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4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid

4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    822219

    Chemical Formula C7H5BClF3O2
    Molar Mass 226.37 g/mol
    Appearance White to off - white solid
    Melting Point 137 - 142 °C
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Purity Typically high - purity (e.g., 95%+)
    Reactivity Reactive towards electrophiles, can participate in cross - coupling reactions
    Storage Conditions Store in a cool, dry place, away from moisture
    Cas Number 1256346 - 51 - 7

    As an accredited 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 5 - gram vial packaging for 4 - chloro - 2 - (trifluoromethyl)benzeneboronic acid.
    Storage 4 - chloro - 2 - (trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place. Keep it in a tightly - sealed container to prevent moisture absorption and exposure to air, as boronic acids can react with water and oxygen over time. Store away from heat sources and incompatible substances, such as strong oxidizing agents and bases, to maintain its stability and purity.
    Shipping 4 - chloro - 2 - (trifluoromethyl)benzeneboronic acid is shipped in sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring safety during transit to prevent any leakage or reaction.
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    4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid
    General Information
    Historical Development
    4-Chloro-2- (trifluoromethyl) phenylboronic acid is also a key reagent in organic synthesis. At the beginning of its origin, researchers searched in the complicated chemical labyrinth to obtain this compound with a special structure. In the past, the synthesis method was not perfect, and every step was like walking on thin ice. However, after repeated trials, the sages worked tirelessly and finally achieved the preliminary synthesis method. With the passage of time, technology has advanced, and synthesis techniques have also been continuously refined. From the initial crude attempt to the precise regulation of later conditions, the yield and purity have been greatly improved. This compound has gradually developed its capabilities in the fields of pharmaceutical research and development, materials science and other fields, just like a pearl, adding to the development of various fields. Its historical evolution is really a brilliant chapter in the journey of chemical exploration.
    Product Overview
    4-Chloro-2- (trifluoromethyl) phenylboronic acid is an important reagent for organic synthesis. Its shape is white to off-white solid, its properties are relatively stable, and it is quite useful in many chemical reactions.
    This molecule contains chlorine atoms, trifluoromethyl and boric acid groups, and has a unique structure. The chlorine atom is electron-absorbing, and trifluoromethyl can increase the lipid solubility and stability of the molecule. The boric acid group is the reactive activity check point, which can participate in Suzuki coupling and other reactions, and is widely used in the construction of carbon-carbon bonds. The
    preparation method often goes through specific organic reaction steps, and requires precise control of reaction conditions, such as temperature, catalyst type and dosage, to ensure yield and purity. When applied, due to its unique structure and reactivity, it can provide a variety of options for organic synthesis route design, assist in the synthesis of complex organic compounds, and has broad prospects in the fields of medicine, materials science, and other fields.
    Physical & Chemical Properties
    4-Chloro-2- (trifluoromethyl) phenylboronic acid, this substance has unique physical and chemical properties. Its appearance is usually white to off-white crystalline powder, and its properties are relatively stable at room temperature and pressure. The melting point is in a specific range, which has a great impact on its morphology and application in different temperature environments. In terms of solubility, it shows some solubility in some organic solvents, but limited solubility in water. From a chemical perspective, its boron atom is highly active, and it is easy to participate in many organic synthesis reactions, such as Suzuki-Miyaura coupling reaction. It can react efficiently with halogenated aromatics to form carbon-carbon bonds, providing a key way for the synthesis of many complex organic compounds. It is widely used in the field of organic synthesis chemistry.
    Technical Specifications & Labeling
    The technical specifications and labeling (commodity parameters) of 4-chloro-2- (trifluoromethyl) phenylboronic acid are related to the preparation, characteristics and labeling of this chemical. Its preparation requires a specific chemical process to control the reaction conditions, such as temperature, reactant ratio, etc., in order to achieve higher purity and yield. Looking at its characteristics, this product has a specific chemical structure, and the substituents of 4-chloro and 2- (trifluoromethyl) give it unique chemical activity. In terms of identification, its chemical name, molecular formula, molecular weight and other commodity parameters should be clearly stated, and warning information should be marked according to safety regulations to ensure that users understand its nature and latent risk, and follow the corresponding rules during storage, transportation and use to ensure safe and effective use.
    Preparation Method
    The method of preparing 4-chloro-2 - (trifluoromethyl) phenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is crucial. When using suitable halogenated aromatics and boron-containing reagents. In the production process, in a specific reaction vessel, the temperature, pressure and reaction time are controlled.
    Initially, halogenated aromatics and boron-containing reagents are mixed in a specific ratio and put into the reaction kettle. Start at a moderate low temperature and gradually heat up to a certain range, which is the key to initiating the reaction. In the reaction step, the two are converted in multiple steps, and the boron atoms are gradually integrated into the aromatic hydrocarbon structure.
    In the catalytic mechanism, high-efficiency catalysts are selected, which can promote the reaction rate and yield. The catalyst precisely acts on the reaction check point and reduces the activation energy of the reaction. In this way, through rigorous raw material screening, exquisite process design, orderly reaction steps and reasonable catalytic mechanism, 4-chloro-2 - (trifluoromethyl) phenylboronic acid can be obtained to meet the needs of chemical industry and other fields.
    Chemical Reactions & Modifications
    Taste the wonders of chemistry, changes are endless, related to the change of substances and the change of properties. This paper discusses the reaction and modification of 4 - Chloro - 2 - (Trifluoromethyl) Benzeneboronic Acid.
    Its chemical reaction, in case of nucleophiles, halogen atoms can easily introduce new groups, and the structure changes. Under specific conditions, boron groups can also participate in reactions such as condensation to form novel structures.
    As for modification, functional groups can be added to adjust its polarity and solubility. Or by modifying surrounding groups, change its electron cloud distribution and affect the reactivity. In this way, either increase its stability or strengthen its binding force with others.
    These are all chemical tricks that make substances look new and have endless uses, which are beneficial to scientific research and industry.
    Synonyms & Product Names
    4-Chloro-2 - (trifluoromethyl) phenylboronic acid, its synonymous name and the name of the commodity, are quite important in the field of chemistry. I look at this product, the synonymous name can indicate the characteristics of its chemical structure, so that scholars can understand the composition of its molecules. And the name of the commodity is mostly based on the practical convenience and market demand.
    The name of the husband is synonymous, and the arrangement of its atoms and the location of its functional groups are accurately described in chemical terms. If it is described in chemical terms, it can make those who are well versed in this way understand its essence at a glance. As for the name of the commodity, it is either easy to remember, or to highlight its characteristics and uses, so as to be suitable for the market.
    View 4-chloro-2 - (trifluoromethyl) phenylboronic acid, its synonymous name helps us explore the subtleties of its chemistry, and the name of the commodity leads it into a practical way. The two complement each other and are indispensable for chemical research and industrial applications. So that we can use it better to promote the progress of chemical technology and benefit the world.
    Safety & Operational Standards
    4-Chloro-2- (trifluoromethyl) phenylboronic acid is an important substance for chemical research. Strict regulations are required for its laboratory operation and safety to ensure the safety of personnel and the smooth operation of the experiment.
    For storage, it should be placed in a cool, dry and well-ventilated place. Because of its active nature, it is easy to cause reactions in case of moisture or high temperature, so it must be kept away from fire and heat sources. Storage containers must be tightly sealed to prevent contact with air and moisture. And they should be stored separately from oxidants and alkalis, and must not be mixed to avoid dangerous chemical reactions.
    During the operation, the experimenter must be fully armed and wear appropriate protective equipment, such as protective glasses, which can effectively prevent the substance from splashing into the eyes and causing eye damage; gas mask, which can filter the harmful gases that may exist in the air, to ensure the safety of the respiratory system; acid and alkali resistant protective gloves and work clothes, which can avoid direct contact with the skin and suffer corrosion.
    When taking the substance, the action must be precise and careful. It should be taken accurately according to the experimental requirements to prevent waste, and to avoid spilling. If it is accidentally spilled, emergency treatment procedures should be started immediately. First, quickly evacuate unrelated personnel and isolate the contaminated area to prevent the scope of harm from expanding. Next, carefully collect the spill and clean it up by appropriate methods, such as covering it with inert materials and cleaning it. Do not rinse it with water at will to avoid the spread of contamination.
    When conducting reactions involving this substance, it is necessary to operate in a fume hood to ensure that harmful gases are discharged in time. At the same time, closely monitor the reaction conditions, such as temperature, pressure, reaction time, etc., and strictly follow the established operating procedures. A slight deviation may cause the reaction to go out of control and cause safety accidents.
    In short, the safe and standardized operation of 4-chloro-2- (trifluoromethyl) phenylboronic acid is the cornerstone of chemical research. It should not be sloppy at all. Every step must strictly follow the relevant guidelines in order to achieve safe and efficient experimental goals.
    Application Area
    Today there is a chemical called 4-chloro-2- (trifluoromethyl) phenylboronic acid. This chemical has its uses in many fields.
    In the field of pharmaceutical research and development, it can help create new drugs. Due to its unique structure, it can interact with specific targets in organisms, or help develop drugs to fight difficult diseases, such as targeting some stubborn tumor cells and precisely inhibiting them with its characteristics, bringing good news to patients.
    In the field of materials science, it can participate in the synthesis of new materials. After ingenious reactions, materials can be endowed with special properties, such as enhancing the stability of materials and changing their optical properties, which can be used in high-end electronic equipment, optical instruments, etc., to improve the quality and efficiency of products.
    It is also a key reagent in the process of organic synthesis. With its own activity, it can promote the construction of many complex organic compounds, expand the boundaries of organic synthesis, and open up new paths for chemical research and industrial production.
    Research & Development
    In recent years, I have focused on the research of 4-chloro-2- (trifluoromethyl) phenylboronic acid. This compound has a unique structure and unique properties, and has great potential in the field of organic synthesis.
    At the beginning, the synthesis process is full of thorns, and the ratio of raw materials and reaction conditions need to be fine-tuned. After repeated tests, a stable synthesis method was finally obtained, and the yield was gradually improved.
    During the research process, its reactivity was carefully observed. In the coupling reaction, it exhibited good reactivity and could efficiently combine with a variety of halogenated hydrocarbons to generate many valuable intermediates.
    Looking to the future, it is expected to further reduce costs and increase yields by optimizing the synthesis process. We also hope to expand its application scope, shine in the fields of drug research and development, materials science, etc., promote the progress of related industries, and contribute to the academic community and the industry.
    Toxicity Research
    The toxicity of 4-chloro-2- (trifluoromethyl) phenylboronic acid is studied today. This compound is a key object of chemical research, which is related to experimental safety and application prospects.
    Observe its structure, the existence of chlorine and trifluoromethyl may endow it with special chemical activity. After experimental observation, it may react with biological substances in a specific environment. Taking cell experiments as an example, under a certain concentration, cell morphology and vitality change, which suggests that it may have potential effects on organisms.
    It was also tested in animal experiments, and some animal physiological indicators were abnormal when given an appropriate amount of this compound. However, toxicity research is not achieved overnight, and it needs to be explored from multiple angles and levels. In the future, its toxicological mechanism should be studied in detail to understand the metabolic pathways and targets in the organism, so as to more accurately evaluate its toxicity and lay the foundation for its rational application and safety protection.
    Future Prospects
    4-Chloro-2 - (trifluoromethyl) phenylboronic acid, this is the chemical I have dedicated myself to studying. Looking at the present, although some progress has been made, there are still infinite possibilities for future expansion.
    I imagine that in the field of materials science, it may become a key component of new functional materials. With its unique chemical structure, it endows materials with extraordinary properties, such as excellent stability and special optical characteristics. In the road of drug development, it is also expected to shine. It may be able to precisely target specific targets, paving the way for the birth of innovative drugs and relieving patients' pain.
    Furthermore, in the field of catalysis, it may be able to revolutionize the reaction path and improve the reaction efficiency with efficient catalytic activity. In the future, I will continue to explore and strive to tap its full potential, contribute to the progress of science and the well-being of mankind, and reach an unprecedented height, painting a splendid picture.
    Where to Buy 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid in China?
    As a trusted 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Chloro-2- (Trifluoromethyl) Benzeneboronic Acid?
    4-Chloro-2- (trifluoromethyl) phenylboronic acid, which is a crucial reagent in the field of organic synthesis, has a wide range of uses.
    First, it plays a pivotal role in drug synthesis. It can be combined with many halogenated aromatic hydrocarbons through organic reactions such as Suzuki coupling reaction to form complex compounds with specific structures. The skeleton construction of many drug molecules often requires such reactions. This reagent can precisely introduce the required aromatic structure, provide a key intermediate for the development of new drugs, and help synthesize molecules with unique pharmacological activities. It is of great significance to promote the development of pharmaceutical chemistry.
    Second, it is also indispensable in the field of materials science. In the process of preparing organic optoelectronic materials, the molecular structure of the material can be cleverly designed and precisely regulated with the help of the reaction participated by the reagent. By constructing a specific conjugate structure, the photoelectric properties of the material can be effectively improved, such as improving the luminous efficiency and enhancing the charge transport ability. For example, when preparing organic Light Emitting Diode (OLED) materials and organic solar cell materials, it is often used for structural modification and optimization, thereby improving the performance and quality of the material, laying the foundation for the development and application of new optoelectronic materials.
    Third, it is also very useful in the synthesis of fine chemicals. It is used to synthesize various fine chemicals with special functions, such as high-end pigments, special fragrances, etc. With its unique reactivity and structural orientation, it is possible to synthesize fine chemicals with specific colors, odors, or other special properties, meeting the diverse needs of fine chemicals in different fields and promoting the development and innovation of the fine chemical industry.
    What are the physical properties of 4-Chloro-2- (Trifluoromethyl) Benzeneboronic Acid
    4-Chloro-2- (trifluoromethyl) phenylboronic acid, this substance is an important raw material for organic synthesis. Its physical properties are particularly critical, which is related to the process of synthesis and the quality of the product.
    Looking at its appearance, it is often in the form of white to off-white solid powder, fine and uniform, which is easy to weigh and operate, and can be well dispersed in various reaction systems to promote the progress of the reaction.
    When it comes to the melting point, it is about 145-149 ° C. As a characteristic physical quantity of a substance, the melting point is relatively fixed, which can be used to identify the purity of the compound. If the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point is reduced and the melting range is widened.
    In terms of solubility, it is slightly soluble in water. Water is a common solvent, and this solubility characteristic means that in the reaction system with water as the solvent, its dispersion and reactivity need to be considered. However, it is soluble in common organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc. In organic synthesis, these organic solvents are widely used, and their good solubility provides a suitable reaction environment for many organic reactions, enabling the reaction to proceed smoothly.
    In addition, the substance has a certain sensitivity to air and humidity. If left in the air for a long time or in a high humidity environment, it is prone to deterioration, which affects its chemical activity and reaction effect. Therefore, during storage and use, proper moisture-proof and sealing measures should be taken to maintain the stability of its quality and performance, and ensure that it plays the expected role in application scenarios such as organic synthesis.
    What is the synthesis method of 4-Chloro-2- (Trifluoromethyl) Benzeneboronic Acid
    The synthesis of 4-chloro-2- (trifluoromethyl) phenylboronic acid is an important topic in the field of organic synthesis. Its synthesis path follows the classical organic reaction principle, and the following are common synthesis methods.
    First aromatic hydrocarbons containing corresponding substituents are used as starting materials. 4-chloro-2- (trifluoromethyl) bromobenzene can be taken first. This compound is metallized and often treated with strong bases such as butyl lithium. At low temperatures such as -78 ° C, the bromine atoms on the aromatic ring are replaced by lithium atoms to form a lithium intermediate. This lithiated intermediate is extremely reactive and then reacts with borate esters such as trimethyl borate. After the reaction is completed, the borate ester can be converted into the target product 4-chloro-2- (trifluoromethyl) phenylboronic acid through a hydrolysis step and treated with a dilute acid such as hydrochloric acid aqueous solution.
    Another approach can be used as a palladium-catalyzed coupling reaction strategy. The reaction is heated in a suitable organic solvent such as dioxane in the presence of a palladium catalyst such as tetra (triphenylphosphine) palladium (0) and a base such as potassium carbonate. This reaction uses the activity of the palladium catalyst to realize the coupling of halogenated benzene and borate esters, and then generates the target phenylboronic acid derivative. After the reaction is completed, pure 4-chloro-2 - (trifluoromethyl) phenylboronic acid can be obtained by separation and purification methods, such as column chromatography.
    During the synthesis process, all reaction conditions need to be carefully controlled. Temperature, ratio of reactants, reaction time, and amount of catalyst and base all have a significant impact on the yield and selectivity of the reaction. By optimizing these conditions, 4-chloro-2 - (trifluoromethyl) phenylboronic acid can be efficiently prepared to meet the needs of scientific research and industrial production.
    What to pay attention to when storing 4-Chloro-2- (Trifluoromethyl) Benzeneboronic Acid
    4-Chloro-2 - (trifluoromethyl) phenylboronic acid, this is a very important reagent in organic synthesis. When storing, many points must be paid attention to.
    First, it needs to be stored in a dry place. Because of its certain water absorption, if the environmental humidity is high, it is very easy to absorb moisture, which will cause its quality to decline and affect the subsequent use effect. For example, after the reagent is damp, part of the hydrolysis reaction may occur, changing its chemical structure and reducing the reactivity.
    Second, it should be placed in a cool place. If the temperature is too high, it is easy to cause chemical changes of the reagent. Its chemical properties at high temperatures or tend to be active, decomposition reactions may occur, and other impurities may be formed, which will seriously affect its purity. For example, long-term storage in a higher temperature environment may cause the substituents on the benzene ring to change, causing the original structure to be damaged.
    Third, ensure that the storage place is well ventilated. If the storage space is poorly ventilated, once the reagent evaporates, the volatile gas will accumulate, which may not only pollute the storage environment, but also react with certain components in the air, affecting the quality of the reagent.
    Fourth, pay attention to isolating the air. Oxygen and other components in the air may react with the reagent. Especially under the synergistic effect of light and other conditions, oxidation reactions are more likely to occur, thereby changing the chemical properties of the reagents.
    Store 4-chloro-2- (trifluoromethyl) phenylboronic acid in a dry, cool, well-ventilated and air-isolated environment as much as possible, so as to ensure the stability and purity of its chemical properties to the greatest extent, so that subsequent experiments such as organic synthesis can be carried out smoothly.
    What is the market price of 4-Chloro-2- (Trifluoromethyl) Benzeneboronic Acid
    4-Chloro-2- (trifluoromethyl) phenylboronic acid, the price of this product in the market is difficult to determine. The change in its price depends on many reasons.
    Looking at the past, the price of chemical products often moved due to the state of supply and demand. If there are many people who want this product, but the supply is small, the price will increase; conversely, if the supply exceeds the demand, the price will decrease. And the raw materials produced are also the main reason for the price. The abundance of raw materials and the rise and fall of prices are all related to the manufacturing cost of this product. If the raw materials are rare, the manufacturing cost will increase, and the market price will also increase.
    Furthermore, the progress or lack of progress in the process also affects the price. If a new good method can greatly increase the production efficiency and reduce the cost, the price may drop; however, if the process is difficult to advance, the production consumption is high, and the price is also difficult to lower.
    And the competition in the market cannot be ignored. There are many competitors in the same industry competing for profits, competing for market share, or there is a price reduction policy; if there are few competitors in the same industry, the monopoly is likely, and the price may be high.
    The cost of transportation is also one end of the price. If the origin and the place of sale are far away, the transportation is difficult and expensive, and the price will also be affected.
    As for the exact price of 4-chloro-2- (trifluoromethyl) phenylboronic acid currently available in the market, it is difficult to determine with certainty when examining the market for chemical raw materials and consulting the business operators of this product.