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4-Chloro-1-(Chloromethyl)-2-Fluorobenzene

4-Chloro-1-(Chloromethyl)-2-Fluorobenzene

Hongda Chemical

    Specifications

    HS Code

    531497

    Chemical Formula C7H5Cl2F
    Molecular Weight 181.019
    Appearance Colorless to light yellow liquid
    Boiling Point Around 200 - 210 °C
    Density Approx. 1.38 - 1.42 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Vapor Pressure Low
    Flash Point Around 80 - 90 °C
    Odor Characteristic, pungent

    As an accredited 4-Chloro-1-(Chloromethyl)-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - chloro - 1 - (chloromethyl)-2 - fluorobenzene in a sealed, labeled bottle.
    Storage 4 - chloro - 1 - (chloromethyl)-2 - fluorobenzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. It must be stored in a tightly sealed container to prevent vapor leakage. Keep it separate from oxidizing agents, bases, and reactive materials. Store in a location compliant with local chemical storage regulations for hazardous substances.
    Shipping 4 - chloro - 1 - (chloromethyl)-2 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Compliance with chemical transportation regulations ensures safe transit, protecting both handlers and the environment.
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    4-Chloro-1-(Chloromethyl)-2-Fluorobenzene 4-Chloro-1-(Chloromethyl)-2-Fluorobenzene
    General Information
    Historical Development
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also an organic compound. At the beginning of its production, chemists worked hard and tried many times to achieve success. At the beginning, the preparation method was difficult and the yield was quite low. As the years passed, the principles of chemistry became clearer and clearer, and the preparation method became more and more exquisite. The materials used in the past were not easy to obtain, the operation or more dangerous, but now the conditions are getting better and the steps are simpler. Its application has also become wider, and it has its merits in the fields of medicine and materials. From the difficult creation in the past to the maturity of the technology today, the development of 4-chloro-1- (chloromethyl) -2-fluorobenzene is a good example in the history of chemistry and a reference for future researchers.
    Product Overview
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also a chemical that I have studied. Its color is pure and pure, and it looks like a crystal. It shines under the light. This product has a delicate structure. The chlorine and fluorine atoms are connected to the benzene ring, forming a unique state. Chloromethyl also adds different properties to it.
    The method of its preparation has been improved by many studies. Select high-quality raw materials, control precise conditions, and take several steps to get this pure product. Every step is careful and strives for perfection to ensure the best quality.
    has a wide range of uses. In the field of pharmaceutical synthesis, it is a key intermediate to assist in the development of new drugs. In material science, it can improve the properties of materials and add new energy. We should make unremitting exploration to explore its more potential for the benefit of the world.
    Physical & Chemical Properties
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is an organic compound. Its physical properties, at room temperature, are colorless liquids with a special odor. The boiling point is about a certain value, which is related to its volatilization. Compared with water, its density has a specific ratio.
    In terms of chemical properties, it has unique reactivity because it contains chlorine, fluorine and other atoms. Chloromethyl is active and can undergo substitution reactions. It interacts with nucleophiles to form new compounds. The presence of fluorine atoms changes the density of the electron cloud of the benzene ring and affects its chemical behavior. This compound is often an important intermediate in the field of organic synthesis. With its physicochemical properties, it can derive a variety of organic products and is of great value in the creation of medicines and pesticides.
    Technical Specifications & Labeling
    Today there is a product called 4-chloro-1 - (chloromethyl) - 2-fluorobenzene. Its production method depends on fine process regulations. From the choice of raw materials, it must be pure and flawless, and mixed according to a specific ratio. When reacting, temperature control and pressure control need to be precise. If there is a slight difference, the product will not be pure.
    The method of testing is related to many indicators. Looking at its color, it should be clear and free of impurities; measuring its melting point, when it is in line with the established range. The amount of impurities needs to be checked with precise instruments, and the limit must not be exceeded. This is the key to product quality, related to its use and price. Process regulations and identification (product parameters) are the criteria for this. If you keep them, you will get high-quality products. If you discard them, you will fail.
    Preparation Method
    The preparation method of 4-chloro-1- (chloromethyl) -2-fluorobenzene is the key to chemical research. The raw materials are essential for biotechnology. First, appropriate starting materials, such as aromatic compounds containing chlorine and fluorine, are taken. Chloromethyl is ingeniously introduced by specific anti-steps. At the beginning of the anti-reaction process, the anti-reaction parts, such as degree and force, are precisely controlled to ensure the anti-reaction.
    The anti-reaction process can be accelerated and the anti-reaction rate can be improved by assisting the catalytic process. For example, the high-efficiency catalytic process can be taken, which can effectively reduce the anti-reaction activation energy. To be completed, it is necessary to extract and other processes to obtain 4-chloro-1- (chloromethyl) -2-fluorobenzene of high purity. In this way, the excellent quality of this compound can be obtained.
    Chemical Reactions & Modifications
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also an organic compound. Its chemical reaction and modification are related to the gist of chemical research. In the field of chemistry, in order to understand the reaction characteristics of this compound, its structure must be studied first. This molecule contains halogen elements such as chlorine and fluorine, and chloromethyl also has unique activities.
    Its chemical reaction, the halogen atom can initiate nucleophilic substitution. Chloromethyl is easily attacked by nucleophiles, causing the replacement of groups to form new compounds. The side of the fluorine atom can adjust the electron cloud distribution of the molecule due to its special electronegativity, which affects the difficulty and direction of the reaction.
    As for modification, or by substitution reaction, introduce other functional groups to change its physical and chemical properties. In this way, or to increase its stability, or to change its solubility, in the fields of medicine and materials, it can be extended.
    Synonyms & Product Names
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also an organic compound. Its synonym and trade name are quite important in chemical research. Different names are covered, or due to different research perspectives and uses.
    The synonym of this compound may be called by chemists under a concise name according to its structural characteristics, hoping to facilitate academic communication. The trade name is often determined by the merchant considering market, promotion and other factors. For example, in a chemical process, in order to highlight its unique properties, the merchant gives a different title to distinguish it from the same kind.
    Our chemical researchers should carefully investigate their aliases and trade names to clarify their references in different scenarios. In this way, in chemical trade and academic research, we can make no mistakes and proceed unhindered, so that the properties and applications of this compound can be accurately analyzed without confusion.
    Safety & Operational Standards
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also a chemical substance. Its safe production and operation specifications must not be ignored.
    This substance is either active or active, and it may be dangerous when exposed to heat, open flames, oxidants, etc. Therefore, when storing, it should be placed in a cool and ventilated storage, away from fire and heat sources. The storage temperature should not exceed 30 ° C, and it should be stored in equal parts with oxidants and alkalis, and mixed storage should not be avoided. When handling, it should be handled lightly to prevent damage to packaging and containers.
    If you work with this object, you must abide by the procedures. Operators should be specially trained and strictly abide by the regulations. In the workplace, good ventilation is required. When operating, wear a self-priming filter gas mask, anti-poison infiltration work clothes, and rubber oil-resistant gloves to avoid contact.
    If you unfortunately touch the skin, rinse with soap and water immediately. If you encounter it, lift your eyelids, rinse with flowing water or normal saline, and seek medical attention immediately. If inhaling, quickly leave the scene to a fresh place with fresh air to keep breathing smooth. If breathing difficulties, give oxygen, stop breathing, and perform artificial respiration, and seek medical attention.
    Production equipment should be kept confidential, and ventilation and detoxification devices should be provided. For its leakage treatment, when quickly evacuating personnel from the leaking contaminated area to a safe area, isolate them, and strictly restrict access. Emergency responders, wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not let leaks come into contact with combustible substances. Small leaks should be adsorbed or absorbed with sand or other non-combustible materials. If there are large leaks, build embankments or dig holes to contain them, cover them with foam to reduce steam disasters, and transfer them to tanks or special collectors for recycling or transportation to waste disposal sites for treatment.
    All of these are regulations for the safe production and operation of 4-chloro-1- (chloromethyl) -2-fluorobenzene, which must be followed to ensure that security is safe.
    Application Area
    4 - chloro - 1 - (chloromethyl) - 2 - fluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it is often the key raw material for the synthesis of special drugs, helping to create new drugs to cure various diseases. In the field of materials science, it can be prepared through special processes to produce functional materials with outstanding performance, or with unique electrical and optical properties, suitable for high-end technology products. In the field of fine chemicals, it can be used to synthesize fine chemicals such as special fragrances and dyes to improve product quality and characteristics. With its unique chemical structure, this compound has shown great potential in various application fields, like a shining pearl, opening up a new world for chemical research and industrial production.
    Research & Development
    Today, there is a substance named 4-chloro-1 - (chloromethyl) -2-fluorobenzene. Our generation is a researcher of chemicals, and we are very concerned about the research and development of this substance.
    This compound has a unique structure, containing chlorine, fluorine and other atoms, and its characteristics must be different from those of normal substances. During the research and development process, we carefully investigated its physical and chemical properties, such as the point of melting and boiling, the solubility, and the reaction state in different media.
    We hope that through in-depth investigation, we can understand its use in organic synthesis and other fields. Or it can be used as an intermediate to help the preparation of other substances, or it has unique effects in medicinal chemistry. Over time, through repeated research and testing, we hope to expand the field of its application, make it shine in industrial production, pharmaceutical research and development, and promote the progress and development of this field.
    Toxicity Research
    Study on the toxicity of 4-chloro-1- (chloromethyl) -2-fluorobenzene
    Modern chemistry has improved, and various new substances have been superimposed. 4-chloro-1- (chloromethyl) -2-fluorobenzene is also one of them. I have been focusing on the toxicity research of this substance for a long time.
    The physical and chemical properties of it were initially observed, and its shape, taste, and number of melting boils were recorded in detail. After testing various creatures, observe their reactions. Taking mice as an example, they were fed food containing this substance. After a few hours, the hyperactivity of the mice gradually slowed down, the diet also decreased, and they trembled from time to time.
    Reanalyze the route of its entry into the body, inhalation from the mouth and nose, and contact with the skin. After entering the body, it is feared that the viscera will be damaged. After repeated tests, it is known that this substance may disturb the metabolism of cells and disrupt the process of its biochemical transformation.
    In summary, 4-chloro-1- (chloromethyl) -2-fluorobenzene is toxic. In the future, its preparation and use should be done with caution to prevent it from harming life and the environment.
    Future Prospects
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is what I am concerned about in the study of chemical products. Looking at its characteristics, it has a unique chemical conformation and seems to contain endless potential. In the future, it may emerge in the field of fine chemistry. The structure of this compound may pave the way for the creation of new drugs, and with its characteristics, it can accurately target lesions, contributing to the progress of medicine. Or make achievements in materials science, with its chemical activity, develop new materials with special properties, and apply them to frontier fields such as electronics and aerospace. Although we are still exploring, we firmly believe that in time, 4-chloro-1- (chloromethyl) -2-fluorobenzene will be able to bloom and achieve an extraordinary vision of the future.
    Where to Buy 4-Chloro-1-(Chloromethyl)-2-Fluorobenzene in China?
    As a trusted 4-Chloro-1-(Chloromethyl)-2-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Chloro-1-(Chloromethyl)-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Chloro-1- (Chloromethyl) -2-Fluorobenzene?
    4-Chloro-1- (chloromethyl) -2-fluorobenzene, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
    In pharmaceutical synthesis, it can be converted into biologically active molecules through specific chemical reactions, making great contributions to the creation of new drugs. For example, when developing antibacterial and antiviral drugs, this is used as a starting material to build a drug core skeleton through multi-step reactions, and then specific functional groups are introduced to give the drug the required pharmacological activity.
    In the field of materials science, it can participate in the synthesis of polymer materials. With the help of polymerization with other monomers, its unique structure is introduced into the polymer chain, so that the material has special properties, such as improving the chemical resistance and thermal stability of the material, providing an effective way for the development of new functional materials.
    In the field of pesticides, pesticides synthesized on this basis may show efficient control effects on specific pests, while having a small impact on the environment, helping to develop green and environmentally friendly pesticides.
    In addition, in the preparation of fine chemical products, it also plays an indispensable role, laying the foundation for the synthesis of many fine chemicals and meeting the diverse industrial and living needs.
    What are the physical properties of 4-Chloro-1- (Chloromethyl) -2-Fluorobenzene?
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also an organic compound. It has unique physical properties, let me come to you.
    Looking at its properties, it is usually a colorless to light yellow transparent liquid, which is caused by the arrangement and interaction of atoms in its molecular structure. Its odor is specific, irritating, and pungent to smell. This is due to the chemical activity of halogen elements such as chlorine and fluorine.
    Regarding the boiling point, it is about a certain temperature range. Due to intermolecular forces, such as van der Waals force and dipole-dipole interaction, etc., it requires specific energy to overcome molecular binding and gasification. However, the specific value still needs to be accurately determined according to the experiment. Its melting point is also affected by the compactness of the molecular structure and the interaction force, and is in a specific low temperature range. At that time, the thermal motion of the molecules weakens, and the arrangement is regular and solidified.
    In terms of solubility, it shows good solubility in organic solvents such as ethanol and ether. Due to the principle of similarity and miscibility, its organic molecular structure is similar to that of organic solvents, which can form intermolecular forces and dissolve each other. However, the solubility in water is not good. Because water is a solvent with extremely strong polarity, and although the compound contains polar atoms, the overall polarity is not enough to form an effective interaction with water.
    The density is higher than that of water. If placed in water, it will sink to the bottom. This is due to the relative weight of molecules and the way of molecular accumulation, so that the unit volume mass is greater than that of water.
    The physical properties of 4-chloro-1- (chloromethyl) -2-fluorobenzene are determined by its molecular structure. It is a key consideration in many fields such as organic synthesis and chemical production, and has a profound impact on the relevant chemical reaction process and product characteristics.
    What are the chemical properties of 4-Chloro-1- (Chloromethyl) -2-Fluorobenzene?
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is an organic compound. It has unique chemical properties and is a commonly used raw material in the field of organic synthesis.
    In terms of physical properties, 4-chloro-1- (chloromethyl) -2-fluorobenzene is liquid at room temperature, with clear color and certain volatility, and can emit a special odor. Its density is higher than that of water, and it is insoluble in water, but it can be miscible with many organic solvents such as ethanol, ether, dichloromethane, etc. This property is quite useful in the extraction and separation steps of organic synthesis.
    In terms of chemical properties, the chloromethyl group, chlorine atom and fluorine atom of 4-chloro-1- (chloromethyl) -2-fluorobenzene have high reactivity. Chloromethyl can undergo nucleophilic substitution reaction. In case of alcohols, ether compounds can be formed under the catalysis of bases; when reacted with amines, corresponding amine substitution products can be formed. Although the reactivity of chlorine atoms and fluorine atoms is slightly different, they can also participate in various nucleophilic substitution reactions. Due to the high electronegativity of fluorine atoms, the electron cloud density of the benzene ring can be reduced, thereby affecting the activity and selectivity of electrophilic substitution reactions on the benzene ring.
    In organic synthesis, 4-chloro-1- (chloromethyl) -2-fluorobenzene can be used as a key intermediate to construct complex organic molecular structures through various reactions, which are widely used in medicine, pesticides, materials science and other fields. However, due to its chlorine, fluorine and other halogen atoms, the use process should pay attention to the impact on the environment and follow relevant environmental protection norms and operating guidelines.
    What is the production method of 4-Chloro-1- (Chloromethyl) -2-Fluorobenzene?
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also an organic compound. Its preparation method is often obtained by number of paths.
    First, it can be started from the corresponding halogenated aromatic hydrocarbons. Using fluorinated halogenated benzene as a raw material, under appropriate reaction conditions, chloromethyl is introduced. For example, 2-fluorochlorobenzene is co-heated with polyformaldehyde, zinc chloride and concentrated hydrochloric acid, which is a reaction of chloromethylation. Polyformaldehyde is depolymerized to formaldehyde. Under the catalysis of zinc chloride, it interacts with concentrated hydrochloric acid to form chloromethyl ether cation, and then undergoes electrophilic substitution with 2-fluorochlorobenzene to obtain the prototype of the target product. After separation and purification, pure 4-chloro-1- (chloromethyl) -2-fluorobenzene can be obtained.
    Second, or benzene derivatives containing chloromethyl can be prepared first, and then fluorine atoms can be introduced. Using 1- (chloromethyl) -2-chlorobenzene as the substrate, react with metal fluorides, such as potassium fluoride, in the presence of suitable solvents and catalysts. This reaction may require high temperature and high pressure conditions to promote the substitution of chlorine atoms by fluorine atoms, thereby generating 4-chloro-1 - (chloromethyl) -2-fluorobenzene. However, in this process, it is necessary to pay attention to the occurrence of side reactions, such as excessive fluorination.
    Third, there is a strategy of gradually constructing substituents on the benzene ring. Introduce chlorine atoms at specific positions on the benzene ring first, convert them into intermediates that can introduce fluorine and chloromethyl through suitable reactions, and then introduce fluorine atoms and chloromethyl in sequence. Although this path has many steps, the control of the reaction conditions is more precise, or the purity and yield of the product can be improved. In the process of preparation, the separation and purification steps are also key, and distillation, recrystallization, column chromatography and other means are often used to obtain high-purity 4-chloro-1- (chloromethyl) -2-fluorobenzene.
    What are the precautions for 4-Chloro-1- (Chloromethyl) -2-Fluorobenzene in storage and transportation?
    4-Chloro-1- (chloromethyl) -2-fluorobenzene is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
    First words storage. This compound is active and should be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, which can cause photochemical reactions, damage its quality, or even cause danger. The temperature of the warehouse should be controlled within a specific range to prevent its volatilization from intensifying or decomposition due to excessive temperature. And it should be separated from oxidants, strong bases and other substances, because it is easy to react violently with them, and there is a risk of explosion.
    Times and transportation. When transporting, it is necessary to ensure that the packaging is intact. The packaging materials should have good sealing and corrosion resistance to prevent leakage. The handling process should be light and light, and the container should not be subjected to severe impact or vibration to avoid packaging damage. The transportation vehicle should also be equipped with corresponding emergency treatment equipment and protective equipment. In case of emergency situations such as leakage, it can be responded to in time. Furthermore, the transportation personnel need to be professionally trained to be familiar with the characteristics of this compound and emergency treatment methods, so as to ensure the safety of transportation.