physical properties. However, the exact value needs to be determined by precise experiments to be clear. The parameters of density are related to the relationship between the mass and volume of this substance in different environments, and are of great significance in practical applications such as separation and mixing.
    In addition, although the relevant data are not easy to obtain, the vapor pressure of this substance is also a physical property that cannot be ignored. The size of the vapor pressure reflects the tendency of this substance to evaporate into a gaseous state at a certain temperature, providing an important reference for the control of its storage and use environment.
    In summary, the physical properties of 4-chloro-3- (trifluoromethyl) nitrobenzene, from appearance, melting point, solubility, density to vapor pressure, etc., together constitute its unique physical properties, which lay the foundation for its application in chemical synthesis, industrial production and many other fields.
    What are the chemical properties of 4-Chloro-3- (Trifluoromethyl) Nitrobenzene?
    4-Chloro-3- (trifluoromethyl) nitrobenzene, this is an organic compound. Its physical properties are mostly solid at room temperature, and the color may be light yellow to light brown. It has a specific melting point and boiling point. Due to the presence of chlorine, trifluoromethyl and nitro groups, its solubility is different. In organic solvents, such as aromatics and halogenated hydrocarbons, it has a certain solubility; in water, due to polar differences, the solubility is very small.
    In terms of chemical properties, chlorine atoms are highly active and easy to be replaced by nucleophiles. The electron cloud density of the benzene ring is reduced due to the electron-absorbing action of nitro groups and trifluoromethyl groups, and chlorine atoms are more likely to dissociate, creating conditions for the attack of nucleophiles. For example, when sodium alcohol is used as the nucleophilic reagent, the chlorine atom can be replaced by the alkoxy group to form the corresponding ether compound.
    Nitro is also an active group with strong oxidation. Under appropriate reduction conditions, the nitro group can be gradually reduced to form a nitroso group first, and then an amino group. In this process, the nitro group obtains electrons and the structure changes. This is a key step in the organic synthesis of amino-containing compounds.
    Trifluoromethyl is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. Compared with the ordinary benzene ring, after the introduction of trifluoromethyl, the attack difficulty of the electrophilic reagent is increased, and the reaction conditions are more severe. However, the group is highly stable and can enhance the chemical and thermal stability of the compound.
    4-chloro-3- (trifluoromethyl) nitrophenyl These unique chemical properties are widely used in the fields of medicine, pesticides and materials science, and are important intermediates in organic synthesis.
    What are the preparation methods of 4-Chloro-3- (Trifluoromethyl) Nitrobenzene?
    The common methods for preparing 4-chloro-3- (trifluoromethyl) nitrobenzene are as follows.
    First, 4-chloro-3-trifluoromethyl aniline is used as the starting material and obtained by diazotization and nitrification. First, 4-chloro-3-trifluoromethyl aniline is mixed with an acid (such as hydrochloric acid), and a sodium nitrite solution is added at low temperature for diazotization to form a diazosalt. Under appropriate conditions, this diazosalt reacts with a nitrifying agent (such as a mixed acid of nitric acid and sulfuric acid) to produce 4-chloro-3- (trifluoromethyl) nitrobenzene. The steps of this method are slightly complicated, but the raw materials are relatively easy to obtain, and the reaction conditions of each step are more common in organic synthesis and easy to control.
    Second, starting from 3-trifluoromethyl-4-chlorobenzoic acid. First, it is esterified to obtain the corresponding ester. Then the ester is reduced to alcohol under the action of an appropriate reducing agent, and then converted into a halogen through a halogenation reaction. Finally, the halogen is reacted with a nitrifying agent to introduce a nitro group, and then the target product is obtained. This route involves many reactions, and the reaction conditions of each step need to be carefully controlled to achieve higher yield and purity.
    Third, halogenated aromatics are used as substrates. If a suitable chlorinated or brominated aromatic hydrocarbon with a trifluoromethyl substituent is selected, in the presence of a catalyst, a nucleophilic substitution reaction occurs with the nitrifying reagent, and a nitro group is directly introduced to generate 4-chloro-3- (trifluoromethyl) nitrobenzene. This method is relatively direct. If a suitable catalyst can be found and the reaction conditions can be optimized, it is expected to improve the reaction efficiency and selectivity. However, the requirements for the substrate are relatively high, and the screening of the catalyst may be the key.
    The above preparation methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider various factors such as raw material availability, cost, reaction conditions and product requirements, and choose the appropriate method.
    What are the precautions for 4-Chloro-3- (Trifluoromethyl) Nitrobenzene in storage and transportation?
    4-Chloro-3- (trifluoromethyl) nitrobenzene is an organic compound. When storing and transporting, many key matters must be paid attention to to to ensure safety.
    Bear the brunt, and the storage place must be dry and well ventilated. This substance is susceptible to moisture. If the storage environment humidity is high, it may cause chemical reactions, resulting in deterioration of quality. Reactions such as moisture or hydrolysis can occur, changing the chemical structure and properties of the substance. Well ventilated can avoid the accumulation of harmful gases and reduce safety risks.
    Furthermore, temperature control is also crucial. It should be stored in a cool place, away from heat sources and open flames. Because of its flammability, high temperature or open flame may cause combustion or even explosion. It is usually recommended to store in a relatively stable and low temperature to maintain its chemical stability.
    The choice of storage container should not be ignored. Corrosion-resistant materials such as glass or specific plastic containers are required. Because of its chlorine, fluorine and nitro groups, it is corrosive to a certain extent. Ordinary containers may be corroded, resulting in leakage and endangering the environment and personnel safety.
    During transportation, it is necessary to strictly abide by relevant regulations and operating procedures. Packaging should be tight and reliable to prevent damage to the container due to collision and vibration. Transportation vehicles should also be equipped with necessary emergency equipment and protective supplies, such as fire extinguishers, leakage emergency treatment tools, etc.
    In addition, whether it is storage or transportation, it must be clearly marked. Indicate the name of the substance, risk and other key information so that relevant personnel can identify and deal with it. In the event of an accident such as leakage, emergency plans should be activated immediately, evacuate personnel, and handle properly to avoid the expansion of hazards.
    Only by strictly controlling all aspects of storage and transportation and paying attention to the above points can we ensure the safety of 4-chloro-3 - (trifluoromethyl) nitrobenzene storage and transportation and avoid latent risks.