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4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene

4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    183853

    Chemical Formula C7H3ClF3I
    Molecular Weight 318.45
    Appearance Typically a colorless to pale - yellow liquid or solid (depending on conditions)
    Boiling Point Estimated to be in a certain range, but exact value needs experimental determination
    Melting Point Needs experimental determination
    Density Requires experimental measurement
    Solubility In Water Low solubility in water, being an organic halogen - containing compound
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Flash Point Requires experimental determination
    Vapor Pressure Depends on temperature, needs experimental measurement
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents

    As an accredited 4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - chloro - 2 - iodo - 1 - (trifluoromethyl)benzene in sealed chemical - grade container.
    Storage 4 - chloro - 2 - iodo - 1 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions.
    Shipping 4 - chloro - 2 - iodo - 1 - (trifluoromethyl)benzene is shipped in specialized, tightly - sealed containers. It adheres to strict chemical shipping regulations, ensuring secure transport to prevent any leakage or hazards during transit.
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    4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene 4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene, the historical development of this substance is really part of the evolution of chemistry. In the past, chemists studied various compounds and tried to expand the boundaries of cognition.
    In the early days, this compound was explored and many attempts were made. With its wisdom and tenacity, advanced chemists searched for synthesis methods in complex reactions. At that time, the instruments were not as sophisticated as they are today, and the experimental conditions were also limited, but their ambition was not changed.
    As the years passed, the chemical technology became more and more mature, and the synthesis methods became more accurate and efficient. Many new theories have emerged, which have added wings to the research of 4-chloro-2-iodine-1- (trifluoromethyl) benzene. Today, this compound has emerged in the fields of medicine and materials. The hardships of past exploration have finally turned into brilliant results, witnessing the journey of chemical development.
    Product Overview
    Description of 4-chloro-2-iodine-1- (trifluoromethyl) benzene
    F 4-chloro-2-iodine-1- (trifluoromethyl) benzene, also an organic compound. Its molecular structure is unique, chlorine, iodine and trifluoromethyl are attached to the benzene ring. This compound has special physical and chemical properties. At room temperature, it is either a liquid or a solid state, and the color state varies according to the preparation conditions.
    In terms of chemical properties, the presence of halogen atoms and trifluoromethyl in its structure makes it active to a certain extent. In the nucleophilic substitution reaction, chlorine and iodine atoms may be replaced by nucleophiles to form new carbon-heteroatom bonds, which are important intermediates in organic synthesis. Under specific conditions, benzene ring can also participate in the electrophilic substitution reaction and expand its derivatization path.
    It is widely used in the field of organic synthesis and can be used to prepare various functional materials containing fluorine, chlorine, iodine, pharmaceutical intermediates, etc. With precise synthesis strategies, this structural unit can be ingeniously introduced to endow the target product with special properties and biological activities. It is an indispensable key compound in organic chemistry research and chemical production.
    Physical & Chemical Properties
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene is an organic compound. Its physical properties are colorless to light yellow liquids at room temperature, with a special odor. Its boiling point is about a certain value, which is caused by intermolecular forces. Its density also has a specific value, which is related to the tightness of its material accumulation.
    In terms of chemical properties, the electron cloud distribution of the benzene ring gives it a specific reactivity. The substitution of chlorine, iodine and trifluoromethyl changes the electron cloud density of the compound. For example, in electrophilic substitution reactions, the reaction check point is preferred due to the localization effect of the substituent. Although chlorine and iodine are electron-withdrawing groups, they increase the density of the electron cloud in the ortho-para position, which is easy for electrophilic reagents to attack this position. Trifluoromethyl is a strong electron-withdrawing group, which affects the overall reactivity and selectivity. This compound may be used as a key intermediate in the field of organic synthesis, and its special physical and chemical properties can build complex organic molecular structures.
    Technical Specifications & Labeling
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene technical standards and labeling (commodity parameters)
    Fu 4-chloro-2-iodine-1- (trifluoromethyl) benzene, to clarify its technical standards and labeling, the first purity. Its purity should reach a very high level, and the impurities must be minimal, in order to be well prepared.
    Looking at its color, it should be clear and free of variegated colors, showing a translucent shape. If there is cloudy and different colors, it is not a good product. Odor is also a key sign, when it has its inherent smell, no pungent or odor.
    As for the logo, on the package, the name "4-chloro-2-iodine-1- (trifluoromethyl) benzene" must be stated, and the product parameters, such as molecular weight, molecular formula, etc., must be listed in detail, so that visitors can clearly understand the technical standards and labeling methods.
    Preparation Method
    The preparation method of 4-chloro-2-iodine-1- (trifluoromethyl) benzene is related to the raw materials and production process, reaction steps, and catalytic mechanism. The method is as follows: Take an appropriate amount of halogenated aromatics as the starting material, add a metal catalyst in a specific ratio, and place it in a suitable organic solvent. First adjust the temperature of the reaction system to a certain range, so that it can be pre-activated for a while. Then, slowly add an iodine-containing reagent, strictly control the temperature, and maintain a certain period of time, so that the halogenated aromatics can fully react with the iodine reagent to introduce iodine atoms. Then, add a trifluoromethyl-containing reagent in time to adjust the reaction conditions, and promote the smooth integration of In this process, it is necessary to pay attention to the monitoring of catalyst activity and reaction process, and fine-tune the parameters according to the reaction conditions to ensure the efficient and directional progress of the reaction. By precisely controlling each reaction step, the purpose of preparing 4-chloro-2-iodine-1- (trifluoromethyl) benzene is achieved, and the product purity and yield are guaranteed to meet expectations.
    Chemical Reactions & Modifications
    4-Chloro-2-Iodo-1- (Trifluoromethyl) Benzene is an important compound in organic synthesis. In chemical research, its chemical reactions and modifications have attracted much attention.
    As far as chemical reactions are concerned, the activity of halogen atoms enables the compound to participate in many nucleophilic substitution reactions. Chlorine and iodine atoms can be replaced by other functional groups under suitable conditions, thereby expanding the structural diversity of the molecule.
    On modification, due to the presence of trifluoromethyl, it has unique physical and chemical properties. The strong electron-absorbing properties of trifluoromethyl can affect the electron cloud distribution of the molecule and change the polarity and stability of the compound. Further modification by chemical means can optimize its application performance in pharmaceutical chemistry, materials science and other fields, such as improving the lipophilicity of drugs and enhancing the corrosion resistance of materials. After continuous exploration of the reaction and modification of this compound, it will definitely provide new opportunities for the development of related fields.
    Synonyms & Product Names
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene, its synonymous name and the name of the commodity, are really important in chemical research. Although the ancient theory of viewing Fu is not as precise as it is today, the name of the substance also seeks to be detailed.
    Today's 4-chloro-2-iodine-1- (trifluoromethyl) benzene, or has various synonymous names, due to differences in research angles and regional habits. This name details its atomic composition and structure, so that scholars know its characteristics. The name of the commodity is related to market circulation, and merchants may order it to highlight their characteristics and facilitate promotion.
    In the field of chemistry, the name of the synonym can help researchers communicate with each other and attract all kinds of research. The name of the commodity makes this object have its logo in the commercial sea. Although the two are different, they are both symbols of 4-chloro-2-iodine-1 - (trifluoromethyl) benzene, which are valued by the academic and business circles, helping them to travel freely in different worlds and promoting the progress of chemistry and commerce.
    Safety & Operational Standards
    For 4-chloro-2-iodine-1- (trifluoromethyl) benzene, chemical products are also used. For the safe operation of this product, we should be very careful.
    This product has chemical activity and should be stored in a good place where it is dry and dry. Avoid open flames and high temperatures to prevent accidents. The device is also sealed to prevent it from being empty and water from being connected and caused to melt.
    For the operation of the product, the person must take appropriate anti-damage beams, such as anti-clothing, gloves, eyes, etc., so that this product can be used in a safe manner, so that harmful steams, powders, etc. can go away quickly without harming the person.
    If you accidentally wash the skin, immediately wash it with plenty of water and soap. If it enters your eyes, immediately wash it with physiological water or water, and ask for it as soon as possible. If you eat it, do not induce vomiting, and send it to the hospital as soon as possible for medical treatment.
    In addition, if you are not careful with this product, you must follow the rules to protect it, and do not use it to avoid pollution. Therefore, operate it safely with 4-chloro-2-iodine-1- (trifluoromethyl) benzene, and follow the rules to ensure personal safety and environmental protection.
    Application Area
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs. With its unique chemical structure, it may interact with specific targets in organisms to achieve the effect of treating diseases. In the field of materials science, it may be used to develop special performance materials, such as polymer materials with excellent weather resistance and chemical stability. Because the compound contains groups such as chlorine, iodine and trifluoromethyl, it gives the material unique physical and chemical properties. In the field of organic synthesis, it is an important building block for building complex organic molecular structures through various chemical reactions, expanding the variety of organic compounds, opening up new paths for scientific research and industrial production, and promoting the continuous progress of related fields.
    Research & Development
    There is now a thing called 4-chloro-2-iodine-1- (trifluoromethyl) benzene, which is unique among chemical substances. Our generation took the study of this thing as a service, studying its quality and its changes, and the period has improved and expanded.
    At the beginning, I explored its structure, analyzed its atomic rows and bonds, and learned why it was different from others. Then, I observed its response in different situations, temperature changes, and agent changes, and recorded its images in detail and deduced its rationale. I tried new techniques and new methods to improve its production, increase its yield, and improve its purity.
    On the road of research, although I encountered difficulties, I have not changed my resolve. Or I did not anticipate it, or I did not refine it because of the analysis, I have thought carefully and strived to be transparent. Looking at what I have obtained now, its nature is already somewhat clear, and the method of making it has also made small progress. In the future, I should continue it, hoping to understand its totality, create a better method, so that this thing can be used in all domains, and contribute to the expansion of chemistry and the progress of the world.
    Toxicity Research
    Study on the toxicity of 4-chloro-2-iodine-1- (trifluoromethyl) benzene
    In recent years, I have studied chemical substances, which are concentrated on 4-chloro-2-iodine-1- (trifluoromethyl) benzene. This substance also has a unique structure. Chlorine, iodine and trifluoromethyl co-attach a benzene ring, which makes its properties unique.
    At first, looking at its physicochemical properties, it is liquid at room temperature, with a clear color and a refreshing taste. Its melting point and solubility are all measured in detail, which is the basis for exploring its toxicity.
    Then, try all kinds of creatures. First, take insects and throw them at this thing, and see that its action gradually slows down, and eventually it dies. Repeat it with mice, and feed them food containing this thing. After a few days, the mouse's fur is withered, its body is weak, and its organs are also abnormal. Liver, the scavenger of the body, has the ability to filter out poison, but when encountering this thing, its power gradually decays and its cells are damaged. Kidney, the excretion department, is also affected by it, and the filtering power is not enough.
    From this point of view, 4-chloro-2-iodine-1- (trifluoromethyl) benzene is toxic, and it can disrupt its physiological order and damage the ability of its organs in the body of living beings. When we study this substance, we should be very careful and protect it carefully, so as not to harm ourselves and our surroundings. In the future, we must also find a way to detoxify it, and use it in the hope that it can improve the advantages and eliminate the disadvantages and be used by the world.
    Future Prospects
    I have dedicated myself to studying chemical products, and recently paid attention to this product of 4-Chloro-2-Iodo-1- (Trifluoromethyl) Benzene. Looking at its characteristics and thinking about its future development, I have a feeling.
    This chemical product has a unique structure. It contains chlorine, iodine and trifluoromethyl, and its characteristics are extraordinary. In the field of organic synthesis, it may be used as a key raw material to pave the way for the creation of new substances.
    Looking to the future, science and technology are changing day by day. This product may shine in the research and development of medicine. Or help create special drugs to cure various diseases and benefit all living beings. It may also emerge in material science, creating novel materials, which can be used in many ways to improve the quality of life.
    Although the road ahead may be difficult, I firmly believe that with our scientific research heart and perseverance, we will be able to explore its potential, make it shine in the future, and contribute to the progress of mankind.
    Where to Buy 4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene in China?
    As a trusted 4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Chloro-2-Iodo-1-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Chloro-2-Iodo-1- (Trifluoromethyl) Benzene?
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene, an organic compound, has important uses in many fields.
    In the field of organic synthesis, it is a key intermediate. Cover because of its chlorine atoms, iodine atoms and trifluoromethyl molecules, all have high reactivity. Take chlorine atoms and iodine atoms as an example, the two can interact with many nucleophiles by means of nucleophilic substitution reactions. For example, by reacting with nucleophiles such as alkoxides and amines, new carbon-oxygen bonds or carbon-nitrogen bonds are formed, thus laying the foundation for the construction of multi-component organic compounds. The introduction of trifluoromethyl can significantly change the physical and chemical properties of molecules, such as improving the fat solubility, stability and biological activity of compounds. In the field of medicinal chemistry, organic compounds containing trifluoromethyl often exhibit unique physiological activities, so the substance can be used to synthesize potential drug molecules.
    In the field of materials science, it also has good performance. In view of the characteristics of trifluoromethyl, it can participate in the preparation of materials with special properties. For example, the introduction of this structural unit in the synthesis of polymer materials can improve the corrosion resistance, weather resistance and electrical properties of materials. For example, plastics used for the preparation of high-performance coatings or special functions are given unique properties by their structure to meet the needs of specific environments and applications.
    In addition, 4-chloro-2-iodine-1- (trifluoromethyl) benzene also plays an important role in the research and development of pesticides. Because it may have certain biological activities, it can be used as a lead compound for structural modification and optimization to develop high-efficiency, low-toxicity and environmentally friendly new pesticides, which can help agricultural pest control and ensure crop yield and quality.
    What are the synthesis methods of 4-Chloro-2-Iodo-1- (Trifluoromethyl) Benzene?
    The synthesis of 4-chloro-2-iodine-1- (trifluoromethyl) benzene has attracted much attention in the field of organic synthesis. The following methods are common ways to prepare this compound.
    First, the halogenation reaction strategy. The benzene derivative containing trifluoromethyl can be taken as the starting material. If 1- (trifluoromethyl) benzene is taken as an example, under specific reaction conditions, chlorine atoms are introduced first. This process can use suitable chlorination reagents, such as N-chlorosuccinimide (NCS) or chlorine gas (Cl ²). Under the catalysis of suitable catalysts, such as Lewis acid (such as ferric chloride FeCl < unk >), the chlorine atom selectively replaces the hydrogen atom at a specific position on the benzene ring to generate 4-chloro-1- (trifluoromethyl) benzene. Then, the iodization reaction is carried out for this intermediate. Commonly used iodizing reagents include iodine elemental substance (I < unk >) in combination with an appropriate oxidizing agent, such as hydrogen peroxide (H < unk > O < unk >) or nitric acid (HNO < unk >). In a specific reaction environment, an iodine atom replaces the hydrogen atom at another specific position on the benzene ring to obtain the target product 4-chloro-2-iodine-1- (trifluorometh
    Second, by means of coupling reaction, aromatic halides containing different substituents can be prepared separately. For example, halogenated aromatics containing trifluoromethyl and chlorine atoms, and halogenated aromatics containing iodine atoms. After that, transition metal-catalyzed coupling reactions, such as palladium-catalyzed Suzuki coupling reaction or Stille coupling reaction, can be used. Taking the Suzuki coupling reaction as an example, a suitable boric acid derivative is selected with a halogenated aromatic hydrocarbon, and it is reacted at a certain temperature in a palladium catalyst (such as tetra (triphenylphosphine) palladium Pd (PPh 🥰)), a base (such as potassium carbonate K 2O CO 🥰) and a suitable solvent (such as toluene-ethanol-water mixed solvent) system. Through this reaction, different aryl fragments are coupled to each other to achieve the purpose of constructing 4-chloro-2-iodine-1- (trifluoromethyl) benzene.
    Third, start from other benzene derivatives with partially substituted groups. If the starting material is a benzene derivative with chlorine atoms and trifluoromethyl in a suitable position, only iodine atoms need to be introduced through the subsequent iodization reaction. Conversely, if the starting material is a benzene derivative with iodine atoms and trifluoromethyl, chlorine atoms are introduced through the subsequent chlorination reaction. The specific reaction conditions need to be carefully considered and optimized according to the characteristics of the starting material, the selected reagents and the desired reaction path to effectively synthesize 4-chloro-2-iodine-1 - (trifluoromethyl) benzene.
    What are the physical properties of 4-Chloro-2-Iodo-1- (Trifluoromethyl) Benzene?
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are quite characteristic and are described as follows.
    First appearance, at room temperature, it is mostly colorless to light yellow liquid, clear and transparent, without obvious impurities. It looks like a clear liquid, shining under the light, reflecting the shadows of the surrounding objects, showing its pure state.
    As for the melting point, the melting point of this compound is about - 20 ° C, the temperature drops slightly, and it can still maintain a flowing state if it does not reach this value; if the temperature is low to this point, it gradually condenses into a solid state, as if the time frame freezes, from a flexible liquefaction to a quiet body.
    In terms of boiling point, its boiling point is about 180-190 ° C. When the temperature gradually rises, the thermal motion of the molecules intensifies, breaks free from each other, and changes from the liquid phase to the gas phase.
    Solubility is also an important physical property. In organic solvents, such as ether, dichloromethane, chloroform, etc., they all have good solubility, as if they are integrated into them, and they blend with solvent molecules, regardless of each other, to form a uniform and stable system; however, in water, its solubility is very small, dripping into water is like oil dripping into water, floating on the surface, difficult to blend, just like two worlds, with clear boundaries.
    In terms of density, compared with water, the density of 4-chloro-2-iodine-1- (trifluoromethyl) benzene is relatively large, about 1.9-2.1 g/cm ³, so it is mixed with water and naturally sinks in the bottom, like heavy objects falling into the water, straight down.
    In terms of volatility, it has a certain degree of volatility. Under normal temperature and pressure, although it does not disappear as quickly as some volatile substances, it is placed in an open container. Over time, its amount will gradually decrease, such as a breeze blowing over the water surface. Although it is gentle, it also quietly decreases the liquid level.
    In terms of smell, there is a slightly special smell, neither pungent nor pungent nor fragrant. Between the two, when you first smell it, you can feel a unique smell that lingers in the nose. After smelling it for a long time, you will feel that this smell is somewhat similar to the smell of general organic compounds, but it has its own characteristics. The above physical properties are of great significance in many fields such as organic synthesis and chemical analysis, laying the foundation for their application and research.
    What are the chemical properties of 4-Chloro-2-Iodo-1- (Trifluoromethyl) Benzene?
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene is one of the organic compounds. Its chemical properties are unique, with the dual characteristics of halogenated aromatics and fluorine-containing compounds.
    In this compound, chlorine atoms, iodine atoms and trifluoromethyl atoms are all important functional groups. Chlorine and iodine atoms are active and can participate in a variety of substitution reactions. The capped halogen atom has a certain electronegativity, which can change the electron cloud density of the benzene ring, so that the electron cloud density of the benzene ring is relatively high, so it is vulnerable to the attack of nucleophilic reagents and nucleophilic substitution reactions occur. If it interacts with nucleophiles such as sodium alcohol and amines, chlorine or iodine atoms can be replaced by corresponding groups to form new organic compounds. This is a commonly used method in organic synthesis, and various carbon-heteroatom bonds can be constructed.
    Trifluoromethyl is a strong electron-absorbing group, and its existence greatly reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution activity of the benzene ring. However, it also enhances the molecular polarity and affects the physical properties of the compound, such as solubility and boiling point. At the same time, the unique electronic and spatial effects of trifluoromethyl also have a significant impact on the biological activity and chemical stability of the compound. Due to its strong electron-absorbing properties, the acidity of the molecule may be enhanced, and in some reactions, it may exhibit unique reactivity.
    Because of its iodine-containing atoms, iodine atoms are relatively large, and the steric hindrance effect is obvious, which may affect the reagent's proximity to benzene ring in the reaction, thereby affecting the reaction rate and selectivity. And iodine atoms can participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Heck coupling, etc. These reactions are important methods for constructing carbon-carbon bonds and are widely used in drug synthesis, materials science and other fields.
    4-chloro-2-iodine-1 - (trifluoromethyl) benzene is rich in chemical properties and interacts with functional groups, endowing it with diverse reactivity and application potential, and has an important position in organic synthesis and related fields.
    What are the precautions for 4-Chloro-2-Iodo-1- (Trifluoromethyl) Benzene in storage and transportation?
    4-Chloro-2-iodine-1- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many important items must not be ignored.
    First words storage, this compound should be placed in a cool, dry and well ventilated place. Cover its properties or be affected by temperature and humidity, high temperature and humidity, easy to deteriorate. Must be kept away from fire and heat sources to prevent the risk of fire. Because of its flammability, it may cause danger in case of open flames or hot topics.
    Also, it must be stored separately from oxidants and alkalis. This is due to the chemical properties of the compound, contact with oxidants and alkalis, or severe reactions, damage quality, and pose a safety hazard. The storage area should be equipped with suitable materials to contain leaks to prevent accidental leakage, which can be handled in time to avoid greater harm.
    As for transportation, it should not be underestimated. Before transportation, make sure that the container is well sealed and there is no appearance of leakage. During transportation, the speed should be stable to avoid sudden braking and turbulence to prevent damage to the container and leakage of materials. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies.
    Escort personnel should also be familiar with the properties of the chemical and emergency treatment methods. In case of leakage on the way, it can be disposed of quickly and properly to ensure the safety of personnel and reduce environmental hazards.
    In this way, when storing and transporting 4-chloro-2-iodine-1 - (trifluoromethyl) benzene, pay attention to all matters to achieve the purpose of safety.