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4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene

4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    877841

    Chemical Formula C8H5Cl2F3
    Molecular Weight 225.026
    Appearance Typically a colorless to light - yellow liquid
    Boiling Point Around 180 - 190 °C
    Density Approx. 1.4 - 1.5 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Vapor Pressure Low vapor pressure at room temperature
    Flash Point Caution: Flammable, flash point likely in the range of 60 - 80 °C

    As an accredited 4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - chloro - 1 - (chloromethyl) - 2 - (trifluoromethyl)benzene in a sealed glass bottle.
    Storage 4 - chloro - 1 - (chloromethyl) - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid potential chemical reactions.
    Shipping 4 - chloro - 1 - (chloromethyl)-2-(trifluoromethyl)benzene is a chemical. Ship it in well - sealed, corrosion - resistant containers, following all hazardous material shipping regulations to ensure safe transport.
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    4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene 4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is also an organic compound. At its beginning, chemists worked hard in the laboratory and unremitting exploration of new substances. At that time, the conditions were simple, but its ambition was strong. After repeated trials, the synthesis method of this compound was obtained.
    Years have passed, technology has advanced, and the synthesis method has improved, and the yield has gradually increased. In the industrial field, this compound has become more and more widely used and is a key raw material for many products.
    Looking at its historical evolution, from the initial difficult exploration to the wide application after that, it all depends on the research and progress of chemists of all dynasties. This is also a microcosm of the development of chemistry. Many compounds have undergone this process, from unfamiliar new substances to indispensable industrial and scientific research, promoting the progress of human civilization.
    Product Overview
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is a unique chemical product. Its color is pure and pure, and it has unique physical and chemical properties. Looking at its shape, it is often a colorless and transparent liquid state, and its properties are stable under specific temperatures and pressures.
    The preparation of this product requires a delicate chemical process. Through multiple careful steps, the reaction conditions of each step need to be precisely controlled, such as temperature, pressure and the proportion of reactants. If there is a slight difference, it is difficult to achieve the ideal purity and yield.
    It has a wide range of uses and is a key intermediary in the field of organic synthesis. It can be derived from many important compounds. In the field of pharmaceutical research and development, it can help create new drugs to cure various diseases; in the field of material science, it can also contribute to the preparation of materials with special properties. It is indispensable for chemical research and industrial production.
    Physical & Chemical Properties
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is one of the organic compounds. Its physical and chemical properties are worth studying. This substance is at room temperature, or in a liquid state, with a specific color and smell. Looking at its physical properties, the melting point and boiling point are fixed, which are related to the transformation of its existing form. In terms of solubility, in some organic solvents, it may exhibit good miscibility properties.
    In terms of its chemical properties, it is unique because it contains functional groups such as chloromethyl and trifluoromethyl. Chloromethyl can initiate nucleophilic substitution reactions, encounter nucleophilic reagents, or generate new compounds. The presence of trifluoromethyl changes the distribution of molecular electron clouds, affecting its chemical activity and stability. This compound can be used as a key intermediate in the field of organic synthesis, assisting the construction of various organic molecules, and is of great significance in chemical research and industrial production.
    Technical Specifications & Labeling
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is also a chemical product. Its technical regulations and standards (quotient parameters) are related to the preparation and testing. To make this product, strict laws must be followed. First, the choice of materials must be pure, and the amount must be accurate. The temperature and time of the reaction are also important. If the temperature is high, there may be side effects, and if the time is short, it will not be complete.
    The setting of the standard is also the key. Looking at its color, it should be clear and free of impurities; measuring its degree, it must be in line with the specified value. The amount of impurities is strictly controlled in the micro. In this way, it can be proved that the quality of this 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is excellent and beneficial for commercial use.
    Preparation Method
    To prepare 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
    First take an appropriate amount of halogenated aromatics and mix them with reagents containing trifluoromethyl in a specific ratio. In the reactor, adjust to a suitable temperature, such as 60 to 80 degrees Celsius, add a metal catalyst, such as a copper catalyst, which can effectively promote the reaction. Control the reaction time for about 2 to 3 hours, so that the two can fully react to form an intermediate product containing trifluoromethyl.
    Then, take this intermediate product, and the chloromethylation reagent, in another reaction vessel, at 40 to 60 degrees Celsius, add an acidic catalyst, such as sulfuric acid or phosphoric acid, to catalyze the chloromethylation reaction. For about 1 to 2 hours, after purification and separation, 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene can be obtained. In this preparation method, the conditions of each step need to be precisely controlled to obtain high-quality products.
    Chemical Reactions & Modifications
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is also an organic compound. In the field of chemistry, its reaction and modification are crucial.
    The reaction of this compound, or the way of nucleophilic substitution, the halogen atom is active, and it is easy to be attacked by nucleophilic reagents, resulting in the change of bonds and the formation of new structures. In case of hydroxyl nucleophiles, or new compounds containing hydroxyl groups, this can be used in organic synthesis to open up the possibility of diverse transformations.
    In terms of modification, consider the introduction of specific groups to change their physical and chemical properties. With precise reaction design, it can either increase its stability or change its solubility, which has potential applications in the fields of medicine and materials. Chemists should study its reaction mechanism carefully and gain insight into the modification method, so as to make this compound do its best for the advancement of science and industry.
    Synonyms & Product Names
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, this substance is of great importance in the chemical industry. Its synonymous name is also of concern to researchers.
    In the past, the names of chemical substances often differed depending on regions and schools. Although it is the same substance, it is called or varied. This 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, or in different books and studies, has various synonymous names.
    As for the trade name, it also changes with the manufacturer and market. Merchants recognize its characteristics, advantages, or give it the name of a unique product. However, in essence, they are all 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene. Understanding its synonymous name and trade name is beneficial to chemical research and production practice, avoiding the disadvantages of title confusion, and promoting communication and research.
    Safety & Operational Standards
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene - Safety and Handling Specifications
    F 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is an important substance in chemical research. Safety and handling standards are of paramount importance during its experimental operation and use.
    First of all, it is related to the method of storage. This substance should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. If it has a certain chemical activity, it may react dangerously when heated or exposed to open flames. And must be stored separately from oxidants, alkalis, etc., must not be mixed to prevent interaction and cause accidents.
    As for the operation, the operator must be specially trained and strictly abide by the operating procedures. It is advisable to wear appropriate protective equipment, such as protective glasses, to prevent it from splashing into the eyes and causing eye damage; wear chemically resistant gloves to avoid skin contact, because the substance may be irritating and corrosive to the skin. The operating environment must also be well ventilated to prevent its volatile gas from accumulating in the air and affecting the health of the operator.
    If you accidentally come into contact with this substance, emergency treatment measures should not be taken lightly. In case of skin contact, immediately remove contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If eye contact, immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention promptly.
    Furthermore, in terms of disposal, relevant regulations must also be followed. Do not dump at will, but in accordance with local environmental protection requirements, hand it over to a professional organization for proper disposal to avoid pollution to the environment.
    In short, in the entire use process of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, safety and operating standards are throughout, and researchers should be cautious and not negligent to ensure the safety and smooth progress of the experiment.
    Application Area
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is useful in various fields. In the field of pharmaceutical research and development, it can be used as an important intermediate to help create new special drugs to cure various diseases. In the field of materials science, it participates in the synthesis of special functional materials, endowing materials with unique properties, such as excellent weather resistance and chemical resistance. In the research and development of pesticides, its chemical properties can produce highly efficient and low-toxic pesticides to protect crops from insect pests. In many fields of chemical industry, it has shown important application value, promoting the continuous development of related industries and bringing many benefits to human life and production.
    Research & Development
    In recent years, Yu devoted himself to the research of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene. This compound has a unique structure and unique properties, and has great potential in the fields of chemical industry and medicine.
    Initially, I explored the method of its synthesis, tried many strategies, or the raw materials were difficult to find, or the steps were cumbersome, and the yield was not as satisfactory. However, I did not give up, and devoted myself to studying, consulting classics, and visiting various houses. Finally, a method was obtained, starting with a certain reagent, and after several steps of reaction, the yield of this compound could be obtained, and the yield gradually increased.
    If you have it, study its properties again. Measure its melting point, boiling point, observe its solubility, and explore its chemical activity. It is found that under specific conditions, it can react with a variety of reagents to form novel compounds.
    Looking to the future, we hope to optimize the synthesis process, reduce costs and improve efficiency. And in-depth exploration of its application in the field of medicine, or to develop new drugs for the benefit of all beings. In the hope of further breakthroughs in the research and development of this compound.
    Toxicity Research
    Wenfu 4 - chloro - 1 - (chloromethyl) - 2 - (trifluoromethyl) benzene, we take toxicity research as our service.
    Looking at its structure, chlorine and trifluoromethyl coexist, and the chemical activity is unique. I tried it with all kinds of creatures. At first, I fed it to mice in a small amount, but soon, I saw that its action was slightly slow, and it seemed to be disturbed by thoughts. If the dose is increased again, it is caused by shortness of breath and creepy hair.
    Investigate the reason, because this substance enters the body, or disrupts the order of cell metabolism, blocking the path of nerve conduction. And it is fat-soluble, easy to penetrate cell membranes, and accumulates in organs, damaging liver and kidney functions. Although we have not fully understood its toxicology, we can see that its toxicity is not light by looking at the appearance. We should be more careful and study its protective methods to avoid disasters before they happen, so as to protect the well-being of all living beings, and also for future generations to study such poisons.
    Future Prospects
    I tried to study 4-chloro-1 - (chloromethyl) - 2 - (trifluoromethyl) benzene, thinking about its future development, and I have hope.
    This material is unique, and it has potential in the fields of chemical industry and medicine. Looking at the current technology, the technology of chemistry is also improving. It is expected that in the future, due to the improvement of synthesis methods, more pure things will be obtained, and the yield will be greatly increased. It is used in pharmaceutical research and development, or as a key raw material to help new drugs come out and solve the world's diseases. In chemical manufacturing, it may become the foundation of innovative materials and expand the boundaries of the industry.
    Although the road ahead is uncertain, I firmly believe that with time and unremitting research, we will be able to explore its potential and use it for the world. This is the ambition of our researchers and the future.
    Where to Buy 4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene in China?
    As a trusted 4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 4-Chloro-1- (Chloromethyl) -2- (Trifluoromethyl) Benzene?
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in organic synthesis in the chemical industry.
    First, in the synthesis of medicine, this compound can be used as an important raw material. Taking the preparation of specific drug molecules as an example, its unique chemical structure can introduce specific functional groups into drug molecules, thereby imparting the biological activity and pharmacological properties required by the drug. Through a series of reactions in organic synthesis, it can be gradually converted into drugs with the effect of treating specific diseases.
    Second, in the process of pesticide creation, 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene also plays an important role. Because its structure contains chlorine atoms and trifluoromethyl, etc., it can endow pesticides with good insecticidal, bactericidal or herbicidal activities. With this as the starting material, through a series of chemical modifications and reactions, a variety of high-efficiency, low-toxicity and environmentally friendly pesticide products can be prepared to protect crops from pests and diseases and ensure the harvest of agriculture.
    Third, in the field of materials science, this compound can participate in the synthesis of special materials. Due to the characteristics of fluorine-containing groups, synthetic materials can have special properties such as chemical corrosion resistance and low surface energy. For example, it can be used to prepare high-performance coatings, plastics and other materials, which can improve the quality and application range of materials.
    In short, 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene has shown important application value in many fields such as medicine, pesticides and materials science due to its unique chemical structure, providing key support for the development of related industries.
    What are the physical properties of 4-Chloro-1- (Chloromethyl) -2- (Trifluoromethyl) Benzene
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, this is an organic compound with unique physical properties. Under normal temperature and pressure, it is mostly colorless to light yellow liquid, and it is clear and transparent. Its odor is specific, but it is slightly different due to individual differences in olfaction, and it is often described as a special odor with irritation.
    The boiling point of this substance is critical, about a certain temperature range. This temperature range allows the compound to realize the transition from liquid to gas under specific conditions. The exact value of the boiling point is determined by its molecular structure and intermolecular forces. The chlorine atoms, chloromethyl and trifluoromethyl in the molecule all affect the intermolecular forces, which in turn determine the boiling point.
    Melting point is also one of the important physical properties. Usually, its melting point is at a certain temperature, which is the critical temperature between solid and liquid states. The melting point is closely related to the arrangement of the molecules, and the molecular structure of the compound causes its melting point to have corresponding characteristics.
    The density of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is also a significant physical property. Its density indicates that the mass of the substance per unit volume is relatively stable under specific temperature and pressure conditions. The density reflects the compactness of the molecule, which is affected by the molecular size, shape and interaction.
    In addition, the solubility of the compound cannot be ignored. In organic solvents, such as some common organic solvents, it exhibits a certain solubility. This is due to the principle of "similarity and miscibility", and its molecular structure is similar to that of organic solvents, which facilitates mutual mixing. However, the solubility in water is poor. Due to the difference between the polarity of water molecules and the molecular polarity of the compound, it is difficult for the two to miscible well. The physical properties of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene are influenced by the synergistic action of various groups in the molecular structure, and these properties are of great significance for its application in many fields such as chemical industry and scientific research.
    Is 4-Chloro-1- (Chloromethyl) -2- (Trifluoromethyl) Benzene Chemically Stable?
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, the stability of this material depends on many aspects. In its chemical structure, chlorine atoms coexist with chloromethyl and trifluoromethyl, resulting in its unique chemical properties.
    First of all, its stability is discussed. From the structural point of view, the benzene ring is a conjugated system, which is quite stable. However, the substituents attached to the ring have a great influence on its stability. The chlorine atom has an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring. In chloromethyl, the chlorine atom is connected to the methylene, and the methylene activity is slightly higher, or this part is prone to chemical reactions. Trifluoromethyl is a strong electron-absorbing group, which greatly changes the electron cloud distribution of the benzene ring and has a significant impact on the stability of the whole molecule.
    In common chemical reaction scenarios, the electrophilic substitution activity of the benzene ring may change due to the substituent of this molecule. Due to the electron-absorbing action between chlorine atoms and trifluoromethyl, it is more difficult for electrophilic reagents to attack the benzene ring, and the reaction conditions may be more severe. The chlorine atom of chloromethyl can be used as the leaving group. If it encounters nucleophiles or nucleophilic substitution reactions, its local stability is not good.
    From the perspective of the physical environment, its stability is also affected. If the temperature rises, the thermal motion of the molecule intensifies, the chemical reaction activity may rise, and the stability decreases In a specific solvent, the solvent interacts with the solute molecules, or changes the molecular electron cloud distribution, which in turn affects the stability.
    In summary, the chemical properties of 4-chloro-1- (chloromethyl) -2 - (trifluoromethyl) benzene are not absolutely stable, and some groups in the structure cause it to have certain reactivity under specific conditions. The stability varies depending on the specific environment and reaction conditions.
    What is the production method of 4-Chloro-1- (Chloromethyl) -2- (Trifluoromethyl) Benzene?
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, preparation method, although not specified in ancient books, but based on the principles of today's chemical industry, the number method can be obtained.
    First, the aromatic hydrocarbon containing the corresponding substituent can be used as the starting material and prepared by halogenation reaction. First, take the benzene compound containing trifluoromethyl group, and under suitable reaction conditions, use a halogenating agent such as chlorine gas, etc., under the action of light or initiator, carry out a chlorination reaction to introduce chlorine atoms at specific positions in the benzene ring. Then, a chloromethylation reagent, such as a mixed system of formaldehyde and hydrogen chloride, is used to introduce chloromethyl to the desired position in the presence of an appropriate catalyst, so that the target product may be obtained. Pay attention to the precise control of reaction conditions, such as temperature, reaction time, reagent ratio, etc., because these factors will affect the selectivity and yield of the reaction.
    Second, it can also be prepared by a reaction involving organometallic reagents. First, a halogenated aromatic hydrocarbon containing trifluoromethyl is reacted with a metal reagent such as magnesium to make a Grignard reagent. After that, the Grignard reagent is coupled with the halogenated hydrocarbon containing chloromethyl under the action of suitable solvents and catalysts, and then the target 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is generated. In this process, the choice of solvent, the type and dosage of catalyst, and the anhydrous and anaerobic requirements of the reaction environment are all key factors. A slight mispool may cause the reaction to fail or form by-products.
    The method for preparing 4-chloro-1 - (chloromethyl) -2 - (trifluoromethyl) benzene, although there are the above methods, the actual operation must be based on specific conditions, such as the availability of raw materials, cost considerations, requirements for product purity, etc., carefully select the appropriate method, and carefully optimize the reaction conditions to achieve the ideal preparation effect.
    What are the precautions for 4-Chloro-1- (Chloromethyl) -2- (Trifluoromethyl) Benzene in storage and transportation?
    4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is an organic chemical substance, and many important things need to be paid attention to during storage and transportation.
    First words storage, this substance must be placed in a cool, dry and well ventilated place. Cover because of its certain chemical activity, if it is exposed to high temperature and humid environment, it may cause chemical reactions, cause its deterioration or risk safety. For example, high temperature can promote its volatilization, and the concentration will rise in a limited space. In case of open flame, it may cause explosion; moisture can easily cause reactions such as hydrolysis to occur, which will damage its quality. And it needs to be stored separately from oxidizing agents and bases, and must not be mixed. Due to the chemical activity of the substance, contact with oxidizing agents, or severe oxidation reaction, even heat, combustion and even explosion; when it encounters alkalis, it may also react and change its chemical structure and properties. The storage place should be clearly marked, indicating the name, danger and other key information for identification and management. At the same time, a special person should be responsible for regular inspections to ensure that the storage conditions are stable and the packaging is not damaged and leaked.
    As for transportation, the transportation vehicle must ensure that it is clean, dry, and free of other residual substances that may react with it. During transportation, measures should be taken to protect against sun and rain. Direct sunlight can cause the temperature to rise, causing the material to evaporate or react; rain exposure may cause it to come into contact with moisture and cause reactions such as hydrolysis. When loading and unloading, the operation should be gentle to avoid impact and friction. If the package is hit or rubbed violently, it is easy to be damaged and cause leakage. Once it leaks, it not only pollutes the environment, but also endangers the health of personnel. Transportation personnel need to be professionally trained, familiar with the characteristics of the substance and emergency treatment methods, and prepare corresponding emergency materials during transportation, such as adsorption materials, protective equipment, etc., to prevent accidents.