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4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene

4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene

Hongda Chemical

    Specifications

    HS Code

    123694

    Chemical Formula C8H8BrFO
    Molecular Weight 221.05
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Data may vary, needs experimental determination
    Melting Point Data may vary, needs experimental determination
    Density Data may vary, needs experimental determination
    Solubility In Water Low solubility, likely insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Flash Point Data may vary, needs experimental determination
    Vapor Pressure Data may vary, needs experimental determination
    Stability Stable under normal conditions, but may react with strong oxidizing agents

    As an accredited 4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4-(bromomethyl)-1-fluoro-2-methoxybenzene packaged in a sealed glass bottle.
    Storage 4-(Bromomethyl)-1 -fluoro-2-methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage. Due to its reactivity and potential hazards, store it separately from oxidizing agents, bases, and incompatible substances. This helps maintain its stability and safety during storage.
    Shipping Ship 4-(bromomethyl)-1-fluoro-2-methoxybenzene in well - sealed, corrosion - resistant containers. Label clearly as a chemical. Ensure compliance with hazardous shipping regulations for safe transportation.
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    4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene 4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene
    General Information
    Historical Development
    Fu 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene is also an organic compound. Its research and development process is really related to the evolution of chemistry. In the past, chemists studied the principle of material change, hoping to obtain new products to meet all needs.
    At the beginning, exploring and synthesizing this compound, chemists worked hard and tried all kinds of things, but they were frustrated. However, they were not discouraged, because they knew that this compound may have great uses in the fields of medicine and materials. After long-term research, the method of improving the synthesis has gradually become more refined from the initial simplicity.
    With the passage of time, the technology has advanced, and the efficiency and purity of synthesizing this compound have increased. Chemists have made unremitting efforts to make the preparation of 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene mature, paving the way for future related research and application, which is an important symbol in the development of chemistry.
    Product Overview
    4- (bromomethyl) -1-fluoro-2-methoxybenzene is also an organic compound. Its shape may be colorless to pale yellow liquid, with a special odor. In the structure of this compound, bromomethyl, fluorine atoms and methoxy groups are arranged at specific positions in the benzene ring, giving it unique chemical properties.
    In the field of organic synthesis, 4- (bromomethyl) -1-fluoro-2-methoxybenzene has a wide range of uses. Because of its active reactivity, bromomethyl can introduce various functional groups through nucleophilic substitution reactions to synthesize complex organic molecules. And the existence of fluorine atoms can significantly change the physical and chemical properties of compounds, such as improving their stability and biological activity. Methoxy groups affect the electron cloud distribution of molecules and indirectly affect their reactivity and selectivity. All these characteristics make 4- (bromomethyl) -1-fluoro-2-methoxybenzene an important raw material in organic synthesis chemistry.
    Physical & Chemical Properties
    4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene is an organic compound. Its physical properties are mostly liquid at room temperature, with a special odor. Looking at its color, it is colorless and transparent, or slightly yellowish. Its boiling point and melting point are specific, and the boiling point is about a certain temperature range, which is determined by intermolecular forces and structures. The melting point is also characteristic, reflecting the molecular lattice arrangement characteristics.
    When it comes to chemical properties, bromomethyl in this compound is active and easy to participate in nucleophilic substitution reactions. Due to the difference in electronegativity of bromine atoms, the polarity of carbon-bromine bonds is strong, and it is easy to attack as nucleophilic reagents. Fluorine atoms affect the distribution of molecular electron clouds, change the density of benzene ring electron clouds, and affect their electrophilic substitution activities. Methoxy power suppliers also affect the reactivity of benzene rings. Overall, the physical and chemical properties of 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene are unique and have important application value in the field of organic synthesis.
    Technical Specifications & Labeling
    Today there is a thing named 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene. In the process of making this thing, the technical specifications and identification (product parameters) should be followed. Looking at the process, it is necessary to carefully observe the quality and quantity of raw materials, and control the temperature, time and pressure of the reaction. The reaction device should be clean and suitable to ensure a smooth reaction.
    Test its quality, according to the standard of the label (product parameters), measure its purity, the amount of impurities, the degree of melting and boiling, etc. The purity must be high, the impurities must be slight, and the degree of melting and boiling should be in line with the standard number. In this way, the quality of 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene can be obtained, and the technical specifications and identification (product parameters) can be used for all purposes.
    Preparation Method
    To prepare 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene this product, the raw materials and production process are very critical. First, take an appropriate amount of 1-Fluoro-2-Methoxybenzene as the starting material, add an appropriate amount of brominating reagents in a specific reaction vessel, such as N-bromosuccinimide (NBS), and use benzoyl peroxide (BPO) as the initiator. The reaction needs to be stirred continuously at a suitable temperature, such as 60 to 80 degrees Celsius. This is the free radical substitution reaction mechanism. After several reactions, when the system is fully reacted, cool down, extract the product with an organic solvent, and then separate and purify it by column chromatography, remove impurities, and finally obtain a pure 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene product. The whole process requires high control of reaction conditions, proportion of raw materials, and finesse of each step to ensure product quality and yield.
    Chemical Reactions & Modifications
    4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene is a key raw material for organic synthesis, which is crucial for its chemical reaction and modification. The reaction of this compound often involves nucleophilic substitution. Because it contains active bromomethyl, it is easy to attack by nucleophilic reagents, and then a variety of derivatives are derived.
    In order to improve its performance, it can be started from multiple ends. First, optimize the reaction conditions, such as precise regulation of temperature, pressure and solvent, which can increase the reaction efficiency and selectivity. Second, the selection of specific catalysts may accelerate the reaction process and reduce the reaction barrier. Third, the modification of molecular structure can change its physical and chemical properties, such as solubility and stability, by introducing specific functional groups.
    With optimized reaction and modification, 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene will be more widely used in the field of organic synthesis, providing a solid foundation for the development of new materials and drugs.
    Synonyms & Product Names
    Today there is a thing called 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene. This thing has many aliases and commodity names in the field of my chemical research.
    Its aliases are all based on its chemical properties and structure. Looking at its structure, it contains bromomethyl, fluorine, methoxy and other groups, so it will also appear in the alias. As for the trade name, it is the name of the merchant for its entry into the market, or its characteristics, or easy to remember, to attract attention.
    Although the names are different, the essence of the thing remains unchanged. In the study of chemistry, it is still important to know the same name of this thing. Under different names, all refer to this specific chemical substance, which can help us communicate accurately and explore its properties in depth, and is beneficial in the process of synthesis and application.
    Safety & Operational Standards
    4- (bromomethyl) -1-fluoro-2-methoxybenzene
    Fu4- (bromomethyl) -1-fluoro-2-methoxybenzene is a common substance in chemical research. During experimental operation, safety is the top priority and must not be taken lightly.
    Handle this substance when in a well-ventilated experimental site. It may be volatile and may easily cause the accumulation of harmful gases in a closed space, endangering the health of the experimenter. Ventilation equipment can effectively disperse harmful gases and ensure the safety of the experimental environment.
    Experimenters should also wear appropriate protective equipment. It is advisable to wear laboratory clothes to protect the body from splashing damage; wear protective gloves, the material must be able to resist the erosion of this substance and prevent the skin from contacting it. Eye protection is indispensable, protective glasses or masks can prevent it from splashing into the eye and causing eye damage.
    When taking 4- (bromomethyl) -1-fluoro-2-methoxybenzene, the action should be stable and accurate. When using finished utensils, be sure to wash them in time to prevent residual substances from affecting the follow-up experiments. If it is accidentally spilled, take proper cleaning measures quickly. Evacuate unrelated personnel first, and then clean them with suitable adsorption materials according to the characteristics of the substance. After collection, dispose of them properly. Do not discard them at will.
    There are also regulations for storing this substance. It should be placed in a cool, dry place, away from sources of ignition and oxidants. Due to its chemical activity, improper storage or danger. It needs to be contained in a suitable container. The container material should be compatible with the substance and well sealed to prevent it from evaporating or reacting with external substances.
    In short, in the research and operation of 4- (bromomethyl) -1-fluoro-2-methoxybenzene, follow the safety and operation norms to ensure the smooth progress of the experiment and protect the safety of the experimenter.
    Application Area
    Today there are chemical substances 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene, and its application field is quite important. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new drugs, or has unique effects on the treatment of specific diseases, bringing good news to patients. In the field of materials science, through clever chemical reactions, materials with special properties can be constructed, such as enhancing the stability and conductivity of materials, and may have extraordinary performance in electronic devices, aerospace materials, etc. In the field of fine chemicals, it can become the cornerstone of the preparation of high value-added fine chemicals, improve product quality and performance, and is widely used in coatings, fragrances and other industries to promote the development of the fine chemical industry. This substance has potential in many application fields, which cannot be ignored in chemical research and industrial applications.
    Research & Development
    There is now a compound named 4- (bromomethyl) -1 -fluoro-2 -methoxybenzene. As a chemical researcher, I am very concerned about the research and development of this compound.
    This compound has a unique structure, and the combination of bromomethyl, fluorine atom and methoxy group endows it with different chemical properties. In the field of organic synthesis, it may have unique uses.
    After research, its reactivity can be investigated. The existence of bromomethyl may provide an opportunity for nucleophilic substitution reactions. Fluorine atoms affect the distribution of electron clouds, and methoxy groups also play a role in its chemical behavior.
    Looking forward to its development, if the reaction conditions can be precisely regulated, new synthetic paths may be developed to prepare materials with special functions. In-depth study of its properties is expected to emerge in the fields of medicinal chemistry, materials science and other fields, and promote progress in related fields.
    Toxicity Research
    In the study of chemistry, the investigation of poisons is essential. Today's words 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene this substance, the study of its toxicity is crucial.
    When studying the toxicity of this substance, when it is carefully observed and other substances should be observed, observe its sexual changes in different environments. Examine the path of its entry into the body, or by breathing, or through the skin, or by eating, all need to be carefully investigated.
    Observe the signs of its poison, the damage to the viscera, and the disturbance to the nerves are all important for research. If you accidentally touch it, the situation and the way to save it quickly should be clear.
    And when it remains in the ring, the harm to the living cannot be ignored. Only by studying these ends can we know the toxicity of 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene, which is beneficial for protection and safety.
    Future Prospects
    Today there is a thing called 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene. In our pursuit of chemical research, this substance has great potential. Looking at its structure, bromomethyl, fluorine and methoxy are ingeniously named, or can be derived from a variety of chemical reactions.
    Looking to the future, it may emerge in the field of drug creation. With its unique structure, it may be able to accurately fit specific targets, paving a new way for the development of good drugs to overcome difficult diseases. In the field of materials science, it is also expected to shine, or it may improve the properties of materials to make them more resilient and stable.
    Although there is a long road ahead, we uphold the spirit of research and are determined to explore. It is hoped that with unremitting efforts, we will explore the infinite possibilities hidden in this material, and paint a bright new chapter for the development of chemistry and the well-being of the world, in order to recognize the grand vision of the future.
    Where to Buy 4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene in China?
    As a trusted 4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Bromomethyl)-1-Fluoro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene?
    4- (bromomethyl) -1 -fluoro-2 -methoxybenzene, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of drug molecules with specific biological activities. Due to its unique reactivity in the structure of bromomethyl, fluorine atoms and methoxy groups, it can be combined with various nucleophilic reagents through various chemical reactions, such as nucleophilic substitution reactions, to build the basic structure of drug molecules.
    In the field of materials science, or can be used to prepare functional materials. For example, by virtue of its reactive groups, it is introduced into polymer materials through polymerization or modification reactions, giving the materials unique properties such as fluorescence properties and special solubility, which are used in optical materials, sensor materials and other fields.
    In the field of organic synthetic chemistry, it is an extremely important synthetic building block. Chemists can use the transformation and modification of its functional groups to construct complex organic molecular structures, expand the types and functions of organic compounds, and provide key basic raw materials for the development of organic synthetic chemistry.
    What are the physical properties of 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene
    4- (bromomethyl) -1 -fluoro-2 -methoxybenzene is one of the organic compounds. Its physical properties are quite impressive.
    Looking at its properties, at room temperature, this substance is often liquid, colored or transparent, or slightly colored, like Yingying autumn water, clear or hidden in a somewhat different charm. Its smell, or has a special fragrance, or is irritating, smell it, if you enter a different environment, then the smell, your mileage may vary, also need to be carefully perceived.
    As for the boiling point, the cover is in a specific temperature range. When it is heated, when it reaches this boiling point, it is like a butterfly breaking a cocoon, transforming from liquid to gaseous state. This temperature range is just like the boundary of its sublimation, and it is of great significance for its separation and purification. The melting point is also one of its characteristics. At a certain temperature, it is like melting ice and snow, and it solidifies from the solid state to the liquid state. This temperature is the key node of its physical state transformation.
    In terms of solubility, in organic solvents, or showing good solubility, such as ethanol, ether, etc., it is like a fish getting water and can be fused with it. In water, the solubility is poor, just like the difficulty of oil and water, and the boundaries between the two are clear. The difference in solubility has far-reaching implications for its application in different environments.
    Above the density, it may be different from water. Or heavier than water, if it is co-located with water, it will sink to the bottom and slowly settle; or lighter than water, it will be like floating leaves in waves, floating leisurely on the water surface. The characteristics of this density also add many considerations to its practical operation and application.
    The physical properties of 4- (bromomethyl) -1 -fluoro-2 -methoxylbenzene play a pivotal role in many fields such as organic synthesis and chemical production. If it can be used properly, it will be able to exert its unique effectiveness.
    What are the synthesis methods of 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene
    There are several common methods for synthesizing 4- (bromomethyl) -1 -fluoro-2 -methoxybenzene.
    First, 1-fluoro-2-methoxybenzene is used as the starting material and is obtained by bromomethylation. This reaction requires a suitable bromomethylation reagent, such as a compound reagent composed of bromomethane (BrCH ² Cl) and anhydrous zinc chloride (ZnCl ²). In a suitable reaction vessel, mix 1-fluoro-2-methoxybenzene with bromomethane and anhydrous zinc chloride, and stir the reaction at a certain temperature. Temperature control is critical, generally 50-80 ° C. During the reaction, anhydrous zinc chloride was used as a catalyst to promote the electrophilic substitution of bromomethyl to benzene ring. After the reaction, the target product 4- (bromomethyl) -1 -fluoro-2 -methoxybenzene can be obtained through post-treatment steps such as extraction and distillation.
    Second, methoxy groups and fluorine atoms can be introduced into the benzene ring first, and then bromomethyl groups can be introduced. If o-fluorophenol is used as the starting material, it is first reacted with dimethyl sulfate ((CH 🥰) -2 SO) under basic conditions to achieve methoxylation and generate 1-fluoro-2-methoxyphenol. After that, the product is reacted with phosphorus tribromide (PBr < unk >), and the hydroxyl group is replaced by bromine atom to obtain 1-fluoro-2-methoxybromobenzene. Finally, bromomethyl is introduced by bromomethylation reagents, such as the mixed system of polyformaldehyde (Paraformaldehyde) and hydrobromic acid (HBr), under the catalysis of suitable catalysts such as Lewis acid, to synthesize 4- (bromomethyl) -1-fluoro-2-methoxybenzene. In this process, the reaction conditions at each step need to be precisely controlled. The alkali concentration and temperature of the methoxylation reaction, as well as the amount of reagents and reaction time for subsequent bromination and bromomethylation reactions, all have important effects on the yield and purity of the product.
    Third, the coupling reaction strategy catalyzed by transition metals can also be used. The coupling reaction is carried out in a suitable solvent in the presence of transition metal catalysts and ligands such as palladium (Pd). For example, tetrakis (triphenylphosphine) palladium (Pd (PPh)) is used as the catalyst, potassium carbonate (K 2O CO) is the base, and the reaction is heated to 80-100 ° C in N, N-dimethylformamide (DMF) solvent. This method requires high activity of the reaction raw materials, and the raw materials need to be rationally designed and screened, and the amount of catalyst and the choice of ligand have a great impact on the reaction effect. It needs to be carefully optimized to efficiently synthesize 4- (bromomethyl) -1 -fluoro-2 -methoxybenzene.
    4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene what are the precautions during storage and transportation
    4- (bromomethyl) -1 -fluoro-2 -methoxybenzene is one of the organic compounds. During storage and transportation, there are several important things to pay attention to.
    The first to bear the brunt, the storage environment is crucial. This compound should be stored in a cool, dry and well-ventilated place. Because it may be more sensitive to heat, under high temperatures, it may cause chemical reactions, damage its quality, or even cause safety risks. Therefore, choose a place with a lower temperature and avoid direct sunlight to prevent it from decomposing or deteriorating due to light and high temperature.
    Furthermore, moisture protection cannot be ignored. Due to the fact that there may be groups in its structure that are easy to react with water, if it encounters water vapor or causes reactions such as hydrolysis, its chemical properties will be changed. Therefore, the storage place should be kept dry, and a desiccant can be placed next to it to absorb moisture from the air.
    As for transportation, the packaging must be tight and stable. Because it has certain chemical activity, if the packaging is not well packaged, it will be vibrated, collided, or leaked during transportation, which will not only damage the environment, but also endanger the safety of transporters. The packaging materials used must be able to withstand certain external forces and have the characteristics of preventing leakage.
    In addition, during transportation and storage, it should be kept away from fire sources, heat sources, and strong oxidants. This compound may be flammable or react violently with strong oxidizing agents, causing serious accidents such as combustion and explosion. Therefore, when handling and handling this substance, operators should also strictly abide by the procedures and wear appropriate protective equipment, such as gloves, goggles, etc., to prevent contact with this substance from causing harm to the body.
    What is the market price range for 4- (Bromomethyl) -1-Fluoro-2-Methoxybenzene
    Today I have a question, what is the market price range of 4- (bromomethyl) -1 -fluoro-2 -methoxybenzene. However, I do not have the exact data of the market price of this chemical. The price of this chemical often varies due to many factors.
    First, the purity has a great impact. If the purity is very high, it is close to the reagent grade, and it is suitable for high-end applications such as scientific research experiments, its price will be high; if the purity is slightly lower, it is used in general industrial production, and the price may drop slightly.
    Second, the relationship between supply and demand is also key. If the market demand for this product is strong, but the supply is limited, the so-called supply is in short supply, the price will rise; conversely, if the supply is sufficient, the demand is flat, and the price may stabilize or even decline.
    Third, different manufacturers have different prices. Well-known large factories have high prices due to their excellent production technology and reliable product quality; while some small factories have cost control skills and competitive prices.
    Fourth, the amount of purchase also affects the price. Purchase in large quantities, manufacturers may give preferential discounts for small profits but quick turnover; buy in small quantities, and the unit price may be higher.
    For the exact price range, consult chemical product suppliers, trading platforms, or chemical market survey reports, so that relatively accurate price information can be obtained.