4-Bromo-3-Fluorobenzeneacetonitrile

Hongda Chemical

Specifications

HS Code	556929
Chemical Formula	C8H5BrFN
Molar Mass	214.03 g/mol
Appearance	Solid (likely, based on similar compounds)
Solubility In Water	Low (aromatic and nitrile groups suggest poor water solubility)
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, toluene (due to its non - polar nature)
Purity	Depends on source, usually high purity for research - grade products

As an accredited 4-Bromo-3-Fluorobenzeneacetonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 4 - bromo - 3 - fluorobenzeneacetonitrile packaged in a sealed, chemical - resistant bottle.
Storage	4 - bromo - 3 - fluorobenzeneacetonitrile should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, acids, and bases to avoid potential chemical reactions. Label the storage container clearly with relevant safety information.
Shipping	4 - bromo - 3 - fluorobenzeneacetonitrile is shipped in well - sealed containers, following strict hazardous chemical regulations. It's transported by approved carriers, ensuring proper handling to prevent leakage and maintain safety during transit.

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General Information

Historical Development

4 - Bromo - 3 - Fluorobenzeneacetonitrile is also an organic compound. Its origin was explored by beginners in the field of chemistry, with the aim of finding new substances to expand the boundaries of chemistry. In the past, the art of organic synthesis was not as refined as it is today, but many sages worked tirelessly.
Beginning with the exploration of the structural derivation of benzene, I gradually paid attention to this halogenated nitrile compound. Although early experiments were difficult and errors occurred frequently, they were all paving stones for the future. With the improvement of chemical technology, the synthesis methods became more and more refined, and the understanding of 4 - Bromo - 3 - Fluorobenzeneacetonitrile also deepened. From the initial glimpse of its properties to the ability to precisely control the synthesis, it has experienced countless trials and errors and improvements. Chemists have used their tenacity to make this compound clear from obscurity by the experimental bench and various instruments and drugs, and have laid a solid foundation for subsequent applications in medicine, materials and other fields.

Product Overview

4-Bromo-3-fluorophenylacetonitrile, Product Overview
4-bromo-3-fluorophenylacetonitrile is a crucial raw material in the field of organic synthesis. Its molecular structure is unique and contains key functional groups such as bromine, fluorine and cyanyl. Bromine atoms have good leaving properties and can efficiently construct carbon-heterobonds in nucleophilic substitution reactions; fluorine atoms are introduced, which significantly change the physical and chemical properties of molecules, such as enhancing lipophilicity and improving metabolic stability.
This product is widely used in the field of medicinal chemistry and can be used as a key intermediate for the synthesis of specific drug molecules. Due to its unique structural characteristics, it is helpful to design and synthesize drugs with high activity and high selectivity. In the field of materials science, or can participate in the preparation of functional materials, with its functional group characteristics to give novel properties to materials.
The preparation process usually involves multi-step organic synthesis reactions, and the reaction conditions need to be precisely controlled to ensure product purity and yield. During storage and transportation, it is also necessary to pay attention to its chemical properties, avoid contact with active substances, and ensure safety. In short, 4-bromo-3-fluorophenylacetonitrile plays a key role in many fields due to its unique structure and properties, and has broad prospects.

Physical & Chemical Properties

4 - Bromo - 3 - Fluorobenzeneacetonitrile, organic compounds are also. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is mostly solid, nearly white in color, crystalline, hard and brittle. The melting point is quite clear, about [specific melting point value], this temperature makes the state of matter change from solid to liquid, which is one of its characteristics. The boiling point is also a key physical property. Near [specific boiling point value], the liquid gradually changes to a gaseous state.
On its chemical properties, the bromine and fluorine atoms in the molecule make the compound have certain reactivity. Nitrile groups are also active and can participate in a variety of reactions. Such as nucleophilic substitution reactions, bromine atoms are easily replaced by nucleophiles to form new derivatives. In the field of organic synthesis, due to these physical and chemical properties, it has a wide range of uses and can be used as an intermediate to produce many high-value compounds through a series of reactions. It is of great significance in the pharmaceutical, materials and other industries.

Technical Specifications & Labeling

4 - Bromo - 3 - Fluorobenzeneacetonitrile is an important organic compound. Its preparation process specification is very critical, the selection of raw materials needs to be accurate, and the reaction conditions should be strictly controlled. In terms of reaction temperature, it should be maintained in a specific range to prevent side reactions from breeding. The reaction time also needs to be accurately controlled to ensure that the reaction is sufficient.
The identification of the product (commodity parameters) should not be underestimated. The appearance needs to be in a specific color state, the purity must reach a high standard, and the impurity content should be strictly limited. Whether its chemical properties are stable or not is related to the expansion of the application field. Accurate identification can enable users to clarify the characteristics of the product and apply it reasonably. In this way, the 4 - Bromo - 3 - Fluorobenzeneacetonitrile of high quality can be obtained to meet the needs of various fields.

Preparation Method

To prepare 4 - Bromo - 3 - Fluorobenzeneacetonitrile, the raw materials, production process, reaction steps and catalytic mechanism are the key. First, 3 - Fluorobenzeneacetonitrile is taken as the starting material, and an appropriate amount of brominating agent, such as liquid bromine or N - bromosuccinimide (NBS), is catalyzed by suitable catalysts such as iron powder or ferric tribromide, and reacted in aprotic solvents such as dichloromethane under temperature control. This is an electrophilic substitution reaction. The bromine ion is polarized by the catalyst to attack a specific position of the benzene ring. After the reaction is completed, it is purified by extraction, washing, drying, distillation and other steps. In addition, other compounds containing bromine and fluorine are also used as raw materials and synthesized by multi-step reaction, but the steps are complicated. We need to study the reaction conditions in detail and control the reaction process in order to achieve the purpose of efficient preparation of this compound.

Chemical Reactions & Modifications

The reaction and denaturation of 4 - Bromo - 3 - Fluorobenzeneacetonitrile. The reaction of this compound is related to many exquisite mechanisms. At the beginning, the control of its reaction conditions, such as temperature and solvent selection, are all key. The desired product can be obtained by initiating the reaction with a specific solvent at a suitable temperature.
However, during the reaction, there are side reactions from time to time, resulting in impure products. In order to obtain the best denaturation, we think about changing it. Improve the reaction path, or change the catalyst, hoping to increase the purity and yield of the product. After several tests, under the action of the new catalyst, the side reactions gradually decrease, and the quality and quantity of the product improve. This should be the study of transformation and transformation, just like the ancient treasure hunt, step by step to find the path, and finally get the method of optimization, paving the way for the subsequent production and use of this thing.

Synonyms & Product Names

4 - Bromo - 3 - Fluorobenzeneacetonitrile is an important chemical compound in the field of chemistry. Its synonyms and trade names are very important in the industry. In the past literature records, such compounds may have different names. Although the years have passed, their core characteristics have not changed.
For this compound, the synonyms may vary depending on the research perspective and synthesis path. Different regions and different research groups have different naming habits. The birth of trade names is often based on marketing activities and product characteristics.
Chemical investigations in the past are mostly remembered in classical Chinese. At that time, although the description of this compound was simple, the accuracy was not inferior. Today, although the scientific expression is more straightforward and clear, it is also possible to look back on the classical records of the past to gain insight into the evolution of its research context. For example, "4-bromo-3-fluorophenylacetonitrile", the modern common name, in the ancient classical language, may have a more ancient title, but they all refer to the same compound, which is of great significance to the inheritance and development of chemical research.

Safety & Operational Standards

4 - Bromo - 3 - Fluorobenzeneacetonitrile Safety and Operating Specifications
4 - Bromo - 3 - Fluorobenzeneacetonitrile, the product of transformation. It is related to its safety and operating specifications and cannot be ignored.
This thing is strong and harmful. Touch it, or hurt the skin, causing redness, swelling and pain; smell it, pungent nose and throat, harming and breathing. Therefore, when handling, protective gear is necessary. Wear protective robes to avoid staining the body; wear protective covers on the hands to avoid touching the skin; cover the face with protective gear to protect the eyes and nose. When
is stored, it is advisable to choose a cool and dry place to avoid fire and heat. Separate from other things to prevent their reaction from changing. The reservoir must be solid and dense to prevent its escape.
As for the operation, it must be done in a well-ventilated place. Do not let dust rise in the air to prevent the harm of inhalation. Do it slowly and carefully to avoid spillage. If there is a sprinkle, clear it quickly. First use a moisture-absorbing thing to collect it, and then discard it in a special device and dispose of it according to regulations.
If you accidentally touch the body, rinse it with water quickly, and rinse it for a long time, and then seek medical treatment. If it enters the eye, you must wash it with water urgently, not slowly, and you must also seek medical treatment.
In short, although 4 - Bromo - 3 - Fluorobenzeneacetonitrile is required for chemical research, it is risky and must comply with safety and operation regulations to keep you safe and smooth.

Application Area

Today there is a thing called 4 - Bromo - 3 - Fluorobenzeneacetonitrile. It has extraordinary uses in many fields.
In the process of medical development, this compound can be used as a key intermediate. When doctors want to make special drugs, they often rely on its unique structure to build a delicate molecular structure and heal diseases. By chemists' ingenious deployment, it can be cleverly combined with other things to breed a powerful "weapon" against diseases.
In the field of material exploration, it also has a place. It may improve material properties, such as enhancing its stability and flexibility, making the material suitable for a variety of environments, adding bricks and mortar to industrial production and daily applications.
Furthermore, in the field of agricultural protection, it may become the cornerstone of the creation of new pesticides. Helping farmers protect crops, resist disease and insect invasion, ensure abundant crops, and maintain people's livelihood. Its wide application and great potential are really treasures in the field of chemistry. It will be further studied by our generation to explore more possibilities.

Research & Development

4-Bromo-3-fluorophenylacetonitrile is a valuable compound in the field of organic synthesis. My research on this product has been going on for several years. At the beginning, I focused on its synthesis path and tried various methods to improve the yield and purity.
The synthesis of this compound in the past has many disadvantages due to complicated steps and harsh conditions. After repeated experiments, I optimized the reaction conditions and used a new catalyst to make the reaction more efficient and gentle. This improvement greatly reduces production costs and improves product quality.
Looking to the future, 4-bromo-3-fluorophenylacetonitrile is expected to show its skills in the fields of medicine, materials and so on. I will continue to explore its new applications, expand its application boundaries, and contribute to scientific progress and industrial development.

Toxicity Research

The chemical industry is related to people's livelihood, but the study of poisons should not be careless. Today there are 4 - Bromo - 3 - Fluorobenzeneacetonitrile this substance, which is quite important in the study of toxicity.
Observe its physical properties, containing bromine, fluorine and other atoms, and have a unique structure. Such organic nitriles are often toxic. Or they can be exposed to the body through respiration or skin, disturbing the biochemical balance of the human body.
The test of toxicity should be done in a rigorous manner. Observe its damage to cells and observe its symptoms in animal bodies. If the dose is slightly increased, it may cause damage to the organs and the nerves.
Therefore, to study the toxicity of this substance, it is necessary to follow the ancient teachings, be cautious, protect the safety of the experimenter, and avoid disasters for the world, so that chemical products are beneficial but harmless, which is the best.

Future Prospects

Husband 4 - Bromo - 3 - Fluorobenzeneacetonitrile, the thing of transformation is also. We study it, hoping that it will not have extraordinary development.
This thing is now, its nature is low, or it can be used for the opposite of general transformation, and other things. It is expected that it will be difficult, in the field of, or it can help research special effects, in order to solve the problem; in the world of materials, or it can create novel materials, in order to solve the need.
There may be a way forward, but we who study it must move forward. With the method of science, study this 4 - Bromo - 3 - Fluorobenzeneacetonitrile, explore its secrets, and seek its essence. When the time has not yet come, it can be used by the world to make great efforts and create blessings. The things that make this kind of thing, in the midst of the generation, will shine with light and help the world to move forward.

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Frequently Asked Questions

As a leading 4-Bromo-3-Fluorobenzeneacetonitrile supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 4-Bromo-3-Fluorobenzeneacetonitrile?

4-Bromo-3-fluorophenylacetonitrile is one of the organic compounds. It has a halogen atom and a cyanyl group, which give it unique chemical properties.
Looking at its halogen atom, bromine and fluorine are both active. Fluorine atoms have extremely high electronegativity, which can cause changes in the density distribution of molecular electron clouds and affect the reactivity. When encountering nucleophiles, fluorine is located in the aromatic ring, or due to electronic effects, it attracts nucleophiles to attack. And its small atomic radius, or in terms of steric resistance, has an impact on the reaction process. Although bromine atoms are less electronegative than fluorine, they are of great significance in many reactions as a good leaving group. During the nucleophilic substitution reaction, bromine ions are easy to leave, paving the way for the entry of new groups.
As for the cyanyl group, it has strong electron-absorbing properties, which can reduce the electron cloud density of the carbon atoms connected to it. This greatly increases the polarity of the molecule, which in turn affects its physical and chemical properties. Cyanyl groups can participate in various reactions, such as hydrolysis. Under suitable conditions, cyanyl groups can be hydrolyzed to obtain carboxylic groups, from which a series of carboxylic acid compounds can be derived. Or nucleophilic addition reactions occur with nucleophilic reagents to enrich the structure of compounds.
The chemical properties of 4-bromo-3-fluorophenylacetonitrile are synergistically shaped by bromine In the field of organic synthesis, with this characteristic, a variety of complex organic molecular structures can be constructed, and the application prospect is quite broad.

What are 4-Bromo-3-Fluorobenzeneacetonitrile synthesis methods?

The synthesis of 4-bromo-3-fluorophenylacetonitrile is an important topic in the field of organic synthesis. In the past, there are various synthesis methods, so let me tell you one by one.
First, 4-bromo-3-fluorobenzoic acid is used as the starting material. First, the acid is heated with thionyl chloride to convert the carboxyl group into an acid chloride. This reaction needs to be controlled by temperature to prevent side reactions. After the acid chloride is formed, it reacts with cuprous cyanide in a suitable solvent, such as N, N-dimethylformamide (DMF), and is replaced by nucleophilic substitution, and the acid chloride group is replaced by cyanyl group, so 4-bromo-3-fluorophenylacetonitrile is obtained. Although this route has clear steps, the toxicity of cuprous cyanide is quite large, and the operation must be cautious and the reaction conditions are strict.
Second, 4-bromo-3-fluorobrobenzyl is used as the raw material. This bromobenzyl can react with magnesium metal to make Grignard reagent in anhydrous ether. Grignard's reagent is very active, and then reacts with cyanyl sources, such as potassium cyanide or sodium cyanide aqueous solution, through nucleophilic addition, to obtain the target product. However, when Grignard's reagent is prepared, it has extremely high requirements for anhydrous and anaerobic environment, and the reaction fails if it is not careful.
Third, 4-bromo-3-fluorobenzaldehyde is used as the starting material. First, it is condensed with malononitrile in the presence of an alkaline catalyst such as piperidine to form an unsaturated nitrile intermediate. Subsequently, the intermediate is catalytically hydrogenated to obtain 4-bromo-3-fluorobenzaldehyde acetonitrile. This route is a bit complicated, but the raw materials are relatively easy to obtain, and the reaction conditions are relatively mild, which may have certain advantages in industrial production.
All synthesis methods have their own advantages and disadvantages, and the selection should be weighed according to the availability of raw materials, reaction conditions, cost and safety.

What are the main uses of 4-Bromo-3-Fluorobenzeneacetonitrile?

4-Bromo-3-fluorophenylacetonitrile has a wide range of uses. It plays a key role in the field of pharmaceutical synthesis. In the process of many drug development, 4-bromo-3-fluorophenylacetonitrile is often used as the starting material. Through various chemical reactions, such as nucleophilic substitution, cyclization and other reaction steps, intermediates with unique structures can be prepared, and then drugs with specific pharmacological activities can be synthesized.
In the creation of pesticides, 4-bromo-3-fluorophenylacetonitrile also has important uses. Because of its specific chemical structure and activity, compounds with high insecticidal, bactericidal or herbicidal properties can be derived. Through chemical modification and structural optimization, new pesticide products with environmental friendliness, high efficiency and low toxicity can be developed.
Furthermore, in the field of materials science, 4-bromo-3-fluorophenylacetonitrile can participate in the synthesis of functional materials. By rationally designing the reaction path, introducing it into the polymer or other material system, endowing the material with special properties such as fluorescence and electrical conductivity, providing a new way for the research and development of new functional materials. In addition, in the basic research of organic synthetic chemistry, 4-bromo-3-fluorophenylacetonitrile is often used as a model compound to explore new reaction mechanisms, develop new catalysts or optimize reaction conditions, and promote the continuous development and progress of organic synthetic chemistry.

4-Bromo-3-Fluorobenzeneacetonitrile need to pay attention to when storing

4-Bromo-3-fluorophenylacetonitrile is an important intermediate in organic synthesis. When storing, many aspects need to be paid attention to.
Choose the first environment. It should be placed in a cool, dry and well-ventilated place. If it is in a high temperature environment, 4-bromo-3-fluorophenylacetonitrile may cause chemical instability due to excessive temperature, which will cause adverse reactions such as decomposition. Humid environment is also not suitable, because it may interact with water vapor and affect quality.
The second point is the importance of packaging. Use a packaging container with excellent sealing performance to prevent excessive contact with air. The purity and quality of 4-bromo-3-fluorophenylacetonitrile are damaged due to the oxidation of oxygen, carbon dioxide and other components in the air, or with 4-bromo-3-fluorophenylacetonitrile.
Furthermore, it is key to keep away from fire and heat sources. 4-bromo-3-fluorophenylacetonitrile is flammable or unstable in case of heat. It is close to fire and heat sources. If there is a little carelessness, it will cause fire or explosion, endangering the safety of personnel and facilities.
In addition, it must be stored separately from oxidants, acids, bases and other substances. 4-Bromo-3-fluorophenylacetonitrile is chemically active, and when mixed with these substances, it is easy to cause chemical reactions, or cause combustion, explosion, or the formation of harmful products.
The storage period should not be ignored. Its status and quality should be checked regularly, and it should be used according to the specified period. After the storage period, 4-bromo-3-fluorophenylacetonitrile may deteriorate, which will affect the use effect.
Handle with care when handling to avoid damage to the packaging container. If the packaging is damaged, the leakage of 4-bromo-3-fluorophenylacetonitrile will not only waste, but also pollute the environment and endanger the health of personnel.

What is the market price of 4-Bromo-3-Fluorobenzeneacetonitrile?

4-Bromo-3-fluorophenylacetonitrile is also an organic compound. Its market price often varies due to changes in time, place, quality and supply and demand.
In the past, in the chemical industry, its price was influenced by multiple factors. The price of raw materials is the first and foremost. If the raw materials for preparing this compound are difficult to obtain and the amount of output varies, it will affect the cost of 4-bromo-3-fluorophenylacetonitrile, and then the price. If the relevant raw materials of bromine and fluorine are in short supply, their price will rise, and the price of this compound will also rise.
The simplicity of the process is also the key. If the preparation method is complicated, requires many steps, expensive equipment and exquisite skills, and consumes huge manpower, material resources and financial resources, the price will be high. On the contrary, if the process is simple and efficient, and the cost is controlled, the price may decrease.
Market supply and demand is more important. If many industries, such as medicine, pesticide manufacturing, etc., have strong demand for 4-bromo-3-fluorobenzene acetonitrile, but the supply is limited, the price will soar; if the supply exceeds the demand, merchants will sell their goods or reduce the price to sell.
Looking at the past state of the chemical market, the price fluctuates between tens of yuan and hundreds of yuan per kilogram. However, this is only an approximation, and the actual price should be studied in detail according to the real-time situation. In different places, the price varies due to the difference in transportation costs and taxes. In prosperous cities, the demand is large and the supply is convenient, and the price may be slightly flat; in remote places, the transportation is difficult and the cost is high, and the price may be slightly higher. Therefore, if you want to know the exact price, you should study the market carefully and consult all suppliers and industry players to obtain an accurate number.