4-Chloro-3-Fluoroiodobenzene

Hongda Chemical

Specifications

HS Code	857097
Chemical Formula	C6H3ClFI
Appearance	Liquid (usually)
Color	Colorless to light - yellow
Odor	Characteristic organic odor
Density	Data may vary, typically in the range of 2 - 3 g/cm³ (approximate)
Boiling Point	Around 220 - 240 °C (approximate)
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform

As an accredited 4-Chloro-3-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 4 - chloro - 3 - fluoroiodobenzene packaged in a sealed glass bottle.
Storage	4 - chloro - 3 - fluoroiodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container to prevent vapor leakage. Due to its potentially hazardous nature, ensure storage is in a location inaccessible to unauthorized personnel and in compliance with local chemical storage regulations.
Shipping	4 - chloro - 3 - fluoroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling to prevent leakage and ensure safety during transit.

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General Information

Historical Development

4-Chloro-3-fluoroiodobenzene is also an organic compound. At the beginning, chemists studied the properties of substances and wanted to obtain special reagents, so they paid attention to this. At the beginning, the synthesis method was difficult, and the yield was quite low. However, the public is determined, and has been studying for a long time to improve the synthesis technique. The raw materials used in the past may be rare, and the steps are cumbersome. Later, there are new ways to choose easier raw materials and optimize the reaction conditions. As a result, the yield gradually increases, and the quality is also good. With the passage of time, this compound has become more and more widely used in the fields of medicine and materials. Chemists use it as a basis to make special drugs and innovative materials. The difficulties of the past have been turned into the convenience of today. Its historical evolution relies on the efforts of chemists and their unremitting exploration to make this compound shine in the path of science.

Product Overview

4-Chloro-3-fluoroiodobenzene is also an organic compound. It may be a colorless to pale yellow liquid with certain chemical activity. In this compound, the atoms of chlorine, fluorine and iodine are connected to the benzene ring, giving it unique chemical properties.
Chlorine atoms on the benzene ring change the distribution of molecular electron clouds, affecting its reactivity and selectivity. Fluorine atoms have strong electronegativity, which can enhance molecular polarity and have significant effects on their physical and chemical properties. Iodine atoms, because of their large atomic radius and special electronic structure, give the compound unique properties in specific reactions.
4-Chloro-3-fluoroiodobenzene is often used in the field of organic synthesis, and can be used as a key intermediate. After various chemical reactions, more complex organic molecular structures can be constructed. It has potential application value in many fields such as pharmaceutical chemistry and materials science, and is important for chemical research and industrial production.

Physical & Chemical Properties

4-Chloro-3-fluoroiodobenzene is an organic compound. Its physical properties are liquid at room temperature, with a clear and transparent color and a special odor. Its boiling point varies widely, about [X] ° C, due to intermolecular forces. The melting point is around [X] ° C, which is related to its lattice structure.
On chemical properties, iodine atoms in this substance are active and easily participate in nucleophilic substitution reactions. Fluorine atoms have strong electronegativity, which changes the density of electron clouds in the benzene ring, affecting their reactivity. Chlorine atoms also contribute to their chemical properties. Under suitable conditions, various substitution and addition reactions can occur. In the field of organic synthesis, it is often an important intermediate due to its unique physical and chemical properties, assisting chemists in constructing complex organic molecular structures for specific chemical purposes.

Technical Specifications & Labeling

Today there is a product called 4 - Chloro - 3 - Fluoroiodobenzene. The technical specifications and identification (product parameters) of this product must be carefully studied.
Looking at its technical specifications, the method of preparation must be rigorous. The selection of raw materials must be pure and free of impurities, and the proportions must be accurate. The reaction conditions, such as temperature, pressure, and duration, are all fixed. If there is a slight difference, the product will not be pure.
As for the marking end, the product parameters must be clear. The proportion of the elements contained should be accurate to the millimeter; the physical properties, such as color, state, and taste, should be detailed. In this way, it is necessary to make this object in the eyes of the user, without obscurity, and to make good use of it, without the risk of misuse, and to ensure its high quality and safe use.

Preparation Method

Now to prepare 4 - Chloro - 3 - Fluoroiodobenzene, the method is as follows:
Raw material and production process: Take an appropriate amount of halogenated aromatics as the initial raw material, which is the basis of the reaction. It needs to have high purity to ensure a smooth reaction.
Reaction steps: First, the halogenated aromatics and specific fluorinated reagents are placed in a suitable reaction vessel, and the temperature is controlled moderately, so that they can fully react to obtain fluorine-containing intermediates. Then, the intermediate product is mixed with chlorinated reagents, and the reaction conditions, such as pH, temperature, etc., are adjusted to further react, so that chlorine atoms are successfully introduced to form key intermediates. Finally, the intermediate is reacted with the iodizing reagent, and after careful operation, 4-Chloro-3-Fluoroiodobenzene is obtained.
Catalytic mechanism: During the reaction, a high-efficiency catalyst is selected, which can reduce the activation energy of the reaction and accelerate the reaction process. The catalyst acts precisely on the reactant molecules in each step of the reaction, guiding the reaction in a predetermined direction, improving the selectivity and yield of the product. In this way, through various steps, the target product 4-Chloro-3-Fluoroiodobenzene can be obtained.

Chemical Reactions & Modifications

4-Chloro-3-fluoroiodobenzene is also an organic compound. In the field of chemistry, its reaction and modification are quite important to scholars.
The reaction of this compound often involves the genus of nucleophilic substitution. Halogen atomic activities are different, chlorine, fluorine and iodine, due to electronegativity and atomic radius differences, each showing characteristics in the reaction. Iodine atoms are relatively active, easy to be replaced by nucleophiles, opening the formation of new bonds.
If modified, chemical modification can be used to adjust its electron cloud density and change its spatial conformation. Introducing different functional groups may change their physical and chemical properties, making them suitable for a variety of synthetic purposes. For example, under specific reaction conditions, treatment with appropriate reagents, or the transformation of its structure, the product with new properties is expected to be used in many fields such as materials science and drug development.

Synonyms & Product Names

4-Chloro-3-fluoroiodobenzene, this is an organic compound. The discussion of its alias and trade name is very important in chemical research.
In the field of Guanfu chemistry, there are many things, often depending on different uses, regions or habits. 4-chloro-3-fluoroiodobenzene, or aliases derived from its structural characteristics, to help researchers express it accurately.
As for the trade name, merchants should highlight the characteristics of the product, target a specific market, or give a unique name. However, whether the alias or trade name should be accurately pointed to this compound to avoid confusion.
In the laboratory, researchers follow the norms, or commonly use their standard names, but in industrial production or commercial circulation, the use of trade names may be more common.
The sorting of 4-chloro-3-fluoroiodobenzene aliases and trade names is conducive to the exchange between academia and industry, and to improve the efficiency of chemical research and application.

Safety & Operational Standards

Safety and operation specifications for 4-chloro-3-fluoroiodobenzene
4-chloro-3-fluoroiodobenzene is also an important substance for chemical research. If you want to use this substance, you must first clarify its safety and operation specifications to ensure that everything goes smoothly and personnel are safe.
Its properties are strong, and it may hurt the skin if it touches it, and it will harm the eyes if it enters the eyes. Therefore, when handling it, you must wear protective gear, such as gloves and eyepieces. Gloves must be resistant to corrosion, and eyepieces should be kept in good condition to prevent slight omissions.
This substance may be volatile, and its gas may be harmful to the body. Therefore, the place to be handled must be well ventilated, so that the foul gas can come out quickly and the clear air can enter quickly. If it is done in the room, a ventilated device should be set up, so that the poisonous gas should not be retained.
Furthermore, there are rules for storage. It is advisable to keep it in a cool and dry place, avoiding fire, heat and light. When storing with other things, you must carefully observe the physical properties and do not restrain each other. If you coexist with unsuitable things, you may be afraid of unexpected changes.
When operating, the method should be stable and accurate. When weighing, you must use precise tools, and do not make slight mistakes. Mixing and reaction steps should be carried out according to the prescribed method. Do not change the steps without authorization, and do not adjust the dose lightly.
If you accidentally touch it, rinse it with water as soon as possible, and seek medical treatment for those who are serious. If it spills on the ground, quickly collect it with an appropriate object, and do not spread it. Packed items should also be disposed of in accordance with regulations, and should not be discarded at will.
For chemical research, safety comes first. Only by following this specification can we ensure safety and promote the progress of research.

Application Area

4-Chloro-3-fluoroiodobenzene is also an organic compound. It has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate to help create special new drugs to treat various diseases and save patients from pain. In material science, it can be used as a raw material for synthesizing novel functional materials, making the materials have unique optoelectronic properties, and can be used in high-end electronic devices. In pesticide chemistry, it can be cleverly modified to become high-efficiency and low-toxicity pesticides, protecting crops from pests and diseases, and ensuring a good harvest. In the process of organic synthesis, it is often the cornerstone of building complex organic molecules. Through various reactions, the variety of organic compounds is expanded. With its unique structure, this compound shines in various application fields, opening up new paths for chemical research and industrial practice, and developing broad prospects.

Research & Development

The rise of modern chemistry is based on the study of matter. There are 4-Chloro-3-Fluoroiodobenzene of this matter today, and its research and development are quite important in the academic community.
At the beginning, it was difficult to obtain this compound, and the yield was quite low. The researchers have tried all kinds of methods. Or change the conditions of the reaction, adjust the temperature and pressure; or make it easy to use the reagent, and seek its purity and quality.
After years of research, it has gradually made progress. The new method is out, the yield has been improved, and the quality has also become better. This achievement is not only meaningful in the laboratory, but also in the application of industry, with broad prospects.
However, the road of research is not final. It is still necessary to study the characteristics of this object in different scenarios and expand its application field. Hope that in the future, due to in-depth research on this object, chemistry can be developed to a new realm, used by the world and benefiting the population.

Toxicity Research

Study on the toxicity of 4-chloro-3-fluoroiodobenzene
There is a substance named 4-chloro-3-fluoroiodobenzene. We take the toxicity study as our business to investigate the properties of this substance in detail.
This compound has a unique structure, with chlorine, fluorine and iodine atoms coexisting on a benzene ring. To understand its toxicity, first observe its performance in chemical reactions. When it combines with other substances, or due to atomic characteristics, the reactive activity is different, and this activity may be associated with toxicity.
Also observe its effect on organisms. Take various organisms as samples and observe their behavior after contact with this substance. Or see the physiological function of the organism changes, metabolism, and even cell damage and tissue damage.
After various investigations, it can be known that the toxicity of 4-chloro-3-fluoroiodobenzene cannot be ignored. In the future, we should take a more careful approach to study its behavior in the environment and in vivo, so as to fully understand its harm and serve as the basis for protection and treatment.

Future Prospects

This compound has a unique structure, and its chlorine, fluorine and iodine atoms coexist, or it can shine in the field of organic synthesis.
My generation expects that in the future it may become a key intermediate for the creation of new drugs. With its special chemical activity, it is expected to develop special drugs for difficult diseases, saving patients from pain. Or in the field of materials science, with its characteristics to help the birth of high-performance materials, applied to electronics, aviation and other frontier industries, to promote the progress of science and technology.
We should uphold the spirit of research and make unremitting exploration, with the hope of tapping its maximum potential, so that it can make unparalleled contributions to the well-being of mankind and the prosperity of science and technology in the years to come.

Where to Buy 4-Chloro-3-Fluoroiodobenzene in China?

As a trusted 4-Chloro-3-Fluoroiodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Chloro-3-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Chloro-3-Fluoroiodobenzene?

4-Chloro-3-fluoroiodobenzene is also an organic compound. It has a wide range of uses and plays an important role in the field of organic synthesis.
First, it can be used as a building block for the construction of complex organic molecules. Due to the existence of halogen atoms (chlorine, fluorine, iodine), they have active chemical properties and can participate in many chemical reactions. Such as nucleophilic substitution reactions, halogen atoms can be replaced by various nucleophiles, thereby introducing different functional groups, laying the foundation for the creation of diverse organic structures. Chemists can use this to carefully build complex molecular structures according to specific needs to meet the needs of drug development, materials science and other fields.
Second, it is also important in medicinal chemistry. The design and synthesis of drug molecules often depend on such halogen-containing organic compounds. Because halogen atoms can affect the electron cloud distribution and spatial structure of molecules, and then change the interaction between molecules and biological targets. Therefore, 4-chloro-3-fluoroiodobenzene may be used as the key structural unit of the lead compound. After chemical modification and optimization, it is expected to develop new specific drugs.
Third, in the field of materials science, it is also indispensable. For example, in the preparation of organic optoelectronic materials, this compound can be integrated into polymer materials or functional materials through specific reactions. Its unique electronic properties and structural characteristics may endow materials with excellent photoelectric properties, such as luminous efficiency, charge transfer ability, etc., which will help the research and development and innovation of new photoelectric materials.
In summary, 4-chloro-3-fluoroiodobenzene, with its unique chemical structure and active reaction properties, plays a pivotal role in many key fields such as organic synthesis, drug development, and materials science. It is indeed an important compound in the field of organic chemistry.

What are the physical properties of 4-Chloro-3-Fluoroiodobenzene?

4-Chloro-3-fluoroiodobenzene is one of the organic compounds. Its physical properties are particularly important and are related to many chemical applications.
First of all, its appearance, at room temperature, is often colorless to light yellow liquid, its color is pure, the appearance is translucent, and there is no obvious turbidity or impurities. This pure appearance lays a good foundation for its application in many fine chemical synthesis.
Second on its melting point and boiling point. The melting point is about a specific low temperature range, and the specific value may vary slightly depending on different measurement conditions. The boiling point is relatively high, and it needs to reach a certain temperature to boil and vaporize. This property is crucial in the separation and purification process. It can be effectively separated from the mixture by means of distillation and other means according to its boiling point difference.
Furthermore, the density of 4-chloro-3-fluoroiodobenzene is also specific. Compared with common organic solvents, its density may be different. This difference has a significant impact on liquid-liquid extraction and other operations, which is related to the state of stratification and then affects the separation efficiency.
In terms of solubility, it exhibits good solubility in some organic solvents, such as common aromatic hydrocarbon solvents, such as toluene and xylene, which can be miscible with it to form a uniform solution system. However, in water, its solubility is minimal, which is due to the characteristics of its molecular structure. Hydrophobic groups dominate, making it difficult to form effective interactions with water molecules.
In addition, 4-chloro-3-fluoroiodobenzene has a certain degree of volatility. Although the volatility is not extremely strong, it will evaporate slowly in an open system. This property needs to be paid attention to during storage and use, and it should be sealed and stored to prevent its volatilization loss and avoid environmental and safety related problems due to volatilization.
To sum up, the physical properties of 4-chloro-3-fluoroiodobenzene vary from appearance, melting point, density, solubility to volatility. These properties are interrelated and together determine their application in organic synthesis, chemical production, and other fields.

What is the chemical synthesis method of 4-Chloro-3-Fluoroiodobenzene?

The chemical synthesis of 4-chloro-3-fluoroiodobenzene is related to the delicate technology of organic synthesis. To make this substance, there are many paths to follow, and now I will describe one of the commonly used methods.
Starting material, 4-chloro-3-fluoroaniline can be selected. First, it is placed in a low temperature environment with sodium nitrite and hydrochloric acid, and the diazotization reaction is carried out. This reaction requires careful control of temperature, often maintained between 0-5 ° C, to convert 4-chloro-3-fluoroaniline into diazonium salts.
After that, take a potassium iodide solution and slowly add it to the diazonium salt system. The diazo group is then replaced by the iodine atom. After this step of reaction, 4-chloro-3-fluoroiodobenzene can be obtained. This substitution process also requires appropriate control of reaction conditions, such as temperature, reaction time and material ratio.
However, this process is not completely smooth, and some difficulties are often encountered. The diazotization reaction is extremely sensitive to temperature. The temperature is slightly higher, and the diazo salt or decomposition decreases the yield. And during the reaction process, side reactions may occur, which affect the purity of the product.
is the purity and yield of the product, and the reaction conditions need to be carefully optimized. Factors such as reaction temperature, reactant concentration and drip rate need to be carefully adjusted. The separation and purification steps are also crucial. High purity 4-chloro-3-fluoroiodobenzene can be obtained by column chromatography, recrystallization and other methods.
Synthesis of 4-chloro-3-fluoroiodobenzene requires familiarity with the organic reaction mechanism, proficiency in operation skills, and careful control of each reaction link to achieve satisfactory synthesis results.

What are the precautions in storage and transportation of 4-Chloro-3-Fluoroiodobenzene?

4-Chloro-3-fluoroiodobenzene is an organic chemical substance. When storing and transporting it, many matters need careful attention.
First words storage. Because of its certain chemical activity, it needs to be placed in a cool, dry and well-ventilated place. Such an environment can effectively avoid deterioration or chemical reactions caused by moisture and high temperature. The temperature of the warehouse should be controlled within a specific range to prevent the material from being unstable due to excessive temperature. It should also be kept away from fires and heat sources, because it is exposed to open flames, hot topics or the risk of combustion and explosion.
Furthermore, it needs to be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed. Due to the contact of these substances, it is easy to trigger violent chemical reactions and cause safety accidents. The storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage from being properly handled in a timely manner.
As for transportation, it should not be taken lightly. Be sure to ensure that the packaging is complete and sealed before transportation. Packaging materials need to be able to resist vibration, collision and friction to avoid material leakage caused by package damage during transportation. During transportation, the relevant regulations on chemical transportation should be strictly followed, and corresponding emergency treatment equipment and protective equipment should be equipped. Transportation vehicles should be kept away from densely populated areas and fire sources. And transportation personnel need to be professionally trained, familiar with the characteristics of the substance and emergency treatment methods, regularly check the status of the goods during transportation, and take immediate measures if there is any abnormality. In this way, the safety of 4-chloro-3-fluoroiodobenzene during storage and transportation can be guaranteed.

4-Chloro-3-Fluoroiodobenzene impact on the environment and human health

4-Chloro-3-fluoroiodobenzene is also an organic compound. Its impact on the environment and human health is of great concern to the world.
At one end of the environment, if this compound is released into nature, it may have multiple effects. It has certain chemical stability and is not easy to rapidly degrade in the environment. It may persist in soil and water for a long time, causing environmental medium pollution. If it enters the soil, it may affect the structure and function of soil microbial community, and disturb the material cycle and energy conversion of soil ecosystems. In water bodies, it may pose a threat to aquatic organisms. Due to biological enrichment, it is transmitted and accumulated along the food chain, harming advanced organisms.
As for human health, the latent risk of 4-chloro-3-fluoroiodobenzene cannot be ignored. Through respiratory tract, skin contact or ingestion, or damage human organs. Or affect the nervous system, cause headache, dizziness, fatigue and other diseases, and even interfere with nerve conduction function. Metabolic and excretory organs such as the liver and kidneys, or increase their burden, damage their normal physiological function, cause liver dysfunction, kidney dysfunction disease. And it may have a certain carcinogenicity, long-term exposure to the environment containing this substance increases the risk of cancer.
To sum up, 4-chloro-3-fluoroiodobenzene poses potential hazards to the environment and human health, and needs to be treated with caution. Effective control measures should be taken in the production, use, and disposal to reduce its adverse effects on the environment and human body.