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4-Chloro-2-Fluoronitrobenzene

4-Chloro-2-Fluoronitrobenzene

Hongda Chemical

Specifications

HS Code

966932

Chemical Formula C6H3ClFNO2
Molecular Weight 177.545 g/mol
Appearance Yellow to brown - colored solid
Boiling Point Approximately 236 - 238 °C
Melting Point 39 - 42 °C
Density 1.488 g/cm³ (estimated for solid state)
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like benzene, toluene
Flash Point Around 101 °C
Vapor Pressure Very low at room temperature

As an accredited 4-Chloro-2-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - chloro - 2 - fluoronitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage 4 - chloro - 2 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in tightly closed containers to prevent leakage. It's a hazardous chemical, so store it in a designated area separated from incompatible substances, following strict safety regulations to avoid risks.
Shipping 4 - chloro - 2 - fluoronitrobenzene is shipped in tightly sealed, corrosion - resistant containers. Transport follows strict hazardous chemical regulations, ensuring proper handling, storage, and safety during transit to prevent spills and environmental/health risks.
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4-Chloro-2-Fluoronitrobenzene 4-Chloro-2-Fluoronitrobenzene
General Information
Historical Development
4-Chloro-2-fluoronitrobenzene is also a genus of chemical products. Its beginning can be traced back to the past. At that time, the science of chemistry was just emerging, and all the wise men exhausted their wisdom and explored the changes of substances. In the field of organic synthesis, the public paid attention to halogenated nitrobenzene. After years of study and trial, the process gradually refined.
Early preparation, the method is quite simple, the yield is not good, and the purity is also insufficient. However, the determination of scholars is firm, and they are unremitting in their pursuit of progress. With the passage of time, science and technology are new, the method of analysis is more clear, and the reaction mechanism is gradually clear. With the advent of new catalysts and solvents, the reaction conditions were optimized, and the yield and purity of 4-chloro-2-fluoronitrobenzene were greatly improved. From the initial exploration to the complete preparation process, it is the hard work of many experts in the field of chemistry, and its evolution is enough for later learning.
Product Overview
4-Chloro-2-fluoronitrobenzene is also an organic compound. Its shape or crystalline body, color or yellowish. This substance has unique chemical properties and is widely used in the field of organic synthesis.
Its preparation method often depends on a specific chemical reaction path. The product is obtained by carefully preparing the reactants and controlling suitable reaction conditions, such as temperature, pressure, and catalyst use.
4-chloro-2-fluoronitrobenzene has important applications in the pharmaceutical, pesticide, and dye industries. In the field of medicine, it can be a key intermediate for the synthesis of specific drugs and help the research and development of new drugs; in the field of pesticides, it can be used as a basic raw material for the creation of high-efficiency pesticides; in the dye industry, it can also provide key ingredients for the preparation of new dyes.
However, when preparing and using this compound, caution must be taken. Because of its toxicity and danger, when operating, strict safety procedures should be followed to ensure the safety of personnel and the environment.
Physical & Chemical Properties
4-Chloro-2-fluoronitrobenzene is also an organic compound. Its physical properties are solid at room temperature, the color is nearly white and yellowish, and it has a specific odor. The melting point is about [specific melting point value]. This specific melting point is very critical for the identification and purification of substances. The boiling point is in the [specific boiling point range], and the characteristics of the boiling point are related to its phase transition under different temperature conditions.
Its chemical properties are active, and the presence of nitro groups changes the electron cloud density of the benzene ring, making it vulnerable to attack by nucleophiles. The substitution reaction of chlorine and fluorine atoms has different reactivity due to the difference in electronegativity between the two. In many organic synthesis reactions, 4-chloro-2-fluoronitrobenzene is often an important intermediate. With its physical and chemical properties, it can synthesize a variety of organic compounds through specific reaction paths, which are widely used in chemical, pharmaceutical and other fields.
Technical Specifications & Labeling
4-Chloro-2-fluoronitrobenzene is an important category of chemical research. Its technical specifications and identification (product parameters) are related to the quality and application.
In terms of technical specifications, it is necessary to clarify its purity, which is the key number. The impurity content must be strictly controlled to ensure the stability of its performance. Its color and shape are also key points, and it should have a specific appearance. Physical parameters such as melting point and boiling point must also be accurately determined to comply with the specifications.
On the logo, the name must be accurate, and "4-chloro-2-fluoronitrobenzene" must not be different. The packaging label should contain a warning to warn of its danger. And product parameters such as content, purity, etc., should be clearly marked so that users can see it at a glance, and it can be safe for scientific research and production.
Preparation Method
4-Chloro-2-fluoronitrobenzene is also an organic compound. The preparation method, raw materials and production process, reaction steps, and catalytic mechanism are all the key points.
To make this product, a specific halogenated aromatic hydrocarbon is often used as the starting material. First take an appropriate halogenated benzene, add fluoride, and under suitable catalytic conditions, perform a nucleophilic substitution reaction. The catalyst used needs to be highly active and selective, so that the fluorine atom can precisely replace the halogen at a specific position.
The reaction step is quite critical, and the temperature, pressure and time of the reaction must be controlled. In the initial stage, slowly heat up to fully mix and activate the raw materials; then maintain stable reaction conditions to promote the orderly progress of the reaction. In this process, the reaction progress is monitored in real time to ensure that the reaction progresses in the expected direction.
The catalytic mechanism is the core of the reaction. The selected catalyst or a specific intermediate is formed with the reactants, which reduces the activation energy of the reaction and accelerates the reaction rate. And the amount and activity of the catalyst have a great impact on the purity and yield of the product. After such various steps and careful operation, 4-chloro-2-fluoronitrobenzene can be obtained.
Chemical Reactions & Modifications
4-Chloro-2-fluoronitrobenzene is also an organic compound. In the field of chemical synthesis, its reaction and modification are often studied by our generation.
The reaction of this compound, the way of nucleophilic substitution is its one path. Its chlorine and fluorine atoms have different activities due to the electron absorption of the nitro group on the benzene ring. Nucleophilic reagents attack it, or replace chlorine, or replace fluorine, depending on the characteristics of the reagent and the reaction conditions.
As for the modification, introduce other groups to change its properties. If under specific conditions, with appropriate reagents, the genus of hydrocarbons and amino groups can be added to obtain new derivatives, and their physical and chemical properties are different.
The research on the reaction and modification of this compound is essential for the manufacture of medicines, pesticides and materials. It can inspire new synthesis methods, expand the application realm, and add bricks and tiles to the road of chemical refinement.
Synonyms & Product Names
4-Chloro-2-fluoronitrobenzene is a chemical substance. There are many opinions on its synonymous name. Or 2-fluoro-4-chloronitrobenzene, although the order is different, the meaning is the same. There are also those who are named for their characteristics, all want to understand the essence of this substance.
The names of commodities in the market are also different. Many merchants use it as a basis and attach trade names to form unique trade names. This is all for easy identification and circulation, but its core is 4-chloro-2-fluoronitrobenzene.
In the field of chemistry, although the names of synonyms and commodity names are different, the things involved are always the same. Scholars need to be discerning, so as not to make mistakes, and it is beneficial to research and production.
Safety & Operational Standards
Specifications for the safety and operation of 4-chloro-2-fluoronitrobenzene
The 4-chloro-2-fluoronitrobenzene is a common compound in chemical research. Its special nature is related to safety and operation standards, and it should not be careless.
In the method of storage, choose a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent accidents. Because of its flammability, if it encounters a fire source, it will cause an instant disaster. Place it away from oxidants, the two will touch, or cause a violent reaction, endangering safety.
When operating, appropriate protective equipment must be used. Protective clothing can protect against its damage to the body, goggles can protect the eyes from damage, and masks prevent harmful particles from entering the body. The operating environment needs to be ventilated and smooth, so that the escaping gas can be discharged in time to avoid accumulation.
When taking it, the action should be slow and steady, and do not sprinkle it. If there is any carelessness, sprinkle it on the table, and clean it up in an appropriate way as soon as possible. Cover it with a moisture-absorbing object first, then collect it carefully and dispose of it according to regulations. Do not let it flow freely, causing pollution to the environment and causing endless harm.
Reaction process, strictly abide by the procedures. When precise temperature control and control, observe the change of its reaction. Due to the slightly poor reaction conditions, the product may be impure or dangerous.
The disposal of waste must comply with environmental protection regulations. It should not be discarded at will, but should be collected separately and handed over to professional institutions for disposal.
In short, the safety and operation standards of 4-chloro-2-fluoronitrobenzene should be kept in mind by researchers and carried out with caution in order to ensure the smooth operation of the experiment and protect their own safety and the environment.
Application Area
4-Chloro-2-fluoronitrobenzene is also a wonder of transformation. It is widely used in the field of medicine and is the basis for making special and good medicines. With its unique structure, it can be used in the combination of medicines to treat various diseases.
In the field of agrochemical, it also shows its ability. Producing strong agricultural agents, protecting crops from pests and fungi, and preserving the fertility of the field.
And in the way of materials, it has extraordinary power. Assist in the research of new materials, add the specificity of materials, or strengthen their quality, or increase their resistance, and use them in various utensils to make them better.
Although there are few things, they are all important in the fields of medicine, agrochemistry, and materials, promoting the progress of various industries and benefiting the world.
Research & Development
In recent years, Yu has been very diligent in the research of chemical substances, especially focusing on 4-Chloro-2-Fluoronitrobenzene. This material quality is very different, and it can be used in various fields.
At the beginning, I studied the method of making it. The ancient method is inconvenient, time-consuming and the yield is not good. Yu and his colleagues worked hard and tried many times, and finally found a new way. The new method saves time and is efficient, and the yield has also increased significantly.
Then, explore its use. In the field of medicine, it can be used as a key raw material to help the research of new drugs; in the field of materials, it can also contribute to the production of high-quality materials.
Looking to the future, we will continue to study, hoping to expand its use and optimize its performance. Make 4 - Chloro - 2 - Fluoronitrobenzene shine in the advancement of science and technology and the goodness of people's livelihood, and become a bright pearl of our scientific research.
Toxicity Research
Today there is a substance named 4-chloro-2-fluoronitrobenzene. As a chemist, I study the toxicity of this substance.
Looking at its structure, chlorine, fluorine and nitro groups are concentrated in the benzene ring. Nitro has strong electron absorption, which can reduce the electron cloud density of the benzene ring and greatly increase its chemical activity. Although chlorine and fluorine have different properties, they both contribute to the toxicity of this substance.
After various experiments, this substance has significant toxicity to organisms. At the cellular level, it can interfere with cell metabolism, cause cell damage and even apoptosis. In animal experiments, it can damage the function of liver, kidney and other organs. Its toxicology or due to the strong oxidation of nitro groups and the special chemical activity of halogen atoms, the structure and function of biological macromolecules are destroyed.
In summary, the toxicity of 4-chloro-2-fluoronitrobenzene cannot be underestimated. In the production and use of various links, caution should be taken to prevent its harm to life and the environment.
Future Prospects
Now View 4 - Chloro - 2 - Fluoronitrobenzene This product has unique properties and has endless potential in the field of chemical industry. Although the world's understanding of it is still shallow at present, I firmly believe that it will shine in the future.
The future development of husband lies in the improvement of scientific research. Our scientific researchers should explore its principles, clarify its chemical properties and reaction rules, and expand its application. Or it can be used in the field of medicine to make special agents to save patients from pain; or it can be used in the field of materials to create excellent materials and meet the needs of industry.
Furthermore, the art of production should also be revolutionized. Seek high efficiency, safety, and environmental protection, so that the production of this product can be improved in quantity and quality, and it is not harmful to the environment. In this way, it can be widely distributed in the world and benefit all people.
Our generation should have great ambitions, take diligence as wings, and wisdom as lamps. Period 4 - Chloro - 2 - Fluoronitrobenzene can develop its great talents in the future, seek well-being for the world, and become an unparalleled career.
Where to Buy 4-Chloro-2-Fluoronitrobenzene in China?
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Frequently Asked Questions

As a leading 4-Chloro-2-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Chloro-2-Fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is also an organic compound. It has a wide range of uses and is a key intermediate in the chemical industry.
First, it can be used to prepare pesticides. Through a series of chemical reactions, 4-chloro-2-fluoronitrobenzene can be converted into pesticide components with specific structures. Its structural characteristics endow pesticides with unique biological activities and can effectively control pests and weeds. For example, in the synthesis of herbicides and insecticides, this is used as a starting material. After substitution, reduction and other steps, high-efficiency and low-toxicity pesticide products can be obtained, which can help agricultural production, protect crops from pests and diseases, and ensure a bumper harvest.
Second, in the field of pharmaceutical synthesis, 4-chloro-2-fluoronitrobenzene also plays an important role. It can be used as a key building block for the synthesis of specific drugs. Because of the chlorine, fluorine and nitro functional groups on the benzene ring, it can participate in a variety of reactions to construct compound structures with pharmacological activities. For example, when synthesizing some antibacterial drugs and nervous system drugs, this is the basic raw material, which can be skillfully chemically modified to achieve the expected pharmacological effects and benefit human health.
Third, in the dye industry, 4-chloro-2-fluoronitrobenzene also has its uses. From it, dyes with specific colors and properties can be prepared through multi-step reactions. Its structure can affect the color, light resistance and washability of the dye. By chemically modifying it, dyes suitable for dyeing different fiber materials can be developed, enriching the chromatography of the textile printing and dyeing industry, and meeting people's needs for diverse fabrics.
In short, the unique chemical structure of 4-chloro-2-fluoronitrobenzene is an indispensable raw material in many industries such as pesticides, pharmaceuticals, and dyes, and has a profound impact on the development of various industries.
What are the physical properties of 4-Chloro-2-Fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is one of the organic compounds. It has many physical properties.
Looking at its appearance, it is often light yellow to light brown crystalline, delicate and tangible. As for the melting point, it is between 32 ° C and 36 ° C. This characteristic makes it possible to change from solid to liquid at a specific temperature. The boiling point is about 235 ° C. When this temperature is reached, the substance will be liquefied into a gaseous state.
The density of 4-chloro-2-fluoronitrobenzene is about 1.52g/cm ³, which is heavier than water. If placed in water, it will sink to the bottom of the water. Its solubility is also an important property. It is slightly soluble in water, but it can show good solubility in organic solvents, such as ethanol, ether, acetone, etc., and can be fused with organic solvents.
Furthermore, this compound is volatile and will slowly evaporate in the air, dissipating its molecules. Because its molecular structure contains functional groups such as chlorine, fluorine, and nitro, it has specific chemical activities and can participate in a variety of chemical reactions, such as nucleophilic substitution reactions. It is widely used in the field of organic synthesis.
To sum up, the physical properties of 4-chloro-2-fluoronitrobenzene lay an important foundation for its application in chemical, pharmaceutical, materials and many other industries. Practitioners need to be familiar with its properties in order to make good use of it.
What is the chemistry of 4-Chloro-2-Fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is also an organic compound. In its molecular structure, above the benzene ring, the chlorine atom occupies the fourth position, and the fluorine atom occupies the second position, and is connected with a nitro group. The chemical properties of this compound are very interesting and have important practical value.
In terms of its reactivity, the nitro group on the benzene ring is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and cause its electrophilic substitution activity to weaken. However, it is precisely because of its existence that the electron cloud density of the adjacent and para-position of the benzene ring is relatively increased. During the nucleophilic substitution reaction, the positions of the chlorine atom and the fluorine atom are vulnerable to the attack of the nucleophilic
Chlorine atoms and fluorine atoms, although both are halogen atoms, are more electronegative and have a larger C-F bond energy. Therefore, in the nucleophilic substitution reaction, chlorine atoms are easier to leave than fluorine atoms. If nucleophilic reagents such as sodium alcohol and amines interact with them, chlorine atoms can be replaced to generate corresponding ether or amine derivatives.
Furthermore, the nitro group can undergo a reduction reaction. With suitable reducing agents, such as iron and hydrochloric acid, nitro groups can be reduced to amino groups to obtain 4-chloro-2-fluoroaniline. This product is widely used in the fields of dyes and pharmaceutical synthesis. 4-Chloro-2-fluoronitrobenzene can participate in many organic synthesis reactions and is an important intermediate for the preparation of complex organic compounds. Its unique chemical properties enable chemists to construct diverse organic molecular structures and play a role in the development of organic synthetic chemistry.
What are the preparation methods of 4-Chloro-2-Fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is an important intermediate in organic synthesis. Its preparation method has been explored in the past, and the number is as follows.
First, halogenation method. Using 2-fluoronitrobenzene as a substrate, chlorine atoms are introduced. Among them, suitable halogenating reagents are required. Commonly used, such as chlorine, under suitable reaction conditions, make it interact with 2-fluoronitrobenzene. The temperature, pressure of the reaction system and the choice of catalyst are all related to the effectiveness of the reaction. If the temperature is too high, side reactions will occur frequently; if it is too low, the reaction rate will be slow. Catalysts such as iron and aluminum can promote the substitution of chlorine atoms, but their influence on the selectivity of the reaction needs to be considered.
Second, nucleophilic substitution method. React with the corresponding aromatic compound with a chlorine-containing nucleophilic reagent. Selecting the appropriate leaving group can make nucleophilic substitution easy to occur. If a chlorine-containing nucleophilic reagent reacts with 2-fluoro-1-nitro-4-a leaving group benzene, the activity of the leaving group and the nucleophilicity of the nucleophilic reagent are the keys to the success or failure of the reaction. If the leaving group activity is not good, it is difficult to leave and hinder the reaction process; the nucleophilic reagent is too weak and cannot effectively attack the substrate.
Third, the diazotization method. The compound containing amino groups is first prepared, and then the chlorine atom is introduced through the diazotization reaction. During this process, the conditions of the diazotization reaction need to be precisely controlled. The amount of nitrous acid, the reaction temperature and time all have a significant impact on the formation and stability of diazo salts. After the formation of diazo salts, react with suitable chlorine sources to obtain 4-chloro-2-fluoronitrobenzene. However, the risk of diazotization is high, and the operation needs to be cautious.
All preparation methods have their advantages and disadvantages. The raw materials of halogenation method are easy to obtain, but the selectivity may be insufficient; the nucleophilic substitution method has better selectivity, but it requires strict substrates and reagents; although the diazotization method can accurately introduce chlorine atoms, the operation is complicated and risky. In actual preparation, when considering the advantages and disadvantages according to the specific situation, choose the appropriate method.
What are the precautions in storage and transportation of 4-Chloro-2-Fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is a commonly used raw material in organic synthesis, which has certain toxicity and danger. When storing and transporting, pay attention to the following things:
First, the importance of storage. This substance should be stored in a cool and well-ventilated place, away from fire, heat sources, and avoid direct sunlight. It is easy to decompose due to heat, or cause danger. And it should be stored separately from oxidizing agents, reducing agents, and alkalis, and must not be mixed to prevent chemical reactions. The warehouse must be equipped with suitable materials for containing leaks. If there is a leak, it can be properly handled in time.
Second, the weight of packaging. Be sure to pack tightly to ensure that the seal is good to prevent material leakage. Commonly used packaging materials need to be able to withstand the corrosion of the substance to ensure the safety of transportation and storage.
Third, be careful when transporting. When transporting, drive according to the specified route and do not stop in densely populated areas and residential areas. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. The handling process needs to be lightly loaded and unloaded to prevent damage to packaging and containers. If the packaging is damaged, the material leaks, which is prone to safety accidents.
Fourth, personnel protection. Personnel who come into contact with this substance must take appropriate protective measures, such as wearing self-priming filter gas masks, chemical safety protective glasses, anti-toxic infiltration work clothes, rubber gloves, etc., to avoid direct physical contact to prevent poisoning or burns. In conclusion, when storing and transporting 4-chloro-2-fluoronitrobenzene, relevant regulations and requirements must be strictly followed in terms of environmental conditions, packaging methods, transportation operations, and personnel protection to ensure safety and prevent accidents.