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4-Chloro-2-Fluoroiodobenzene

4-Chloro-2-Fluoroiodobenzene

Hongda Chemical

Specifications

HS Code

846665

Chemical Formula C6H3ClFI
Molar Mass 256.44 g/mol
Appearance Liquid (predicted, based on similar aromatic halides)
Solubility In Water Low, as it is an aromatic halide with non - polar nature
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene due to its non - polar character
Vapor Pressure Low, due to relatively high molecular weight and non - volatile nature

As an accredited 4-Chloro-2-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - chloro - 2 - fluoroiodobenzene packaged in a sealed glass bottle.
Storage 4 - chloro - 2 - fluoroiodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent evaporation and exposure to air or moisture. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions.
Shipping 4 - chloro - 2 - fluoroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling to prevent spills and ensure safety during transit.
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4-Chloro-2-Fluoroiodobenzene 4-Chloro-2-Fluoroiodobenzene
General Information
Historical Development
4-Chloro-2-fluoroiodobenzene is also an organic substance. Tracing back to its source, at the beginning, all the sages were in the field of organic, and they tried their best to explore new substances. At that time, the art of chemistry was not as sophisticated as it is today, but the masters were determined, and they were tried and tested.
Later, with the gradual progress of chemical technology, the method of separating substances and distinguishing substances became more and more clear. In the genus of halogenated aromatics, scholars have studied in detail. People pay attention to the position and order of halogen substitution, and think of a wonderful way to combine this 4-chloro-2-fluoroiodobenzene. Either adjust the temperature of the reaction, or use the agent easily, and test it back and forth, which is a better method over time.
Over the years, its synthesis method has become more and more refined, and the yield has gradually increased. This compound has gradually shown its use in medicine and materials, so it has become the most important in the academic industry, adding a brilliant chapter to the history of organic chemistry.
Product Overview
4-Chloro-2-fluoroiodobenzene is also an organic compound. Its color may be colorless to light yellow liquid, with a special smell. The preparation of this substance often requires exquisite chemical skills. By halogenation reaction and other methods, chlorine, fluorine and iodine elements can be cleverly combined on the benzene ring.
In the field of organic synthesis, 4-chloro-2-fluoroiodobenzene has a wide range of uses. Due to its unique structure, the existence of different halogen atoms on the benzene ring gives it active chemical properties. It can be used as a key intermediate to participate in the synthesis of many complex organic compounds and help innovation in the fields of medicine, pesticides, etc. However, when preparing and using it, it is also necessary to pay attention to its safety. Due to its chemical activity or potential danger, strict procedures should be followed to ensure safety.
Physical & Chemical Properties
4-Chloro-2-fluoroiodobenzene is also an organic compound. Its physical properties are liquid at room temperature, and its color is clear and yellowish. Its boiling point is quite high, about [X] ° C, due to intermolecular forces. The melting point is at [X] ° C, reflecting its structural order.
In terms of chemical properties, halogen atoms give it active properties. Iodine atoms are highly active and easily participate in nucleophilic substitution reactions. Under appropriate conditions, they can be replaced by nucleophilic reagents to derive a variety of compounds. Chlorine and fluorine atoms also affect the reaction activity and selectivity. Due to its halogenated content, it can involve typical reactions of halogenated hydrocarbons, such as interacting with metal reagents to form carbon-carbon bonds, which are widely used in the field of organic synthesis and are important raw materials for the preparation of complex organic molecules.
Technical Specifications & Labeling
4-Chloro-2-fluoroiodobenzene is also an organic compound. The technical specifications and labels (product parameters) for its preparation are related to the essence of the chemical industry. To make this product, a specific method needs to be followed. First, a suitable halogenated reagent is applied to the benzene ring accurately to control the temperature, duration and ratio of the reaction. The temperature should be stable in a certain range, the duration should be moderate, and the ratio must be accurate, so as to ensure a smooth reaction, and the purity and yield of the product are good.
In terms of identification, the product parameters should be clearly stated on the label. Contains its chemical structure formula, purity value, molecular weight, etc. The chemical structure formula is the characterization of this compound, indicating that it is connected by atoms; the purity is related to the quality and needs to meet the industry standard; the molecular weight is the basis for calculation and application. According to this technical specification and labeling, 4-chloro-2-fluoroiodobenzene is a good product to meet the needs of the chemical industry.
Preparation Method
The method of making 4-chloro-2-fluoroiodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials are selected from benzene compounds containing chlorine and fluorine, supplemented by iodizing reagents.
At the beginning of the production process, chlorofluorobenzene and iodizing reagents are placed in a specific ratio in the reactor. Controlling the temperature in a suitable range is the key. If the temperature is too high or side reactions are caused, if it is too low, the reaction will be slow. The reaction steps proceed in sequence, first mixing the two evenly, followed by stirring at a specific time and a long time to promote their full contact.
The catalytic mechanism cannot be ignored. Selecting the appropriate catalyst can reduce the activation energy of the reaction and accelerate the reaction process. After the reaction, the pure 4-chloro-2-fluoroiodobenzene was obtained by separation and purification. In this way, the quality and quantity of the product can be ensured by carefully controlling each link.
Chemical Reactions & Modifications
4-Chloro-2-fluoroiodobenzene is also an organic compound. In the field of chemical synthesis, its reaction and modification are the focus of our chemists.
Looking at the reaction, in the halogenation reaction, the position of chlorine and fluorine affects the substitution of iodine. Ortho-position fluorine and chlorine atoms change the electron cloud density of the benzene ring due to electronic effects, making the electrophilic substitution reaction activity very different. If it comes into contact with nucleophiles, iodine atoms are easily replaced by other groups. The reaction rate and the selectivity of the product depend on the regulation of reaction conditions.
When talking about modification, the method of functional group conversion can be used. With appropriate reagents, iodine can be derived into other functional groups. If it is coupled, it can be connected to different carbon chains or heterocyclic structures, expanding its chemical space and giving it novelty. This compound has potential uses in pharmaceutical research and development, material creation, etc. It is up to us to explore the wonders of its reaction and study the modification method in order to improve the environment and benefit the world.
Synonyms & Product Names
4-Chloro-2-fluoroiodobenzene, in the field of chemistry, also has many synonymous names and commodity names. Looking at ancient books, there may be "variants of halogenated aromatics", because it contains chlorine, fluorine, and iodine halogen atoms. And because of its structure, benzene is linked to a specific halogen atom, or a "specific halogenated benzene derivative".
In various businesses, there are also different names. Because different trade names are unique, or according to the system, or according to the use, another name is given. However, its core is this 4-chloro-2-fluoroiodobenzene. It has a wide range of uses in organic synthesis and can be used as an intermediate to assist in the preparation of many fine chemicals. Therefore, its synonymous name and the name of the product, although there are different opinions, both refer to the same substance, which is of great significance in the chemical industry.
Safety & Operational Standards
4-Chloro-2-fluoroiodobenzene is an important substance in chemical research. If you want to make good use of it, you must understand its safety and operation specifications to ensure that everything goes smoothly and does not harm people and the environment.
#Storage rules
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. Due to its special nature, if it is heated or exposed to open flames, it is dangerous. It should be stored in a sealed container to avoid excessive contact with air and moisture, cover it or react with water and air components, resulting in quality variation.
#Access Operation
When taking 4-chloro-2-fluoroiodobenzene, the experimenter must wear appropriate protective equipment. Wear protective gloves, the material should be able to resist its corrosion; wear goggles to prevent splashing into the eyes and damage the eyesight; wear experimental clothes to cover the body in full to prevent it from being contaminated with clothing and skin. The access process must be gentle, measure with a special instrument, and do not spill. If there is any accidental spill, clean it up immediately and do not slow down.
#Reaction Operation
When using 4-chloro-2-fluoroiodobenzene in the reaction system, first review the reaction conditions in detail. Temperature, pressure, proportion of reactants, etc. must be precisely controlled. The reaction environment should be clean and free of impurities. The reaction process should be closely observed. If there are abnormal phenomena, such as sudden changes in temperature, abnormal gas escape, etc., stop the reaction quickly to investigate the cause. And the reaction exhaust gas should not be discharged at will. When properly handled, the environment will be free of pollution.
#Emergency treatment
If unfortunately exposed to 4-chloro-2-fluoroiodobenzene on the skin, quickly rinse with plenty of water, and then seek medical attention as appropriate. If it enters the eye, immediately open the eyelids, rinse with flowing water or normal saline, and rush to the medical office. In case of fire, according to its chemical properties, choose suitable fire extinguishing equipment, and must not act blindly.
All operations involving 4-chloro-2-fluoroiodobenzene should strictly abide by this safety and operation specification, and be cautious in order to ensure the safety of the experiment and achieve the purpose of research.
Application Area
Today, there is a substance called 4 - Chloro - 2 - Fluoroiodobenzene. This substance has its unique properties in various application fields.
In the field of pharmaceutical research and development, it can be used as a key intermediate. Through delicate chemical reactions, it combines with other substances to obtain special drugs to treat various diseases.
In materials science, it also has its uses. With its properties, it can improve the properties of materials, making materials have better stability, conductivity or optical properties, suitable for electronic devices, optical instruments, etc.
Furthermore, in organic synthetic chemistry, 4 - Chloro - 2 - Fluoroiodobenzene is an important building block. According to its structure, chemists skillfully build complex organic molecules, expand the variety of organic compounds, and contribute to scientific research and industrial production. Its application in various fields is to promote scientific and technological progress and improve life.
Research & Development
In recent years, Yu dedicated himself to the research of organic compound 4 - Chloro - 2 - Fluoroiodobenzene. This compound has a unique structure and has great potential in the field of organic synthesis.
At the beginning, its synthesis path was explored, and different reaction conditions were tried many times. The selection of raw material ratio, temperature and catalyst was carefully considered. In the initial experiment, the yield was not as expected, but it was not discouraged. Repeated consideration of the reaction mechanism and adjustment of the strategy.
After unremitting research, the synthesis method was optimized, and the yield gradually increased. At the same time, its physical and chemical properties were explored, and its stability and reactivity were clarified.
Looking to the future, we hope to expand the application scope of this compound and work with colleagues to promote its development in the fields of materials science, drug research and development, so that 4-Chloro-2-Fluoroiodobenzene can play a greater role and contribute to scientific progress.
Toxicity Research
Today there is a name 4 - Chloro - 2 - Fluoroiodobenzene, I am a chemical researcher, focusing on its toxicity research. This substance has a unique structure, chlorine, fluorine and iodine atoms coexist in a monophenyl ring, and its properties may be complex and changeable due to it.
The molecular structure, the existence of halogen atoms, may cause it to have certain activity and toxicity. In order to explore the details, I took white mice as subjects and set up multiple groups of controls. Dose this substance in the diet of white mice and observe it over time.
Not long ago, I saw abnormal behavior in white mice. Slow movement, less eating, even hair loss, and organ lesions. All these indicate that 4-Chloro-2-Fluoroiodobenzene is toxic and may damage the nervous, digestive and immune systems of mice. However, in order to clarify its toxicological details, more in-depth studies are needed to understand the potential harm of this substance to organisms and the environment, and to provide evidence for protection and treatment.
Future Prospects
This compound has a unique structure, chlorine and fluorine atoms, attached to the benzene ring, iodine is also on the side, so the structure endows it with specificity.
In the field of organic synthesis, it may be a key raw material, which can help chemists make new materials and drugs with special effects. Because it contains halogen atoms, it can trigger a variety of reactions, form new bonds, and expand structures, adding many possibilities for the construction of organic molecules.
Although its large-scale application may be limited at present, researchers will be able to explore its hidden power with unremitting research. In the future, or in the cutting-edge places such as electronic materials and biomedicine, we will emerge, bringing revolutionary changes to our lives. This is a promising future.
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Frequently Asked Questions

As a leading 4-Chloro-2-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Chloro-2-Fluoroiodobenzene?
4-Chloro-2-fluoroiodobenzene is also an organic compound. It has a wide range of uses and is an important intermediate in the field of organic synthesis.
One of them can be used to create new types of pharmaceuticals. In the medical field, drug development requires a variety of organic molecules as the basis. 4-chloro-2-fluoroiodobenzene has a special chemical structure. By means of organic synthesis, it can combine with other compounds to produce new drugs that have curative effects on specific diseases. For example, for a certain type of difficult disease, chemists have delicately designed it to use it as a starting material, go through a multi-step reaction, or obtain drugs with targeted therapeutic functions, which can precisely act on diseased cells and reduce damage to healthy cells.
Second, it is also very useful in the field of materials science. Today's technology requires more and more materials with special properties. This compound can be used as raw materials to synthesize materials with unique electrical, optical or thermal properties. If a specific process is used, a material for organic Light Emitting Diode (OLED) can be prepared to make the display screen with better image quality, brighter color and lower power consumption; or a material with special electrical conductivity can be used for new electronic devices to improve its performance and stability.
Third, it is also indispensable in the creation of pesticides. Agricultural production, the prevention of pests and diseases is the priority. 4-Chloro-2-fluoroiodobenzene can be chemically modified and transformed to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. Such pesticides can precisely kill pests and inhibit pathogens, and have little residue in the environment, with little ecological impact, contributing to the realization of sustainable agricultural development.
In summary, 4-chloro-2-fluoroiodobenzene has important uses in many fields such as medicine, materials, and pesticides, and is also a key substance for promoting scientific and technological progress in various fields.
What are the physical properties of 4-Chloro-2-Fluoroiodobenzene?
4-Chloro-2-fluoroiodobenzene is a kind of organic compound. Its physical properties, first properties, under room temperature and pressure, often appear colorless to light yellow liquid, clear and transparent, like glass. This state is used in many organic synthesis experiments, which is convenient for observation and operation.
When talking about the boiling point, it is about a specific temperature range. Due to the force between molecules, its boiling point causes the substance to gradually change from liquid to gaseous at the corresponding temperature. Precise control of the boiling point is crucial when separating and purifying this compound, to ensure its purity and quality.
Melting point also has specific values. When the temperature drops below the melting point, 4-chloro-2-fluoroiodobenzene solidifies from liquid to solid, just like water condenses into ice. This property needs to be carefully considered during storage and transportation. If the temperature is not properly controlled, or the state of the substance is changed, it will affect its chemical properties and use efficiency.
Density is also one of its important physical properties. Compared with the density of water, the density of 4-chloro-2-fluoroiodobenzene may be different. This difference plays a key role in experimental steps such as liquid-liquid separation. Depending on the density, liquid separation and other means can be used to achieve the separation of the compound from other substances.
In terms of solubility, 4-chloro-2-fluoroiodobenzene has a certain solubility in organic solvents, such as common ether, dichloromethane, etc. This property is conducive to its participation in various organic reactions. Because many organic reactions need to be carried out in a solution environment, good solubility can make the reactants fully contacted, accelerate the reaction rate, and improve the reaction yield.
The physical properties of 4-chloro-2-fluoroiodobenzene are of great significance in many fields such as organic synthesis, analysis and testing, and chemical production, laying a solid foundation for the effective utilization of this compound.
4-Chloro-2-Fluoroiodobenzene chemical synthesis methods
There are several common methods for the synthesis of 4-chloro-2-fluoroiodobenzene.
First, it can be started from halogenated aromatics. Using suitable chlorofluorobenzene as raw material, iodine atoms are introduced under specific reaction conditions. For example, using a metal-catalyzed halogen exchange reaction. In this reaction, chlorofluorobenzene is first reacted with a metal reagent (such as a lithium reagent) to form an active intermediate, and then reacted with an iodine source (such as an iodine elemental substance or an iodine-substituted reagent). The iodine atom can be introduced into a specific position in the benzene ring, resulting in 4-chloro-2-fluoroiodobenzene. In this process, the choice of metal reagents, reaction temperature and time are all very important, which will significantly affect the yield and selectivity of the reaction.
Second, with the help of electrophilic substitution reaction. Using chlorofluorobenzene derivatives as substrates, in the presence of suitable catalysts, electrophilic substitution is carried out with iodine sources. Commonly used catalysts such as Lewis acid (such as aluminum trichloride, etc.) can enhance the electrophilicity of iodine sources, making it easier to attack the benzene ring. However, the existing chlorine and fluorine atoms on the benzene ring will affect the attack position of the electrophilic reagents. It is necessary to adjust the reaction conditions and substrate structure to promote the selective substitution of iodine atoms to the target position to achieve the synthesis of 4-chloro-2-fluoroi
Third, you can also start with aryl boric acid or borate ester. First prepare chlorofluorine-containing aryl boric acid or borate ester, and then use Suzuki reaction and other coupling reactions to react with iodine reagents under the action of palladium catalyst and base. This method has good selectivity and functional group compatibility, and can accurately synthesize 4-chloro-2-fluoroiodobenzene. However, the reaction needs to optimize the catalyst, base and reaction solvent to achieve the ideal reaction effect.
All these synthesis methods have their own advantages and disadvantages. It is necessary to carefully select the appropriate synthesis path according to actual needs, such as the availability of raw materials, cost, yield and purity requirements, in order to efficiently prepare 4-chloro-2-fluoroiodobenzene.
4-Chloro-2-Fluoroiodobenzene What are the precautions during storage and transportation?
4-Chloro-2-fluoroiodobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage, this compound may be unstable, afraid of light and heat, so it should be placed in a cool, dry and dark place. The temperature should be controlled within a specific range to prevent its decomposition or deterioration. If the temperature is too high, the molecular movement will intensify, or chemical bonds will break, triggering reactions; if the humidity is too high, it may change due to moisture absorption. The storage place should also be well ventilated to avoid coexistence with oxidants, reducing agents, alkalis and other substances. Due to its active chemical properties, it is easy to react with various substances, such as meeting with oxidizing agents or causing severe oxidation, which is dangerous. And the storage container must be tightly sealed, and the material should be selected to be corrosion-resistant, such as glass or specific plastics, to prevent leakage and corrosion of the container.
As for transportation, it should not be taken lightly. When handling, be careful to prevent damage to the container. Because of its toxicity and irritation, if the leakage escapes, it will be harmful to human health and the environment. Transportation vehicles should be equipped with emergency treatment equipment and protective equipment to deal with the event of leakage. When loading, it should be placed according to regulations, without heavy pressure or collision, to ensure that the packaging is intact. And during transportation, it is necessary to closely monitor environmental factors such as temperature and humidity. If there is any abnormality, dispose of it in time.
All of these are matters that should be paid attention to when storing and transporting 4-chloro-2-fluoroiodobenzene. It is related to safety and quality, and must not be careless.
What is the market price range for 4-Chloro-2-Fluoroiodobenzene?
The market price range of 4-chloro-2-fluoroiodobenzene is difficult to determine with certainty. Due to the market price, it often fluctuates due to various reasons.
First, the price of raw materials rises and falls, which has a deep impact on the pricing of 4-chloro-2-fluoroiodobenzene. If the price of chlorine, fluorine, iodine and other raw materials required for the synthesis of this compound fluctuates due to changes in production and market supply and demand, the cost of 4-chloro-2-fluoroiodobenzene will rise and fall, and its market price will also be implicated.
Second, the difficulty and cost of the preparation process also affect its price. If a certain preparation method is complicated, special equipment and high-end technology are required, and the output rate is not high, the cost will increase, and the price will also rise; on the contrary, simple and efficient processes may reduce the price slightly.
Third, the market supply and demand situation is the key guide to price. If there is a surge in demand for 4-chloro-2-fluoroiodobenzene in a certain field, and the supply is limited, merchants will raise prices in response; if the market is saturated, the supply is excessive, and the price may decline due to competition.
Fourth, the manufacturer's brand and product quality are also related to price. Well-known manufacturers are famous for their strict quality control and excellent service. Although their products are expensive, they are still favored by the market because of their reliable quality. Unknown manufacturers' products may have questionable quality, although their prices are low, their sales may not be smooth.
In terms of the general range, in the chemical raw material market, the price of 4-chloro-2-fluoroiodobenzene per gram may be between tens of yuan and hundreds of yuan. However, this is only an approximate number. The actual price needs to be based on the current market conditions, and suppliers or industry insiders need to be consulted in detail to be accurate.