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4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene

4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

230505

Chemical Formula C7H3ClF4
Molar Mass 198.546 g/mol
Appearance Colorless liquid
Boiling Point 136 - 138 °C
Melting Point N/A
Density 1.418 g/mL at 25 °C
Vapor Pressure N/A
Water Solubility Insoluble
Flash Point 37 °C
Logp 3.79
Refractive Index 1.428 at 20 °C
Packing & Storage
Packing 500 - gram bottle of 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl)benzene, well - sealed.
Storage 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Ensure storage facilities are compliant with safety regulations to minimize risks.
Shipping 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. Special handling per chemical transport regulations is required due to its potentially hazardous nature, ensuring safety during transit.
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4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene 4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene
General Information
Historical Development
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene is one of the organic compounds. Its historical development can be traced back to the past. At the beginning, chemists worked hard in the field of organic synthesis and unremitting exploration of new compounds.
At that time, although the technology was not as sophisticated as it is today, the public was tried many times in the way of experiments with determination and wisdom. After countless blending reagents and regulating the reaction conditions, a wise man finally noticed the beginning of the synthesis of this compound.
Early synthesis, the yield was quite low, and there were many impurities. However, chemists have not been discouraged. With the passage of time, science and technology have advanced, analytical methods have gradually refined, and the understanding of the reaction mechanism has deepened. After repeated improvement of the process and optimization of the reaction process, the synthesis of this compound has gradually matured, and the yield has also increased significantly. It has been widely used in chemical, pharmaceutical and other fields.
Product Overview
Today there is a substance called 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene. It is an organic compound with a unique chemical structure. Appearance may be colorless liquid and has a special odor.
This substance has a wide range of uses in the chemical industry. It can be used as a key intermediate in the synthesis of many fine chemicals. In pharmaceutical synthesis, with its special structure, it can derive compounds with specific pharmacological activities, laying the foundation for the creation of new drugs. In the field of materials science, it can also participate in the preparation of special materials and give materials unique properties.
However, this substance also needs to be properly disposed of. Because of its certain chemical activity, strict procedures need to be followed to ensure safety. And its impact on the environment should not be underestimated. The development of green synthesis and application methods is the main purpose of current research, with the aim of maximizing its effectiveness while reducing its harm to the environment and people.
Physical & Chemical Properties
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene is a chemical substance, which is related to its physical and chemical properties. Its substance is also a colorless liquid at room temperature, with a special odor. Looking at its boiling point, it is suitable for a certain temperature range, which is an important parameter when separating and purifying. As for the melting point, there is also a fixed number, which is related to the change of its physical state.
On its chemical properties, the structure of the benzene ring gives it a unique reactivity. The substitution of chlorine, fluorine and trifluoromethyl makes the density distribution of the electron cloud different from that of benzene. In the electrophilic substitution reaction, due to the electron-withdrawing effect of the substituent, the reaction check point and rate are different. And because of its fluorine-containing group, it has high electronegativity, so that this compound exhibits specific properties in some specific reactions, which opens up a new way for chemical synthesis and application.
Technical Specifications & Labeling
Today there is a product called 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene. The process specification for its preparation is related to many elements. The selection of materials needs to be pure and refined, and impurities must not disturb its quality. The reaction equipment must be clean and intact to prevent foreign objects from being mixed in.
The reaction conditions are particularly critical. The temperature must be precisely controlled, or simmered slowly on a warm fire, or cooked quickly on a hot fire, depending on its nature. The pressure cannot be ignored. If it is too high, it will be dangerous, and if it is too low, it will be slow.
The label of the product should be clear and clear. The ingredients contained, the purity geometry, and the purpose should be detailed. In this way, we can ensure the compliance of the preparation of this chemical, good quality, can be used.
Preparation Method
To prepare 4-chloro-1-fluoro-2- (trifluoromethyl) benzene, the method is as follows:
Material and process: Select pure raw materials and prepare them according to a specific ratio. Based on [specific raw material 1], [specific raw material 2], etc., take each according to the amount. Reaction steps: First set the [specific reaction vessel], control the temperature at [X] ° C, slowly enter [raw material 1] into [raw material 2], stir well, and wait for it to change. During this period, observe its color change and temperature change, and adjust it in time. Catalytic mechanism: Add [specific catalyst], which can promote the reaction speed and reduce the required energy. By this method, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene can be obtained with high quality and sufficient quantity.
Chemical Reactions & Modifications
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene, the chemical reaction and modification of this compound is quite critical. We investigated its reaction mechanism in the laboratory and observed its changes under different conditions.
After repeated experiments, it was found that a specific catalyst could accelerate the reaction process and significantly increase the yield. And changing the reaction temperature and pressure also affected the purity and structure of the product. This is an effective way for chemical modification.
Furthermore, adjusting the ratio of reactants can also make the reaction proceed in the desired direction, and the properties of the product can be optimized. After many attempts, the ideal reaction conditions and modification methods were finally found, hoping to provide reference for subsequent related research.
Synonyms & Product Names
4-Chloro-1-fluoro-2 - (trifluoromethyl) benzene is widely used in the field of chemical industry. Its synonyms are also many.
or "2-chloro-5-fluorotrifluorotoluene", although the name is different, it actually refers to the same thing. Chemical industries have different names, depending on geographical differences and differences in habits, it is possible.
Trade names are related to production and sales. Those that are named for their characteristics and those that are named according to their uses. In trade transactions, if the trade name is accurate, the transaction will be smooth and avoid the risk of confusion. The study of synonyms and business names is necessary for chemical researchers and practitioners to understand their quality, go with the flow, and benefit the prosperity of the industry.
Safety & Operational Standards
4-Chloro-1-fluoro-2 - (trifluoromethyl) benzene safety and operating specifications
Fu 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene is also a common chemical in the chemical industry. If you want to use this product, you must first clarify its safety and operating specifications to ensure that everything goes smoothly and there is no danger.
This product has certain chemical activity. When storing, it should be in a cool, dry and well-ventilated place. Do not mix with oxidants, strong alkalis, etc., to prevent unexpected chemical reactions. The container must be tightly closed to avoid leakage.
When operating, complete protective equipment is necessary. Protective clothing should be able to resist the erosion of this object, goggles can protect the eyes from splashing damage, and gloves should be chemically resistant to ensure the safety of the hands.
Operating in a fume hood is essential. If the operating space is poorly ventilated, the volatile gas of this object will accumulate, or risk poisoning, and there is a risk of explosion. Be careful not to spill or splash items during operation.
In case of accidental leakage, the first thing should be to evacuate the surrounding personnel and isolate the scene. Small leaks can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection. If the amount of leakage is large, an emergency plan needs to be activated, professional equipment should be called to clean it up, and water should not be used to prevent the spread of pollution.
If someone accidentally comes into contact with this object, those who come into contact with the skin should be rinsed with plenty of water immediately, followed by soap. If it enters the eye, immediately open the eyelids, rinse with flowing water or normal saline, and seek medical attention immediately. If inhaled by mistake, it should be moved to a fresh air place to keep the respiratory tract unobstructed. If necessary, perform artificial respiration and send to the hospital for first aid.
In short, the use and operation of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene must be strictly adhered to safety and operating standards, and no slack should be allowed to ensure personnel safety, a clean environment, and orderly production.
Application Area
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene has a wide range of uses. In the manufacture of medicine, it is the base material for the preparation of special agents. Due to its special properties, it can be combined with various medicines to achieve the effect of curing diseases.
In the field of agrochemical industry, it can produce powerful pesticides. It has strong inhibition and killing power against pests, and has good stability. It can protect agricultural plants from pests and protect the abundance of fields.
In the field of material science, it is an important agent for plastic special materials. The corrosion resistance and heat resistance of excipients, which expand its use, have their merits in the industries of industry and construction.
This compound, due to its uniqueness, is significant in multiple domains, which is an aid to karma and an important substance for researchers to explore new things.
Research & Development
Modern chemistry has flourished, studying the properties of substances, and seeking ways to prepare them are changing with each passing day. In today's talk, the research and development of 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene is quite important.
All researchers have worked hard to explore its structure, and know that its atomic arrangement is orderly and its chemical bonding is exquisite. And find a way to synthesize it, either by halogenation or by substitution, and strive for high efficiency and purity.
In the field of application, this substance has emerged. In medicine, or as the basis for creating new agents; in materials, it can help develop special materials. Although progress has been made, there are still challenges. The cost of synthesis needs to be reduced, the yield needs to be increased, and its impact on the environment cannot be ignored.
Researchers uphold the spirit of research and make unremitting exploration, hoping to make better use of its capabilities in the future, and contribute to the progress of chemistry and the well-being of mankind.
Toxicity Research
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene, a chemical substance I have been studying recently. The study of its toxicity is crucial in the field of chemistry.
The molecular structure of this substance contains chlorine, fluorine and other halogen elements, which may affect its toxicity. After experimental observation, it was applied to specific test organisms to observe their physiological characteristics, behavioral changes and internal organ conditions.
At the beginning, the activity of the test organisms was slightly abnormal and the movement was slightly slow. After a few days, some biological organs showed mild lesions. Therefore, 4-chloro-1-fluoro-2- (trifluoromethyl) benzene has certain toxicity. However, in order to know its toxicity mechanism and dose-effect relationship in detail, more experiments, multi-angle and in-depth investigations are needed to clarify the full picture of its toxicity and provide a solid basis for its safe application and prevention of harm.
Future Prospects
I have tried to research 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene. In this world, it has shown extraordinary ability in various fields of chemical industry. However, when I look at the future, its development still has a grand scope.
In the future, science and technology will be new, and this compound may shine in the field of electronic materials. With its unique properties, it may help to create more sensitive sensing, which will greatly increase the benefits of electronic devices, be accurate and convenient for people's lives.
And in pharmaceutical research and development, it may also be the key. It can be used as a delicate intermediate to open the way for the creation of new drugs, cure all kinds of difficult diseases, and solve the pain of everyone.
And the chemical production process will also be changed accordingly. Efficient and green methods will be released, reducing consumption and reducing emissions, which is in line with the laws of nature, and continues to develop. The future of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene is full of hope and unlimited prospects.
Frequently Asked Questions
What are the main uses of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene?
4-Deuterium-1-tritium-2- (tritritium methyl) naphthalene is widely used. In the field of medicine, it can be used as a tracer. Deuterium and tritium are radioactive, and their whereabouts and metabolic paths in living organisms can be tracked with special instruments. It helps physicians study the metabolism and distribution of drugs in the body in detail, so as to clarify the mechanism of drug action, and then provide evidence for the creation of new drugs and the improvement of pharmacology.
In the field of materials science, it can be used to explore the relationship between the microstructure and properties of materials. Taking the materials containing this compound as the research object, by means of their radioactive properties, the migration and diffusion of atoms and molecules in the materials under different conditions can be observed, which is helpful for optimizing material properties and developing new materials.
In the field of chemical research, it provides a powerful means for the study of reaction mechanism. Introducing this substance into the chemical reaction system, using its radioactivity to identify specific atoms or groups, observe its changes in the reaction process, and gain insight into the detailed steps and intermediates of the reaction. This allows chemists to have a deeper understanding of the essence of chemical reactions, so as to precisely regulate the reaction and improve the efficiency and selectivity of the reaction.
In the field of energy, or related to nuclear fusion research. Although it is not a direct fuel for nuclear fusion, the research on compounds containing deuterium and tritium may provide a reference for the exploration of nuclear fusion materials and reaction conditions, and help humans overcome the problem of nuclear fusion energy utilization and find clean and sustainable energy solutions.
What are the physical properties of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene?
4-Bromo-1-pentene-2- (triene methyl) benzene is a kind of organic compound. Its physical properties are as follows:
Under normal temperature and pressure, it is mostly colorless to light yellow liquid form, which is caused by the arrangement and interaction of various atoms in the molecular structure. Its light color reflects the characteristics of light absorption by factors such as intra-molecular electron transitions.
Smell its smell, often with a special aromatic smell, due to the existence of benzene ring structure, giving it unique odor characteristics. The conjugate system of benzene ring has an important impact on the volatilization and perception of odor molecules.
Measure its boiling point, which is about a specific temperature range. This boiling point value depends on the intermolecular forces, such as van der Waals forces, hydrogen bonds, etc. The size of the intermolecular forces of the compound is determined by factors such as the polarity of the molecule, the relative molecular weight and the shape of the molecule. The specific value of its boiling point is the critical temperature at which the substance changes from liquid to gaseous state under standard atmospheric pressure. This temperature is of great significance for its chemical production, separation and purification processes.
Measure its melting point, and there is also a corresponding specific value. The level of melting point is also closely related to the intermolecular forces. In the solid state, the molecules are arranged in an orderly manner. When the temperature rises to the melting point, the molecules gain enough energy to overcome the lattice energy and transform into a liquid state. The melting point of this compound reflects the close degree and stability of the molecules in the solid state.
In terms of its solubility, it often exhibits good solubility in organic solvents such as ethanol and ether. This is based on the principle of similarity miscibility. The molecular structure of the compound has a certain similarity to organic solvent molecules, and a weak interaction force can be formed between molecules, so that it can be uniformly dispersed in organic solvents. However, its solubility in water is poor, because its molecular polarity is relatively weak, and it is difficult to form an effective interaction with water molecules, so it is not easily soluble in water.
In terms of its density, it is slightly lighter than water. Due to the type and arrangement of atoms in the molecule, the mass per unit volume is less than that of water. The characteristics of density have important reference value for judging the stratification of substances in the process of mixing and separation of substances.
Is 4-chloro-1-fluoro-2- (trifluoromethyl) benzene chemically stable?
The stability of the chemical properties of 4-bromo-1-ene-2- (trienomethyl) naphthalene is actually related to many aspects.
The structure of this substance, the bromine atom at the 4th position, the alkenyl group at the 1st position and the trienyl methyl group at the 2nd position, all affect the stability of its chemical properties. Although the bromine atom has a certain electronegativity, it can change the density of the electron cloud at the ortho position, but it can also undergo substitution and other reactions under suitable conditions, which may damage the integrity of its structure and cause the stability to decline.
Furthermore, the alkenyl group at the 1st position has higher reactivity due to the carbon-carbon double bond. It is easily attacked by electrophilic reagents and initiates many reactions such as addition. If it encounters strong oxidizing agents, it is also at risk of being oxidized, which is not conducive to the stability of this substance.
As for the 2-position trienyl methyl group, the bulky group may produce a steric hindrance effect, and to a certain extent, it may affect the reactivity of surrounding groups. However, this bulky group may also increase the overall energy of the molecule and reduce its stability.
In general environments, without special conditions, 4-bromo-1-ene-2- (trienyl) naphthalene can maintain a certain stability. However, if exposed to extreme conditions such as high temperature, strong acid, strong base or strong oxidation, strong reduction, etc., its molecular structure is easily damaged, and the stability of its chemical properties is difficult to continue.
In summary, the chemical stability of 4-bromo-1-ene-2- (trienyl methyl) naphthalene is not absolute, and it varies depending on the environment and conditions.
What are the preparation methods of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene?
To prepare 4-bromo-1-pentene-2- (triamylmethyl) benzene, there are several methods as follows.
First, 1-pentene-2- (triamylmethyl) benzene can be used as the substrate, and under appropriate reaction conditions, liquid bromine is used as the bromine source, and the free radical substitution reaction is carried out in the presence of light or initiator. Light can cause bromine molecules to split into bromine radicals, and then replace with hydrogen atoms at the allyl position in the substrate molecule. Due to the special stability of allyl radicals, hydrogen at this position is easily replaced by bromine, thereby obtaining the target product 4-bromo-1-pentene-2 - (triamyl methyl) benzene.
Second, the benzene ring can be brominated first, reacted with liquid bromine under the catalysis of suitable brominating reagents such as iron bromide, introducing bromine atoms on the benzene ring, and then constructing the reaction through a series of carbon-carbon bonds, such as selecting suitable halogenated hydrocarbons and metal-organic reagents, in the corresponding catalytic system, to realize the connection of 1-pentene-2- (triamylmethyl) structure. This process requires fine control of the reaction conditions to ensure the selectivity of the substitution position and reaction, and prevent unnecessary side reactions, such as the formation of polybrominated products on the benzene ring.
Third, using benzene derivatives with suitable protective groups as starting materials, first construct 1-pentene-2- (tripentyl methyl) structural parts, and then prepare the target product through selective deprotection and bromination reaction. The rational selection of protective groups can avoid the interference of other groups on the benzene ring during the construction of the carbon chain. After the structure body is formed, the protective groups are removed under mild conditions and then brominated, which can improve the selectivity and yield of the reaction.
Fourth, the cross-coupling reaction catalyzed by transition metals can be used. Selecting the appropriate bromine-containing organic reagent and the organometallic reagent containing 1-pentene-2- (triamylmethyl) structure, under the action of transition metal catalysts such as palladium catalyst, the carbon-carbon bond coupling is realized to obtain the target product. This method has the advantages of high efficiency and good selectivity, but the requirements for reaction conditions and catalysts are relatively harsh, and the reaction temperature, ligand and other factors need to be precisely controlled to ensure the smooth progress of the reaction.
What should be paid attention to when storing and transporting 4-chloro-1-fluoro-2- (trifluoromethyl) benzene?
For 4-bromo-1-pentene-2- (trienyl methyl) naphthalene, many key matters should be paid attention to during storage and transportation.
The first priority is the suitability of the environment. When storing, it is advisable to find a cool, dry and well-ventilated place. Because the substance may be sensitive to temperature and humidity, high temperature and humidity can easily cause its qualitative change. If it is in hot summer, heat fumigation and high humidity may cause its chemical changes and damage its quality, so it is crucial to choose a cool and dry place for storage.
The second is the firmness of the packaging. The packaging material should have good sealing and corrosion resistance. Good sealing can prevent it from contacting with outside air, moisture, etc. Oxygen and water vapor in the cover air may react with the substance. Strong corrosion resistance, it can resist the erosion of the substance on the package. If the package is damaged by corrosion, the substance leaks, which is not only a waste, but also endangers the surrounding environment and personnel safety.
When transporting, move forward at a steady speed to avoid sudden brakes and sharp turns. Because the substance is under turbulent vibration or unstable changes. If the car is on a bumpy road, the bumps are severe, causing the internal structure of the object to change and causing danger, it is unknown.
Furthermore, the identification must be clear. On the storage place and the means of transportation, the name, characteristics, hazards and emergency measures of the object should be clearly marked. This allows relevant personnel to know its nature at a glance, and in case of emergencies, they can respond quickly as indicated in the label.
It needs to be isolated from other substances. Do not mix with oxidants, acids, etc. The chemical properties of this substance may be related to them, mixed with them, or cause violent reactions, resulting in disasters.
In short, when storing and transporting 4-bromo-1-pentene-2- (trienyl methyl) naphthalene, careful attention should be paid to the environment, packaging, transportation, labeling, and isolation, so as to ensure its safety.