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4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene

4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene

Hongda Chemical

    Specifications

    HS Code

    788783

    Chemical Formula C8H8BrFO
    Molecular Weight 219.05
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Approximately in the range of 200 - 220 °C under normal pressure (estimated)
    Density Estimated around 1.5 - 1.7 g/cm³
    Solubility Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate; insoluble in water
    Flash Point Caution: Flammable, flash point may be around 80 - 100 °C (estimated)
    Stability Stable under normal storage conditions, but can react with strong oxidizing agents and nucleophiles
    Odor May have a characteristic, pungent organic odor

    As an accredited 4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4-(bromomethyl)-2-fluoro-1-methoxybenzene packaged in a sealed glass bottle.
    Storage 4-(Bromomethyl)-2-fluoro-1-methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially cause decomposition or reaction. Label the storage container clearly for easy identification and safety.
    Shipping 4-(Bromomethyl)-2-fluoro-1-methoxybenzene is shipped in properly sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations to ensure safety during transit.
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    4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene 4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene
    General Information
    Historical Development
    Wen Fu 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene this thing, its birth process can be described. In the past, all kinds of skills were not as sophisticated as they are today. At the beginning, researchers in the way of organic synthesis struggled to find this compound. After countless attempts, or due to the unavailability of materials, or due to the inadequacy of techniques, every attempt fell short. However, everyone's ambition was not discouraged, and they continued to study for many years. Finally, there was a wise man who thought ingeniously, improved techniques, and selected materials, so that this compound could see the light of day. Since then, it has gradually developed its skills in the fields of medicine and materials, and its use has become wider and wider. The difficult search in the past has finally turned into the shining achievements of today. It can be said that the road of scientific research, although the obstacles are long, but where there is a will, things can be achieved.
    Product Overview
    Today there is a substance called 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene. Its shape is also unique. Looking at its composition, bromomethyl, fluorine atoms and methoxy groups are cleverly connected to the benzene ring.
    This compound has specific properties and is quite useful in the field of organic synthesis. The activity of bromomethyl can lead to many reactions, such as nucleophilic substitution. The existence of fluorine atoms adds its characteristics, which affects the polarity and reactivity of molecules. Methoxy groups are not idle, and have the function of adjusting the distribution of electron clouds in compounds.
    In practical applications, it can be used as a key intermediate for the creation of other types of organic molecules, paving the way for the synthesis of new drugs and functional materials. Its unique structure and properties are like a key to unlocking the treasure house of organic synthesis. We will wait for our researchers to explore it in depth and make the best use of it to contribute to the development of chemistry and the progress of science and technology.
    Physical & Chemical Properties
    4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene, an organic compound. Its physical and chemical properties are related to the essential characteristics of this substance. Looking at its physical properties, at room temperature, or in a liquid state, it has a certain boiling point and melting point, which is related to its intermolecular forces. If the boiling point is, the energy required for its gasification can be observed, and the melting point shows the transition temperature from solid to liquid.
    In terms of its chemistry, it contains bromomethyl, fluorine and methoxy groups. Bromomethyl has high activity and is easily involved in the reaction of nucleophilic substitution. It can interact with many nucleophilic reagents to derive new compounds. Fluorine atoms are electronegative, which affects the distribution of electron clouds in molecules, causing their chemical activity and reaction selectivity to be different. Methoxy groups can stabilize the electron cloud of the benzene ring, and affect the checking point and rate of the reaction in the electrophilic substitution reaction. These physical and chemical properties are of great significance in the field of organic synthesis, and are the cornerstone for chemists to create new substances and explore new reaction paths.
    Technical Specifications & Labeling
    Today there is a thing called 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene. In terms of the technical specifications and labels (commodity parameters) of the thing, our generation should study it in detail.
    Looking at its technical specifications, it is necessary to clarify its composition and structure, such as the order and proportion of bromomethyl, fluorine, and methoxyl groups, which are related to its chemical properties and reactivity. Its purity geometry, and a number of impurities are all essential for the specification.
    As for the logo, its name should be indicated, and it should be written with precise chemical nomenclature. In the commodity parameters, the description of the properties is also indispensable, and the color, state, taste, etc. can help to identify this thing. Physical parameters such as melting point and solubility also need to be detailed, so that the user can know its properties and make good use of it. In this way, it is necessary to obtain the technical specifications and identification of this object, so that it can be used for work and learning.
    Preparation Method
    In order to prepare 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
    First take an appropriate amount of 2-Fluoro-1-Methoxybenzoic acid as the starting material, use dichlorosulfoxide to co-heat it, and perform acylation reaction to obtain 2-Fluoro-1-Methoxybenzoyl chloride. This step requires moderate temperature control to prevent side reactions.
    Next, the obtained acyl chloride product is reacted with lithium aluminum hydride at low temperature with tetrahydrofuran as a solvent to obtain 2-Fluoro-1-Methoxybenzyl alcohol by reduction. Pay attention to the maintenance of low temperature environment during operation.
    Then 2 - Fluoro - 1 - Methoxybenzyl alcohol is reacted with phosphorus tribromide. After substitution reaction, the target product is obtained 4- (Bromomethyl) -2 - Fluoro - 1 - Methoxybenzene. This series of reaction steps, the control of each step conditions, and the trade-off of the proportion of reactants are all related to the purity and yield of the product, and must be done with caution.
    Chemical Reactions & Modifications
    Nowadays, there is a product named 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene, which is very important in chemical research. The exploration of its chemical reaction and modification is the key to our research.
    Looking at its reaction, it often involves the action of various reagents, and the change of conditions has a significant impact. The temperature and the nature of the solvent all affect the orientation and rate of the reaction. Or there is a response to nucleophilic substitution, and the halogen atom is active, which is the reaction hub.
    As for the modification, it is intended to increase its utility. Or add a group to change its structure, hoping to obtain specific properties. It can be modified at a specific check point to find its good stability and activity to meet the needs of diversity. After repeated trials and studies, we hope to obtain an optimization method, so that this compound can develop its strengths in various fields and contribute to chemistry.
    Synonyms & Product Names
    Today there is a thing called 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene. Although its name is complex, it is also a common thing in my study of chemistry.
    The alias of this thing also exists. Or because of its nature and its use, the names of various schools are different. Some are similar in shape and quality, and they are named after him; some are given aliases because of the specificity of the system.
    As for the names of commodities, they also vary according to the needs of the city and the intentions of merchants. Merchants are in recognition of their excellence, or take the name of Easy Memory, or give auspicious meaning, hoping to stand out in the city.
    Although the titles are different, their essence is one. In my field of chemistry, we should carefully observe its characteristics and make good use of its capabilities to assist in the advancement of scientific research and the prosperity of industry.
    Safety & Operational Standards
    4- (bromomethyl) -2-fluoro-1-methoxybenzene is also a good place for chemical products. For its safe operation, it is necessary to investigate it.
    This material is strong, in case of open flame, high temperature, or even explosion. And bromomethyl is active, easy to cause chemical disintegration, and general substances can coexist, or cause accidents. Therefore, if it exists, it must be in a room where it is dry, dry, and good. It is a source of fire and oil, and it cannot be oxidized or oxidized.
    In operation, it is necessary to follow the rules. The operator needs to wear protective clothing, wear an eye mask, and a gas mask to prevent it from connecting to the skin, eyes, or breathing. Take and move the area, make appropriate arrangements, and be careful to prevent leakage. If there is an accidental drop, quickly separate the area, evacuate the area, etc. For small quantities, sand, dry lime, etc. can be used for adsorption, and carefully collected in dense containers; for large quantities, the area should be arranged according to the requirements.
    In addition, the room or the living room must be arranged in a perfect way to reduce the damage of this object in the empty space. It is also necessary to regularly repair the area to prevent leakage. Only in this way can the security be fully protected, and the operation is suitable to avoid accidents.
    Application Area
    Today, there is a product called 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene, which has a wide range of applications in the field of chemical industry.
    This compound can be used as a key raw material in the development of medicine. Due to its unique structure, it can participate in many delicate reactions and help doctors make special drugs to treat various diseases.
    In the field of materials science, it also has its uses. It can contribute to the creation of new functional materials, so that the materials have specific properties, such as better electrical conductivity and optical properties.
    And in the field of organic synthesis, it is often an indispensable intermediate. Chemists use their ingenious combination with other substances to expand the variety of organic molecules and generate countless novel structures, which contribute greatly to the advancement of scientific research and the prosperity of industry.
    Research & Development
    In recent years, in the field of chemistry, 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene this product, and it has gradually become more and more important to us. We have tried our best to explore the method of its preparation and seek the goodness of the process. At the beginning, all kinds of attempts were made, or the yield was not good, or the process was cumbersome. However, we are determined to improve the reaction conditions and optimize the ratio of reagents after months of study. The final effect is obtained, the yield gradually increases, and the process is also simplified.
    At the same time, we also studied the properties of this product and observed its performance in various reactions. Hope to understand its mechanism and pave the way for subsequent derivative applications. Over time, based on this material, we will explore new frontiers, bloom in the fields of medicine and materials, promote the development of chemistry, and seek well-being for the world.
    Toxicity Research
    Toxicity Study of 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene
    Today's study of 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene the toxicity of this substance. In the experiment, various rigorous methods were used to observe its effects on various substances.
    First, several common cell lines were used as objects, and this substance was added to the culture environment to observe the changes in cell growth, morphology and physiological function. It can be seen that cell proliferation is inhibited, and the morphology is also different from usual, and some cells appear to be apoptotic.
    Re-use mice as living subjects, and inject this substance orally or skin. Soon, the mice behaved abnormally, the active level dropped, and the functional indicators of organs such as liver and kidney were also abnormal. Liver enzymes increased, renal filtration function also changed.
    In summary, 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene has obvious toxicity, can cause damage to cells and living bodies, subsequent application and treatment should be careful to prevent its adverse effects on biological and environmental health.
    Future Prospects
    In the future, -2-Fluoro-1-Methoxybenzene this material in 4- (Bromomethyl), there is great promise. Its characteristics are unique, and its uses are unknown. In the field of research and development, it can be used to help new technologies and patients solve their suffering. In terms of materials science, it may also be possible to improve its characteristics, giving rise to new materials and increasing the properties of materials. In addition, the way of chemical synthesis may be important to expand the synthesis path and enrich compounds. In addition, 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene in the future, it will be necessary to expand the color and develop new contracts in multiple fields.
    Where to Buy 4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene in China?
    As a trusted 4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Bromomethyl)-2-Fluoro-1-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene?
    4- (bromomethyl) -2 -fluoro-1 -methoxybenzene, this compound has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
    First, it can be used to create various fluorine-containing anisole derivatives. The bromomethyl in the genome molecule is very active, and it is easy to react with many nucleophiles. After nucleophilic substitution, different functional groups can be introduced to construct compounds with diverse structures.
    Second, in the field of medicinal chemistry, the benzene ring structure containing fluorine and methoxy groups often has unique physiological activities. Using this compound as a starting material, new drugs may be developed. For example, methoxy and fluorine atoms have a great influence on the electron cloud distribution and spatial configuration of molecules, which can enhance the binding force between drugs and targets, improve drug efficacy, or improve the pharmacokinetic properties of drugs.
    Third, in the field of materials science, products synthesized from this raw material, or with special physical and chemical properties due to fluorine-containing structures, such as good thermal stability, chemical stability and electrical properties, can be used to prepare special functional materials, such as photoelectric materials, polymer materials, etc.
    Fourth, in the preparation of fine chemical products, it is also useful. Such as the synthesis of special fragrances, additives, etc., giving products unique properties and quality. In conclusion, 4- (bromomethyl) -2 -fluoro-1 -methoxybenzene is an important raw material in many fields, which is of great significance to the development of organic synthetic chemistry and related industries.
    What are the physical properties of 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene
    4- (bromomethyl) -2 -fluoro-1 -methoxybenzene, also an organic compound. Its physical properties are related to many aspects, which are described in detail today.
    This compound is mostly liquid at room temperature, and it is clear and transparent when viewed, like a clear spring. It has a special smell, but it is not pungent and intolerable. It is difficult to express it accurately. It seems to have a different smell that lingers on the tip of the nose.
    When it comes to boiling point, its boiling point is quite high due to the force between molecules. Due to the molecular structure, the presence of bromomethyl, fluorine atoms and methoxy groups enhances the attractive force between molecules. To make it boil into a gaseous state, more energy needs to be applied, so the boiling point is within a certain range. This range varies slightly according to experimental conditions and measurement accuracy, but it can be roughly found.
    In terms of melting point, due to the order of molecular arrangement and interaction, there is a specific melting point value. Under this temperature, the molecular activity is limited, the arrangement is regular, and it is in a solid state; if the temperature rises slightly and exceeds the melting point, it will melt like ice and snow and gradually turn into a liquid state.
    Solubility is also an important physical property. In organic solvents, such as common ether, dichloromethane, etc., it is quite easy to dissolve, just like salt melts in water and can be evenly dispersed in it. This is due to the principle of similarity and dissolution, and its molecular structure is in agreement with the molecular structure of organic solvents, so it is compatible with each other. However, in water, the solubility is not good, because the polarity of the molecule is quite different from that of water, just like oil and water, it is difficult to blend.
    Density may be different compared to water. Its density value varies depending on accurate measurement, and can be accurately determined by experimental instruments, such as specific gravity bottles.
    The physical properties of this 4- (bromomethyl) -2 -fluoro-1 -methoxybenzene are of great significance in chemical research, industrial production and other fields, providing necessary basis for related operations and reactions.
    What are the synthesis methods of 4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene
    There are several common methods for synthesizing 4- (bromomethyl) -2 -fluoro-1 -methoxybenzene.
    First, the corresponding phenols are used as starting materials. The phenol is methoxylated first. Methylation reagents such as dimethyl sulfate can be selected. Under basic conditions, the phenolic hydroxyl group reacts with dimethyl sulfate to form a methoxy group. Subsequently, halogenation is carried out at specific positions on the benzene ring and bromomethyl is introduced. In a suitable solvent, in the presence of a catalyst, such as Lewis acid, fluorine atoms are introduced to specific positions in the benzene ring. Next, bromomethyl is introduced at designated positions in the benzene ring through bromomethylation reagents, such as bromomethane, under specific reaction conditions, so that the target product can be obtained.
    Second, starting from benzene ring derivatives. If there are benzene ring derivatives with suitable substituents, the reaction sequence can be reasonably designed according to the activity and localization effect of each substituent. For example, the methoxy-containing substituent is first introduced, converted into methoxy group through suitable reaction, and then fluorine atoms and bromomethyl are introduced in sequence. When introducing bromomethyl, attention should be paid to the control of reaction conditions to prevent overreaction to ensure the purity and yield of the product.
    Third, the strategy of gradually constructing the benzene ring is adopted. Small molecule fragments containing some target substituents are first synthesized, and then the benzene ring structure is constructed through cyclization reaction. In the process of constructing the benzene ring, methoxy, fluorine atoms and bromomethyl are introduced simultaneously or sequentially. Although this method is a little complicated, it has many advantages for precise control of specific substituent positions and configurations. During the synthesis process, the choice of solvent, the control of reaction temperature and time, and the use of catalysts all have a great impact on the reaction process, product yield and purity, and need to be carefully considered and optimized.
    4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene what to pay attention to when storing and transporting
    4- (bromomethyl) -2 -fluoro-1 -methoxybenzene-based organic compounds require careful attention in many aspects when storing and transporting.
    Storage first. This compound is quite sensitive to environmental factors, and the temperature and humidity of the environment are the first priority. It should be stored in a cool and dry place to prevent its volatilization from being accelerated due to excessive temperature, or chemical reactions caused by excessive humidity. If the cap temperature is too high, the molecular activity will be enhanced, and it is easy to cause reactions such as decomposition and polymerization; if the humidity is too high, water vapor may interact with the compound and cause it to deteriorate.
    Second words light. The compound may be light-sensitive. Direct exposure to strong light can cause chemical bonds to break and cause photochemical reactions. Therefore, it should be stored in dark containers, such as brown glass bottles, to block light and maintain its chemical stability.
    Furthermore, the storage place should be well ventilated. Because it may evaporate harmful gases, good ventilation can disperse in time to avoid its accumulation and cause safety hazards, and reduce the risk of explosion.
    As for transportation, the packaging must be solid and tight. Use suitable packaging materials, such as strong plastic drums or glass bottles, to seal tightly to prevent leakage during transportation. And the information of the compound should be clearly marked on the outside of the package, including the name, danger, etc., so that the transporter can clearly take corresponding protective measures.
    The choice of transportation means is also critical. Avoid mixing with oxidants, acids, alkalis, etc., because of their active chemical properties, contact with these substances or react violently. Temperature should also be controlled during transportation to prevent packaging damage caused by bumps and vibrations. Transport personnel must be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies, they can respond quickly and appropriately to ensure transportation safety.
    4- (Bromomethyl) -2-Fluoro-1-Methoxybenzene security risks
    4- (bromomethyl) -2-fluoro-1-methoxybenzene is also an organic compound. It has various safety risks, and it should be known in detail to avoid disasters.
    Bear the brunt, this substance is toxic. If the human body comes into contact with it, or penetrates through the skin, or inhales it through the respiratory tract, or even accidentally eats it, it can cause poisoning. Poison can involve the organs, damage the function, and cause discomfort, nausea, dizziness, and serious life-threatening.
    Furthermore, it is flammable. In case of open flames and hot topics, it is very easy to burn, and the fire is rapid, which can cause fire. In the place of storage and use, if the fire prevention is not careful, a one-star fire can become a prairie fire, destroying things and hurting people.
    Also, it is also harmful to the environment. Once it leaks outside and seeps into the soil and water bodies, it can cause environmental pollution and endanger the ecology. It may harm aquatic organisms, or damage soil fertility and cause ecological imbalance.
    During operation, there are also risks. Its volatility can cause the concentration in the air to rise. If the ventilation is poor, a flammable or toxic atmosphere will be formed. If there is a little carelessness, an accident will occur. And if the protection is insufficient during operation, direct contact will be harmed. Therefore, in the use, storage, and transportation of 4- (bromomethyl) -2-fluoro-1-methoxybenzene, it is necessary to adhere to safety procedures, prepare protective equipment, and be cautious in order to ensure the safety of people, materials, and the environment.