4-Bromo-2-(Trifluoromethoxy)Benzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code	716736
Chemical Formula	C7H3BrClF3O3S
Molecular Weight	337.51
Appearance	Typically a solid
Solubility In Water	Low, as it contains non - polar benzene ring and hydrophobic groups
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Reactivity	Reactive due to the presence of sulfonyl chloride group (reacts with nucleophiles)
Stability	Stable under normal conditions, but reactive with certain reagents
Odor	Likely has a pungent odor due to the sulfonyl chloride group

As an accredited 4-Bromo-2-(Trifluoromethoxy)Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 4 - bromo - 2 - (trifluoromethoxy)benzenesulfonyl chloride in sealed chemical - grade vial.
Storage	4 - bromo - 2 - (trifluoromethoxy)benzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and incompatible substances such as strong bases, reducing agents. Store in a tightly sealed container to prevent moisture ingress, which could lead to hydrolysis. Ensure proper labeling for easy identification and to adhere to safety regulations.
Shipping	4 - bromo - 2 - (trifluoromethoxy)benzenesulfonyl chloride is a chemical. Ship it in well - sealed, corrosion - resistant containers. Follow proper hazardous material shipping regulations, ensuring secure packaging to prevent leaks during transit.

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4-Bromo-2-(Trifluoromethoxy)Benzenesulfonyl Chloride

General Information

Historical Development

4-Bromo-2- (Trifluoromethoxy) Benzenesulfonyl Chloride is a delicate chemical. In the past, at the beginning of chemical research, exploring such compounds was like searching for light in the dark night. At that time, the experimental conditions were crude, and the instruments were far from as accurate as they are today.
However, with perseverance and unremitting research, previous scholars gradually uncovered the mysteries of chemical substances. After repeated attempts, failures and improvements, they gradually gained an understanding of various reaction mechanisms.
With the passage of time and technological progress, the means to study this compound are increasingly abundant. From basic reaction exploration to precise synthesis path optimization, countless efforts have been poured into every step. Many chemists worked day and night in the laboratory, eventually bringing the preparation and application of 4-Bromo-2- (Trifluoromethoxy) Benzenesulfonyl Chloride to the current level, adding a strong touch to the development of the chemical field.

Product Overview

4-Bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride is a crucial compound in the field of organic synthesis. Its properties are white to white crystalline powder, with specific physical and chemical properties. The melting point is within a certain range, and it has its characteristics for the stability of heat and light.
This compound has a wide range of uses in organic synthesis. Often used as a sulfonylation reagent, it can react with many compounds containing active hydrogen, such as alcohols, amines, etc., to form corresponding sulfonamides or sulfonate derivatives. Through such reactions, diverse organic molecular structures can be constructed, which is of great significance in the fields of medicinal chemistry, materials science, etc.
Preparation of this compound usually requires a multi-step reaction, involving steps such as halogenation, etherification, and sulfonyl chlorination. Each step requires precise control of reaction conditions, such as temperature, ratio of reactants, and use of catalysts, to ensure the formation of high-yield and high-purity products.

Physical & Chemical Properties

4-Bromo-2- (Trifluoromethoxy) Benzenesulfonyl Chloride, which is an important intermediate in organic synthesis. Its physical properties are mostly solid at room temperature, white or off-white, with a specific melting point. Due to many special groups in the molecular structure, its melting point has a unique value. Its chemical properties are active, among which sulfonyl chloride groups are prone to nucleophilic substitution reactions, which can react with nucleophiles such as alcohols and amines to generate corresponding sulfonates and sulfonamides. And halogen bromine can also participate in various substitution reactions, expanding its application in organic synthesis. And because it contains trifluoromethoxy, it is endowed with certain chemical stability and special electronic effects, and has a wide range of uses in pharmaceutical chemistry, materials science and other fields.

Technical Specifications & Labeling

4-Bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride is a chemical we have been working on. Its process specifications and identification (product parameters) are crucial to the quality and use of this product.
Process specifications, starting from the selection of raw materials, must be carefully selected, and impurities must be removed to ensure the purity of the reaction. During the reaction, conditions such as temperature and pressure need to be precisely controlled, and a slight deviation may cause the product to be impure. If the reaction temperature should be constant in a certain range, the fluctuation should not exceed a millimeter.
In terms of identification (product parameters), the appearance should be a specific color state, with uniform color and no noise. The purity must be extremely high, and the impurity content is minimal. In addition, its physical and chemical properties parameters, such as melting point, boiling point, etc., also need to be accurately determined and recorded in detail for inspection. In this way, this product can be used in various fields and live up to our research.

Preparation Method

The preparation method of 4-bromo-2- (trifluoromethoxy) benzenesulfonyl chloride is related to the raw material and production process, reaction steps and catalytic mechanism.
To prepare this product, first take an appropriate amount of 4-bromo-2-hydroxyanisole as the initial raw material, and mix it with the trifluoromethoxylation reagent in a specific ratio in the reactor. The temperature is controlled in a suitable range, such as 50 to 80 degrees Celsius. This is because the temperature is too high or side reactions occur, and the reaction is slow if it is too low.
Then, the catalyst is slowly added, and the amount of catalyst needs to be precisely controlled. Most of them are expensive and may cause overreaction, and the catalytic effect is not good. Under the catalysis, the two start to react, and after several hours, the reaction process is closely monitored to ensure that the reaction is complete.
After the reaction is completed, the product is purified through various steps such as distillation and extraction. During distillation, the target product 4-bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride is extracted according to the difference in the boiling point of each substance. In this way, the product with higher purity can be obtained to meet the needs of all parties.

Chemical Reactions & Modifications

4-Bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride, the transformation and modification of this compound, is the key to our research. In the past, the preparation of this compound often had the difficulty of yield not meeting expectations and frequent side reactions.
To improve it, it is necessary to study the reaction conditions carefully. Temperature control is extremely important. In the past, due to temperature deviation, the reaction direction was inaccurate. If the temperature can be accurately adjusted, it may increase the main reaction rate and reduce the disturbance of side reactions.
Furthermore, the choice of catalyst cannot be ignored. Trying a new catalyst may change the activation energy of the reaction, optimize the reaction path, and improve the purity and yield of the product. After this change, the phase 4-bromo-2-trifluoromethoxy-benzenesulfonyl chloride can be significantly modified, paving the way for subsequent research and application.

Synonyms & Product Names

4-Bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride, the synonym and trade name of this substance, is very important for chemical research. The study of Guan Fugu is also true in the naming of the substance. This compound is a synonym or another name related to its structure and characteristics. The trade name is established for the convenience of circulation.
In the past, the scholars studied and studied the name of the substance in detail. Today, this chemical, the synonym can be named according to its chemical composition and reaction characteristics. The trade name may be easy to remember and unique, in order to distinguish it from others. Chemists study this substance to understand its synonyms and trade names, which can facilitate academic communication, facilitate the repetition of experiments, and the inheritance of results. Although ancient and modern events are special, they are in the same vein in the distinction between name and truth. Examining its synonyms and trade names in detail is really beneficial to the progress of chemical research.

Safety & Operational Standards

4-Bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride is an important substance in chemical research. Safety and operating standards are of paramount importance when using and studying this compound.
In terms of safety, this substance is dangerous. It may cause serious irritation to the skin, eyes and respiratory tract. Therefore, when operating, researchers must be fully armed, wearing protective clothing, tight protective gloves, and equipped with a protective eye mask to prevent inadvertent contact. If the skin is unfortunately exposed, rinse with plenty of water immediately, and then seek medical treatment. If it enters the eye, it needs to be rinsed with flowing water or normal saline immediately, and seek medical attention quickly.
The operating specifications should not be ignored. This compound should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent accidents. During the use process, be sure to operate in a fume hood to avoid the spread of its volatile gas in the laboratory. When weighing and transferring, the action should be gentle and precise, and beware of spilling. After use, the experimental equipment should be strictly cleaned to prevent subsequent pollution or danger caused by residual substances.
Furthermore, the disposal of its waste should also follow strict regulations. It should not be discarded at will, and it must be properly collected and disposed of in accordance with relevant environmental protection requirements to ensure environmental safety. Only in this way can the process of studying 4-bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride not only achieve the research purpose, but also ensure the safety of personnel and the environment.

Application Area

4-Bromo-2 - (trifluoromethoxy) benzenesulfonyl chloride is also a chemical substance. Its application field is quite wide. In the field of medicine, it can be used as a key intermediate to help synthesize special drugs and treat various diseases in the world. In the field of pesticides, it can be an active ingredient to make high-efficiency pesticides and protect crops from pests and diseases. And in material science, it also has its use, or it can optimize the properties of materials and make them have better characteristics. The application of this product in various fields is like a pearl in a box, waiting to be discovered by those who know it, so as to develop its capabilities and benefit the world.

Research & Development

Today, there is a product, named 4 - Bromo - 2 - (Trifluoromethoxy) Benzenesulfonyl Chloride. We are chemists, study its characteristics, and seek its entry.
At first, investigate its structure in detail, explore the connection of atoms, and find out where the functional groups are. Use various instruments to analyze its spectrum and know its electronic state, which is the foundation for subsequent research.
Then, study the method of synthesis. Try various paths, choose the best and use it. Control the reaction conditions, such as temperature, pressure, and the ratio of agents, in order to obtain high-purity products. Although the process is difficult, we study it relentlessly, and gradually obtain exquisite methods.
And think about the use of this thing. In medicine, it is the key to creating new agents; in materials, it is unique. We make unremitting exploration, expecting it to shine in various fields, promote the progress of science and technology, and use it for the world, becoming the grand cause of our scientific research.

Toxicity Research

The name of the substance is 4 - Bromo - 2 - (Trifluoromethoxy) Benzenesulfonyl Chloride. In the matter of our generation's chemical research, the study of its toxicity is of paramount importance. In the past, all kinds of chemical materials were reviewed in detail. This substance may also be potentially harmful and affect the body of living beings.
Observe the test of all kinds of poisons in the past, and observe them from a subtle place. To understand the toxicity of this substance, test it on all kinds of organisms, observe their reactions, and observe their changes. If you take mice as an experiment, observe how they behave and viscera function after eating this substance. Or observe its effect on plant growth, observe whether it is in the soil and hinders the germination and growth of seedlings.
Furthermore, study the changes in the environment, whether it is easy to decompose, and what is the nature of the decomposed substance. In this way, after careful investigation, we can obtain the true appearance of its toxicity, so that when the world uses this substance, we should be cautious to avoid disasters.

Future Prospects

Today there is a product named 4 - Bromo - 2 - (Trifluoromethoxy) Benzenesulfonyl Chloride. I look at this compound, its unique nature and extraordinary potential. In the future development, it is expected to emerge in the field of medicine. It may become a key raw material for the development of new special drugs to solve the suffering of many patients. Or make achievements in materials science, providing an opportunity for the creation of novel high-performance materials. With time, through in-depth research and unremitting exploration, we will be able to tap its endless potential, bring well-being to the world, achieve an extraordinary career, and develop the grand vision of the future. Live up to the pursuit of scientific research of our generation.

Where to Buy 4-Bromo-2-(Trifluoromethoxy)Benzenesulfonyl Chloride in China?

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Frequently Asked Questions

As a leading 4-Bromo-2-(Trifluoromethoxy)Benzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-bromo-2- (trifluoromethoxy) benzenesulfonyl chloride?

4-% -2- (triethoxy) benzoic acid, often acetylated hydrochloric acid, hydrochloric acid derivative. Its main uses are as follows:
The way to relieve pain, it can relieve pain, toothache, pain and other pain. This can inhibit the activity of oxidase (COX), reduce prostaglandin synthesis, and relieve pain. Such as on the bed, it is often used for the treatment of cold, and moderate pain.
In addition, in the cardiovascular field, it has the function of anti-platelet aggregation. It can prevent thrombosis and is commonly used to prevent myocardial infarction, stroke and other cardiovascular diseases. Platelet aggregation is a major cause of thrombosis, which can irreversibly inhibit platelet COX-1, oligothromboxane A 2O synthesis, and inhibit platelet aggregation, reducing cardiovascular events.
It is also slightly useful in work. It can be used as a raw material for the synthesis of certain oils, dyes and other refined chemicals. Because it contains an active group, it can be used to synthesize and reverse other useful compounds.

What are the synthesis methods of 4-bromo-2- (trifluoromethoxy) benzenesulfonyl chloride?

4-Bromo-2 - (trifluoromethoxy) benzaldehyde is an important intermediate in organic synthesis, and its synthesis method is as follows:
1. ** Phenols are used as starting materials **:
-phenol reacts with trifluoromethylation reagents to obtain trifluoromethoxybenzene, such as p-bromophenol reacts with trifluoromethyl halogenation reagents in suitable solvents, such as N, N-dimethylformamide (DMF), and bases, such as potassium carbonate, react to obtain 4-bromo-1 - (trifluoromethoxy) benzene. After Vilsmeier-Haack reaction, N, N-dimethylformamide and phosphorus oxychloride are used as reagents. Under heating conditions, formyl groups can be introduced into the benzene ring to obtain 4-bromo-2 - (trifluoromethoxy) benzaldehyde. This process requires attention to the control of reaction conditions, such as temperature and reagent ratio, to improve the yield and selectivity.
2. ** Nucleophilic Substitution of Halogenated Aromatics **:
- With bromobenzaldehyde-containing derivatives as raw materials, it reacts with trifluoromethoxylation reagents. For example, 2-bromo-4-formyl anisole and trifluoromethyl reagent under the action of suitable solvent and catalyst, nucleophilic substitution reaction, methoxy is replaced with trifluoromethoxy, and the target product is obtained. Among these, the selection of high-efficiency catalysts and suitable reaction solvents is critical to the success of the reaction, which can improve the reaction rate and product purity.
3. ** Transition metal-catalyzed coupling reaction **:
- If 4-bromo-2-halobenzaldehyde is used with trifluoromethoxy reagent, the coupling reaction occurs in the presence of transition metal catalysts, such as palladium catalysts, ligands and bases. This method has mild conditions and high selectivity, and can effectively synthesize 4-bromo-2- (trifluoromethoxy) benzaldehyde. However, attention should be paid to the cost of catalyst and recycling to reduce production costs.

What are the physical properties of 4-bromo-2- (trifluoromethoxy) benzenesulfonyl chloride?

4-Diethoxy-benzaldehyde, which is a white to pale crystalline powder. Its melting temperature is between 128 and 132 ° C. At this temperature, it solidifies other fluids. This property is very important for the preparation, determination, and reaction of certain specific substances.
Its solubility is very special, and it can be soluble in common solvents, such as ethanol and acetone. Ethanol can disperse 4-diethoxy-2 (triethoxy) benzaldehyde by interacting with it. The carbonyl group of acetone can also form a weak interaction to promote dissolution. However, it is insoluble in water, and due to the poor performance of water, the non-toxic part of 4-1-2- (triacetoxy) benzaldehyde is too large, so that the interaction between water and water is not enough to overcome the force of its own molecules, so it dissolves.
Its low performance, under normal conditions, the molecular force is low, and the molecule can escape the liquid phase and enter the liquid phase to obtain sufficient energy. This property allows it to maintain the existence form of the phase in the normal environment, which is not easy to be lost due to loss, and is especially advantageous for the use of survival and maintaining its physical quantity during certain periods of time.
In addition, its qualitative performance is good. Under normal storage conditions, if unfavorable factors such as light, high temperature and moisture are avoided, its chemical performance can be determined. In case of acid and environmental conditions, its chemical properties may be damaged due to reactions such as hydrolysis. In case of pollution, its group and acetoxy group or will generate reactions, resulting in its transformation.

What are the storage conditions for 4-bromo-2- (trifluoromethoxy) benzenesulfonyl chloride?

4-% hydrazine-2- (triethylamino) quinoxaline borane solution should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. This liquid is flammable, and it is easy to burn in case of open flames and hot topics. Therefore, the storage environment temperature should be strictly controlled. Generally, it should be kept below 20 ° C. The humidity should not be too high, and 40% -60% is appropriate.
Because of its chemical activity, it needs to be stored separately from oxidizing agents and acids, and mixed storage should not be avoided. The storage container must be made of corrosion-resistant material with good sealing to prevent leakage. At the same time, the storage area should be equipped with suitable containment materials so that it can be dealt with in time in the event of leakage to avoid causing greater harm. During handling, it should be handled lightly to prevent damage to packaging and containers.
Lightning protection equipment should also be installed in the warehouse to deal with lightning weather and avoid safety accidents caused by lightning strikes. In addition, special personnel should be arranged to regularly inspect the storage environment and containers to check whether there are abnormal temperatures and humidity, as well as whether the containers are leaking or corroded. If any problems are found, they need to be dealt with in time to ensure the safe storage of 4-% hydrazine-2- (triethylamino) quinoxaline borane solution.

What is the market price of 4-bromo-2- (trifluoromethoxy) benzenesulfonyl chloride?

4-Hydroxy-2- (trifluoromethoxy) benzaldehyde is an important fine chemical in the chemical industry and is widely used in medicine, pesticides, materials and other industries. Its market price often fluctuates due to factors such as quality, purity, supply and demand, and production process.
In terms of quality and purity, high-purity 4-hydroxy-2- (trifluoromethoxy) benzaldehyde is more popular in high-end medicine and electronic material manufacturing and other fields with strict purity requirements, and the price is relatively high. If the purity can reach more than 99%, the price per kilogram may reach several thousand yuan; while if the purity is slightly lower, such as about 95%, the price may be greatly reduced, or only a few hundred yuan per kilogram.
The supply and demand situation also has a huge impact on its price. If the market demand is strong, such as the development of new drugs by pharmaceutical companies, and the production and supply fail to keep up in time, the price is bound to rise; on the contrary, if the market demand is weak and the supply is excessive, the price will fall.
The production process also affects the price. Advanced and efficient production processes can reduce production costs and enhance product competitiveness. Some of the innovative synthetic routes can reduce raw material consumption and improve yield, and the product price may be more advantageous. If the cost of traditional processes is higher, the product price will also be affected by them and higher.
According to market observations, the current market price of 4-hydroxy- 2- (trifluoromethoxy) benzaldehyde is 500-1000 yuan per kilogram for ordinary industrial grade, with a purity of 95% -97%; for pharmaceutical grade and a purity of more than 99%, the price per kilogram may be 2000-5000 yuan. However, the market situation changes, and prices are also jumping up and down. Industry players need to pay attention to market dynamics in real time in order to grasp price trends.