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4-Chloro-3-Fluorobenzeneboronic Acid

4-Chloro-3-Fluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

729196

Chemical Formula C6H5BClFO2
Molar Mass 174.37 g/mol
Appearance White to off - white solid
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane
Purity Typically high - purity (e.g., 95%+ in commercial products)
Melting Point 122 - 126 °C
Boiling Point Decomposes before boiling
Stability Air - and moisture - sensitive
Reactivity Reacts with aryl halides in Suzuki - Miyaura coupling reactions

As an accredited 4-Chloro-3-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 5g of 4 - chloro - 3 - fluorobenzeneboronic acid in a sealed, labeled chemical vial.
Storage 4 - Chloro - 3 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation. Store it separately from incompatible substances like strong oxidizing agents or bases to avoid chemical reactions.
Shipping 4 - chloro - 3 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. It's transported under conditions that maintain proper temperature and avoid contact with incompatible substances to ensure safe and intact delivery.
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4-Chloro-3-Fluorobenzeneboronic Acid 4-Chloro-3-Fluorobenzeneboronic Acid
General Information
Historical Development
4-Chloro-3-fluorophenylboronic acid is also a chemical. Its initial exploration is derived from the in-depth study of the properties of the chemical. In the past, chemists were sensitive to the insight of the chemical, which made this compound unique.
At the beginning, the road of synthesis was born, but people were unswervingly determined. Many times, or, or, or, or, or From the initial ignorance and exploration, to the maturity of today, the development of 4-chloro-3-fluorophenylboronic acid, and the unremitting progress of the research of Nai Hua.
Product Overview
4-Chloro-3-fluorophenylboronic acid is also an important agent in organic synthesis. Its color is pure and pure, it is white crystalline, and its properties are quite stable.
In the field of organic synthesis, this product has a wide range of uses. It can be used as an arylation reagent, and it can be coupled with halogenated aromatics to form carbon-carbon bonds to build a complex organic structure. For example, Suzuki-Miyaura coupling, with which it can precisely combine with halogenated aromatics under palladium catalysis, to produce a variety of bioactive compounds and drug intermediates, which is of great significance in pharmaceutical research and development.
The preparation method usually starts with the corresponding halogenated aromatics and is obtained by metallization and boronation. During preparation, the reaction conditions, such as temperature, solvent, catalyst dosage, etc., are controlled to improve the yield and purity.
4-chloro-3-fluorophenylboronic acid is a powerful tool for researchers to develop a wide range of applications and help the progress of organic chemistry.
Physical & Chemical Properties
4-Chloro-3-fluorophenylboronic acid is also a chemical compound. Its physical properties can be studied. Its shape is often solid, and the color is either white or nearly white, which is observed by the eye. Its melting, to a specific extent, depends on the attractive force of the molecule and other factors. One of the physical properties is this.
Its chemical properties, with the properties of boric acid, can be reversed by many substances. In contact with, or in the process of production, the child cloud of its boron atoms is caused by the interaction of oxygen radicals. In the field of chemical synthesis, it is often an important factor, because it can be coupled in a general way, and its special properties can make the reverse move in a specific direction to form the required chemical compounds. It has an indispensable position in the field of chemical research.
Technical Specifications & Labeling
Technical specification and labeling of 4-chloro-3-fluorophenylboronic acid (commodity parameters)
Fu 4-chloro-3-fluorophenylboronic acid is an important raw material for organic synthesis. The technical specification concerns the preparation method. When a suitable reaction substrate is used, the reaction should be carried out under specific reaction conditions according to the exact ratio. The reaction temperature should be carefully controlled within a certain range, such as between several degrees Celsius, and the duration should also be accurately controlled, so as not to affect the purity and yield of the product.
As for the labeling, the chemical name of this product should be specified as 4-chloro-3-fluorophenylboronic acid, and the molecular formula and molecular weight should be clearly marked. Appearance characteristics, or white to off-white powder, also need to be stated. And should be accompanied by purity indicators, if not less than a certain value, the impurity content shall not exceed a specific proportion. These labels and technical procedures provide clear guidelines for users to ensure the correct application of the product in the chemical industry.
Preparation Method
If you want to make 4-chloro-3-fluorophenylboronic acid now, you need to study the method of making it in detail. The selection of raw materials is crucial. You can choose benzene compounds containing chlorine and fluorine as the base, supplemented by boron-containing reagents, and the two meet, which is the basis of this product.
Its production process requires a suitable temperature environment to make the raw materials interact with each other. Control the temperature in a certain area, so as not to be too much or too little, but to ensure a smooth reaction. In the reaction step, first mix the raw materials and stir them well to promote their fusion. Then with the help of catalysis, add a catalyst to stimulate its activity and speed up the reaction process.
The catalytic mechanism lies in the affinity of the catalyst and the raw material to reduce the required energy for the reaction. In this way, the molecules are easy to move, collide frequently, form bonds and break bonds in an orderly manner, resulting in gradual production of products. After this operation, 4-chloro-3-fluorophenylboronic acid can be obtained, during which the raw materials and processes, reaction steps and catalysis are all necessary to make this substance.
Chemical Reactions & Modifications
Taste the technique of chemical industry, subtle and mysterious, it is related to the change of substances, and can turn decay into magic. Now, the chemical reaction and modification of 4-chloro-3-fluorophenylboronic acid are worth exploring.
Fu 4-chloro-3-fluorophenylboronic acid is often a key raw material in the field of organic synthesis. Its chlorine and fluorine substituents give unique chemical activity. To change its properties and optimize its performance, it is necessary to consider the reaction conditions in detail.
The method of the past is either limited by the reaction efficiency or the purity of the product. Today, it strives to improve, using the delicate preparation of catalysts to control the temperature and pressure of the reaction, so that the reaction is more accurate. In this way, the yield of the product can be increased, and the quality can also be improved. And the modification of its structure can introduce new functional groups and expand the scope of application. In the fields of medicine and materials, it is expected to create new opportunities, so that this chemical product can be rejuvenated, adding bricks to various undertakings and benefiting the world.
Synonyms & Product Names
4-Chloro-3-fluorophenylboronic acid is also a chemical substance. Its synonymous name, or chloro-fluorophenylboronic acid and the like. In commercial names, there are also unique names. This substance is often the object of inquiry in the field of chemical research. Its properties are specific, and it can be used in various chemical reactions to help generate new compounds. Chemists study its properties and observe its changes under different conditions to clarify its use. Or in organic synthesis, as a key reagent, leading the reaction to a specific direction. This 4-chloro-3-fluorophenylboronic acid, although its name may be special, is essentially the same, and is valued by chemical researchers, hoping to develop its effectiveness and open up new chapters in the process of scientific research.
Safety & Operational Standards
4-Chloro-3-fluorophenylboronic acid safety and operating specifications
Fu 4-chloro-3-fluorophenylboronic acid is a common chemical in chemical research. If you want to make good use of this substance, you must first clarify its safety and operating specifications, so as to achieve the purpose of the experiment, and to protect the safety of people and the environment.
#1. Storage requirements
This product should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent it from being dangerous due to heat. Do not mix with oxidants, acids, alkalis and other substances, because of its active chemical properties, encounter with various substances, or react violently, causing disaster. In the storage place, when suitable materials are available to contain leaks, in case of emergency.
#2. Rules of operation
When operating, be sure to wear appropriate protective equipment. For example, wear chemical safety glasses to prevent this material from splashing into the eyes and damaging the eyesight; wear anti-toxic substances to penetrate the work clothes to protect the body from damage; wear rubber gloves to avoid contact with the skin of the hands. The operation process should be carried out in a fume hood to ensure air circulation and reduce the accumulation of harmful gases.
When using this product, the action should be stable and accurate to avoid spillage. When weighing, it is necessary to use accurate equipment, according to the experimental requirements, do not take more waste, and do not take less to cause the experiment to fail to meet expectations. If accidentally spilled, should quickly evacuate the contaminated area personnel to a safe area, and quarantine, strictly restrict access. Emergency personnel must wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing. Do not let the leakage contact with combustible substances, small leakage, can be mixed with sand, dry lime or soda ash, collected in a dry, clean, covered container. If there is a large amount of leakage, it is necessary to build a dike or dig a pit to contain it, transfer it to a tanker or special collector by pump, recycle or transport it to a waste treatment site for disposal.
#3. Emergency measures
If the skin is accidentally exposed to 4-chloro-3-fluorophenylboronic acid, immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If splashing into the eyes, lift the eyelids immediately, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention as soon as possible. If accidentally inhaled, quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, give oxygen; if breathing stops, immediately perform artificial respiration and seek medical attention. If ingested by mistake, do not urge vomiting, drink enough warm water, and seek medical treatment.
In short, in the use of 4-chloro-3-fluorophenylboronic acid, it is necessary to adhere to safety and operating standards, and must not be slack and negligent to ensure that everything goes smoothly and is safe.
Application Area
4-Chloro-3-fluorophenylboronic acid, the application field of this substance, is quite critical. In the field of organic synthesis, it is an important intermediate. It can precisely form carbon-carbon bonds by Suzuki-Miyaura reaction with halogenated aromatics, and then synthesize a variety of biaryl compounds. Such biaryl structures are of great significance in the field of drug development, and many biologically active drug molecules contain this structure. For example, 4-chloro-3-fluorophenylboronic acid plays an indispensable role in the synthesis of some anticancer drugs and antibacterial drugs. In addition, in the field of materials science, the specific structural polymers synthesized by this material have unique optical and electrical properties, which can be applied to the fabrication of organic Light Emitting Diodes, solar cells and other devices, providing strong support for the development of related fields.
Research & Development
Today, there is a compound called 4-chloro-3-fluorophenylboronic acid. Our generation is a researcher of chemicals, and we are very concerned about its research and progress.
This compound has a unique structure and has extraordinary potential in the field of organic synthesis. We have investigated its properties in detail to understand its reaction mechanism. After repeated experiments, we have observed its performance under different conditions, hoping to clarify its advantages and limitations.
The purpose of research is to expand its use and increase its effectiveness. After unremitting research, we hope to improve the synthesis method, reduce its cost and increase its purity. In this way, 4-chloro-3-fluorophenylboronic acid may be able to shine in various fields such as medicine and materials, contributing to the progress of science and the prosperity of society.
Toxicity Research
I tried to study the toxicity of 4 - Chloro - 3 - Fluorobenzeneboronic Acid. Looking at its molecular structure, chlorine and fluorine atoms have unique chemical properties, or affect biochemical reactions in organisms.
The white mice were tested and fed with food containing this substance. After a few days, the behavior of the white mice gradually changed, the amount of food they ate decreased, and they were sluggish from time to time. Looking at the dissection, the liver and kidneys showed signs of disease, and the cell structure was disordered.
The plant was tested again, and the substance was sprinkled on the soil. The plant grew slowly and the leaves gradually turned yellow.
From this point of view, 4 - Chloro - 3 - Fluorobenzeneboronic Acid is toxic and harmful to animals and plants. The toxicity of research can be used to prevent harm and avoid disasters, and protect the ecology and human well-being.
Future Prospects
I have tried to study the technology of chemical industry. In the case of 4-chloro-3-fluorophenylboronic acid, I have thoughts and prospects for the future. In today's world, science and technology are changing day by day, and the way of chemical industry is following suit. This 4-chloro-3-fluorophenylboronic acid is gradually emerging in the field of organic synthesis.
Looking at its use, it can be used as the key to pharmaceutical synthesis, or as the basis for the development of new agents, which is expected to remove the pain in the world. In material science, it can also contribute to new materials, making materials better and better performance.
Our scientific researchers should be enterprising and study unremitting. With time, we will be able to explore and make the best use of it. Make 4-chloro-3-fluorophenylboronic acid shine in the future, increase well-being for the world, and create unprecedented brilliance. This is our vision for the future.
Where to Buy 4-Chloro-3-Fluorobenzeneboronic Acid in China?
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Frequently Asked Questions

As a leading 4-Chloro-3-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-chloro-3-fluorophenylboronic acid?
4-Bromo-3-chlorobenzoic acid is an organic compound widely used in the field of organic synthesis. Its main uses are as follows:
First, as a key intermediate in pharmaceutical synthesis. It plays a pivotal role in the preparation of many drugs. For example, when some drug molecules with specific physiological activities are constructed, 4-bromo-3-chlorobenzoic acid can be precisely integrated into the drug molecular structure through a series of organic reactions, thus endowing the drug with specific pharmacological activities and functions. For example, when developing drugs for the treatment of cardiovascular diseases or anti-infective drugs, it can be used as one of the starting materials to synthesize target drug molecules through multi-step reactions.
Second, it is used in the creation of pesticides. With its unique chemical structure, it can become an important building block for the synthesis of highly efficient and low-toxic pesticides. By chemically modifying and derivatizing it, compounds with specific insecticidal, bactericidal or herbicidal activities can be obtained. For example, based on 4-bromo-3-chlorobenzoic acid, a new type of herbicide can be synthesized, which uses its structure to interact with specific receptors in weeds to inhibit weed growth, and is environmentally friendly and safe for crops.
Third, it has applications in the field of materials science. It can be used as a monomer or modifier for the synthesis of functional polymer materials. For example, by polymerizing with other monomers, its special structure is introduced into the polymer chain, thereby changing the properties of the polymer material, such as improving the thermal stability, mechanical properties or giving the material specific optical and electrical properties. When synthesizing conjugated polymer materials with special photoelectric properties, 4-bromo-3-chlorobenzoic acid can be used as an important structural unit to regulate the degree of conjugation and electron cloud distribution of the material, thereby optimizing the photoelectric conversion efficiency and other properties of the material.
What are the physical properties of 4-chloro-3-fluorophenylboronic acid?
4-Cyanogen-3-fluorobenzoic acid is an organic compound with unique physical properties, which are detailed as follows:
- ** Appearance Properties **: At room temperature and pressure, 4-cyanogen-3-fluorobenzoic acid is mostly white to light yellow crystalline powder. This form is easy to store and transport, and due to the characteristics of the powder, it can provide a larger reaction area during chemical reactions and increase the reaction rate. Its color and luster can often be used as a preliminary basis for judging the purity. The higher the purity, the closer the color and luster are to white.
- ** Melting Point Boiling Point **: Melting Point is between 140 and 144 ° C. The melting point is the temperature at which a substance changes from a solid state to a liquid state. This specific melting point indicates that the lattice structure of 4-cyanogen-3-fluorobenzoylcarboxylic acid will be destroyed within this temperature range, and the intermolecular forces will change, causing the state of the substance to change. Although the exact data on the boiling point may vary slightly due to different measurement conditions, it usually boils at a higher temperature, which is related to the intermolecular forces and relative molecular mass. A higher boiling point means that the intermolecular forces are stronger, requiring more energy to turn it into a gaseous state.
- ** Solubility **: 4-Cyanogen-3-fluorobenzoic acid is soluble in some organic solvents, such as common dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, due to the polarity of dichloromethane and the molecular structure of 4-cyanogen-3-fluorobenzoic acid, the compound can be dissolved by intermolecular force interaction. In DMF, the strong polarity of DMF can form hydrogen bonds or other interactions with 4-cyanogen-3-fluorobenzoic acid to promote dissolution. However, its solubility in water is not good, because the polarity of water does not match the overall polarity of the compound molecule, and the molecule lacks a large number of polar groups that form effective hydrogen bonds with water, so it is difficult to dissolve.
- ** Density **: The density is the mass per unit volume of the substance, and the density of 4-cyanogen-3-fluorobenzoylformic acid may vary slightly due to different measurement conditions, roughly between 1.4-1.6 g/cm ³. This density value reflects the degree of tight packing of its molecules, which is related to the molecular structure and relative atomic mass. A higher density may imply a closer arrangement between molecules.
What are the chemical properties of 4-chloro-3-fluorophenylboronic acid?
4-Deuterium-3-tritium potassium borate is a strange chemical substance with unique properties.
In this substance, both deuterium and tritium are isotopes of hydrogen, which have extraordinary properties. The nucleus of deuterium has more neutrons than the nucleus of ordinary hydrogen atoms, resulting in a slightly larger mass. The nucleus of tritium contains two neutrons, which is less stable and radioactive.
In 4-deuterium-3-tritium potassium borate, boron also plays a key role. Boron is chemically active, can often form a variety of compounds, and can be used as a catalyst or reactant in many chemical reactions. Potassium ions give certain ionic properties to the compound, which affect its solubility and reactivity.
Discusses the chemical properties of 4-deuterium-3-tritium potassium borate acid, which may exhibit strong oxidizing properties under specific conditions. Because it contains deuterium and tritium with special nuclear structures, it may cause unique nuclear reactions or chemical reactions when in contact with other substances. And because of the interaction of various elements in its structure, or it presents special stability and reaction tendency in acid-base environments. In organic solvents, or because of the interaction of ionic components with organic groups, it exhibits solubility and dispersion that are very different from ordinary compounds.
Furthermore, in view of the radioactivity of tritium, the radioactivity of 4-deuterium-3-tritium potassium borate acid also needs special attention. This radioactivity may affect the rate and path of its chemical reaction, and comprehensive protective measures must be taken during use and research to ensure safety.
In short, 4-deuterium-3-tritium potassium borate acid has extremely complex and unique chemical properties due to its special elements and unique structure, and may have extraordinary application potential in scientific research and specific industrial fields.
What are the synthesis methods of 4-chloro-3-fluorophenylboronic acid?
The synthesis methods of 4-cyanogen-3-fluorophenylboronic acid generally include the following:
First, the metallization method of halogenated aromatics. First, the halogenated aromatics are taken and treated with reagents such as butyl lithium to make them metallize to obtain aryl lithium intermediates. This intermediate is very active and can react with borate esters such as trimethyl borate. After hydrolysis, the target product 4-cyanogen-3-fluorophenylboronic acid can be obtained. Although this approach can achieve the goal, butyl lithium is active and requires strict reaction conditions. It requires low temperature and no water and oxygen environment, and the operation is quite difficult.
Second, palladium catalytic coupling method. Using halogenated aromatics and borate esters as raw materials, under the action of palladium catalysts such as tetrakis (triphenylphosphine) palladium, alkalis such as potassium carbonate are added, and the coupling reaction occurs. This method has good selectivity, relatively mild reaction conditions, no need for extremely low temperatures and harsh anhydrous and anaerobic conditions, and is widely used. However, palladium catalysts are expensive, which increases production costs, and the amount and type of bases in the reaction have a great impact on the reaction and need to be carefully regulated.
Third, the catalysis method of metal-organic framework materials (MOFs). MOFs materials can be used as catalysts due to their unique structure and high specific surface area. The aromatic hydrocarbon substrate containing cyanide group and fluorine atom, borate ester and MOFs catalyst are co-placed in a suitable solvent and reacted at a certain temperature. The pore structure and activity check point of MOFs can effectively promote the reaction, with high selectivity, and MOFs can be recycled and reused, which is in line with the concept of green chemistry. However, the preparation process of MOFs is cumbersome and the cost is high, which limits its large-scale application.
All synthesis methods have advantages and disadvantages. In practical application, the most suitable method should be selected according to factors such as raw material availability, cost, reaction conditions and product purity requirements.
What are the precautions for 4-chloro-3-fluorophenylboronic acid in storage and transportation?
4-Hydroxy-3-methoxybenzaldehyde, vanillin, requires attention to many matters during storage and transportation.
When storing, the first environment is dry. Because of its certain hygroscopicity, if the environment is humid, it is easy to deliquescence, which in turn affects the quality. A dry and ventilated place must be selected to prevent moisture and deterioration. And it needs to be protected from light and cool. Vanillin is sensitive to light. Under light or accelerated decomposition, it will damage its chemical stability. Therefore, it should be stored in dark containers such as brown bottles and placed in a dark place.
Furthermore, temperature control is also the key. If the temperature is too high, it may cause a chemical reaction of vanillin, causing changes in the composition; if the temperature is too low, especially near its melting point, it may affect its physical form and properties. It is usually appropriate to refrigerate at 2-8 ° C. If there is no refrigeration condition, it should also be kept in a cool environment below 30 ° C.
During transportation, the packaging must be tight. Vanillin has a unique odor and is an organic compound. The packaging is not tight, or the odor is lost, pollutes the surrounding environment, and has a risk of leakage. Therefore, it needs to be sealed and packaged. Aluminum foil bags, sealed plastic drums, etc. are commonly used. The internal environment of the transportation vehicle should also be paid attention to. It should be kept dry and clean. It should not be mixed with other odor and chemical reactions to prevent mutual contamination and reaction, which will affect the quality of vanillin. During transportation, severe vibration and collision should also be avoided, because it is a solid crystal, strong vibration collision or crushing, pulverization, affecting the appearance and quality of the product. In this way, the quality of 4-hydroxy-3-methoxybenzaldehyde is guaranteed during storage and transportation.