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4-Bromo-3-Fluorobenzenesulfonamide

4-Bromo-3-Fluorobenzenesulfonamide

Hongda Chemical

Specifications

HS Code

279818

Name 4-Bromo-3-Fluorobenzenesulfonamide
Molecular Formula C6H5BrFNO2S
Molecular Weight 254.077
Appearance Solid
Color White to off - white
Melting Point 146 - 148 °C
Boiling Point N/A
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in some organic solvents like DMSO
Purity Typically high purity (e.g., 95%+)
Flash Point N/A

As an accredited 4-Bromo-3-Fluorobenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - bromo - 3 - fluorobenzenesulfonamide in sealed, chemical - resistant packaging.
Storage Store 4 - bromo - 3 - fluorobenzenesulfonamide in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. It should be stored in a tightly closed container to prevent moisture absorption and potential reactions. Label the storage container clearly to avoid mix - ups and ensure proper handling.
Shipping 4 - bromo - 3 - fluorobenzenesulfonamide is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring safe handling during transit to prevent any leakage or damage.
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4-Bromo-3-Fluorobenzenesulfonamide 4-Bromo-3-Fluorobenzenesulfonamide
General Information
Historical Development
4 - Bromo - 3 - Fluorobenzenesulfonamide is a product of modern chemistry. Back in the past, the development of chemistry has been studied by generations of talents. In the past, chemistry was still ignorant and many substances were not recognized.
As the years passed, researchers continued to explore, and their understanding of the structure and properties of matter deepened. 4 - Bromo - 3 - Fluorobenzenesulfonamide was born due to the refinement of analytical technology and the improvement of synthetic methods.
In the early years, researchers could only analyze simple compounds, and then with wisdom and perseverance, they broke through many difficulties to synthesize this complex sulfonamide compound. The process, like overcoming thorns, every step is full of hardships. However, the unremitting efforts finally paid off, 4 - Bromo - 3 - Fluorobenzenesulfonamide emerged in the field of chemistry, laying the foundation for subsequent scientific research and application.
Product Overview
4-Bromo-3-fluorobenzenesulfonamide is also the chemical product I studied. This product has unique properties, showing the shape of white to white crystalline powder, and it is delicate in appearance. Its melting point is worth noting, about [X] ° C, this property is crucial in chemical applications.
In terms of chemical structure, above the benzene ring, bromine and fluorine atoms cleverly occupy positions, giving the substance a different chemical activity. Sulfonamide groups also add many reaction possibilities. In terms of solubility, it is slightly soluble in common organic solvents and even more insoluble in water. This property determines its behavior in different media.
This product can be used as a key intermediate in the field of medicinal chemistry to assist in the synthesis of new drugs, which is expected to contribute to the well-being of patients; in the field of materials science, or because of its special structure, it provides novel ideas for the development of new materials and promotes the optimization and improvement of material properties.
Physical & Chemical Properties
4 - Bromo - 3 - Fluorobenzenesulfonamide, the chemical material is also. Its properties are white and powder-like, and its appearance is plain and smooth. In the melting process, the liquid is dissolved at a specific degree, and the result of this degree is the best.
Its solubility is soluble in multi-solubility, but slightly soluble in water. This property is due to its dispersion and reaction in different environments. Its chemical activity, due to bromine, fluorine and sulfonamide groups, has a specific reverse orientation. It can be multi-action, or nuclear substitution, or other chemical reactions to form new compounds. This is the key to research and expands the basis of chemical knowledge.
Technical Specifications & Labeling
Technical specification and identification of 4-bromo-3-fluorobenzenesulfonamide (product parameters)
To prepare 4-bromo-3-fluorobenzenesulfonamide, bromide, fluoride and sulfonating agent materials should be prepared first. In a clean kettle, the temperature is moderately controlled, bromide and fluoride are combined, accompanied by a catalyst, and the reaction is slowly stirred. When the reaction is completed, add a sulfonating agent, continue to stir and raise the temperature to make the sulfonation complete.
Should be completed, the pure product should be analyzed by distillation. Looking at its color, it should be pure white without any impurities; measuring its melting, it should be in line with the standard. Measure its quality, and the impurities must be slight. The label of this product, when the name is "4-bromo-3-fluorobenzenesulfonamide", lists its molecular formula and molecular weight in detail, and notes its nature and danger, so that the user can clearly know.
Preparation Method
This 4 - Bromo - 3 - Fluorobenzenesulfonamide is made, and the raw materials are prepared first. Take 3 - fluorobromobenzene, sulfonate it in a suitable vessel, add concentrated sulfuric acid and fuming sulfuric acid, control the temperature moderately, so that the sulfonation reaction is sufficient, and get 3 - fluoro - 4 - bromobenzenesulfonic acid.
The second is amidation. Mix the prepared 3 - fluoro - 4 - bromobenzenesulfonic acid with ammonia water, and under certain conditions, make it amide. During this period, pay attention to the reaction process and adjust the temperature and pressure in a timely manner. After the reaction is completed, the impurities are removed through the separation and purification steps to obtain pure 4-Bromo-3-Fluorobenzenesulfonamide.
This preparation method, the raw materials are easy to obtain, the reaction steps are orderly, and the control is proper, which can stabilize the output of the target product. It also has reference value in industrial production.
Chemical Reactions & Modifications
In recent years, the chemical reaction and modification of 4 - Bromo - 3 - Fluorobenzenesulfonamide have been quite experienced. The initial step of the chemical reaction of this compound often involves the sulfonation of halogenated aromatics, and suitable conditions need to be selected to promote the precise insertion of sulfonyl groups. However, the traditional method has many drawbacks, the yield is not ideal, and the side reactions occur frequently.
In order to seek modification, I have explored new methods. Try to enter it with a new catalytic system, hoping to improve the reaction path and improve its efficiency. At the beginning, the progress is difficult, and the catalytic activity and selectivity are difficult to combine. After many trials and errors, the catalytic ratio and temperature adjustment have gradually turned around. Under the new system, the yield of 4-Bromo-3-Fluorobenzenesulfonamide is significantly improved, and the side reaction is also controlled.
From the perspective of chemical reaction and modification, it is necessary to base on tradition, boldly innovate and repeatedly explore, in order to obtain ideal results and expand the application of this compound.
Synonyms & Product Names
Today there is a thing called 4-Bromo-3-Fluorobenzenesulfonamide. Although its name is different from that of common people, it also has many synonyms. This chemical thing can be called "4-Bromo-3-fluorobenzenesulfonamide", which is a popular name based on its chemical structure.
When it is sold in the city, merchants may also take different trade names to call it. Due to commercial promotion and labeling, although it refers to the same thing, it has different names. However, no matter how the name changes, its chemical essence has not changed, and it is a chemical substance of this specific structure. We are scholars, and when we study this thing, we should understand its many synonymous names and trade names, so that we can accurately recognize and use it in different situations without confusion, so as to facilitate the smooth progress of scientific research.
Safety & Operational Standards
4 - Bromo - 3 - Fluorobenzenesulfonamide is a chemical product that I have recently developed. It is essential to explain in detail the safety and operating practices of this product.
In terms of safety, the first priority is its chemical properties. This substance has specific chemical activities and may react with certain substances. To ensure safety, store in a dry, cool and well-ventilated place away from fire, heat and oxidizing substances. Because it may be toxic and irritating, protective measures are essential during operation. Operators wear protective clothing, protective gloves and goggles to prevent skin contact and eye splashing. If you accidentally touch the skin, you should immediately rinse with a large amount of water; if it enters the eyes, you need to rinse quickly with flowing water and seek medical attention as soon as possible.
In terms of operating specifications, you must be fully familiar with the process and precautions before the experiment. Use a precise measuring tool to measure to ensure accurate dosage. The reaction process needs to be strictly controlled by temperature and speed, and operated in accordance with established procedures. After the reaction is completed, the product treatment cannot be ignored. Follow environmental protection requirements, dispose of waste reasonably, and do not dump it at will to prevent pollution of the environment.
The safety and operation specifications of this product are related to personnel safety and the success or failure of the experiment. We chemical researchers must always strictly observe it and do not allow any mistakes.
Application Area
4 - Bromo - 3 - Fluorobenzenesulfonamide, it is also an exquisite product. Its application is an important raw material for the development of new materials in the field of technology. With its unique properties, it can improve the quality and anti-corrosion of materials. With its unique properties, it can help people find a cure and save people. In the field of materials science, it also has its place of use. It can improve the characteristics of materials, such as increasing its quality and anti-corrosion. With its unique properties, it can be cleverly combined with other materials to greatly improve the properties of materials. The use of this product is like exploring the unknown key, creating a new path in various fields, promoting the development of technology and improving it, for the benefit of the world.
Research & Development
In recent years, I have been researching more chemical substances, and today I am talking about 4 - Bromo - 3 - Fluorobenzenesulfonamide this product. At the beginning, to obtain this substance, the road to experimentation was quite difficult. The choice of raw materials and the degree of proportions need to be carefully considered.
After several attempts, the exploration of reaction conditions, and unremitting research. The temperature, the amount of catalyst, are all related to the product. Every failure, not discouraged, repeated thinking, adjustment strategy.
Fortunately, there is a breakthrough in the end. Not only can this product be stabilized, but the purity is gradually increasing. However, my heart is not enough, I want to explore more possibilities. In the field of application, think about the reaction between it and various things, or it can be used as a new material for medicine or electronics.
I will use this material as the basis to open up new horizons, gain more benefits in chemical research, and add new colors to the industry. This is my ambition.
Toxicity Research
Today's research 4 - Bromo - 3 - Fluorobenzenesulfonamide This thing, its toxicity is related to people's livelihood, must be observed.
I explore with ancient methods, take a few of this thing, and test it with various conditions. Observe its phase transformation with other things, and observe its changes in different environments.
After many studies, we have begun to see clues. This thing can undergo subtle changes in some media, or involve the increase or decrease of toxicity. However, if you want to understand it in detail, you need to widely accept all methods and study its reasons.
The matter of toxicity is a matter of life. I should do my best to study the toxicity of 4 - Bromo - 3 - Fluorobenzenesulfonamide, in order to solve the confusion of the world, avoid its harm, and protect the well-being of the people.
Future Prospects
Guanfu 4 - Bromo - 3 - Fluorobenzenesulfonamide this thing, although it has been slightly gained in the current research, it still exists in a vast and unexplored land. Looking forward to the future, I hope to be able to find a simple and efficient way to synthesize it, reduce its cost and increase its yield. And hope that in the performance research, its characteristics in different situations can be detailed, so as to be able to expand its application domain.
Or use cutting-edge technology to expand its use in medicine and materials. The road of medicine may be a new agent for treating diseases, saving patients from sinking diseases; the field of materials may be a new type of material, which should be diverse. This is the unfinished vision, but also our research people day and night thinking, with the intention of effort, to its bright realm, the future of glory.
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Frequently Asked Questions

As a leading 4-Bromo-3-Fluorobenzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 4-Bromo-3-Fluorobenzenesulfonamide?
4-Bromo-3-fluorobenzenesulfonamide, this is an organic compound with unique chemical properties. In terms of physical properties, it is usually white to light yellow crystalline powder with a certain melting point. Due to factors such as intermolecular forces, the melting point is within a specific range, but the specific value will change due to purity and other conditions.
Chemically, it contains a sulfonamide group (-SO ² NH ²), which gives it a certain hydrophilicity. The nitrogen atom in the sulfonamide group has a lone pair of electrons and can bind to protons, so it can appear weakly basic in an acidic environment. And this group can participate in a variety of reactions, such as reacting with acyl chloride, acid anhydride, etc., to form amide derivatives, to achieve molecular structure modification and functional expansion.
Furthermore, the bromine (Br) and fluorine (F) atoms on the benzene ring affect the distribution of molecular electron clouds. Bromine atoms can undergo nucleophilic substitution reactions. Under suitable nucleophilic reagents and reaction conditions, bromine atoms can be replaced by other groups, such as hydroxy (-OH), amino (-NH2O), etc., to synthesize organic compounds with different functions. Fluorine atoms can enhance molecular stability due to their high electronegativity, affect the electron cloud density of the benzene ring, and affect other reactivity on the benzene ring, so that the density of the electron cloud of the benzene ring is relatively reduced, and the electrophilic substitution reactivity changes.
In addition, the chemical properties of 4-bromo-3-fluorobenzenesulfonamide are also restricted by reaction conditions, such as temperature, solvent, catalyst and other factors will affect the reaction rate and product selectivity. When high temperature or specific catalysts exist, the reaction activity or enhancement makes the reaction more likely to occur.
This compound is rich in chemical properties and is widely used in organic synthesis, pharmaceutical chemistry and other fields, laying the foundation for the preparation of a variety of high value-added organic compounds.
What are the main uses of 4-Bromo-3-Fluorobenzenesulfonamide?
4-Bromo-3-fluorobenzenesulfonamide is also an organic compound. It has a wide range of uses and is often a key intermediate in the creation of new drugs in the field of medicinal chemistry. Due to its unique chemical structure, it can participate in a variety of chemical reactions to build a molecular framework with specific biological activities, which helps to develop antibacterial, anti-inflammatory, anti-tumor and other drugs.
In materials science, it also has its uses. Or it can be introduced into polymer systems through specific reactions to improve the properties of materials, such as enhancing their stability, adjusting their electrical properties, and even endowing materials with special optical properties, paving the way for the development of new functional materials.
Furthermore, in the field of agricultural chemistry, 4-bromo-3-fluorobenzenesulfonamide may be used to synthesize highly efficient and low-toxic pesticides. With its structural characteristics, pesticide products with high selectivity to pests and environmental friendliness may be designed to contribute to the sustainable development of agriculture, ensure the harvest of crops, and reduce the adverse impact on the ecological environment. In short, it has important uses in many fields and is an indispensable substance for chemical research and industrial production.
What is 4-Bromo-3-Fluorobenzenesulfonamide synthesis method?
To prepare 4-bromo-3-fluorobenzenesulfonamide, the following ancient method can be used.
First take 3-fluorobenzene as the starting material, and react with fuming sulfuric acid or chlorosulfonic acid. This process needs to be carried out at an appropriate temperature and reaction environment. Taking fuming sulfuric acid as an example, at a lower temperature, sulfate will selectively replace the hydrogen of bromine and fluoro-ortho-sites on the benzene ring. Due to the positioning effect of fluorine and bromine, the sulfonic acid group mainly enters the appropriate position between the two to form 4-bromo-3-fluorobenzenesulfonic acid or its anhydride.
If chlorosulfonic acid is used, its activity is stronger than fuming sulfuric acid, the reaction may be more violent, and the purpose of sulfonation can be achieved. The 4-bromo-3-fluorobenzenesulfonic acid or acid anhydride is generated, and then reacts with ammonia. Ammonia can react with the group of sulfonic acid or acid anhydride, and the hydroxyl group in the sulfonic acid group is replaced by an amino group, or the acid anhydride reacts with ammonia to open the ring, and finally converts to 4-bromo-3-fluorobenzenesulfonamide.
During the reaction period, factors such as temperature, ratio of reactants, and reaction time If the temperature is too high, it may cause side reactions, which will affect the purity and yield of the product. Improper proportion is not conducive to the reaction to produce the target product. After the reaction, the pure 4-bromo-3-fluorobenzenesulfonamide can be obtained by separation and purification methods, such as crystallization and column chromatography.
What is the market outlook for 4-Bromo-3-Fluorobenzenesulfonamide?
4-Bromo-3-fluorobenzenesulfonamide is one of the molecules in the field of organic compounds. It has potential applications in many industries such as chemical industry and medicine, so the market prospect is quite promising.
In the chemical industry, it can be a key intermediate for the synthesis of special materials. Today's material science is booming, and the demand for materials with special properties is increasing. 4-Bromo-3-fluorobenzenesulfonamide, due to its unique molecular structure, contains halogen atoms such as bromine and fluorine and sulfonamide groups, which can endow the synthesized materials with properties such as excellent stability and corrosion resistance. With the rise of high-end manufacturing, industries such as aerospace, electronic information and other industries continue to rise in demand for special materials. This compound is in the chemical synthesis path and may welcome a broader market space.
In the field of medicine, its importance should not be underestimated. Many drug research and development efforts are dedicated to finding high-efficiency and low-toxicity active ingredients. The structural characteristics of 4-bromo-3-fluorobenzenesulfonamide make it biologically active and can be used as a lead compound for drug molecular design and optimization. The modern pharmaceutical industry is developing rapidly, and there is an urgent need for new drugs to deal with various difficult diseases. Therefore, if there is a breakthrough in drug research and development based on this compound, it will definitely drive a significant increase in its market demand.
However, its market development also faces challenges. The process of synthesizing this compound may be technically difficult, and precise reaction conditions control and efficient synthesis processes are required to ensure its yield and purity. Technical bottlenecks may limit its large-scale production, which in turn affects market supply and costs. And market competition is also a factor that cannot be ignored. The development and production of similar or alternative compounds may pose a threat to the market share of 4-bromo-3-fluorobenzenesulfonamide.
Overall, 4-bromo-3-fluorobenzenesulfonamide has a promising market prospect due to its potential application value in the chemical and pharmaceutical fields. However, in order to fully tap its market potential, it is still necessary to break through technical difficulties, respond to competitive challenges, and seek long-term development.
What 4-Bromo-3-Fluorobenzenesulfonamide need to pay attention to when storing and transporting
4-Bromo-3-fluorobenzenesulfonamide is a chemical substance. When storing and transporting it, many matters need to be paid careful attention.
Let's talk about storage first. This substance should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to temperature and humidity, high temperature and humidity may cause chemical changes or even cause deterioration. Therefore, the warehouse temperature should be properly regulated, usually 15-30 ° C, and the humidity should be maintained at 40% - 70%. In addition, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because this substance comes into contact with these substances, or causes violent chemical reactions, endangering safety. The storage place should also be equipped with suitable materials to contain the leakage, so as to prevent accidental leakage and deal with it in a timely and effective manner.
As for transportation. Make sure that the packaging is complete and sealed before transportation. The packaging material should have good corrosion resistance and sealing to prevent the leakage and volatilization of substances. During transportation, make sure that the container does not leak, collapse, fall or damage. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. And the transportation should be carried according to the specified route, and do not stop in residential areas and densely populated areas. Because if it leaks in crowded places, it may cause serious harm to people's health and the environment. At the same time, transportation personnel also need to undergo professional training, be familiar with the characteristics of the substance and emergency treatment methods, and closely monitor during transportation to ensure safe transportation.