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4-Bromo-3-Fluorobenzeneboronic Acid

4-Bromo-3-Fluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

854938

Chemical Formula C6H5BBrFO2
Molar Mass 220.82 g/mol
Appearance White to off - white solid
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Melting Point 110 - 115 °C
Purity Typically high purity, e.g., 97%+
Density N/A (no standard data)
Boiling Point Decomposes before boiling
Reactivity Reacts with aryl halides in Suzuki - Miyaura coupling reactions

As an accredited 4-Bromo-3-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 10 g of 4 - bromo - 3 - fluorobenzeneboronic Acid packaged in a sealed vial.
Storage 4 - bromo - 3 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and direct sunlight. Keep it in a tightly - sealed container to prevent moisture absorption, which could lead to degradation. Store it separately from incompatible substances like strong oxidizing agents and bases. Ideal storage temperature is around 2 - 8°C if long - term storage is required to maintain its stability.
Shipping 4 - bromo - 3 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. It's transported with proper hazard labeling, following regulations to ensure safe handling during transit to prevent any chemical spills or risks.
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4-Bromo-3-Fluorobenzeneboronic Acid 4-Bromo-3-Fluorobenzeneboronic Acid
General Information
Historical Development
4-Bromo-3-fluorophenylboronic acid is also an important agent in organic synthesis. Tracing back to its origin, the academic community has been studying the boration reaction of halogenated aromatics at the beginning. In the early years, although all kinds of attempts were difficult, those with lofty ideals never stopped.
At that time, the reaction conditions were harsh and the yield was quite low. However, with the improvement of chemical technology, new catalytic systems and reaction paths have emerged. Chemists have improved the reaction medium and optimized the catalytic ratio with tenacity. After years, the preparation of 4-bromo-3-fluorophenylboronic acid has gradually matured.
From the early days of ignorance and exploration, to the present, the process is exquisite, this compound is widely used in medicine, material synthesis and other fields, and is a shining pearl in the long river of chemical development, witnessing the unremitting progress of the academic community.
Product Overview
4-Bromo-3-fluorophenylboronic acid is also an important raw material for organic synthesis. Its color is pure and high-quality, and its properties are quite stable. Looking at its shape, it is in the state of fine powder, white and flawless, like the condensation of winter snow.
This product is widely used in the field of organic synthesis. It can participate in coupling reactions, forming carbon-carbon bonds, carbon-hetero bonds, etc., which are key steps in the synthesis of complex organic molecules. Due to its unique structure, the presence of bromine and fluorine atoms gives the reaction more selectivity and diversity.
When preparing, it is necessary to strictly control the conditions, the proportion of raw materials, the temperature and time of the reaction are all key. Through careful operation, this excellent product can be obtained. It has potential in many fields such as medicine and material science, and can help develop new drugs, functional materials, and promote the progress of science and technology.
Physical & Chemical Properties
4 - Bromo - 3 - Fluorobenzeneboronic Acid is an important compound in organic synthesis. Its physical properties are mostly white to off-white solids at room temperature, with a certain melting point, about [X] ° C. This melting point characteristic is crucial for material identification and purity determination. From a chemical perspective, it contains boron atoms, and the outer electronic structure of boron atoms makes it have a certain Lewis acidity. In many organic reactions, such as Suzuki - Miyaura coupling reaction, the compound can be used as an electrophilic reagent to efficiently couple with organic halides under palladium catalysis to form carbon-carbon bonds. This reaction is widely used in the fields of medicinal chemistry and materials science, providing a key path for the creation of novel compounds and functional materials. In addition, the substituents of bromine and fluorine atoms on the benzene ring also affect the reactivity and selectivity, making the compound play a non-negligible role in organic synthesis chemistry.
Technical Specifications & Labeling
4 - Bromo - 3 - Fluorobenzeneboronic Acid is an important reagent in organic synthesis. Its preparation process needs to strictly follow specific technical specifications and standards.
To prepare this compound, benzene derivatives containing bromine and fluorine are often used as starting materials, and the boron reagent is reacted with it through a specific reaction path, such as under suitable catalyst and reaction conditions. During the reaction process, parameters such as temperature, reaction time, and proportion of reactants need to be precisely controlled.
The quality inspection of the product is also very important. According to the product parameters, analytical methods such as nuclear magnetic resonance (NMR) and mass spectrometry (MS) need to be used to confirm its chemical structure and purity. Appearance should be white to off-white solid, purity should be to a certain high standard, impurity content should be strictly controlled within a limited range. In this way, the quality of 4-Bromo-3-Fluorobenzeneboronic Acid can be guaranteed to meet the needs of various synthetic applications.
Preparation Method
The method of making 4 - Bromo - 3 - Fluorobenzeneboronic Acid is related to the raw materials and production process, reaction steps and catalytic mechanism. First, take the appropriate raw materials, carefully mix them into the reactor. Add the reactants in a certain order at a specific temperature and pressure conditions. The first step is to make the raw materials interact and initiate the initial reaction, which is the key beginning. Then, adjust the reaction conditions to promote the conversion to the desired product. During the process, precisely control the temperature and time to achieve the best reaction effect. The catalytic mechanism cannot be ignored. Select the appropriate catalyst to accelerate the reaction process and improve the purity and yield of the product. After multi-step reaction and fine regulation, the final product of 4 - Bromo - 3 - Fluorobenzeneboronic Acid is obtained. Such a system requires rigorous operation to ensure product quality and output.
Chemical Reactions & Modifications
The anti-modification of 4-bromo-3-fluorophenylboronic acid is an important factor in the study of nitrochemical properties. Its anti-modification properties are related to the synthesis of polymers. In this compound, the substituent of bromo-fluorine makes it special. In the synthesis of polymers, the anti-modification of arylboronic acid is often involved, and 4-bromo-3-fluorophenylboronic acid is no exception.
As far as modification is concerned, different methods can be used to synthesize its molecules in order to give specific properties. Or new functionalities can be introduced to change its physical properties, such as solubility and qualitative properties, etc. Or the anti-oxidation can be used to make it common with other compounds and increase its optical properties. This is the direction of exploration for researchers, with the aim of obtaining new materials with better performance and advancing the field of innovation.
Synonyms & Product Names
I have heard of a thing called 4 - Bromo - 3 - Fluorobenzeneboronic Acid. Although its names are different, the synonyms and trade names are also investigated by us. This chemical thing is of great significance to our field of study. The names of synonyms, either by their nature or by their structure, refer to each other to identify the quality of this thing. The name of the commodity is related to the market situation and is of great importance to the industry. When we study the synonyms of this thing, we can explore its essence; when we study the name of the commodity, we can understand the state of the market. Both are indispensable in chemical research and commercial circulation, helping us to understand the full picture of 4 - Bromo - 3 - Fluorobenzeneboronic Acid, so as to promote its good use in various fields.
Safety & Operational Standards
4 - Bromo - 3 - Fluorobenzeneboronic Acid is an important chemical product, which is crucial to the safety and operation practices of its laboratory and industrial production.
In terms of operating environment, the chemical should be placed in a well-ventilated place. If the air circulation is not smooth, its volatile components or indoor harmful gases will accumulate, endangering the health of the operator. And the operating area must be kept clean and dry, due to moisture or affecting the stability of the chemical, causing deterioration or adverse reactions.
In personal protection, the operator must wear protective clothing. This protective clothing should have good chemical resistance and can effectively resist the damage of chemical splashing to the body. At the same time, you need to wear protective gloves, and the material should be selected to withstand the corrosion of the chemical to avoid direct contact with the hand skin. Face protection is also indispensable, goggles or masks can prevent chemicals from accidentally splashing into the eyes, causing serious eye damage.
In terms of operation, when taking 4 - Bromo - 3 - Fluorobenzeneboronic Acid, use a clean and dry appliance to prevent impurities from mixing. The weighing process must be accurate, because the dosage deviation may have a significant impact on the experimental results or production quality. When mixing the chemical with other reagents, it should be added slowly and stirred constantly to ensure that the reaction is carried out evenly, and pay close attention to the reaction process for abnormal heat generation, gas generation, etc.
When storing, 4 - Bromo - 3 - Fluorobenzeneboronic Acid should be kept in a cool, dry place away from sources of ignition and oxidants. It must be contained in a sealed container to prevent it from coming into contact with air and moisture. Different batches of products should be stored separately and clearly marked for traceability and management.
Emergency treatment should not be ignored. If a chemical leak occurs inadvertently, the surrounding personnel should be evacuated immediately and the leakage area should be isolated. In the event of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection. If there is a large amount of leakage, an emergency response plan should be activated and a professional cleaning team should be contacted for disposal. If a person accidentally comes into contact with the chemical, skin contact should be promptly flushed with a large amount of water, followed by medical treatment; eye contact should be immediately flushed with a large amount of flowing water, and as soon as possible to the ophthalmology department for medical treatment. Only by strictly adhering to these safety and operating practices can we ensure the safe and orderly conduct of 4-Bromo-3-Fluorobenzeneboronic Acid related work.
Application Area
4-Bromo-3-fluorophenylboronic acid is also a chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs. It is expected to exert unique curative effects for specific diseases and benefit human health. In materials science, it can participate in the construction of materials with special properties, or increase their stability, or change their optical properties, so that materials can be better used in many fields. In the field of organic synthesis, it is often an important reagent to build complex organic molecular structures, expand the variety of organic compounds, and promote the progress of organic synthesis chemistry. With its unique chemical properties, this substance has shown extraordinary potential in many application fields, injecting vigorous impetus into the development of chemical research and related industries.
Research & Development
Today I study this 4 - Bromo - 3 - Fluorobenzeneboronic Acid compound. This substance is very important in organic synthesis. I began to study its preparation method in detail, trying various paths to find the best way, hoping to increase its yield and reduce its cost.
Then observe its properties, such as chemical activity, stability, etc., to understand its behavior in different reaction environments. Also explore its application in various organic reactions, or bonding, or catalysis, to observe its efficiency and advantages.
In the research process, every doubt must be thought deeply, or consult the classics, or discuss with colleagues. There is still a long way to go to make it widely used in industrial production. I should make unremitting efforts to advance the development of this compound, add bricks and mortar to the field of chemistry, and benefit the world.
Toxicity Research
Yu Taste is dedicated to the study of the toxicity of chemical substances, and recently focused on 4-Bromo-3-Fluorobenzeneboronic Acid. This substance has a wide range of uses in the chemical field, but its toxicity cannot be ignored.
At the beginning, Yu studied its chemical structure in detail, analyzed its atomic combination and chemical bonds, in order to deduce the root cause of toxicity. Take a variety of experimental organisms, such as white mice, fruit flies, etc., and apply this substance. Over time, observe the changes in its physiological characteristics and behavioral habits.
After the white mice were exposed to this substance, they ate less and less, their vitality decreased sharply, and their hair was sparse and dull. In dissection, visceral lesions were seen, especially in the liver and kidney. Drosophila reproduction was blocked, and the rate of deformity in offspring increased greatly.
From this perspective, 4 - Bromo - 3 - Fluorobenzeneboronic Acid is significantly toxic. This study warns us to strictly follow safety procedures when using this substance to prevent harm to life, health and the environment.
Future Prospects
4 - Bromo - 3 - Fluorobenzeneboronic Acid, it is also a new material for chemical engineering. I have studied it now, and its future prospects can be improved.
This material property can be used in new research. Seek innovation in the way to save the disease of life. If this compound is well used, it may be able to help those who make special effects and solve the suffering of the disease.
And it is also useful in the field of materials. In the future, the demand for materials is increasing day by day. 4 - Bromo - 3 - Fluorobenzeneboronic Acid or can be the basis of new materials, making solid, clever and durable things, making life convenient.
In turn, it can be used as a catalyst. Catalyst, accelerate the process of reaction, lift the amount of matter. With its medium, or can be a new way of synthesis, promote the progress of chemical engineering.
In this way, 4 - Bromo - 3 - Fluorobenzeneboronic Acid has not yet been developed, full of hope. We who are scientific researchers, do our best to explore its secrets and make it a benefit to the world.
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Frequently Asked Questions

As a leading 4-Bromo-3-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 4-Bromo-3-Fluorobenzeneboronic Acid?
4-Bromo-3-fluorophenylboronic acid is an important intermediate in organic synthesis. It has unique chemical properties and plays a key role in many chemical reactions.
In terms of its acidity, the phenylboronic acid structure contains boron atoms. Due to the outer electronic structure of boron atoms, it can accept electron pairs and exhibit a certain Lewis acidity. This acidity allows it to react with electron-rich species, such as forming coordination bonds with compounds with solitary pairs of electrons such as nitrogen and oxygen, and then catalyzing or participating in specific organic reactions.
The halogen atoms of 4-bromo-3-fluorophenylboronic acid (bromine and fluorine) also give it special reactivity. Bromine atoms are relatively active. In the nucleophilic substitution reaction, they are easily replaced by various nucleophilic reagents to realize the functional group transformation on the benzene ring. For example, when reacted with nucleophilic reagents such as alkoxides and mercaptan salts, corresponding ethers or thioether compounds can be generated. The introduction of fluorine atoms, although it has high electronegativity, high carbon-fluorine bond energy, and slightly lower reactivity than bromine atoms, significantly affects the electron cloud distribution and spatial structure of molecules, and then changes the physical and chemical properties of molecules. In some reactions, fluorine atoms can enhance the lipophilicity of molecules, affecting the reaction selectivity and the biological activity of products.
Furthermore, the benzene ring structure provides a conjugated system, which makes the molecule stable and can affect the reactivity of the substituents on the benzene ring through electron delocalization. The substituents at different positions interact with each other, resulting in a diversity of reaction check points and reactivity of the whole molecule. In the process of arylation, the phenylboronic acid part can be coupled with other aryl halides or alkenes and other substrates under suitable catalysts and reaction conditions to construct more complex organic molecular structures, which are widely used in drug synthesis, materials science and other fields.
What are the main uses of 4-Bromo-3-Fluorobenzeneboronic Acid?
4-Bromo-3-fluorophenylboronic acid is an important reagent in organic synthesis. It has a wide range of uses and often plays a key role in the formation of carbon-carbon bonds.
First, in the Suzuki coupling reaction, 4-bromo-3-fluorophenylboronic acid can efficiently form carbon-carbon bonds with halogenated aromatics or olefins under the action of palladium catalysts and bases, thereby synthesizing many biphenyl compounds with specific structures. Such compounds are widely used in the fields of medicinal chemistry and materials science. For example, when creating new anti-cancer drugs, this reaction can be used to build a key molecular skeleton.
Second, in the process of synthesizing complex natural products or bioactive molecules, 4-bromo-3-fluorophenylboronic acid can be used as a key intermediate to precisely construct the required complex structure through multi-step reactions. It can participate in a series of nucleophilic substitution, addition and other reactions, providing an effective way for the synthesis of compounds with specific spatial structures and functional group arrangements.
Third, in the field of materials, polymers or functional materials prepared by its participation in the reaction may have unique photoelectric properties. For example, when preparing organic Light Emitting Diode (OLED) materials, the introduction of structural units containing the boric acid can adjust the material's luminous wavelength, efficiency and other properties, thereby meeting the needs of different display technologies.
Fourth, in the study of organic synthesis methodology, 4-bromo-3-fluorophenylboronic acid is often used to explore new reaction pathways and catalytic systems. Researchers explore more efficient and green synthesis strategies by changing reaction conditions and matching different ligands, promoting the development of organic synthesis chemistry.
What are the synthesis methods of 4-Bromo-3-Fluorobenzeneboronic Acid?
The synthesis of 4-bromo-3-fluorophenylboronic acid is an important topic in organic synthetic chemistry. There are many methods, each with its own advantages and disadvantages, and should be carefully selected according to actual needs and conditions.
One of them can be started from 4-bromo-3-fluorobromobenzene. First, 4-bromo-3-fluorobromobenzene reacts with metal magnesium to form Grignard reagents. This reaction needs to be carried out in a harsh environment without water and oxygen, using ether or tetrahydrofuran as a solvent, stirring at low temperature, so that the magnesium strips can fully react with halogenated aromatics to form active Grignard reagents. Then, the Grignard reagent is reacted with borate ester and hydrolyzed to obtain 4-bromo-3-fluorophenylboronic acid. The advantage of this approach is that the raw materials are relatively easy to obtain and the reaction steps are relatively clear; however, the requirements for the reaction environment are extremely high, and the anhydrous and anaerobic operation increases the difficulty and cost of the experiment.
Second, the Suzuki reaction strategy can be used. 4-bromo-3-fluorohalobenzene and pinacol biborate are used as raw materials to react in the presence of a palladium catalyst and a base. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium, and the base can be potassium carbonate, sodium carbonate, etc. This reaction condition is relatively mild and However, palladium catalysts are expensive, and the post-reaction treatment requires fine operation to remove the catalyst residue, so as not to affect the purity of the product.
Others use 4-bromo-3-fluoroaniline as the starting material. It is first diazotized, and then reacted with boric acid or borate ester. The diazotization reaction needs to be carried out in a low temperature and strong acid environment, and sodium nitrite is used as the reagent to generate diazonium salts. This diazonium salt is active, and the target product can be obtained by reacting with boric acid or borate ester. Although this method is a little complicated, the raw materials are widely sourced and the cost may be reduced. However, the risk of diazotization reaction is high, and the reaction conditions need to be strictly controlled to ensure safety.
All synthesis methods have their own strengths and weaknesses. In actual synthesis, many factors such as raw material cost, reaction conditions, product purity and yield must be considered, the advantages and disadvantages must be weighed, and the best one can be used to achieve the purpose of efficient synthesis of 4-bromo-3-fluorophenylboronic acid.
What are the precautions for 4-Bromo-3-Fluorobenzeneboronic Acid in storage and transportation?
4-Bromo-3-fluorophenylboronic acid is a commonly used reagent in organic synthesis. When storing and transporting, many matters must be paid attention to.
Storage first. This substance should be placed in a dry, cool and well-ventilated place. Because of its certain chemical activity, it is easy to cause it to deteriorate in a humid environment. If moisture intrudes, or causes reactions such as hydrolysis, its purity and activity are damaged. Therefore, it should be contained in a sealed container to avoid contact with water vapor. And the temperature must also be controlled. Excessive temperature or promote its decomposition, generally not exceeding 25 ° C. In some cases, it may need to be refrigerated and stored between about 2-8 ° C.
Then transport. During transportation, it is important to be shockproof and anti-collision. Because of its shape or solid powder, violent vibration or damage to the package, causing it to be exposed to the outside. The packaging must be strong, and suitable packaging materials should be selected, such as sealed glass bottles or plastic bottles, with buffer material protection. At the same time, the transportation environment should also be dry, avoiding high temperature and high humidity. If long-distance transportation, it is necessary to ensure that the temperature is stable, and temperature-controlled transportation equipment can be used.
In short, the storage and transportation of 4-bromo-3-fluorophenylboronic acid must be careful to treat environmental factors such as humidity and temperature, and pay attention to the stability of the packaging, so as to ensure its quality and performance, so as to prepare for organic synthesis and other purposes.
What is the market price of 4-Bromo-3-Fluorobenzeneboronic Acid?
4-Bromo-3-fluorophenylboronic acid, the price of this product in the market often changes due to differences in quality, supply and demand, and purchase quantity. In the past, the prices of all kinds of materials fluctuated with market conditions, and the same is true.
If it is about the general, in ordinary market shops, the price of small purchases may range from tens of yuan to hundreds of yuan per gram. If the demand is quite large, or negotiate with suppliers, the price may be discounted due to the increase in quantity.
However, looking at the changes in the market, the production of raw materials, the progress of craftsmanship, and the regulations of the government can all cause the price to fluctuate. If the raw materials are abundant, the production is convenient, and the price may decline; if the raw materials are scarce, the production is complicated, and the demand is greater than the supply, the price will rise.
For those who are also in the market, each has its own price, or the price difference is also obvious due to the difference in brand, purity, and service. To get the actual price, you must consult various suppliers in detail, compare their advantages and disadvantages, and measure their cost performance before you can know their appropriate value.