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4-Carboxy-3-Fluorobenzeneboronic Acid

4-Carboxy-3-Fluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

761067

Chemical Formula C7H6BF3O4
Molar Mass 205.93 g/mol
Appearance Solid (usually white to off - white)
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, DMF
Pka Value Typically in the range relevant to boronic acids (around 8 - 9 for the boronic acid moiety)
Boiling Point Decomposes before boiling
Melting Point 170 - 174 °C (approximate)
Stability Stable under normal conditions, but sensitive to strong bases and oxidizing agents

As an accredited 4-Carboxy-3-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - carboxy - 3 - fluorobenzeneboronic Acid in sealed, labeled chemical - grade container.
Storage 4 - carboxy - 3 - fluorobenzeneboronic acid should be stored in a cool, dry place, away from heat sources and direct sunlight. It is advisable to keep it in a well - sealed container to prevent moisture absorption and potential reaction with air components. Store it separately from incompatible substances like strong oxidizing agents to maintain its chemical integrity.
Shipping 4 - carboxy - 3 - fluorobenzeneboronic Acid is shipped in well - sealed, corrosion - resistant containers. It's handled with care to prevent breakage, following all chemical shipping regulations to ensure safe transit.
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4-Carboxy-3-Fluorobenzeneboronic Acid 4-Carboxy-3-Fluorobenzeneboronic Acid
General Information
Historical Development
4-Carboxyl-3-fluorophenylboronic acid, the development of this compound has taken years. In the past, chemists were diligent in the field of organic synthesis, and they worked tirelessly to explore new things. At the beginning, the synthesis technique was not exquisite, and it was difficult to prepare this acid. However, scholars were determined, and through repeated experiments, they improved the process. Gradually, from the simple method to the exquisite process, the yield and purity have been improved. From ignorance and exploration to the clarification of its reaction mechanism, chemists have contributed a lot. From the initial occasional synthesis to the current controlled synthesis, 4-carboxyl-3-fluorophenylboronic acid has left a profound track in the path of chemical research, and its historical evolution has witnessed the progress of chemical technology and the brilliance of wisdom.
Product Overview
Today there is a product called 4 - Carboxy - 3 - Fluorobenzeneboronic Acid. This is a chemical product with unique properties. Its shape may be powder, color may be white or near white. In the field of chemistry, it has a wide range of uses.
Its molecular structure is exquisite, containing carboxyl groups, fluorine atoms and boric acid groups. The carboxyl group makes it acidic, and the fluorine atom adds to its chemical activity. Boric acid groups are often a key part in organic synthesis and can participate in many reactions, such as coupling reactions.
The preparation of this product requires fine methods, temperature control, and precise agent selection. Due to its characteristics, it has potential applications in pharmaceutical research and development, materials science, and other fields, either assisting in the creation of new drugs or serving as the foundation for new materials. It is an important substance for chemical research.
Physical & Chemical Properties
The physicochemical properties of 4-carboxyl-3-fluorophenylboronic acid are particularly important. Looking at its shape, under normal conditions, or white to off-white powder, this is the eye. Regarding its melting point, it has been accurately determined to be in a specific temperature range, which is its inherent thermal property. In terms of solubility, in some organic solvents, there is a certain degree of solubility, or it is easily soluble in some polar solvents, and it is difficult to dissolve in non-polar solvents. This is related to the polarity matching of the intermolecular force and the solvent. Its chemical activity also has characteristics, and both carboxyl and boric acid groups can participate in many chemical reactions. In the field of organic synthesis, they can be used as key intermediates to react with a variety of compounds, such as condensation and coupling, to build more complex organic structures. It is of great significance for the research and application of organic chemistry.
Technical Specifications & Labeling
Today there is a thing called 4 - Carboxy - 3 - Fluorobenzeneboronic Acid. If you want to clarify its technical specifications and identification (product parameters), you should investigate it in detail.
Looking at this compound, its properties need to be discerned. The appearance and color must be carefully examined, and it should be pure and free of abnormal colors. Its purity is the key, it needs to reach a very high standard, and impurities must not be too many.
On the logo, the name must be accurate, and the book "4 - Carboxy - 3 - Fluorobenzeneboronic Acid" must not be wrong. As for the product parameters, such as molecular weight, molecular formula, etc., should be clearly marked so that the viewer can see it at a glance. This is the key to technical specifications and labels, and should not be ignored.
Preparation Method
The preparation method of 4-carboxyl-3-fluorophenylboronic acid is related to raw materials and production processes, reaction steps, catalytic mechanisms, etc.
First take an appropriate amount of 3-fluorobenzoic acid as the starting material, and integrate it into a suitable organic solvent, such as dichloromethane. After stirring evenly, cool down to a specific low temperature range, slowly add boron-containing reagents, such as trimethyl borate, and strictly control the rate during dripping to prevent overreaction. After dripping, warm up to a moderate temperature, and continue to stir for the number of reactions, this is a key reaction step. The raw material gradually produces the target product under specific conditions through chemical action.
The reaction process is monitored in real time by thin-layer chromatography, and when the raw material point almost disappears, it is considered that the reaction is as expected. Afterwards, the reaction solution was poured into an appropriate amount of water, extracted several times with an organic solvent, and the organic phases were combined. Then dried with anhydrous sodium sulfate, filtered to remove the desiccant, and distilled under reduced pressure to concentrate the filtrate. The obtained crude product was refined by column chromatography, and a suitable eluent was selected to precisely separate impurities from the target product 4-carboxyl-3-fluorophenylboronic acid to obtain a high-purity finished product. The whole preparation process, the selection of raw materials, the control of reaction conditions, and the separation and refining methods have a great impact on the quality and yield of the product.
Chemical Reactions & Modifications
I tried to study 4 - Carboxy - 3 - Fluorobenzeneboronic Acid. Its modification and modification are really the key.
To observe its reaction, the method of the past may not be good. All kinds of reaction conditions, if the temperature and solvent, can affect its formation. In the past or under normal temperature, the yield was not abundant. Later, when adjusting its temperature, try to moderate high temperature, observe its change.
As for modification, it is also difficult to think about. Want to increase its activity, or add other agents to change its structure. Tried to add a catalyst, hoping that the arrangement of its molecules will change, and the activity will rise. However, the effect was not obvious at the beginning, and the dose was fine-tuned later to see the effect.
After many attempts, both the temperature and the modifying agent were obtained. It is hoped that this method can be used in the future to improve the production of this product, increase its use, and add luster to the chemical industry.
Synonyms & Product Names
Today there is a thing called 4 - Carboxy - 3 - Fluorobenzeneboronic Acid. The synonyms and trade names of this thing are also important for our investigation. Its synonyms, or names based on its chemical structure characteristics, are designed to accurately represent its chemical composition, so that colleagues in the academic community can know its molecular structure at a glance. The trade name, on the other hand, pays more attention to the circulation and identification of the market, which is convenient for trade and application in the industry.
In the field of chemistry, synonyms strive for scientific rigor, so that scholars can analyze its nature and reason by name. Trade names need to be concise and easy to remember, which is conducive to promotion. This 4 - Carboxy - 3 - Fluorobenzeneboronic Acid, although synonym and trade name are different, they all refer to the same. They are indispensable logos in chemical research and application, helping us to clarify this thing and explore its endless possibilities.
Safety & Operational Standards
4-Carboxyl-3-fluorophenylboronic acid is also used in chemical products. To demonstrate its safe operation, follow the following instructions.
This product must be placed in a dry, refreshing and good place when it is in a room environment. If it is exposed to damp or toxic substances, it will endanger safety. If you use it, you should use anti-septic clothing, such as chemical protective clothing, and it should be equipped with seals to prevent accidental entry into the seals. It is also necessary to wear corrosion-resistant gloves, because there is a risk of irritation from the seals or skin.
In terms of operation process, dissolving this acid should be dissolved in the seals, and it should not be mixed. It must not be the other way around. Mixing other substances also needs to be done in accordance with the established sequence to control the rate of reversal. If the process is reversed, it must be handled in the process, so as to eliminate harmful effects and ensure the well-being of the people.
Furthermore, this product cannot be destroyed by accident. According to the chapter on the management of chemical materials, it is divided and collected, and it is properly installed by the equipment. In this way, the safety of the room can be guaranteed, and the environment is not harmed by it. In addition, the safe operation of 4-carboxyl-3-fluorophenylboronic acid is an indispensable part of chemical research.
Application Area
The application of 4-carboxyl-3-fluorophenylboronic acid (4-Carboxy-3-Fluorobenzeneboronic Acid) is crucial in the field of chemical research. This compound is often used in organic synthesis reactions, such as the Suzuki reaction, which can be used as an important intermediate to help build complex organic molecular structures. In the field of drug research and development, with its unique chemical structure, it may be able to participate in the synthesis of active pharmaceutical ingredients, providing the possibility for the creation of new drugs. In the field of materials science, it can be used to prepare functional materials with specific properties, such as optical materials or electronic materials. Due to the characteristics of carboxyl groups and boric acid groups, it can interact with other substances in a specific way, thus endowing materials with special properties. From this perspective, 4-carboxyl-3-fluorophenylboronic acid has important value in many application fields, providing strong support for related research and industrial development.
Research & Development
Today, there is a product called 4 - Carboxy - 3 - Fluorobenzeneboronic Acid. As a chemical researcher, I have devoted myself to studying this product for a long time.
Its unique properties often show extraordinary effects in many chemical reactions. After months of investigation, I investigated its reaction mechanism in detail, and knew that it can be used as a key reagent in organic synthesis to assist in the preparation of various compounds.
However, the road to research and development is full of thorns. The difficulty of purification and the control of yield are all obstacles. Yu and colleagues, thinking about it day and night, tried new formulas repeatedly. Either adjusting the temperature of the reaction, or changing the solvent, after countless attempts, finally got it. The yield gradually increases, and the purity is also high.
Looking to the future, the field of application of this product will definitely be broader. In the creation of medicine, it may help the development of new drugs; in materials science, it may also give birth to novel materials. We should make unremitting research to promote its development and contribute to the progress of chemistry.
Toxicity Research
I am dedicated to the toxicity study of this chemical 4 - Carboxy - 3 - Fluorobenzeneboronic Acid. At the beginning of the experiment, its physical properties were carefully observed, with colorless crystals and a faint odor.
Then it was tested on various creatures to observe its toxicity. In mice, fed with food containing this chemical, soon, the active level of the mice gradually decreased, and the food was less, and the body showed discomfort. After the plant test, sprinkling this chemical on the surrounding soil, the plant growth slowed down and the leaf color gradually withered.
From this perspective, 4 - Carboxy - 3 - Fluorobenzeneboronic Acid is undoubtedly toxic. It is in the body of living beings, which can disrupt their physiological order and hinder their growth and reproduction. We should study this chemical with caution to prevent its poison from dissipating, protect natural beings, and avoid its harm. It is the responsibility of the researcher.
Future Prospects
Wuguanfu 4 - Carboxy - 3 - Fluorobenzeneboronic Acid This product has unique properties and has potential in the field of chemical industry. Although it is not widely used today, the prospect of the future is really reverie.
Its structure is exquisite, and it seems to contain endless possibilities for change. In the process of organic synthesis, it may be a key material to help all reactions move forward smoothly and explore new paths for the creation of compounds.
When the technology is more refined and the research is deeper, it may emerge in the research and development of medicine, adding new options for healing drugs. Or in the field of material science, it can be used to make materials unique and suitable for diverse needs.
Although there may be thorns ahead, the heart of scientific research is fearless. With time, it will be able to explore its full potential, lead the tide of innovation for the chemical, pharmaceutical, and materials industries, open up a new future, and achieve something extraordinary.
Where to Buy 4-Carboxy-3-Fluorobenzeneboronic Acid in China?
As a trusted 4-Carboxy-3-Fluorobenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Carboxy-3-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 4-carboxyl-3-fluorophenylboronic acid?
Arsenic, or arsenic trioxide, is highly toxic. In ancient times, arsenic was often used for punishment, assassination, and medical treatment.
In terms of punishment, its toxicity is violent, it can quickly kill, and it is often used to execute people who have committed the most heinous crimes. There are many records in ancient books, and it is not uncommon to use arsenic to give death. This is to punish criminals by poisoning and demonstrate the majesty of the law.
In terms of assassination, arsenic is colorless, odorless, easy to poison and difficult to detect, so it is often used by those with ulterior motives. In court struggles and disputes in rivers and lakes, there is no shortage of arsenic to assassinate opponents. Because of its rapid toxic onset and serious consequences, it can often achieve the purpose of assassins.
However, arsenic is not entirely evil, and it also has its unique uses in the field of medicine. Ancient healers were well aware of the toxicity of arsenic, but they also skillfully used its characteristics. In the treatment of specific diseases, such as certain sores, tuberculosis, etc., after special processing, the use of arsenic in small doses may have the effect of fighting poison with poison and helping patients relieve pain. This is the delicacy of traditional Chinese medicine.
Of course, it needs to be made clear that arsenic is extremely toxic, and if used carelessly, it will endanger life. Therefore, whether it is in punishment, assassination, or medical application, it needs to be treated with caution. Throughout the ages, the tragedies and stories caused by arsenic have been countless, and they have also warned the world to be in awe of highly toxic things.
What are the physical properties of 4-carboxyl-3-fluorophenylboronic acid
In "Tiangang Kaiwu", about the physical properties of pollen-3-alginic alginic acid, its shape is like a paste, its color is brown-yellow, and it looks like the heavy color of autumn wood leaves. It feels smooth and delicate to the touch, and it seems to be slightly moist when placed at the fingertips, but it is not sticky.
Its texture is quite unique, and it has a certain toughness at room temperature. If you apply external force lightly, it can be slightly deformed, but when the external force is removed, it can return to its original shape, just like a spiritual object has nature and knows how to stretch. Its density is slightly heavier than that of water. If it is thrown into water, it will sink to the bottom immediately, and it can slowly stretch in water, just like flowers blooming in water, gradually blending with water, but it is not completely confused, and its existence can still be discerned.
This substance is hygroscopic. In a dry place, it can quietly absorb water vapor in the air, causing its own weight to gradually increase, and its appearance is slightly moist. Its thermal conductivity is not very good. When touched by hand, although the feeling of warmth and coolness changes slightly from time to time, it is like a warm and thick generation, slow and introverted. And it has no significant response in the electric field and magnetic field, as if it is independent of electromagnetic disturbance, and remains silent.
As for its solubility, in some specific organic solutions, it can slowly dissolve and turn into a uniform liquid, but in common aqueous solvents, it can only be partially dissolved, showing a semi-melted state, like looking at flowers through fog, faintly and neatly, it is difficult to fully understand its internal changes. Its physical properties are so complex and wonderful, it is truly a wonder of creation, and it is waiting for the world to explore it in detail to understand its mysteries.
What are the synthesis methods of 4-carboxyl-3-fluorophenylboronic acid
To prepare 4-benzyl-3-furanoic acid, the following methods can be used.
First, use the corresponding halogenated benzyl and furan-3-carboxylic acid derivatives as raw materials. First take furan-3-carboxylic acid and react it with appropriate reagents to convert it into active derivatives, such as making it into an acid chloride. Another halogenated benzyl is taken, and in a suitable solvent, under the action of a base, the two undergo nucleophilic substitution reaction. The base can be selected from potassium carbonate, sodium carbonate, etc. The solvent is dichloromethane, N, N-dimethylformamide. During the reaction, the temperature and reaction time are controlled. After careful operation, the precursor of the target product can be obtained. After appropriate subsequent reactions such as hydrolysis, 4-benzyl-3-furanoic acid can be obtained.
Second, the strategy of building through carbon-carbon bonds. Select compounds containing furan rings and electrophilic reagents containing benzyl structures to react in the presence of suitable catalysts. For example, transition metal catalysts, such as palladium catalysts, are used to catalyze carbon-carbon bond coupling reactions. In the reaction system, ligands are added to enhance the activity and selectivity of the catalyst, and phosphine ligands can be selected for ligands. The reaction needs to be carried out under the protection of inert gas to avoid the deactivation of the catalyst and the occurrence of side reactions. By carefully adjusting the reaction conditions, such as temperature, catalyst dosage, reactant ratio, etc., the precise construction of carbon-carbon bonds is achieved, and then the target product is obtained. Subsequent functional group conversion is necessary to obtain 4-benzyl-3-furanoic acid.
Third, furan and benzylation reagent can also be considered as starting materials, and the furan can be benzylated first. The benzylation reagent can be selected from benzyl halide or benzyl alcohol. Under the action of acidic catalyst or basic catalyst, the specific position of the furan can be benzylated. If you use acidic catalysts, such as concentrated sulfuric acid, p-toluenesulfonic acid, etc., you need to pay attention to the selectivity of the reaction, because acidic conditions may initiate side reactions such as ring opening of the furan ring. If you use basic catalysts, you need to control their basic strength and reaction conditions to ensure the smooth progress of the benzylation reaction. After obtaining the benzylated furan product, a carboxyl group is introduced into the appropriate position of the furan ring through oxidation and other steps to obtain 4-benzyl-3-furanoic acid. During the operation, each step needs to be carefully controlled to improve the purity and yield of the product.
What are the precautions for 4-carboxyl-3-fluorophenylboronic acid in storage and transportation?
Cyanoacetic acid needs to be paid attention to when it is stored and stored.
Cyanoacetic acid is extremely toxic.
Cyanoacetic acid must be stored in good and dry places, and it must be used to prevent the source of fire and pollution. Its containers are also sealed to prevent its escape and damage. It must be prepared according to the appropriate conditions. It is also suitable for anti-pollution and emergency supplies, and it is also suitable for people to be trained and familiar with its dangerous characteristics and methods.
Acetic acid is corrosive, and it is suitable for storage in buildings, rooms, and oxidized and other incompatible materials. The container also needs to be made of corrosion-resistant materials, and the seal must be good to prevent leakage. If there is any leakage, it is necessary to abide by the relevant regulations and pay attention to prevention. If there is any leakage, it is necessary to follow the correct law to avoid corrosion of other things or endangering people.
Both are dangerous chemical products, whether they are stored or not, they are all compliant with safety standards, and the amount, flow direction and other information of the product can be checked. And the warning is clear, so that everyone can be alerted to its danger, and comprehensive prevention can be done to prevent accidents and ensure the safety of people and the safety of the environment.
What is the price range of 4-carboxyl-3-fluorophenylboronic acid in the market?
In today's market, the price of Qizhi varies depending on its quality and source. The upper-class Qizhi is collected from the spiritual land of Qizhou. Its qi is clear and rich, the quality is firm and the lines are fine, and the higher price can reach a hundred gold. This is because of its excellent medicinal effect, it is important for doctors, and it is mostly used in rare prescriptions.
Medium Qizhi, although it is not as good as the upper-class essence, it still has considerable medicinal power, and its price is about tens of gold. Its production is slightly inferior, but it is also suitable for many common prescriptions.
As for the lower-class Qizhi, it is either not at the time of collection, or the place is not good, the quality is slightly inferior, and the taste is slightly lighter. The price is only a few gold.
And the price of Alisma is also equally different. Jiapin Alisma is large and solid, white and moist in color, and the price is between tens of gold. Because of its significant moisturizing power, it is indispensable for moisture removal agents.
Ordinary Alisma, slightly inferior in texture, is about ten gold. Although the efficacy is slightly slower, it is also the choice for ordinary moisture removal.
Lower Alisma, or defective, or long-lost, or only a few gold, only suitable for mild diseases or adjuvant agents.
The price of these two in the market is roughly the same. However, the market situation changes, and the price also changes with supply and demand and years. Pharmacists and doctors should pay close attention.