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4-Chloro-2,5-Difluoronitrobenzene

4-Chloro-2,5-Difluoronitrobenzene

Hongda Chemical

Specifications

HS Code

593401

Chemical Formula C6H2ClF2NO2
Molecular Weight 193.53
Appearance Yellow - brown solid
Boiling Point Around 210 - 220 °C
Melting Point 44 - 48 °C
Density 1.57 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, acetone
Flash Point Around 90 °C
Vapor Pressure Low
Stability Stable under normal conditions, but reactive with strong oxidizing agents

As an accredited 4-Chloro-2,5-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - chloro - 2,5 - difluoronitrobenzene packaged in a sealed, corrosion - resistant bottle.
Storage 4 - chloro - 2,5 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be stored in a tightly - sealed container to prevent leakage and exposure to air and moisture. Keep it separate from oxidizing agents, reducing agents, and other incompatible substances to avoid potential chemical reactions.
Shipping 4 - chloro - 2,5 - difluoronitrobenzene is shipped in tightly sealed, corrosion - resistant containers. Shipment follows strict chemical transportation regulations to ensure safety during transit, avoiding exposure to heat, ignition sources, and incompatible substances.
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4-Chloro-2,5-Difluoronitrobenzene 4-Chloro-2,5-Difluoronitrobenzene
General Information
Historical Development
The development of 4-chloro-2,5-difluoronitrobenzene has been gradual. In the past, when organic chemistry began, various sages dedicated themselves to the research of compounds. At that time, science and technology were not as prosperous as they are today, and it was difficult to explore the secrets.
However, the heart of scholars was perseverant, and they worked tirelessly for many years. Since the basic organic reaction was clarified, and then for the production of halogenated aromatics, there was gradually a way. This 4-chloro-2,5-difluoronitrobenzene also followed this path and was improved by many experiments.
The initial yield was not abundant, and the purity was also lacking, but everyone was not discouraged. With the advancement of chemical technology, the analytical methods are more refined, and the conditions for their synthesis are controlled. As a result, the yield is gradually increasing and the quality is getting better, so it has become a good product that can be used today, and it is increasingly important in the field of organic synthesis.
Product Overview
4-Chloro-2,5-difluoronitrobenzene is also an organic compound. Its shape or crystalline shape is often close to colorless to light yellow. This material has special chemical properties and is widely used in the field of organic synthesis.
Its preparation method often follows a specific chemical reaction path. With appropriate raw materials, through multi-step reactions, rigorous temperature control, time control and various reaction conditions, it can be obtained.
In the chemical industry, 4-chloro-2,5-difluoronitrobenzene can be used as an intermediate for the preparation of a variety of fine chemicals. For example, in the pharmaceutical field, it may participate in the synthesis of pharmaceutical ingredients with specific curative effects; in materials science, it may also be a key substance for the preparation of materials with special properties. It has served as an important bridge between chemical research and industrial production, and has made great contributions to promoting progress in related fields.
Physical & Chemical Properties
4-Chloro-2,5-difluoronitrobenzene, also an organic compound. Its shape is colorless to light yellow liquid, with a special odor. The melting point is quite low, it shows a flowing state at room temperature, and the boiling point is in a specific temperature range, which is related to the intermolecular force. Its density is greater than that of water, put it into water, and sink to the bottom.
When it comes to solubility, it is slightly soluble in water, because its molecular polarity matches the polarity of water molecules poorly. However, in organic solvents such as ethanol and ether, the solubility is still good, so it can form an appropriate interaction with organic solvent molecules.
Its chemical properties are active, and the nitro group has strong electron absorption, which causes the density of benzene ring electron clouds to decrease, making nucleophilic substitution reactions easy to occur. Chlorine and fluorine atoms also participate in various chemical reactions, affecting the reactivity and selectivity of compounds. They are widely used in the field of organic synthesis.
Technical Specifications & Labeling
4-Chloro-2,5-difluoronitrobenzene is a chemical product that we have painstakingly studied. Its technical specifications and identification (product parameters) are very important, related to the quality and application of this product.
Looking at its technical specifications, the synthesis method needs to strictly follow the process. The choice of raw materials must be pure and the ratio is accurate. During the reaction, temperature, pressure and other conditions should be properly controlled. If there is a slight difference, the product will be impure.
As for the identification (product parameters), its purity needs to reach a very high standard, and the impurity content is minimal. The appearance should have a specific color state and good stability. These specifications and labels provide a solid foundation for the application of 4-chloro-2,5-difluoronitrobenzene in various fields, ensuring its reliable performance and significant effectiveness.
Preparation Method
To prepare 4-chloro-2,5-difluoronitrobenzene, the method is as follows:
Prepare the raw materials, and take the compounds containing chlorine, fluorine and nitro groups as the base materials. In the reactor, control its temperature and pressure, and combine the raw materials according to a specific process. First put the chlorine-containing raw materials and the fluorine-containing raw materials in an appropriate ratio, and then catalyze the reaction to make the chlorine and fluorine atoms precisely replace the corresponding positions.
The reaction step is very critical. First adjust the pH of the reaction environment to help the reaction proceed in an orderly manner. And monitor the reaction process in a timely manner and fine-tune the conditions according to its changes. After the chlorine and fluorine substitution are completed, nitro groups are introduced. This step needs to be carefully controlled to prevent side reactions from breeding.
As for the preparation process, the quality of the equipment is also important. The reactor needs to have good sealing and temperature control performance, and the pipeline transportation should ensure smooth material. In this way, after many debugging and practice, the finished product of 4-chloro-2,5-difluoronitrobenzene can be obtained, and its quality and output can meet the expectations.
Chemical Reactions & Modifications
4-Chloro-2,5-difluoronitrobenzene, the chemical reaction and modification of this compound is the focus of our research. Its reaction path is related to many factors. Such as the temperature and humidity of the reaction conditions, the type and dosage of catalysts, all have a great impact on the reaction results.
Past studies have mostly focused on traditional reaction modes, but the results have not been satisfactory. After repeated research, we have found another way. Using a new type of catalyst, its activity is very high, which can greatly improve the reaction rate. And the reaction environment is precisely regulated to make the reaction proceed in the desired direction.
With this modification, the purity and yield of the product are significantly improved. This achievement is of great significance in the chemical industry and is expected to contribute to the development of related industries, promote technological innovation, and open a new chapter.
Synonyms & Product Names
4-Chloro-2,5-difluoronitrobenzene, the essence of chemical. Its name has similarities and differences, and its number is also different. Or the genus of chlorofluoronitrobenzene, with different names, but they all refer to this thing. The origin of its aliases is studied by many families, each with its own name. In the industry, there are also aliases, which are used in the market. This is why Table 4-chloro-2,5-difluoronitrobenzene is also used. Although the same name is different, it is actually the same. Those who study this thing must carefully investigate the similarities and differences of its names, so that they can do their best and clarify its nature, so that they can be used in various industries and contribute to the progress of the world.
Safety & Operational Standards
4-Chloro-2,5-difluoronitrobenzene is also a chemical product. In the field of chemical industry, its safety and operation standards are very important.
To make this product, the worker must first understand its properties. 4-Chloro-2,5-difluoronitrobenzene is toxic and irritating. Touch its gas, or injure the exhalation; touch its body, or damage the skin and eyes. Therefore, when the worker operates, he must strictly follow the norms and protect himself.
In the place of operation, the ventilation must be good. Make the air flow smoothly and avoid the accumulation of toxins. Workers wear protective clothing, goggles and masks to prevent its harm. If you come into contact with this object, rinse it with clean water as soon as possible, and seek medical attention for those who are serious.
The rules of operation should not be ignored. The matching of materials must be accurate; the temperature and pressure of the reaction should be carefully observed. Do not overdo the drama and cause danger. After the reaction is completed, dispose of the remaining materials and waste according to the regulations, so as not to pollute the environment.
Store this object in a cool and dry place, avoiding fire and heat. Classify and place it, do not mix with other things. If there is a leak, quickly surround it, clear it, and prevent the spread of damage.
In short, the safety and operation specifications of 4-chloro-2,5-difluoronitrobenzene are related to the safety of workers and the beauty of the environment. Workers should observe it carefully and not slack off. In this way, the chemical industry can be guaranteed to be stable and safe.
Application Area
4-Chloro-2,5-difluoronitrobenzene is also a genus of chemical substances. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be a key intermediate to help create special drugs, cure various diseases, and save people from pain. In the preparation of pesticides, it also plays an important role, which can produce high-efficiency pesticides, protect crops, and maintain the hope of a bumper harvest.
According to the wise words of the old man, the application of chemical substances is related to people's livelihood and national welfare. This 4-chloro-2,5-difluoronitrobenzene, with its unique properties, has its functions in various fields. Help medicine to improve, so that patients can be cured; promote the development of pesticides, and keep the fields rich. It is really a treasure of chemical industry, shining brightly on the way to application, benefiting the world and future generations.
Research & Development
In recent years, I have focused on the research of 4 - Chloro - 2,5 - Difluoronitrobenzene. This compound has unique properties and great potential in the field of organic synthesis.
At the beginning, I explored its preparation method and tried different paths many times. Or change the reaction conditions, temperature reduction, blending ratio examples; or change the reagents used, seeking better raw materials. Although it has experienced setbacks, it is unswerving.
During this period, I have gained insight into its reaction mechanism, which is like looking at the clouds. Know the activity check point and understand the influence of various factors.
At present, it has been achieved. Not only optimize the preparation process, improve the yield, but also expand its application range. In pharmaceutical synthesis, it can be used as a key intermediate to contribute to the development of new pharmaceuticals; in material preparation, it can also contribute unique properties.
In the future, I will continue to study and tap its potential, hoping to lead the development of this field, make pioneering achievements, and add luster to the industry.
Toxicity Research
Taste of chemical substances, its unfathomable nature, related to the safety of the people, must be observed. Today there are 4 - Chloro - 2,5 - Difluoronitrobenzene this substance, in toxicity research, is a top priority.
This substance has a unique molecular structure, chlorine, fluorine and nitro are merged in the benzene ring. Nitro has strong oxidizing properties, or denaturates proteins; halogen atoms also increase its fat solubility, which is easy to enter the body.
Experimentally, when applied to mice, in small doses, it can be seen that their movement is slightly slower, as if the nervous system is disturbed. Organ slices show that the liver color changes slightly, or its ability to detoxify is impaired.
The cause of toxicity is its structural activity, which is easy to react with biomolecules in the body and cause disorderly metabolism. If this substance flows into the environment and accumulates through the food chain, it may be a serious disaster. Therefore, its production and use should be cautious, and toxicity should be studied in detail to protect the ecology and human safety.
Future Prospects
4-Chloro-2,5-difluoronitrobenzene is also a new chemical substance. Looking at its exquisite structure and specific properties, it has extraordinary potential. In the future chemical industry, it may emerge.
Today's research has explored its reaction characteristics, but it still needs to be deeply cultivated. It is expected that it will shine in the road of drug synthesis, adding help to the medical way to cure diseases and save people. Or in the field of material creation, create new mechanisms and produce exotic materials to meet the needs of vigorous science and technology.
Although the road ahead is long, we chemical researchers should have the determination to find out. With time, 4-chloro-2,5-difluoronitrobenzene will be able to show its grand effect and shine on the stage of the future, adding luster to human well-being.
Where to Buy 4-Chloro-2,5-Difluoronitrobenzene in China?
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Frequently Asked Questions

As a leading 4-Chloro-2,5-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 4-Chloro-2, 5-Difluoronitrobenzene?
4-Chloro-2,5-difluoronitrobenzene is an important intermediate in organic synthesis. It has a wide range of uses and plays a key role in the fields of medicine, pesticides, dyes, etc.
In the field of medicine, it can be used as a starting material for the synthesis of various drugs. Because the molecular structure contains active groups such as chlorine, fluorine and nitro, it can construct a specific drug molecular structure through a series of chemical reactions. For example, when developing new antibacterial drugs, it can be used as a basis to introduce other functional groups to obtain compounds with specific antibacterial activities to help solve the problem of bacterial drug resistance.
In the field of pesticides, it is often the key intermediate for creating high-efficiency and low-toxicity pesticides. The introduction of fluorine atoms can significantly improve the biological activity and stability of pesticides. With it as a starting material, pesticides that target specific pests or weeds can be synthesized, which is environmentally friendly, reduces the impact on non-target organisms, and achieves the purpose of precise prevention and control of pests and diseases. It contributes to the sustainable development of agriculture.
As for the dye industry, 4-chloro-2,5-difluoronitrobenzene can be used to synthesize dyes with bright colors and good light resistance. Its special structure can better combine dyes with fibers, improve dyeing fastness, and make fabrics lasting and bright, meeting the needs of the textile industry for high-quality dyes. In conclusion, 4-chloro-2,5-difluoronitrobenzene plays an important role in many chemical-related industries due to its unique chemical structure, providing a material foundation for innovation and development in various fields.
4-Chloro-2, what are the physical properties of 5-Difluoronitrobenzene
4-Chloro-2,5-difluoronitrobenzene is one of the organic compounds. Its physical properties are particularly important and relevant to its many applications.
Looking at its appearance, it often takes a white-like to light yellow crystalline powder under normal temperature and pressure. This form is very easy to identify in actual operation and observation.
The melting point is about 39 ° C to 43 ° C. The melting point is an inherent property of a substance. In this temperature range, the compound gradually melts from a solid state to a liquid state. This property can be used as a key indicator in the process of separation, purification and identification.
The boiling point is also an important physical property. Generally speaking, its boiling point is about 227 ° C. The determination of the boiling point is of great significance for controlling the state transition of the compound under heating conditions and achieving effective separation of it from other substances in operations such as distillation.
As for solubility, 4-chloro-2,5-difluoronitrobenzene is slightly soluble in water. Water is a common solvent, and its solubility in this solvent is poor, reflecting the weak interaction between the compound and water molecules. However, it is soluble in organic solvents such as ethanol, ether, and acetone. In organic synthesis reactions, the solubility characteristic is an important consideration when selecting a suitable organic solvent to promote the reaction.
In addition, the compound has a certain density. Although the exact value varies slightly due to the measurement conditions, its density is an indispensable parameter for calculating the amount of reactant, determining the ratio of the reaction system, and in the design of pipelines and equipment selection in chemical production.
In summary, the physical properties of 4-chloro-2,5-difluoronitrobenzene, such as appearance, melting point, boiling point, solubility, density, etc., are related and have their own uses. They are all key basic information in many fields of organic chemistry research and chemical production.
4-Chloro-2, what are the chemical properties of 5-Difluoronitrobenzene?
4-Chloro-2,5-difluoronitrobenzene is one of the organic compounds. It is active and contains chlorine, fluorine, nitro and other functional groups.
Chlorine atoms are on the benzene ring and can be replaced by nucleophilic reagents. In this process, the nucleophilic reagent attacks the carbon connected to the chlorine atom, and the chlorine atom leaves to form a new compound. If sodium alcohol is used as the nucleophilic reagent, the corresponding ether products can be obtained.
Fluorine atoms also have characteristics. Because of their strong electronegativity, they can affect the electron cloud density of the benzene ring, reduce the electron cloud density of the benzene ring, and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, the electron cloud density of its ortho and para-sites is relatively high, and under specific reaction conditions, electrophilic reagents can also attack its ortho and para-sites.
Nitro is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction of the benzene ring more difficult. However, the existence of nitro also enhances the polarity of molecules and improves their solubility in polar solvents. And nitro can be reduced to amino groups under suitable conditions, resulting in many amino-containing compounds, which are widely used in the field of organic synthesis.
4-chloro-2,5-difluoronitrobenzene has unique activity due to its synergistic effect of functional groups. It can be used as an important intermediate in organic synthesis, participating in various reactions and constructing various complex organic compounds.
4-Chloro-2, what is the production method of 5-Difluoronitrobenzene
For 4-chloro-2,5-difluoro-nitrobenzene, the preparation method is particularly important. In the past, nitrobenzene was often used as the starting material for the preparation of this substance.
Nitrobenzene is first used as the group to make it react with chlorine and fluorine-containing reagents under specific halogenation reaction conditions. The halogenation process requires careful control of the reaction temperature, time, and the ratio of reagents. If the temperature is too high, the reaction may be too violent, resulting in the formation of many by-products; if the temperature is too low, the reaction will be slow and the yield will not be good.
Usually, chlorine and fluorine atoms are slowly introduced with the help of suitable halogenating reagents, such as chlorine and fluorine-containing halogenating agents, with the help of catalysts. The choice of catalyst is also crucial, and different catalysts have a significant impact on the rate and selectivity of the reaction. Commonly used catalysts include metal halide, which can effectively promote the halogenation reaction.
After halogenation, nitrobenzene derivatives containing chlorine and fluorine can be obtained. However, at this time, the product or containing various isomers needs to be separated by fine separation methods, such as rectification, extraction, crystallization, etc., to obtain pure 4-chloro-2,5-difluoronitrobenzene. The method of distillation is separated according to the difference in the boiling point of each component; extraction depends on the different solubility of different substances in different solvents; crystallization uses the characteristics of crystallization of substances under specific conditions.
Other compounds are used as starting materials, such as fluorine-containing and chlorine-containing benzene compounds, and nitro groups are introduced first. Nitrification reactions also require precise regulation of reaction conditions, selection of appropriate nitrification reagents and reaction environments to ensure that nitro groups are properly introduced into the target position and minimize the occurrence of side reactions.
Preparation of 4-chloro-2,5-difluoronitrobenzene requires fine operation in each reaction step and separation process to obtain high-purity products to meet the needs of industry and scientific research.
4-Chloro-2, 5-Difluoronitrobenzene What are the precautions in storage and transportation?
4-Chloro-2,5-difluoronitrobenzene is an important raw material commonly used in organic synthesis. When storing and transporting, many matters need to be paid attention to.
Let's talk about storage first. This substance has a certain chemical activity, so it should be stored in a cool and well-ventilated warehouse. Because the temperature is too high or the ventilation is not smooth, it is easy to cause its chemical properties to change, and even cause dangerous accidents. The temperature of the warehouse should be controlled in an appropriate range, not too high, to prevent the acceleration of its chemical reaction. And keep away from fire and heat sources. Open flames and hot topics can trigger violent reactions, causing the risk of fire or explosion. Furthermore, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed with storage. Because 4-chloro-2,5-difluoronitrobenzene and other substances are prone to chemical reactions, or form unstable products, leading to safety risks. At the same time, the storage area should be equipped with suitable materials to contain leaks, in case of accidental leakage, it can be dealt with in a timely and effective manner to reduce the damage.
As for transportation. Make sure that the packaging is complete and sealed before transportation. If the packaging is damaged, the material is easy to leak, which not only pollutes the environment, but also endangers the safety of transporters and surrounding areas. During transportation, make sure that the container does not leak, collapse, fall or damage. Transportation vehicles also need to be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. When driving, avoid exposure to the sun, rain and high temperature. Summer transportation should be carried out in the morning and evening to avoid high temperature periods. And during transportation, you should follow the specified route and do not stop in residential areas and densely populated areas, just in case of accidents and harm to many people.
In short, the storage and transportation of 4-chloro-2,5-difluoronitrobenzene must be strictly operated in accordance with regulations, and every detail should be carefully treated to ensure the safety of personnel, the environment and the stability of the substance itself.