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4-Bromo-(Trifluoromethoxy)Benzene

4-Bromo-(Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

739642

Chemical Formula C7H4BrF3O
Molecular Weight 241.005
Appearance Colorless to light yellow liquid
Boiling Point 170 - 172 °C
Melting Point N/A
Density 1.648 g/mL at 25 °C
Vapor Pressure N/A
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Flash Point 61.1 °C
Refractive Index 1.474

As an accredited 4-Bromo-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - bromo - (trifluoromethoxy)benzene in a sealed, corrosion - resistant bottle.
Storage 4 - bromo - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. This is to prevent evaporation, reaction with air components, and potential leakage that could pose safety risks due to its chemical properties.
Shipping 4 - bromo - (trifluoromethoxy)benzene is shipped in well - sealed, corrosion - resistant containers. Adequate labeling indicating its chemical nature is applied. Shipment follows strict hazardous chemical transportation regulations for safe delivery.
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4-Bromo-(Trifluoromethoxy)Benzene 4-Bromo-(Trifluoromethoxy)Benzene
General Information
Historical Development
The development of 4-bromo- (trifluoromethoxy) benzene can be described. In the past, organic chemistry was just emerging, and all the sages were dedicated to the research of new substances. At that time, it was difficult to explore the method of combining halogenated aromatics with fluorine-containing groups.
At the beginning, I tried to combine the two by the usual method, but the reaction was obedient and the yield was low. After years of research, the method of organic synthesis was refined. Chemists have gained insight into the reaction mechanism, improved the conditions, and used catalysis to make the bromo group and trifluoromethoxy group can be properly combined.
And now, this compound is widely used in the fields of medicine and materials. The difficult development of the past has become the convenience of today. Its development process depends on the diligence and wisdom of chemists, enabling this special organism to grow in the world.
Product Overview
4-Bromo- (trifluoromethoxy) benzene is a unique product among organic compounds. It may be a colorless liquid with a special odor. This compound has a wide range of uses in the field of organic synthesis.
In its structure, bromine atoms and trifluoromethoxy groups are connected to the benzene ring, giving it unique chemical properties. With the activity of bromine atoms, it can participate in a variety of nucleophilic substitution reactions and is a key node in the construction of complex organic molecules. The existence of trifluoromethoxy groups greatly affects the electron cloud distribution of molecules and changes the polarity and stability of compounds.
In the fields of materials science and medicinal chemistry, 4-bromo- (trifluoromethoxy) benzene shows important application potential. In material synthesis, it can be used as a functional monomer to prepare polymer materials with special properties. In drug development, its structural characteristics may help to improve the biological activity, lipophilicity and metabolic stability of drugs.
Physical & Chemical Properties
4 - Bromo - (Trifluoromethoxy) Benzene is an organic compound, and its physicochemical properties are particularly important. Looking at its physical properties, it is mostly colorless to light yellow liquid at room temperature, with a special odor. Its boiling point is about a specific range, which is related to its state change at different temperatures, and is very important in separation and purification operations.
When it comes to chemical properties, the bromine atom in this compound has high activity and can participate in many substitution reactions. The presence of trifluoromethoxy also affects the distribution of its electron cloud, which changes the density of the electron cloud on the benzene ring, which in turn affects its electrophilic substitution reaction activity. Because of its fluorine atom, the compound has certain stability and unique chemical activity. The study of the physicochemical properties of this compound is of great significance in the field of organic synthesis, and may lead to the development of new reaction pathways and the preparation of more valuable derivatives.
Technical Specifications & Labeling
There is a product today, named 4 - Bromo - (Trifluoromethoxy) Benzene. Its technical regulations and identification (commodity parameters) are crucial to the quality and characteristics of this product.
Looking at its technical regulations, the proportion of components and the geometry of impurities should be detailed, and the impurities should be accurate and not deviated by the millimeter. And its physical properties, such as color, taste, and state, should also be clear. As for the parameters such as melting point, boiling point, and density, it is necessary to be precise to consider the basis of application.
In the logo, the product parameters should be fully listed, so that the viewer can see at a glance. The name should be correct, and the origin and batch should be marked to trace its origin. And safety warnings are also indispensable to clarify its hazards, so as to ensure that those who use it are safe. In this way, the combination of technical regulations and the way of marking is beneficial to both business and research.
Preparation Method
To prepare 4 - Bromo- (Trifluoromethoxy) Benzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
In terms of raw materials, when taking suitable halogenated benzene and reagents containing trifluoromethoxy groups. Bromobenzene is preferred for halogenated benzene, and its bromine atom activity is moderate, which is convenient for subsequent reactions. Reagents containing trifluoromethoxy groups, when reactive and stable, such as potassium trifluoromethoxy.
In the production process, the method of nucleophilic substitution can be adopted. In the reaction vessel, bromobenzene and reagents containing trifluoromethoxy are placed, and an appropriate amount of organic solvents, such as N, N - dimethylformamide, are dissolved to create a suitable reaction environment.
The reaction steps are as follows: First, the reaction system is heated to a certain temperature, about 80 to 100 degrees Celsius, which prompts the molecular movement to intensify and improves the reaction probability. During this process, the negative ions containing the trifluoromethoxy reagent attack the benzene ring of bromobenzene, and the bromine atom leaves to form the target product.
In terms of catalytic mechanism, an appropriate amount of phase transfer catalyst, such as tetrabutylammonium bromide, can be introduced. It can promote the ion transfer between the two-phase reactants, accelerate the reaction rate, increase the yield, and make the reaction proceed more efficiently, resulting in 4-Bromo- (Trifluoromethoxy) Benzene.
Chemical Reactions & Modifications
Today, there is a compound 4 - Bromo - (Trifluoromethoxy) Benzene, which is the gist of our research in chemical reaction and modification.
Looking at its structure, the bromine atom and the trifluoromethoxy group are connected to the benzene ring, and this unique structure endows it with different chemical activities. In the reaction, the bromine atom can be used as a check point for nucleophilic substitution. Due to its electronegativity difference, it is easy to attract nucleophilic reagents to attack and substitution reactions occur, which in turn change the molecular skeleton and expand the types of compounds.
The existence of trifluoromethoxy affects the electron cloud density of the benzene ring due to its strong electron absorption, which decreases the electron cloud density of the benzene ring and causes the electrophilic substitution reaction activity to change. To modify it, the reaction conditions can be regulated by means of organic synthesis, and appropriate reagents can be selected to involve bromine atoms or trifluoromethoxy groups in the reaction, in order to obtain new compounds with specific properties, which can be used in the fields of medicine, materials, etc.
Synonyms & Product Names
4-Bromo- (trifluoromethoxy) benzene is also a new product of chemical. Although its name is different from the common name, it also has many synonymous names.
The name of this thing is synonymous or named for its structural properties. Or bromotrifluoromethoxy benzene, which covers its molecule, the bromine atom is connected to the trifluoromethoxy group on the benzene ring.
As for the trade name, the merchant may have another good name for its characteristics or to facilitate its promotion. Or fluorobromophenyl ether, this name contains both fluorine and bromine elements, as well as the structure of the ether, so that those who smell it know its properties.

The synonymous name and the trade name, although the expressions are different, refer to this 4-bromo- (trifluoromethoxy) benzene. In the field of chemical research, scholars are familiar with its names, so that they can travel freely in the literature, communicate freely, explore its mysteries, study its uses, and contribute to the prosperity of the chemical industry.
Safety & Operational Standards
Code for safety and operation of 4-bromo (trifluoromethoxy) benzene
Fu 4-bromo (trifluoromethoxy) benzene is also an important raw material for chemical synthesis. In its experimental and production links, safety and standardized operation are the top priority, which is related to human life and the smooth production.
#1. Storage safety
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Because of its certain chemical activity, it may cause uncontrolled reaction when heated. The reservoir should be made of corrosion-resistant materials, such as glass or specific plastics, to prevent leakage. And it must be stored in isolation from oxidizing agents, reducing agents, alkalis, etc., to avoid their interaction and cause harm.
#2. Operating Specifications
When operating, appropriate protective equipment must be worn. Wear chemical safety glasses to protect your eyes from splashing liquid; wear anti-toxic substances to penetrate work clothes to prevent them from contacting the skin; wear rubber gloves to prevent direct touch. The operating environment must be well ventilated, or a local exhaust device should be installed to disperse the volatile gas in time to prevent it from accumulating in the air.
When taking it, the action should be slow and stable to prevent spilling. Weighing accurately, according to the amount required for experiment or production, do not be greedy for waste and danger. If there is any spillage, quickly cover the adsorption with inert materials such as sand and vermiculite, and then dispose of it properly.
#3. Emergency treatment
If it accidentally touches the skin, immediately rinse with a large amount of flowing water, and then seek medical attention for careful investigation. Those who enter the eyes need to immediately open the eyelids, rinse with flowing water or normal saline, and quickly go to the medical office. If inhaled, quickly leave the scene to a place with fresh air to keep the respiratory tract unobstructed. If breathing is abnormal, apply artificial respiration and rush to the hospital.
Production or experimental sites, when preparing emergency treatment equipment and suitable fire extinguishing materials. In case of fire, according to its characteristics, choose dry powder and carbon dioxide fire extinguishers to put out the fire. Do not use water to prevent its reaction with water from aggravating the damage.
In summary, during the use of 4-bromo (trifluoromethoxy) benzene, strict adherence to safety and operating standards can ensure personnel safety, orderly production, avoid chemical risks, and promote scientific research and production.
Application Area
4 - Bromo - (Trifluoromethoxy) Benzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs to treat various diseases. Due to its unique chemical structure, it can precisely bind to specific targets in organisms, so it has significant pharmacological activity.
In the field of materials science, this compound also has extraordinary functions. It can be used to prepare materials with special properties, such as materials with excellent optoelectronic properties, which play an important role in the manufacture of optoelectronic devices, so that device performance can be optimized and improved.
And in the field of pesticide chemistry, 4 - Bromo - (Trifluoromethoxy) Benzene is also useful. It can participate in the synthesis of high-efficiency and low-toxicity pesticides, assist in agricultural pest control, ensure high crop yields, and contribute to agricultural development.
Research & Development
Today there is a thing named 4 - Bromo - (Trifluoromethoxy) Benzene. With the heart of scientific research, we study the properties of this thing and seek its development.
Study the properties of this thing, observe its chemical characteristics, and explore the law of its reaction. Observe its structure and think about the change of its interaction with other things. In the experimental room, after a lot of attempts, analyze its composition, understand its characteristics, and hope to fully understand its chemical wonders.
Seek its development and hope to expand its use. Or it can be used in the manufacture of medicine to help heal diseases; or it can be used in the manufacture of materials and the ability of additives. Gathering the wisdom of everyone, finding its new path, looking at the realm of industry and scientific research, they can all develop their growth and make achievements. With unremitting efforts, this substance will bloom and shine, leaving a strong pen in the path of scientific research and development.
Toxicity Research
The judgment of material properties is related to the safety of people's livelihood. It is urgent to study the toxicity of 4 - Bromo - (Trifluoromethoxy) Benzene today.
Looking at its structure, bromine and trifluoromethoxy are polymerized, or it has unique properties. After various experiments, animals are tested to observe its reaction. At the beginning, the tested animals, eating a little, not a few, gradually appear tired state, slow movement, and depressed expression.
Looking at its diffusion in the environment, if it flows in water and soil, it is afraid of sewage sources and damages plants and trees. Vegetables are planted in the soil, and their leaves are gradually wilted and their vitality is depleted.
From this point of view, 4 - Bromo - (Trifluoromethoxy) Benzene is not lightly toxic, and it is harmful to the biological body and the natural environment. It is urgent to study its prevention and control strategies to ensure the calmness of all living things.
Future Prospects
I have dedicated myself to studying the compound 4 - Bromo - (Trifluoromethoxy) Benzene. This substance has unique properties and has potential application prospects in many fields. Looking at its chemical structure, the combination of bromine and trifluoromethoxy gives it special activity.
Looking forward to the future, it may shine in the field of medicine. Because it has specific chemical activities, it may be used as a key intermediate to help the development of new drugs and explore effective therapies for difficult diseases. In the field of materials science, it is also expected to give birth to innovative materials. With its unique properties, it can improve material properties, such as enhancing material stability and enhancing its functionality.
I firmly believe that over time, through the unremitting research of fellow researchers, 4 - Bromo - (Trifluoromethoxy) Benzene will be able to demonstrate its great potential, contribute extraordinary strength to the progress of human society, and lead the future of technology and life to a new realm.
Where to Buy 4-Bromo-(Trifluoromethoxy)Benzene in China?
As a trusted 4-Bromo-(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Bromo-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 4-Bromo- (Trifluoromethoxy) Benzene?
4-Bromo (trifluoromethoxy) benzene is an important compound in organic chemistry. It has a wide range of uses and plays a key role in many fields.
First, in the field of drug synthesis, this compound is often a key intermediate. The way of drug development is like a journey to explore hidden treasures. The construction of many drug molecules requires delicate design and combination of various chemical groups. The unique structure of 4-bromo (trifluoromethoxy) benzene, containing bromine atoms and trifluoromethoxy groups, can be introduced into target drug molecules through many chemical reactions, such as nucleophilic substitution reactions. Bromine atoms are highly active and can provide a variety of possibilities for reactions, helping pharmaceutical chemists to construct complex structures with specific biological activities. The strong electron-absorbing properties of trifluoromethoxy groups can significantly change the physical and chemical properties and biological activities of compounds, such as improving the lipid solubility of drugs, making them easier to penetrate biofilms, enhancing the ability of drugs to bind to targets, and then improving drug efficacy.
Second, in the field of materials science, 4-bromo (trifluoromethoxy) benzene also plays an important role. Today's materials research seeks to develop new materials with special properties. With this compound as a starting material, materials with special electrical, optical or thermal properties can be prepared through polymerization or other organic synthesis methods. For example, it can be used to synthesize organic optoelectronic materials, which show unique advantages in the fields of organic Light Emitting Diode (OLED) and solar cells. Its structural characteristics can affect the electronic transport and luminescence properties of the material, providing the possibility for high-efficiency photoelectric conversion and luminescence.
Third, in the field of pesticide synthesis, 4-bromo (trifluoromethoxy) benzene is also an indispensable ingredient. The development of pesticides is aimed at effectively controlling crop diseases and pests and ensuring food security. The structural characteristics of this compound can endow pesticides with specific biological activities, such as insecticidal, bactericidal or weeding effects. Through rational design and modification, the introduction of pesticides into pesticide molecules can enhance the targeting and environmental friendliness of pesticides, reduce the impact on non-target organisms, and enhance their stability and effectiveness in the environment.
What are the physical properties of 4-Bromo- (Trifluoromethoxy) Benzene?
4-Bromo (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are particularly important. Looking at its properties, under normal temperature and pressure, it is a colorless to light yellow liquid with a clear texture, like autumn water.
In terms of its boiling point, it is between 170-172 ° C. This number of boiling points makes the substance a gas-liquid transformation state at a specific temperature environment. As for the melting point, it is usually around -10 ° C. At this temperature, the substance will gradually solidify from a liquid state and turn into a solid state.
Its density is about 1.72 g/cm ³, which is heavier than water. If placed in water, it will sink to the bottom of the water. The vapor pressure of this substance is quite small at 25 ° C, about 0.13 kPa or so, which makes the substance volatile at room temperature less significant.
4-bromo (trifluoromethoxy) benzene also has its own characteristics of solubility. It is well miscible in organic solvents such as ethanol, ether, and dichloromethane. However, in water, the solubility is extremely low and almost insoluble. This difference in solubility is due to the molecular structure of the substance, and the properties of its organic groups make it more likely to mate with organic solvents.
Its refractive index is about 1.458-1.460. This optical property allows light to be refracted at a specific angle when passing through the substance, providing an important basis for its identification and analysis.
In summary, the physical properties of 4-bromo (trifluoromethoxy) benzene are of critical significance in organic synthesis, chemical production and related research fields, helping researchers and producers to understand its characteristics and make good use of it.
What are the chemical properties of 4-Bromo- (Trifluoromethoxy) Benzene?
4-Bromo (trifluoromethoxy) benzene is an important compound in organic chemistry. Its chemical properties are unique and it is widely used in the field of organic synthesis.
In this compound, the bromine atom is active and can often participate in nucleophilic substitution reactions. Because the bromine atom has good departure properties, it is easily replaced when encountering nucleophilic reagents, forming new carbon-heteroatomic bonds. If it reacts with nucleophilic reagents such as alkoxides and amines, it can generate corresponding ethers or amines. This property lays the foundation for the construction of complex organic molecular structures.
The trifluoromethoxy part endows the compound with special physical and chemical properties. Trifluoromethoxy has strong electron absorption, which can reduce the electron cloud density of the benzene ring and affect the reactivity of other substituents on the benzene ring. In the aromatic electrophilic substitution reaction, trifluoromethoxy acts as a meta-localization group to guide the electrophilic reagent to attack the benzene ring meta-site. This localization effect is crucial in the design of organic synthesis routes, which helps to precisely control the reaction check point and improve the selectivity of target products.
4-bromo (trifluoromethoxy) benzene also exhibits good thermal and chemical stability. The high carbon-fluorine bond energy in its structure makes the compound resistant to heat, oxidation and hydrolysis. In some organic synthesis processes that require high temperature or harsh reaction conditions, it can maintain structural integrity and ensure the smooth progress of the reaction.
In common organic solvents such as dichloromethane, chloroform, and toluene, 4-bromo (trifluoromethoxy) benzene has good solubility, which facilitates its participation in the homogeneous reaction, enabling the reactants to be fully mixed and contacted, which is conducive to the efficient occurrence of the reaction. In conclusion, 4-bromo (trifluoromethoxy) benzene plays a key role in drug synthesis, materials science, and many other fields due to its active bromine atom, unique trifluoromethoxy group, and good stability and solubility. It is an important basic raw material in the research and application of organic synthetic chemistry.
What are the synthesis methods of 4-Bromo- (Trifluoromethoxy) Benzene
The synthesis method of 4-bromo (trifluoromethoxy) benzene has been known for a long time and is described in detail below.
First, 4-bromophenol is used as the starting material. This is a common starting material. In the reaction bottle, add an appropriate amount of 4-bromophenol, use potassium carbonate as the base, and mix in a suitable organic solvent, such as N, N-dimethylformamide (DMF). Then, slowly add trifluoromethylsulfonic acid anhydride dropwise, and control the reaction temperature to a certain range, about 50-60 degrees Celsius, for the number of reactions. In this process, the activity of trifluoromethyl sulfonate anhydride is high, and the phenolic hydroxyl group of 4-bromophenol undergoes nucleophilic substitution reaction. After post-treatment, such as extraction, distillation and other steps, the target product 4-bromo (trifluoromethoxy) benzene can be obtained.
Second, starting from 4-bromochlorobenzene. 4-bromochlorobenzene is placed in a reaction vessel with anhydrous potassium fluoride and crown ether catalysts, such as 18-crown-6, in a reaction vessel with cyclobutane sulfone as solvent. Heating to a higher temperature, about 180-200 degrees Celsius, the chlorine atom is replaced by fluoride ions to form 4-bromofluorobenzene. Then, in another reaction system, using 4-bromofluorobenzene as the substrate, under alkaline conditions, such as potassium hydroxide in an alcohol solution, nucleophilic substitution reaction occurs with sodium trifluoromethoxide, carefully adjusting the reaction conditions, after separation and purification, 4-bromo (trifluoromethoxy) benzene can also be obtained.
Third, benzene is used as the starting material and is first brominated. Mix benzene with liquid bromine, use iron powder or iron tribromide as the catalyst, and react at room temperature to obtain bromobenzene. Next, bromobenzene is nitrified, and under the action of mixed acid of concentrated sulfuric acid and concentrated nitric acid, at a specific temperature range, such as 50-60 degrees Celsius, p-bromonitrobenzene is formed. Then through reduction reaction, p-bromo nitrobenzene is reduced to p-bromo aniline with iron powder and hydrochloric acid as reducing agent. P-bromo aniline is reacted by diazotization, reacted with sodium nitrite and hydrochloric acid at low temperature to form diazonium salt. Finally, the diazotide is reacted with sodium trifluoromethoxy through a series of complex transformations, and finally 4-bromo (trifluoromethoxy) benzene can be obtained. Although this route is complicated, it is also a feasible method.
What is the price range of 4-Bromo- (Trifluoromethoxy) Benzene in the market?
The market value of 4-bromo (trifluoromethoxy) benzene can be determined by factors such as cost.
First, the balance of supply and demand is of paramount importance. If the market demand for this compound is high, but the supply is limited, the price will be low; conversely, if the supply is low, the price will drop.
Second, the cost of producing this compound is also a major factor in determining the price. The cost of raw materials, the ease of synthesis, and the energy consumption of the production process all affect the cost, which affects the market.
Third, the cost of quality also has a significant impact. High-grade 4-bromo (trifluoromethoxy) benzene, due to its higher requirements in multi-precision and high-end applications, is often high in cost; while those with slightly lower cost, or can be used for general purposes, are low in cost.
Fourth, the market price should not be ignored. If there are many suppliers in the market to provide this compound, the price will be intense, and the price may decline due to factors; conversely, if there are few suppliers, its price may be maintained at a high level.
According to the concept of "Tiangong Products", the quality of products is subject to multi-party control. 4-Bromo (trifluoromethoxy) benzene is not available in the market, but generally speaking, in the chemical raw material market, its price per gram may range from 10 yuan to 100 yuan. This price is for consideration, and the market price is determined by many factors such as background, supply and demand, and quality.