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4-Chloro-3-Nitrotrifluoromethylbenzene

4-Chloro-3-Nitrotrifluoromethylbenzene

Hongda Chemical

    Specifications

    HS Code

    484961

    Chemical Formula C7H3ClF3NO2
    Molecular Weight 225.55
    Appearance Yellow to light brown liquid
    Boiling Point 214 - 216 °C
    Melting Point 28 - 30 °C
    Density 1.578 g/cm³
    Solubility Insoluble in water, soluble in organic solvents
    Vapor Pressure Low
    Flash Point 97 °C
    Stability Stable under normal conditions

    As an accredited 4-Chloro-3-Nitrotrifluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1kg of 4 - chloro - 3 - nitrotrifluoromethylbenzene packaged in airtight, corrosion - resistant containers.
    Storage 4 - chloro - 3 - nitrotrifluoromethylbenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions.
    Shipping 4 - chloro - 3 - nitrotrifluoromethylbenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under strict safety protocols, ensuring separation from incompatible substances during transit to prevent risks.
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    4-Chloro-3-Nitrotrifluoromethylbenzene 4-Chloro-3-Nitrotrifluoromethylbenzene
    General Information
    Historical Development
    Wenfu 4 - Chloro - 3 - Nitrotrifluoromethylbenzene this thing, its origin is not overnight. At the beginning, Zhu Xian devoted himself to the field of chemistry, wanting to explore the wonders of material changes. When organic synthesis was on the rise, the public worked hard to find a way to create new things.
    At that time, the exploration of fluorine-containing, halogen-containing and nitro compounds was on the rise. Researchers in the laboratory, through countless proportions and reactions. Either by chance, or with subtle ideas, the method of synthesizing this 4 - Chloro - 3 - Nitrotrifluoromethylbenzene was finally obtained.
    Its method has gradually matured, from the initial niche research to the industry known. With the evolution of science and technology, the synthesis process is optimized, and the output is also increasing. The application has also expanded from pure academic inquiry to medicine, materials and other fields, which is of great significance to the development of today's chemical industry.
    Product Overview
    4-Chloro-3-nitrotrifluoromethylbenzene is also an organic compound. It is a colorless to light yellow liquid with a special odor. This substance has a wide range of uses in the chemical industry and is often a key raw material for the synthesis of a variety of fine chemicals.
    The preparation method follows a specific chemical reaction path. Under suitable reaction conditions, the corresponding reactants interact with each other according to specific proportions, temperature, pressure and other factors, and the compound can be obtained after several steps of reaction.
    However, the preparation process needs to abide by the operating procedures, because it involves many chemical reagents and reaction conditions, which may cause safety hazards and product quality problems. And this compound must also follow specific requirements when stored and transported to prevent deterioration or cause danger. In the process of chemical synthesis, 4-chloro-3-nitrotrifluoromethylbenzene is indispensable, laying the foundation for the birth of many high-end chemicals.
    Physical & Chemical Properties
    4-Chloro-3-nitrotrifluorotoluene is an organic compound. Its material has unique physical and chemical properties. Looking at its physical properties, it is a colorless to light yellow liquid at room temperature, with a specific odor. Its boiling point is quite high, about 180 degrees, which makes it boil and vaporize under specific temperature conditions. The melting point is relatively low, causing it to be liquid in general environment.
    On chemical properties, because it contains groups such as chlorine, nitro and trifluoromethyl, it is active. Nitro groups have strong electron absorption, which reduces the density of electron clouds in benzene rings and is prone to nucleophilic substitution reactions. Chlorine atoms are also active check points for reactions and can interact with many nucleophilic reagents. The existence of trifluoromethyl enhances the stability and fat solubility of compounds, and is widely used in the field of organic synthesis. It is a key raw material for many fine chemicals. The study of its physicochemical properties is of great significance for expanding the boundaries of organic synthesis.
    Technical Specifications & Labeling
    4-Chloro-3-nitrotrifluorotoluene is also an organic compound. Its process specifications and identification (product parameters) are the key to manufacturing and quality.
    The method of manufacturing requires strict procedures. The choice of raw materials must be pure and the proportion is accurate. The reaction conditions, temperature and pressure are all fixed, or in a closed vessel, with the help of catalysis, to phase all things. After the reaction is completed, the separation and purification are repeated, and the impurity and sperm are removed to obtain a good product.
    In the logo, it contains the name taboo and chemical formula, indicating its quality. There are also characteristics, such as color and odor. As for the physical and chemical properties, the point of melting and the ability to dissolve are all well remembered. This is the logo of the product. Users know its properties before they can use it well. It is used in chemical everything to ensure safety and improve efficacy. Process specifications and labels are the foundation of the product and cannot be ignored.
    Preparation Method
    The preparation method of 4-chloro-3-nitrotrifluoromethylbenzene is related to the raw materials and production process, reaction steps, and catalytic mechanism.
    To prepare this substance, first take the appropriate raw materials. Starting with a specific aromatic hydrocarbon, its structure is stable and it has a modifiable check point. With chlorine-containing reagents, such as thionyl chloride, the chlorine group is introduced by virtue of its reactivity of chlorine atoms. The addition of nitrogenation reagents, mixed acids of nitric acid and sulfuric acid are common here, and the nitro group falls in the appropriate position of aromatic hydrocarbons due to the strong oxidation and electrophilicity of the mixed acid. As for the introduction of trifluoromethyl, or the use of reagents containing trifluoromethyl, through a specific reaction mechanism, the grafting of functional groups is
    The reaction steps are rigorous and orderly. In a suitable reaction vessel, control the temperature, pressure and choose the right solvent. First, the aromatic hydrocarbon is heated with the chlorination reagent, and the chlorine atoms are replaced by the aromatic hydrocarbon hydrogen atoms. After chlorination is completed, the temperature is lowered, the mixed acid is slowly added, and the nitro group is cleverly occupied. Then trifluoromethyl is introduced, or under alkali catalysis, the trifluoromethyl reagent is reacted with the intermediate.
    The catalytic mechanism is also key. Chlorination or use a metal catalyst to activate the chlorine reagent to reduce the reaction energy barrier. During nitroization, sulfuric acid helps the dissociation of nitric acid to generate electrophilic nitro positive ions. Trifluoromethylation, base activation reagent, nucleophilic substitution. In this way, 4-chloro-3-nitrotrifluoromethylbenzene can be obtained through various steps of delicate operation.
    Chemical Reactions & Modifications
    In the field of chemistry, its reaction and modification are of great importance to our research.
    Looking at its structure, chlorine, nitro and trifluoromethyl are combined on the benzene ring. Chlorine has the property of nucleophilic substitution. When encountering nucleophilic reagents, it is often easy to leave, resulting in the formation of new bonds. Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring. In electrophilic substitution, the activity of ortho-para is reduced, and the meso is relatively increased.
    In order to change its properties, or to choose nucleophilic substitution, the method of exchanging chlorine atoms with suitable reagents can obtain other derivatives and expand their uses. Or by reducing the nitro group, the nitro group is converted into an amino group to increase its reactivity and diversity.
    In the process of organic synthesis, the detailed study of the reaction and modification of 4-Chloro-3-Nitrotrifluoromethylbenzene can pave the way for the creation of new materials, drug development, etc., opening up endless possibilities.
    Synonyms & Product Names
    4-Chloro-3-nitrotrifluorotoluene is also a chemical substance. Its synonymous name and the name of the product are more elegant in the industry. The synonymous name of this product, or "m-nitro-p-chlorotrifluorotoluene", is justified by its location. As for the trade name, different trade names may have different names.
    In various chemical lists, all names of this product are listed in detail. The synonymous name is easy for scholars to communicate and study, so that they know that it is the same product. And the trade name is used by merchants to identify and facilitate customers to buy. Although the names are different, they all refer to this 4-chloro-3-nitrotrifluorotoluene. Therefore, when the industry studies and operates this product, it is necessary to carefully distinguish its synonymous name and commodity name in order to avoid mistakes.
    Safety & Operational Standards
    4-Chloro-3-nitrotrifluoromethylbenzene is an important chemical compound in the chemical industry. During its experiment and production process, safety and operating standards are of paramount importance, which is related to the lives of personnel and the smooth production.
    In terms of safety, this compound is dangerous. Its chemical properties are active, or it reacts with various substances. Therefore, when storing, it must be placed in a cool, dry and well-ventilated place, away from fire, heat and oxidants. The storage container should be firmly sealed to prevent leakage. During access, the operator should be strictly protected. Wear protective clothing, which must be resistant to chemical corrosion and can effectively block the contact of the compound to the body. Wear protective gloves, the material should be able to resist the erosion of the compound. Goggles are also indispensable to protect the eyes from possible spills.
    In terms of operation specifications, careful planning is required before the experiment. Familiar with the reaction principle and process, accurately calculate the amount of raw materials required to avoid waste and danger. During the reaction process, the reaction conditions are strictly controlled. Temperature needs to be precisely controlled. Too high or too low may cause the reaction to go out of control or the product to be impure. Pressure cannot be ignored, and it should be adjusted in a timely manner according to the reaction requirements. The stirring speed is also critical to ensure that the reactants are fully mixed. After the reaction is completed, the product should be handled with caution. Separation and purification operations are carried out according to the specifications to ensure the purity of the product. Waste cannot be discarded at will, and should be properly disposed of according to environmental protection requirements to prevent environmental pollution.
    The safe production and operation of 4-chloro-3-nitrotrifluoromethylbenzene requires everyone to be in awe and strictly abide by safety and operating standards in order to ensure the safety and efficiency of chemical production.
    Application Area
    4-Chloro-3-nitrotrifluoromethylbenzene, this compound has a wide range of application fields. In the field of pharmaceutical synthesis, it is a key intermediate, which can help synthesize special drugs, cure various diseases, and save lives. In the creation of pesticides, with its unique chemical properties, it can develop high-efficiency and low-toxicity pesticides, protect crops, resist pests and diseases, and maintain the hope of a bumper harvest. In the field of materials science, it also has its own uses. It can participate in the preparation of high-performance materials and improve material properties, such as enhancing heat resistance and corrosion resistance. From this perspective, 4-chloro-3-nitrotrifluoromethylbenzene plays an indispensable role in many practical fields, promoting the development and progress of related industries.
    Research & Development
    Yu is dedicated to the research of chemical substances, and recently focused on 4 - Chloro - 3 - Nitrotrifluoromethylbenzene. Its unique properties have great potential in the field of organic synthesis.
    Begin to explore its preparation method. After many attempts, the traditional path was improved, the reaction conditions were optimized, and the yield was improved. After weighing the reaction temperature and the ratio of the reactants, a more ideal solution was finally obtained.
    Then, its application was studied. After observing its reaction with different reagents, it was found that it can be used to create new pharmaceutical intermediates. This discovery opens up a new path for pharmaceutical research and development.
    Thinking about the future development of this product, it is necessary to expand the scope of application. Or emerge in materials science, such as the preparation of polymer materials with special properties.
    Yu will make unremitting efforts to promote the progress of chemistry with this material and contribute to the development of science and technology.
    Toxicity Research
    Today there is a thing called 4 - Chloro - 3 - Nitrotrifluoromethylbenzene. As a chemical researcher, I have been focusing on the study of its toxicity for a long time.
    The toxicity of this thing is related to the safety of life. After repeated investigation, with the inspection of ancient methods and the analysis of new techniques, many clues have been obtained. It may enter the body through the mouth and nose, or through the skin. After entering the body, it disturbs the flow of qi and blood, and messes up the functions of the internal organs. In light cases, the head is dizzy, nausea is about to vomit; in severe cases, it will damage the liver and kidneys, endangering life.
    However, it will take time to find out the details. I will study it day and night with a rigorous attitude, hoping to fully understand its toxicity, avoid disasters for the world, protect the well-being of all things, and live up to the responsibility of the researcher.
    Future Prospects
    Wuyan 4 - Chloro - 3 - Nitrotrifluoromethylbenzene this thing for a long time. Looking at its properties, it has unique properties, and in various reactions, it often shows extraordinary effects.
    Looking to the future, it can be used for medical creation, or it can open up new paths. It can make special drugs, treat intractable diseases, and bring good news to the sick. In the field of materials, there is also potential. With its characteristics, it may be able to develop new materials for aerospace, electronics and other important fields to improve the performance of related devices.
    Furthermore, the method of synthesis should also be refined. Looking for a simpler, more efficient and environmentally friendly way to reduce its cost, increase its yield, make this product more popular, grow in various industries, become a driving force for future development, and lead the progress of science and technology and industry.
    Where to Buy 4-Chloro-3-Nitrotrifluoromethylbenzene in China?
    As a trusted 4-Chloro-3-Nitrotrifluoromethylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Chloro-3-Nitrotrifluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Chloro-3-Nitrotrifluoromethylbenzene?
    4-Chloro-3-nitrotrifluoromethylbenzene is a crucial compound in the field of organic synthesis. Its uses are quite extensive and are described below.
    First, in the field of medicinal chemistry, this compound is a key intermediate. Taking the synthesis of specific anti-infective drugs as an example, the chlorine atoms, nitro groups and trifluoromethyl groups in the structure can be modified by specific chemical reactions to construct molecular structures with unique biological activities. Drug developers can adjust the interaction between drugs and biological targets by precisely manipulating these functional groups, improve the efficacy and selectivity of drugs, and help develop more efficient and safe anti-infective agents.
    Second, in the field of pesticide chemistry, 4-chloro-3-nitrotrifluoromethylbenzene also plays a pivotal role. It can be used to prepare new insecticides. Because of its trifluoromethyl content, it can endow the compound with unique physical and chemical properties, enhance its ability to interfere with the nervous system or physiological metabolic process of pests, and disrupt the normal physiological function of pests, so as to achieve the purpose of efficient insecticidal. And such pesticides based on this compound are often environmentally friendly, reducing the adverse impact on the ecological environment while ensuring agricultural production.
    Third, in the field of materials science, it also has its uses. Can be used as a starting material for the synthesis of special functional materials. For example, by polymerizing with other compounds containing specific functional groups, polymer materials with special optical and electrical properties can be prepared. Such materials may be applied to optoelectronic devices, such as organic Light Emitting Diodes (OLEDs). With their unique structure, they endow materials with specific luminescence or electrical conductivity, opening up new directions for the development of materials science.
    In summary, 4-chloro-3-nitrotrifluoromethylbenzene has shown application value that cannot be ignored in many fields such as medicine, pesticides and materials science, promoting continuous progress and innovation in related fields.
    What are the physical properties of 4-Chloro-3-Nitrotrifluoromethylbenzene?
    4-Chloro-3-nitrotrifluoromethylbenzene is one of the organic compounds. Its physical properties are quite unique, let me tell you one by one.
    Looking at its properties, at room temperature, it is mostly colorless to light yellow liquid. The appearance is clear, and it can be seen as clear water, but its properties are not comparable to the mildness of water. Its smell is unique. Although it has no fragrant fragrance, it has a pungent smell and is uncomfortable to smell. This smell is a warning sign, suggesting that users should be cautious.
    When it comes to the melting point, the melting point is about -14 ° C, and the boiling point is about 205 ° C. The melting point is low, making it mostly liquid at room temperature. The boiling point is relatively high, and in order to gasify it, it needs to provide more energy. This characteristic determines that it is relatively stable under general conditions and is not easy to evaporate and dissipate.
    Furthermore, its density is greater than that of water, about 1.62g/cm ³. If it is placed in the same place as water, it will sink to the bottom of the water due to its density. The boundary between the two is clear, such as the determination of yin and yang.
    Solubility is also an important physical property. 4-Chloro-3-nitrotrifluoromethylbenzene is insoluble in water, and water is a polar solvent. The polarity of this compound is weak. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. In such solvents, it can be uniformly dispersed, just like fish getting water. This property is very useful in organic synthesis and other fields. It can be used as a reaction medium or for separation and purification.
    In addition, its vapor pressure is low, and it is not easy to produce a large amount of steam. This property reduces the possibility of danger caused by vapor diffusion during storage and use. However, although the vapor pressure is low, it should not be taken lightly, because it has certain toxicity. Even if a small amount of steam is inhaled, it may endanger human health.
    In summary, the physical properties of 4-chloro-3-nitrotrifluoromethylbenzene have their own uses and risks. Users must be familiar with their properties and operate with caution in order to ensure safety and make good use of them.
    What is the chemistry of 4-Chloro-3-Nitrotrifluoromethylbenzene?
    4-Chloro-3-nitrotrifluoromethylbenzene is also an organic compound. Its chemical properties are particularly important and are related to many chemical reactions.
    This compound has functional groups such as halogen atoms (chlorine), nitro groups and trifluoromethyl groups. Although the chlorine atom is affected by the conjugation effect of the benzene ring, it still has a certain activity. In nucleophilic substitution reactions, under suitable conditions, it can be replaced by nucleophilic reagents. For example, in the case of strong nucleophilic reagents such as sodium alcohol, at appropriate temperatures and solvents, the chlorine atom can be replaced by an alkoxy group to form the corresponding aromatic ether.
    The nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, makes the benzene ring more stable, and enhances the positive electricity of the adjacent and para-position carbon atoms. This effect results in a decrease in the electrophilic substitution activity of the benzene ring, and the presence of nitro groups makes it more difficult for the aromatic ring electrophilic substitution to occur. However, under some special conditions, if there are strong electrophilic reagents and the reaction conditions are intense, electrophilic substitution can still occur, but the substitution check point is often different from the normal benzene ring electrophilic substitution, which is affected by the localization effect of nitro and chlorine atoms.
    Trifluoromethyl is also a strong electron-absorbing group, which has a significant effect on the benzene ring Due to its fluorine-containing atoms, the compound is endowed with unique physical and chemical properties, such as enhanced fat solubility. In chemical reactions, trifluoromethyl can affect the reaction rate and selectivity, such as in some redox reactions, it can change the electron cloud distribution of the active center of the reaction, which in turn affects the reaction process.
    In short, 4-chloro-3-nitrotrifluoromethylbenzene contains functional groups that interact with each other, presenting unique chemical properties. In the field of organic synthesis, it can be used as an important intermediate for the construction of complex organic molecules, to achieve the transformation of various functional groups and the creation of new compounds.
    What are 4-Chloro-3-Nitrotrifluoromethylbenzene synthesis methods?
    The synthesis of 4-chloro-3-nitrotrifluoromethylbenzene is a subject of much concern in the field of chemistry. There are various synthesis routes, and the following are the common ones.
    First, trifluoromethylbenzene is used as the starting material. Shilling trifluoromethylbenzene is chlorinated with chlorine. Under appropriate reaction conditions, such as in the presence of suitable catalysts, chlorine atoms can be introduced into the benzene ring to form chlorotrifluoromethylbenzene. Then, the resulting chlorotrifluoromethylbenzene is nitrified with a nitrifying agent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid. This process requires precise control of the reaction temperature and time before the nitro group can be introduced at a suitable position to obtain 4-chloro-3-nitrotrifluoromethylbenzene.
    Second, nitrotrifluoromethylbenzene is used as the starting material. First, nitrotrifluoromethylbenzene is chlorinated. In a suitable catalyst and reaction environment, chlorine atoms are selectively connected to specific positions in the benzene ring, and then the target product is synthesized. In this process, the choice of catalyst and the control of reaction conditions are extremely critical, which directly affect the yield and purity of the product.
    Third, chlorinated nitrobenzene can also be used as the starting material, and trifluoromethyl can be introduced first. Reagents containing trifluoromethyl can be used to achieve the substitution of trifluoromethyl to specific positions on the benzene ring under specific reaction conditions and catalysts, resulting in 4-chloro-3-nitrotrifluoromethylbenzene.
    Each synthesis method has its own advantages and disadvantages. In practice, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, the purity and yield of products and many other factors, and carefully select the most suitable synthesis path to achieve efficient and economical synthesis goals.
    What are the precautions in storage and transportation of 4-Chloro-3-Nitrotrifluoromethylbenzene?
    4-Chloro-3-nitrotrifluoromethylbenzene is an organic compound. When storing and transporting, pay attention to many matters.
    First storage, this substance should be placed in a cool, dry and well-ventilated place. Cover because of its certain chemical activity, high temperature and humid environment, it is easy to cause it to deteriorate, cause its chemical properties to change, and damage the use efficiency. And should be placed separately from oxidizing agents, reducing agents, alkalis and other substances. Depending on its chemical properties, if it is mixed with their substances, it may cause severe chemical reactions, causing fire, explosion and other dangerous situations. At the same time, the storage place should be clearly marked, indicating its name, nature and hazard information, so as to facilitate identification and management, and regular inspection is required to check whether the packaging is damaged or leaked.
    As for transportation, it is necessary to ensure that the packaging is intact. Packaging must meet relevant safety standards to effectively prevent material leakage. During transportation, the speed should be stable, and violent actions such as sudden braking and sharp turns should be avoided to prevent packaging damage due to vibration and collision. Transportation vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. In case of emergencies, they can respond in time. Furthermore, transportation personnel should be professionally trained to be familiar with the nature of this substance and emergency treatment methods. In the event of leaks and other accidents, they can be dealt with quickly and scientifically to minimize harm.
    All of these are important for the storage and transportation of 4-chloro-3-nitrotrifluoromethylbenzene.