4-Chloro-2-fluorophenylboronic acid, with a content of 98%, has a wide range of main application fields. This compound is particularly important in the field of organic synthesis. First, it is often a key reagent for building carbon-carbon bonds. In the Suzuki-Miyaura coupling reaction, 4-chloro-2-fluorophenylboronic acid can efficiently form biaryl or alkenyl aromatics with halogenated aromatics or olefins under the action of suitable catalysts and bases. Such reactions are useful in pharmaceutical chemistry, materials science and other fields.
In the field of pharmaceutical chemistry, it has a lot of help. Drug developers use the Suzuki-Miyaura coupling reaction to introduce specific aromatic structures using 4-chloro-2-fluorophenylboronic acid to optimize the activity, selectivity and pharmacokinetic properties of drug molecules. The synthesis of many new drugs depends on this reaction and the participation of this compound.
In the field of materials science, 4-chloro-2-fluorophenylboronic acid also has outstanding performance. In the preparation of organic optoelectronic materials, polymers or oligomers with specific conjugated structures can be constructed through the coupling reactions they participate in. Such materials exhibit unique photoelectric properties in organic Light Emitting Diodes (OLEDs), organic solar cells and other devices, which are of great significance for improving device efficiency and stability.
In addition, in agricultural chemistry, 4-chloro-2-fluorophenylboronic acid may be used as an intermediate for the synthesis of new pesticides. After appropriate reaction transformation, compounds with high insecticidal, bactericidal or herbicidal activities can be generated, contributing to ensuring crop growth and improving yield. Its application in various branches of organic synthesis has promoted the development and progress of many disciplines such as drugs, materials and agricultural chemistry.

4-Chloro-2-Fluorobenzeneboronic Acid (4-Chloro-2-Fluorobenzeneboronic Acid) is an important intermediate in the field of organic synthesis and is widely used in the construction of various complex organic compounds. Its synthesis methods are rich and diverse, and the following common ones are described in detail:
1. ** Grignard reagent method **:
- Using 4-chloro-2-fluorobromobenzene as the starting material, in anhydrous ether or tetrahydrofuran and other organic solvents, it reacts with magnesium chips to generate the corresponding Grignard reagent 4-chloro-2-fluorophenyl magnesium chloride. This reaction needs to be carried out in a strictly anhydrous and oxygen-free environment. Due to the extremely active Grignard reagent, it is very easy to react with water or oxygen and fails.
- Then, 4-chloro-2-fluorophenylmagnesium chloride is reacted with borate esters, such as trimethyl borate or triethyl borate, at low temperature. After the reaction is completed, the pH of the reaction system is adjusted with dilute acids (such as dilute hydrochloric acid), which prompts the hydrolysis of borate esters into boric acid, resulting in 4-chloro-2-fluorophenylboronic acid. The advantage of this method is that the reaction route is relatively direct and the yield is considerable; however, the disadvantage is that the preparation of Grignard reagent requires strict anhydrous and anaerobic conditions, which requires high requirements for reaction equipment and operation.
2. ** Lithium reagent method **:
- Lithium halogen exchange reaction occurs with lithium reagents such as butyl lithium in anhydrous ether or tetrahydrofuran under low temperature conditions. This reaction requires strict temperature, and usually needs to be carried out at a low temperature (such as -78 ° C) to ensure the selectivity of the reaction and the stability of the lithium reagent.
- Next, 4-chloro-2-fluorophenyl lithium is reacted with borate ester, and the subsequent treatment is similar to the Grignard reagent method. After hydrolysis, the target product is obtained. The lithium reagent method has high reactivity and relatively mild reaction conditions, but the price of lithium reagent is higher, and the operation process also needs to be strictly anhydrous and anaerobic, which increases the cost and difficulty of operation.
3. ** Palladium Catalytic Coupling Method **:
- 4-chloro-2-fluorohalobenzene (such as 4-chloro-2-fluorobromobenzene or 4-chloro-2-fluoroiodobenzene) is selected with biborate pinacol as a reactant, in the presence of a palladium catalyst (such as tetra (triphenylphosphine) palladium, etc.), a ligand (such as tri-tert-butylphosphine, etc.) and a base (such as potassium carbonate, sodium carbonate, etc.), in an organic solvent (such as 1,4-dioxane, toluene, etc.).
- This reaction couples halobenzene with pinacol diborate to form boron-containing intermediates through palladium-catalyzed coupling mechanism, and then hydrolyzes to obtain 4-chloro-2-fluorophenylboronic acid. The palladium catalytic coupling method has the advantages of relatively mild reaction conditions and high selectivity, which can effectively avoid the occurrence of some side reactions; however, palladium catalysts are expensive, and the type and dosage of ligands and bases used in the reaction have a great influence on the reaction results, which requires fine regulation.

4-Chloro-2-fluorophenylboronic acid (4-Chloro-2-Fluorobenzeneboronic Acid), with a content of 98%, the market price varies due to many factors, and it is difficult to determine the value.
In the past, in the market of chemical raw materials, the price was often determined by the state of supply and demand, the simplicity of the manufacturing process, and the price of raw materials. If the demand for this product is wide, and the supply is rare, the price will rise; if the preparation technique is simple, and the raw materials are easy to obtain and cheap, the price may decline.
Looking at the market of chemical materials in the past, new products have first appeared. Because of the difficulty in preparation, few people know about it, and the price is often high. And the method of preparation is gradually mature, the number of producers increases, and the price often falls. However, in case of shortage of raw materials, or changes in government orders, production is limited, and the price rises again.
4-chloro-2-fluorophenylboronic acid, its use may involve fields such as medicine and materials. Pharmaceutical research and development requires strict purity, and high purity is expensive. Material synthesis, if the dosage is large, the price is also affected by the scale effect.
Today is different from the past. The chemical market is changing rapidly. If you want to know its exact price, you should consult chemical trading houses, raw material suppliers, or refer to the real-time quotation of the chemical information platform to get a near-real price.

4-Chloro-2-fluorophenylboronic acid, with a content of 98%. This is an important raw material for fine chemicals. When storing and transporting, many matters must be paid attention to.
Let's talk about storage first. Because of its certain chemical activity, the first thing to do is to choose a dry place. Humid gas is easy to cause its hydrolysis and deterioration. If it is located in a humid and hot place in the south, it is necessary to pay more attention to moisture prevention. When it is contained in a sealed container, it can be supplemented with a desiccant to ensure a dry environment. Furthermore, temperature is also critical. It should be stored in a cool place to avoid high temperature and hot topics. If it is very hot in summer, if there is no temperature control in the warehouse, it may cause its chemical properties to be unstable or decompose. In addition, the storage place should be kept away from fire This substance encounters an open flame or a strong oxidant, or causes the risk of combustion or explosion, just like the ancients said "water and fire are incompatible", and the two coexist, and the disaster is easy to occur.
As for transportation, the packaging must be tight. Choose high-quality packaging materials to ensure that the packaging is not damaged and leaked on a bumpy road. Loading and unloading vehicles should also be handled with care, and should not be handled brutally to prevent damage to the packaging. Special considerations are also required for transportation vehicles. It is necessary to choose a well-ventilated one, and it should not be transported on the same vehicle as flammable, explosive, and strong oxidants to avoid "fire at the city gate, which will affect the pond fish" and cause chain dangers. Transportation personnel also need professional training to be familiar with their characteristics and emergency response methods. In case of emergencies on the way, they can respond quickly to ensure the safety of transportation.

4-Chloro-2-fluorophenylboronic acid, with a content of 98%, the Quality Standard is related to many aspects.
The first to bear the brunt is the appearance. This product is usually a white to off-white crystalline powder with a fine and uniform texture and no impurities, foreign objects or color changes visible to the naked eye. If the appearance does not match, it may suggest that the product has been contaminated or chemically changed during preparation and storage.
The purity level, the established 98% purity, needs to be verified by precise analysis methods such as high performance liquid chromatography (HPLC). This method can clearly distinguish the peak of the target compound and impurities, and accurately calculate the purity based on the peak area. The type and content of impurities cannot be ignored, such as organic impurities, inorganic impurities, etc., all need to be strictly controlled. Organic impurities or from reaction by-products, inorganic impurities or from raw material residues, production equipment introduction, etc.
Melting point is also a key indicator. 4-chloro-2-fluorophenylboronic acid should have a specific melting point range. Generally speaking, the melting point measured by the melting point meter should be consistent with the literature or established standards, and the deviation is very small. Abnormal melting point may suggest crystal shape change, impurity mixing, and then affect product performance.
Moisture content is also the focus. Excessive moisture or product agglomeration, hydrolysis and other adverse phenomena affect stability and reactivity. Moisture is often measured by Karl Fischer method to ensure that it is within the specified range.
In addition, the content of heavy metals must also be strictly limited. It may affect the catalytic performance of the product in a specific reaction, and it is related to the safety of subsequent applications. It is often detected by atomic absorption spectroscopy and other methods to ensure that the content of heavy metals is extremely low and meets relevant standards.
In terms of packaging and storage, sealed packaging should be used to prevent moisture and oxidation. Storage conditions are also exquisite. It should be placed in a cool and dry place to avoid high temperature and strong light to ensure that the product maintains the established Quality Standards during the shelf life. All of these are the key to ensuring the quality of 4-chloro-2-fluorophenylboronic acid.