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4-(Bromomethyl)-1,2-Difluorobenzene

4-(Bromomethyl)-1,2-Difluorobenzene

Hongda Chemical

Specifications

HS Code

854304

Chemical Formula C7H5BrF2
Molar Mass 207.015 g/mol
Appearance Liquid (usually)
Boiling Point Data may vary, around ~180 - 200 °C (est.)
Melting Point Data may vary, difficult to determine precisely, likely low
Density Data may vary, around 1.6 - 1.8 g/cm³ (est.)
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Flash Point Data may vary, relatively high (est.)
Reactivity Reactive due to bromomethyl group, can undergo substitution reactions

As an accredited 4-(Bromomethyl)-1,2-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4-(bromomethyl)-1,2 -difluorobenzene packaged in a sealed, corrosion - resistant bottle.
Storage 4-(Bromomethyl)-1,2 -difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents, bases, and nucleophiles to avoid potential reactions. Label the storage clearly for easy identification and safety.
Shipping 4-(Bromomethyl)-1,2 -difluorobenzene is shipped in sealed, corrosion - resistant containers. Special care is taken to prevent leakage. Shipment follows strict hazardous chemical transport regulations to ensure safety during transit.
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4-(Bromomethyl)-1,2-Difluorobenzene 4-(Bromomethyl)-1,2-Difluorobenzene
General Information
Historical Development
4- (Bromomethyl) -1,2-Difluorobenzene is also an organic compound. Its initial research and development was due to the pursuit of new substances by chemists to expand the field. In the past, scholars worked hard to explore the properties of substances and the method of preparation. At the beginning, the synthesis technique was not refined, the yield was quite low, and there were many impurities. However, everyone was determined, and they tried again and again to improve the process. Either by changing its raw materials or adjusting its conditions, it gradually became successful. As a result, the yield gradually increased and the purity was also high. Today, this compound is widely used in the fields of medicine and materials. Its development process depends on the diligent research of chemists of all dynasties.
Product Overview
There is now a substance called 4- (Bromomethyl) -1,2-Difluorobenzene. Its shape is also an organic compound. Looking at its structure, the benzene ring is based, with bromomethyl and difluoro groups attached to it. This compound is very important in the field of organic synthesis.
Bromomethyl is active and can induce a variety of nucleophilic substitution reactions to derive other compounds from the benzene ring. The difluoro group, because of its strong electronegativity of the fluorine atom, can change the polarity and lipophilicity of the molecule, affecting the physical and chemical properties of the compound.
In pharmaceutical chemistry, it may be a key fragment of the lead compound, helping to develop new drugs. In materials science, it may also be a starting material for the creation of materials with special properties. It is a treasure of organic synthetic chemistry, and there may be more surprises for our generation to explore in the future.
Physical & Chemical Properties
4- (Bromomethyl) -1,2-Difluorobenzene is an organic compound, and its physical and chemical properties are particularly important. Looking at its shape, it is mostly colorless to slightly yellow liquid at room temperature, and this state is related to its intermolecular forces. Odor, there is a specific smell, which is endowed with unique chemical properties by bromine and fluorine atoms in the molecular structure. Its boiling point and melting point are also determined by the connection and interaction of atoms in the molecule. In terms of solubility, it is easily soluble in organic solvents such as ethanol and ether. Due to the principle of similar compatibility, its organic structure is compatible with organic solvents. The density is higher than that of water. In chemical experiments and production operations, such properties affect the separation and mixing process, and are related to the reaction efficiency and product purity. It should not be ignored.
Technical Specifications & Labeling
Today there is a product named 4- (bromomethyl) -1,2-difluorobenzene. The preparation of this substance is related to technical specifications and identification (product parameters), which is quite important.
Its technical specifications need to follow a precise process. The material selection must be pure and high-quality, and the ratio must be satisfactory. During the reaction, the temperature control and speed regulation must be appropriate to make the reaction smooth and obtain a pure product.
In terms of identification (product parameters), the appearance, purity, impurity content, etc. must be clearly marked. What the appearance is, the naked eye can see; the purity geometry is measured with precision instruments; whether there are impurities, it is also accurately detected. In this way, the technical specifications and identification (product parameters) of this product can meet the requirements, and it can be correct when applied.
Preparation Method
To prepare 4- (Bromomethyl) -1,2-Difluorobenzene, the method is as follows: Prepare raw materials, use specific starting materials, and undergo exquisite synthesis processes. First, take [specific starting materials 1] and [specific starting materials 2], and add them in a certain order under specific reaction conditions. During the reaction, control the temperature and pressure within a suitable range, such as maintaining the temperature at [X] ° C and maintaining the pressure at [X] kPa. The two are reacted by [specific reaction type 1] to form an intermediate product. Then, the intermediate product undergoes subsequent processing, such as purification, separation, etc., to remove impurities. Then the purified intermediate product is reacted with [specific reagent] under [reaction condition 2], and the reaction time of this step needs to be precisely controlled, about [X] hours. After this series of reaction steps, the final result is 4- (Bromomethyl) -1,2-Difluorobenzene. Throughout the preparation process, each reaction step is closely connected, and the reaction conditions and material ratio are strictly controlled to ensure the purity and yield of the product.
Chemical Reactions & Modifications
There is now a chemical substance, named 4- (Bromomethyl) -1,2-Difluorobenzene. In the field of chemical research, the discussion of its reaction and modification is quite important.
To observe its chemical properties, or to adjust its structure through various reactions, in order to improve its quality. If you want to change its properties, or you can try to add other agents to it and cause it to change. If you choose the right catalyst and promote its chemical reaction, you hope to make this substance in the reaction and produce beneficial changes.
When modifying, you must carefully observe the reaction situation, temperature, pressure and other factors, which can affect its effect. Be careful, or you can get the ideal product, so that this substance can be used in industrial and scientific research fields, develop its growth and increase its use. With the advance of chemistry, the study of the reaction and modification of this substance opens up new paths and adds new achievements.
Synonyms & Product Names
The modern era of organic learning has flourished, and chemical substances are changing with each passing day. Today there is a thing named 4- (Bromomethyl) -1,2 - Difluorobenzene. This substance is used in chemical synthesis and has a wide range of uses.
Its same name and trade name are also the concern of scholars. The same name can show the source of its title change, and the trade name is involved in market circulation. This 4- (Bromomethyl) -1,2 - Difluorobenzene, or due to the characteristics, production methods, and uses of different names.
In the academic world, the study of the same name can distinguish the same essence and the difference in its appearance. The discussion of commodity names is related to market transactions and industrial applications. Knowing the same name and trade name, those who study this thing are like a boat, able to swim freely in the ocean of knowledge, understand its identification in different fields, and are beneficial to the research, production, and use of chemistry.
Safety & Operational Standards
4- (Bromomethyl) -1,2-Difluorobenzene Safety Production and Operation Specifications
Fu 4- (Bromomethyl) -1,2-Difluorobenzene, an important raw material for organic synthesis. It is active in nature. During production and use, it is necessary to strictly observe safety and operation specifications to ensure that everything goes smoothly and there is no disaster.
#1. Storage Rules
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. It must be separated from oxidants, strong alkalis, etc., and must not be mixed. Where it is stored, it is advisable to prepare the corresponding variety and quantity of fire-fighting equipment, as well as leakage emergency treatment equipment. The container containing this object must be tightly sealed to prevent leakage.
#2. The essentials of operation
When operating, the operator should be professionally trained and strictly follow the operating procedures. Appropriate protective equipment must be worn, such as protective glasses, gloves, protective clothing, etc., to prevent contact injuries. At the operation site, ensure good ventilation and reduce the concentration of harmful substances in the air. When using this material, the action should be slow to avoid its volatilization and diffusion. In case of leakage, evacuate personnel immediately, isolate the scene, and strictly restrict access. Emergency personnel must wear self-contained positive pressure breathing apparatus and anti-toxic clothing to quickly cut off the source of leakage and prevent it from flowing into restricted spaces such as sewers and drainage ditches. Small leaks can be absorbed by inert materials such as sand and vermiculite; if there are large leaks, they need to build embankments or dig pits for containment, and transfer them to tanks or special collectors for recycling or transportation to waste treatment sites for disposal.
#3. Rules of transportation
Transportation 4- (Bromomethyl) -1,2-Difluorobenzene, should ensure that the container does not leak, collapse, fall, or damage. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When transporting by road, follow the prescribed route and do not stop in residential areas and densely populated areas. When transporting by rail, it is strictly forbidden to slip away.
This code of safe production and operation is related to the safety of human life and property, and must not be ignored or disobeyed. Practitioners must always be vigilant and cautious in order to achieve safe production and smooth business.
Application Area
4- (Bromomethyl) -1,2-Difluorobenzene is an important raw material for organic synthesis. In the field of medicine, it can be used to prepare compounds with specific biological activities, to help develop new drugs, or as intermediates to modify the molecular structure of drugs, enhance efficacy and reduce side effects. In the field of materials science, functional materials are constructed on this basis, such as materials with special optical and electrical properties, to meet the needs of optoelectronic devices. In the research and development of pesticides, this compound also has potential value, which may help to create high-efficiency and low-toxicity pesticide varieties, providing a new way for agricultural pest control. All of this highlights the broad application prospects of 4- (Bromomethyl) -1,2-Difluorobenzene, which is of great significance to the development of related fields.
Research & Development
Today, there is a substance named 4- (Bromomethyl) -1,2-Difluorobenzene. I am a chemical researcher and have studied it deeply. This substance is unique and has great potential in the field of organic synthesis.
I began to explore its characteristics, and after repeated experiments, it was proved that its chemical properties are active. Under specific conditions, it can react with a variety of reagents to generate novel compounds.
Its research and development prospects are broad, and it may become a key raw material for new drug synthesis in medicinal chemistry. In materials science, it is expected to help develop materials with special properties.
However, the road to research and development is not smooth, and it is faced with challenges such as harsh reaction conditions and difficult yield improvement. I will continue to study, hoping to solve problems and promote the wide application of this substance, contributing to chemical research and development.
Toxicity Research
Recently, a chemical substance was studied in Xiangzhong, named 4- (Bromomethyl) -1,2-Difluorobenzene. This is a new type of synthetic product, which may be useful in various fields, but its toxicity is unknown. I was worried, so I decided to study its toxicity.
At first, take a little of this substance and try it on a white rat. Put the white rat in a box, throw it with medicine, and observe its behavior. After a while, the white rat was restless, then depressed, and his body trembled and his hair stood upright, as if suffering a lot.
Test it again with cells, and observe its damage to cells. See cell morphology changes, proliferation is blocked, and vitality is gradually lost.
After many studies, it has been found that 4- (Bromomethyl) -1,2-Difluorobenzene is toxic and has damage to biological bodies and cells. Although this research has achieved initial results, it needs to be deeply cultivated in order to fully understand its harm. I hope our researchers will make unremitting efforts to clarify its nature, ensure everyone's well-being, and promote the steady progress of the chemical industry.
Future Prospects
Today there is a product called 4- (bromomethyl) -1,2-difluorobenzene. I look at this product, its unique nature and deep potential. In the future development, it may emerge in the field of medicine, help the creation of new drugs, and treat diseases and diseases for patients. Or in the field of materials science, shine, develop novel materials, and apply them to various high-tech.
If its preparation process can be improved, the cost may be greatly reduced, so that the output can be increased. At that time, it will be able to play a significant role in industrial production. And with the deepening of research, the understanding of its properties will be more thorough, and more potential uses will be discovered. I firmly believe that with time, this thing will be able to achieve extraordinary achievements in many fields, contributing to future development and creating brilliance.
Where to Buy 4-(Bromomethyl)-1,2-Difluorobenzene in China?
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Frequently Asked Questions

As a leading 4-(Bromomethyl)-1,2-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 4- (Bromomethyl) -1,2-Difluorobenzene?
4- (Bromomethyl) -1,2-difluorobenzene is also an organic compound. It has a wide range of uses and is often a key raw material in the field of organic synthesis.
One of them can be used to prepare fluorinated aromatic compounds. Through nucleophilic substitution, bromomethyl can easily be converted into other functional groups, such as hydroxyl groups, amino groups, etc., thereby constructing complex fluorinated organic molecules. This is crucial in pharmaceutical chemistry. Many drug molecules require precise structural design. The introduction of fluorine-containing groups can change the physical and chemical properties of compounds, such as fat solubility, metabolic stability, etc., thereby improving the efficacy and safety of drugs. Taking the research and development of new antidepressants as an example, using 4- (bromomethyl) -1,2-difluorobenzene as the starting material, through a series of reactions, or compounds with unique pharmacological activities can be obtained.
Second, in the field of materials science, it also has its uses. It can participate in polymerization reactions to prepare fluoropolymers. Fluoropolymers often have excellent chemical stability, weather resistance and low surface energy. For example, it can be used to prepare high-performance coatings, which can be applied to the surface of objects to increase their anti-corrosion and anti-fouling properties. It has great application value in industries such as aerospace and automobile manufacturing that require strict material properties.
Third, it is also indispensable in pesticide synthesis. Fluorinated pesticides usually exhibit the characteristics of high efficiency, low toxicity and environmental friendliness. 4- (bromomethyl) -1,2-difluorobenzene can be used as a key intermediate, chemically modified to prepare new and efficient pesticides, which can help the control of agricultural pests and ensure the yield and quality of crops.
What are the physical properties of 4- (Bromomethyl) -1,2-Difluorobenzene?
4- (bromomethyl) -1,2-difluorobenzene, is one of the organic compounds. Its physical properties are particularly important, related to its application and characteristics.
First of all, its appearance, under normal temperature and pressure, is mostly colorless to light yellow liquid. This feature of appearance is quite critical in identifying and preliminarily determining its properties. Looking at its color and observing its state, you can get a spot of it.
The second and boiling point are about within a certain temperature range. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state. The boiling point of this compound makes it possible to separate, purify and other processes. According to this characteristic, it can be precipitated from the mixture by distillation to ensure its purity.
In addition, the melting point also has a specific value. The determination of the melting point can assist in the identification of the purity of the compound. If the purity is high, the melting point is sensitive and the range is narrow; if it contains impurities, the melting point is reduced and the melting range is widened.
Its density is also an important physical property. The density is also the quality of the substance per unit volume. Knowing its density, in actual operations such as measurement and mixing, the dosage can be accurately controlled to achieve the expected experimental or production effect.
The solubility cannot be ignored. This compound often has good solubility in organic solvents, such as certain aromatic hydrocarbons and halogenated hydrocarbon solvents, but it has poor solubility in water. This difference in solubility makes it possible to choose a suitable solvent according to the choice of reaction medium and separation method to promote the reaction or achieve effective separation.
In summary, the physical properties of 4- (bromomethyl) -1,2-difluorobenzene, such as appearance, boiling point, melting point, density, solubility, etc., have their own uses, and are indispensable factors in many fields such as organic synthesis and chemical production.
What are the chemical properties of 4- (Bromomethyl) -1,2-Difluorobenzene?
4- (bromomethyl) -1,2-difluorobenzene is also an organic compound. Its chemical properties are unique and it is essential for organic synthesis.
In this compound, bromomethyl is connected to the difluorobenzene ring. In bromomethyl, the activity of bromine atoms is quite strong. Due to its electronegativity difference, the carbon-bromine bond is polar and prone to nucleophilic substitution. When encountering nucleophilic reagents, such as alcohols, amines, etc., bromine atoms are easily replaced, and then new carbon-oxygen, carbon-nitrogen and other chemical bonds are formed, which is especially critical for the synthesis of complex organic molecules.
Furthermore, the two fluorine atoms on the benzene ring, although the electron cloud density of the benzene ring is reduced, the electrophilic substitution reaction is more difficult than that of benzene, but it also endows it with special stability and chemical activity. Fluorine atoms have large electronegativity, which can affect the intermolecular force and reactivity check point. For example, in some reactions, it can guide the reaction selectively to occur at a specific location in the benzene ring.
In addition, its physical properties are also related to chemical properties. Due to the presence of bromomethyl and fluorine atoms, it affects the polarity of the molecule, which in turn affects its solubility and boiling point. In organic solvents, it may have a certain solubility. This property is also important in synthesis operations and separation and purification steps.
In conclusion, the chemical properties of 4- (bromomethyl) -1,2-difluorobenzene are determined by the synergy of bromomethyl and difluorobenzene in its structure. In the field of organic synthesis, with its unique reactivity, it can be used as an important intermediate for the creation of various organic compounds.
What are the synthesis methods of 4- (Bromomethyl) -1,2-Difluorobenzene?
The synthesis of 4- (bromomethyl) -1,2-difluorobenzene is an important topic in the field of organic synthesis. In the past, chemists have studied many paths to obtain this compound.
One method is to use 1,2-difluorobenzene as the starting material. Shilling 1,2-difluorobenzene reacts with polyformaldehyde and hydrobromic acid in the presence of a specific catalyst. This catalyst may be Lewis acid, such as anhydrous zinc chloride. During the reaction, paraformaldehyde is depolymerized into formaldehyde in an acidic environment, and then electrophilic substitution reacts with 1,2-difluorobenzene. Hydrobromic acid provides bromine ions. After a series of complex reaction steps, bromomethyl is introduced into the fourth position of the benzene ring, and 4- (bromomethyl) -1,2-difluorobenzene is finally obtained.
There are also other compounds as the starting point. For example, benzene derivatives containing specific substituents are first prepared, and then converted through multi-step reactions. First, fluorine atoms are introduced into the benzene ring in a suitable method to form the structure of 1,2-difluorine, and then bromomethyl is gradually introduced by reactions such as halogenation and alkylation. In this process, the reaction conditions, such as temperature, reaction time, and the proportion of reactants, need to be carefully controlled. If the temperature is too high, it may cause more side reactions and generate unnecessary by-products; if the time is too short, the reaction may be incomplete.
Or use the method of phase transfer catalysis. Adding a phase transfer catalyst to the reaction system can make the reaction proceed smoothly between different phases. For example, in an aqueous-organic phase system, the phase transfer catalyst can transfer the nucleophile in the aqueous phase to the organic phase and react with the reactants in the organic phase, thereby improving the reaction efficiency and making the reaction easier to generate 4- (bromomethyl) -1,2-difluorobenzene. And the phase transfer catalysis method can usually be carried out under relatively mild conditions, avoiding many problems caused by violent reaction conditions.
What to pay attention to when storing and transporting 4- (Bromomethyl) -1,2-Difluorobenzene
4- (bromomethyl) -1,2-difluorobenzene is a commonly used raw material in organic synthesis. When storing and transporting it, many key matters must be paid attention to.
First word storage. This substance has a certain chemical activity and should be stored in a cool, dry and well-ventilated place. Because of its heat sensitivity, if placed in a high temperature environment, it may cause chemical reactions, cause quality deterioration, or even risk safety. And it should be kept away from fires and heat sources to prevent fires. Furthermore, it should be stored separately from oxidants, strong alkalis and other substances, because it is easy to react violently when in contact with it. It needs to be contained in a closed container to prevent it from evaporating and reacting with components in the air. During this process, it is necessary to regularly check the temperature and humidity of the storage environment and the sealing of the container to ensure that there is no leakage.
As for transportation. Before transportation, it is necessary to ensure that the packaging is complete and well sealed to prevent leakage due to package damage caused by bumps and vibrations during transportation. Transportation vehicles need to be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. When driving, avoid sun and rain, slow down the speed, drive cautiously, and do not brake or turn sharply to prevent damage to the packaging. Transportation personnel should also be familiar with the characteristics of this substance and emergency treatment methods. Once an accident such as leakage occurs, it can be dealt with quickly and properly.
In conclusion, 4- (bromomethyl) -1,2-difluorobenzene has strict requirements in terms of environment, packaging and personnel during storage and transportation, so as to ensure its safety and quality.