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4-Bromo-2-Fluorobenzenethiol

4-Bromo-2-Fluorobenzenethiol

Hongda Chemical

Specifications

HS Code

902476

Chemical Formula C6H4BrFS
Molar Mass 207.06 g/mol
Appearance Typically a liquid (but appearance can vary based on purity and conditions)
Solubility In Water Low solubility in water (due to non - polar benzene ring and hydrophobic - like groups)
Solubility In Organic Solvents Soluble in common organic solvents such as dichloromethane, chloroform, etc. (due to its organic nature)

As an accredited 4-Bromo-2-Fluorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - bromo - 2 - fluorobenzenethiol packaged in a sealed chemical - grade bottle.
Storage 4 - bromo - 2 - fluorobenzenethiol should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of a material resistant to corrosion. Since it may be reactive and potentially harmful, store it separately from oxidizing agents and incompatible substances to prevent dangerous reactions.
Shipping 4 - bromo - 2 - fluorobenzenethiol is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring proper labeling and secure packaging to prevent leaks during transit.
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4-Bromo-2-Fluorobenzenethiol 4-Bromo-2-Fluorobenzenethiol
General Information
Historical Development
The industry of chemical industry is changing with each passing day, and new things are emerging one after another. 4 - Bromo - 2 - Fluorobenzenethiol This product, its origin is also the result of careful exploration by wise men when they are pursuing chemical research.
At the beginning, the researchers in the sequence and workshop, thinking hard, and using chemical methods, wanted to make this novel thing. After several years, repeated trials, or due to differences in raw materials, or changes in techniques, the results were not obvious.
However, the public was not discouraged, and continued to persevere, observing changes in the slightest, adjusting the square and reforming it. Finally, it was achieved, and this 4 - Bromo - 2 - Fluorobenzenethiol was obtained. Its birth was not achieved overnight, but was actually the work of time and the gathering of all sages. Since then, it has emerged in various fields of chemical industry, opened a new chapter, and laid the foundation for future generations to study the road, paving the stone, waiting for those who come to explore it and increase its use.
Product Overview
4 - Bromo - 2 - Fluorobenzenethiol is also an organic compound. In its molecular structure, above the benzene ring, the bromine atom and the fluorine atom are separated into two and four positions, and there are thiol groups attached. This substance has unique properties. It may be liquid at room temperature and has a special odor.
It is widely used in the field of organic synthesis. It can be used as a key intermediate to introduce specific functional groups through many reactions to build complex organic structures. For example, in nucleophilic substitution reactions, the sulfur atom of the thiol group is nucleophilic and can react with substrates such as halogenated hydrocarbons to achieve the construction of carbon-sulfur bonds, providing an effective path for the synthesis of sulfur-containing organic compounds.
Because its structure contains halogen atoms, it can participate in a series of reactions of halogenated aromatics and expand the diversity of compounds. It has potential application value in materials science, medicinal chemistry and other fields, and is expected to provide key building blocks for new drug development and functional material creation.
Physical & Chemical Properties
4 - Bromo - 2 - Fluorobenzenethiol is an organic compound whose physicochemical properties are of great importance. Looking at its physical properties, at room temperature, this substance may be in a liquid state with a special odor due to sulfur atoms. Its boiling point may be in a specific range due to intermolecular forces, or it may evaporate at a certain temperature range. Its density also has unique values, depending on the molecular structure and atomic mass.
On chemical properties, because it contains halogen atoms such as bromine and fluorine, it has high chemical activity. Bromine atoms can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, bromine atoms may be replaced to form new compounds. Fluorine atoms have strong electronegativity, which affects the distribution of molecular electron clouds, changes the density of benzene ring electron clouds, and affects its electrophilic substitution reactivity. Sulfur-containing thiol groups are reductive and can participate in redox reactions, and react with oxidants to form corresponding oxidation products.
Technical Specifications & Labeling
Today there is a product, name 4 - Bromo - 2 - Fluorobenzenethiol. Its technical specifications and identification (product parameters) are the requirements of our research.
In terms of technical specifications, the synthesis method must be accurate. The choice of materials must comply with the regulations of high quality, and the temperature and time of the reaction are fixed. For example, the ratio of starting materials is related to the purity and quantity of the product. The reaction equipment must also be clean and appropriate to avoid defilements.
In terms of identification (product parameters), the appearance of color and state should be clear, such as pure color and uniform state. The standard of purity must reach the value of accuracy, and the amount of impurities must be strictly controlled at the lower limit. Its physical properties, such as melting and boiling points, are the weight of the logo, and accurate measurement is required to prove the quality. In this way, this product can be used in various applications to show its full potential and be valued by the industry.
Preparation Method
To prepare 4 - Bromo - 2 - Fluorobenzenethiol, the raw materials, production process, reaction steps and catalytic mechanism are as follows. First, take an appropriate amount of 2 - fluorobenzene as the starting material, add an appropriate amount of potassium thioacetate to a specific reactor, use potassium carbonate as the acid binding agent, and use N, N - dimethylformamide (DMF) as the solvent, control the temperature at about 80 ° C, and continue to stir the reaction for about 6 hours. This step of the reaction is a process of nucleophilic substitution. The thioacetate ion nucleophilic attacks the benzene ring carbon of 2 - fluorobenzene, causing the bromine ion to leave. After the reaction is completed, it is cooled to room temperature, extracted with ethyl acetate, and the organic phase is washed with saturated saline. After drying with anhydrous sodium sulfate, the intermediate 2-fluorobenzenthioacetate is distilled under reduced pressure.
Then, the intermediate is dissolved in an appropriate amount of ethanol, an appropriate amount of aqueous sodium hydroxide is added, and the temperature is raised to 60 ° C. The reaction is stirred for about 4 hours. In this step, the ester bond is broken under alkaline conditions to form the sodium salt of the target product 4-Bromo-2-Fluorobenzenethiol. After the reaction is completed, it is acidified with dilute hydrochloric acid, and then extracted with dichloromethane. The organic phase is dried and distilled to obtain pure 4-Bromo-2-Fluorobenzenethiol. Throughout the process, the reaction conditions are mild, the yield is acceptable, and each step is easy to operate and control.
Chemical Reactions & Modifications
The beauty of chemistry lies in seeking new qualities in response to changes. Today there is 4 - Bromo - 2 - Fluorobenzenethiol, and its chemical response and change can be quite studied.
Looking at its response, the method of the past may have complicated disadvantages. The reaction conditions are harsh, the material consumption is quite high, and the yield is not high. However, today is different from the past. The research of many virtuous people focuses on the method of catalysis. The emergence of new catalysts makes the reaction mild and easy. Those who needed high temperature and strong pressure in the past can also do it at room temperature and pressure today.
As for the change of its properties, chemists use subtle thinking to change its structure. Adding and subtracting groups, adjusting the density of its electron cloud, so that this substance is beneficial in terms of solubility and stability. This is the work of chemists' unremitting research, so that the chemistry is new and new, so as to benefit the world.
Synonyms & Product Names
In today's world, there is a name 4 - Bromo - 2 - Fluorobenzenethiol. This substance is quite important in the chemical industry, but its name is complex, and people often seek its synonymous name and trade name for simplicity.
The synonymous name is established by the academic community or industry for the convenience of communication and memory in long-term study and practice. As for the trade name, it is mostly determined by the manufacturer according to the needs of marketing and promotion, and its name may be easier to remember or highlight its characteristics.
4 - Bromo - 2 - Fluorobenzenethiol, or has a synonymous name such as "2 - fluoro - 4 - bromothiophenol", which is called according to the order of its chemical structural elements. Compared with the original English name, it is more in line with the habits of Chinese chemistry learners. The product names, or vary depending on the manufacturer, are named after their unique uses, and are named after brand associations, hoping to show their characteristics in the market and be recognized by customers. In this way, although the synonyms and product names are different, they both refer to this important chemical substance, which has its own uses in industry exchanges and business exchanges.
Safety & Operational Standards
4 - Bromo - 2 - Fluorobenzenethiol is a chemical substance, and its safety and operating practices need to be explained in detail.
When preparing and using this substance, safety is the first priority. It may be toxic and irritating, so the operation should be carried out in a well-ventilated place, preferably in a fume hood to prevent the accumulation of harmful gases and endanger the human body. Operators must wear appropriate protective equipment, such as protective gloves, goggles and lab clothes, to avoid contact with skin and eyes. In case of accidental contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
In terms of operating specifications, the use of this substance should be precise, and the amount required for the experiment should be carefully measured to prevent waste and excessive danger. Its storage should also not be ignored. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants, to prevent violent reactions. After use, the remaining substances must not be discarded at will, and must be properly disposed of in accordance with relevant regulations to prevent environmental pollution.
When using 4-Bromo-2-Fluorobenzenethiol in a chemical reaction, the reaction conditions, such as temperature, pH, etc., should be strictly controlled. Operate according to the established experimental process, pay close attention to the reaction process, and take corresponding measures immediately if there is any abnormality. In this way, the safety of the operation process can be ensured and the experiment can be carried out smoothly.
Application Area
Today there is a product called 4 - Bromo - 2 - Fluorobenzenethiol. This substance has a wide range of application fields. In the field of pharmaceutical research and development, it can be a key raw material to help synthesize special drugs to treat various diseases and save patients from pain. In the field of materials science, it is also very useful, which can optimize material properties, make materials have better properties, or increase their stability, or enhance their electrical and thermal conductivity. Furthermore, in the fine chemical industry, it can be used as an additive to make chemical products of better quality and wider use. The important performance of 4 - Bromo - 2 - Fluorobenzenethiol in the application field is an indispensable substance, which is a key driving force for the development of many industries.
Research & Development
In recent years, in the field of chemistry, I have specialized in the study of 4 - Bromo - 2 - Fluorobenzenethiol. Its unique properties, in various reactions, show a different effect, quite interesting for my research.
At the beginning, analyze its structure, explore the wonderful arrangement of atoms, and explain the principle of chemical bonding. Also check its physical properties, such as the melting point and the energy of dissolution, to lay the foundation for subsequent experiments.
When experimenting, try different methods to make it. Or adjust the temperature of the reaction, or change the amount of reagents, or choose more solvents. After repeated attempts, the yield is gradually increased, and the quality is also good.
And consider its application in organic synthesis. By participating in the coupling reaction, it can establish novel carbon-sulfur bonds and expand the types of compounds. In materials science, it also has potential applications, which can endow material specificity.
I believe that with time and in-depth research, 4 - Bromo - 2 - Fluorobenzenethiol will be used in chemical, pharmaceutical and other fields to develop its talents and achieve wider development.
Toxicity Research
I am committed to the toxicity study of 4 - Bromo - 2 - Fluorobenzenethiol. It is gradually emerging in the chemical industry, but the investigation of toxicity should not be ignored.
At the beginning, various experiments were used to investigate its effects on organisms. Take mice as samples and feed them with food containing this substance. Soon, the behavior of the mice was different from usual, or manic or depressed, and the hair lost its luster. Then try it with plants, add an appropriate amount of this substance to the cultivation soil, the plant growth was sluggish, and the leaves gradually wilted.
From this point of view, 4 - Bromo - 2 - Fluorobenzenethiol is quite toxic. This toxicity is harmful to the physiological function and growth and development of organisms. During industrial production and use, it is necessary to strictly abide by the procedures and take comprehensive protection to avoid its toxicity endangering life and causing harm to the environment. It is necessary to be cautious in order to ensure the safety of people and all things.
Future Prospects
Today there is a thing called 4 - Bromo - 2 - Fluorobenzenethiol, which I have studied in the field of chemistry. Looking at this substance, its characteristics are unique and it contains endless potential.
Looking forward to the future, I hope to be able to explore its properties in depth. Or we can explore its unique curative effect on the road of medicine, and use its delicate structure to develop new medicines, cure various diseases, and solve the suffering of the world. Or in the world of materials, open up a new world, and use it as a basis to create exotic materials, which can be applied to high-tech and lead the trend of the times.
I am convinced that with time and unremitting research, this 4 - Bromo - 2 - Fluorobenzenethiol will bloom brightly, contribute to the progress of mankind, and draw a grand blueprint for the future.
Where to Buy 4-Bromo-2-Fluorobenzenethiol in China?
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Frequently Asked Questions

As a leading 4-Bromo-2-Fluorobenzenethiol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Bromo-2-Fluorobenzenethiol?
4-Bromo-2-fluorothiophenol is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the creation of medicine, this compound is of great value. The special chemical properties of the thiophenol group and the halogen atom can participate in various chemical reactions to build a molecular structure with specific biological activities. In this way, new drugs may be developed for the treatment of diseases, such as the development of antibacterial and anti-cancer drugs. Because the specific structure can be precisely combined with the target in the organism, so as to achieve the therapeutic effect.
Second, in the field of materials science, 4-bromo-2-fluorothiophenol is also useful. It can be used to prepare materials with special properties through the reaction it participates in. For example, after polymerization with other monomers, polymer materials with unique electrical and optical properties can be generated for the manufacture of electronic devices and optical components, such as organic Light Emitting Diodes (OLEDs), sensors, etc., to improve the performance of related devices.
Furthermore, it can also be seen in the synthesis of pesticides. Its chemical structure can endow pesticides with specific biological activities, such as insecticidal and weeding effects. Through rational design and modification, new pesticides with high efficiency, low toxicity and environmental friendliness may be created to meet the needs of agricultural production.
In short, 4-bromo-2-fluorothiophenol has shown important application potential in many fields such as medicine, materials, and pesticides due to its unique chemical structure, providing a key material basis and synthetic raw material for the development of various fields.
What are the physical properties of 4-Bromo-2-Fluorobenzenethiol?
4-Bromo-2-fluorothiophenol, is one of the organic compounds. It has the following physical properties:
In terms of normal conditions, it is a colorless to light yellow liquid with a clear texture and is easy to identify visually. This color state characteristic can provide an intuitive basis for preliminary judgment of the state of the substance in chemical production and experimental observation.
Smell, emits a special odor, although difficult to describe accurately, it is different from common odorless substances. This unique odor can be used as a way of sensory identification in actual operation, but because it may be irritating, it needs to be handled with caution.
When talking about the boiling point, it is about a specific temperature range. As an important physical constant of a substance, the boiling point is of great significance when separating and purifying the compound. By controlling the temperature to reach its boiling point, the substance can be vaporized and separated from the mixture, and then pure 4-bromo-2-fluorothiophenol can be obtained.
Its melting point also has corresponding values. The melting point determines the critical temperature for the substance to change from solid to liquid. During storage and transportation, the ambient temperature needs to be controlled according to the melting point to prevent accidental changes in the state of the substance, which affects its quality and performance.
In terms of solubility, 4-bromo-2-fluorothiophenol exhibits a certain solubility in organic solvents such as ethanol and ether. This property is extremely critical in organic synthesis reactions, enabling it to fully contact and mix with other reactants in suitable solvents, promoting the smooth progress of the reaction and improving the reaction efficiency and product purity.
Density is also one of the important physical properties. Its density value is helpful for the measurement and separation of substances in practical operation. For example, in the process of liquid-liquid separation, according to the density difference, the substance can be stratified with other liquids of different densities to achieve the purpose of separation.
In addition, 4-bromo-2-fluorophenylthiophenol has active chemical properties due to its thiophenol group, and is widely used in the field of organic synthesis. It can participate in many reactions and synthesize organic compounds with diverse structures. It plays a key role in many fields such as medicine, pesticides, and materials science.
4-Bromo-2-Fluorobenzenethiol chemical synthesis methods
4-Bromo-2-fluorobenzothiophenol is also an organic compound. The synthesis method is often obtained by starting with bromine and fluorine-containing benzene, supplemented by sulfur source, and after various reactions.
One method is to first take 4-bromo-2-fluorobromobenzene as a substrate and combine it with metal reagents, such as magnesium powder, in anhydrous ether and other inert solvents to form 4-bromo-2-fluorophenyl magnesium bromide. Afterwards, carbon disulfide is introduced to produce 4-bromo-2-fluorophenyl dithiocarboxylate, and then acid-lyzed to obtain 4-bromo-2-fluorophenylthiophenol. In this way, the Grignard reaction needs to be anhydrous and oxygen-free to prevent side reactions.
There are also those who use 4-bromo-2-fluoronitrobenzene as the initial material. First, a reducing agent, such as iron and hydrochloric acid, is nitrogenated to an amino group to obtain 4-bromo-2-fluoroaniline. Then, after co-heating with thiocyanate, through a series of reactions such as diazotization and thiocyanation, the amino group is converted to thiocyanate, and finally the thiocyanate group is reduced by a method such as zinc powder and hydrochloric acid, so that the thiocyanate group is changed to a thiol group, and then 4-bromo-2-fluorothiophenol is obtained. There are many steps in this diameter, so the raw material is easy to obtain.
Another example is to start with 4-bromo-2-fluorophenol. First, the phenolic hydroxyl group is converted into a group that is easy to leave, such as p-toluenesulfonate. Then, it is reacted with sulfur sources such as sodium hydride in an appropriate solvent to replace the leaving group with thiohydrogen to obtain 4-bromo-2-fluorobenzene thiophenol. This method focuses on the activation of phenolic hydroxyl groups to make the reaction smooth.
Synthesis has advantages and disadvantages. Grignard reaction method is simple in steps, but harsh in conditions; nitrobenzene is used as the starting material, and the raw material is easy to obtain and proliferated in steps; the method of starting with phenol requires fine treatment of phenolic hydroxyl groups. When choosing the method, it is determined according to various factors such as the convenience of raw materials, equipment, and cost calculation.
4-Bromo-2-Fluorobenzenethiol What are the precautions in storage and transportation?
4-Bromo-2-fluorothiophenol is an organic compound. During storage and transportation, many key matters need to be paid attention to.
First safety protection. This compound may be irritating, toxic and other hazards, and may damage the human body if it touches the skin, eyes or inhales its volatiles. When storing, be sure to store it in a cool, well-ventilated place, away from fire and heat sources, and must be stored separately from oxidants and acids. Do not mix it to prevent severe chemical reactions. During transportation, operators should wear protective clothing, protective gloves and goggles and other equipment, and handle it carefully to avoid damage to packaging and containers.
Second is the packaging requirement. Packaging must be tight to ensure a good seal to prevent leakage. Commonly used packaging materials should be able to withstand the corrosion of the compound and have a certain strength. They can resist external forces such as vibration and collision during transportation, and prevent material leakage due to package rupture.
Furthermore, pay attention to environmental impact. In the event of leakage, 4-bromo-2-fluorothiophenol may cause pollution to soil, water and other environments. The storage site should be equipped with suitable containment materials so that it can be quickly collected and treated in the event of leakage. During transportation, if there is a leakage, emergency measures should be taken in time to prevent the spread of pollution.
In addition, storage and transportation should strictly follow relevant regulations and standards. Whether it is the storage site conditions, or the transportation vehicles, personnel qualifications, etc., all must comply with the corresponding regulations, and the transportation documents should specify the nature, hazards, and emergency treatment methods of the compound in detail, so that relevant personnel can respond properly when necessary.
What is the market price range for 4-Bromo-2-Fluorobenzenethiol?
The market price range of 4-bromo-2-fluorothiophenol is difficult to determine with certainty. The price of this chemical is often influenced by many factors, just like the changing situation and unpredictable.
First, the cost of raw materials has a deep impact on its price. If the starting materials required for the synthesis of this compound are difficult to obtain, or the price fluctuates greatly due to season, origin, supply and demand, it will directly transmit to the price of 4-bromo-2-fluorothiophenol. For example, if the price of bromine and fluorine-related raw materials soars due to scarcity of resources, the cost of 4-bromo-2-fluorothiophenol will surely rise, and the price will also rise.
Second, the difficulty and complexity of the production process are also key factors. If the production of 4-bromo-2-fluorothiophenol requires many complicated steps, demanding reaction conditions, and special equipment and catalysts, the production cost will inevitably increase significantly, and its market price will also rise accordingly.
Third, the relationship between market supply and demand also affects the fluctuation of prices. If the demand for 4-bromo-2-fluorothiophenol is strong in many industries, but the production supply is difficult to meet, just like the trend of water, the price will rise; on the contrary, if the market demand is low and the supply is excessive, the price will fall.
Fourth, the market competition situation should not be underestimated. If many manufacturers in the market produce 4-bromo-2-fluorothiophenol, the competition is fierce, and the manufacturers compete for shares, or the price will be lowered; if the market is almost monopolized, only a few companies can produce, and the price may be controlled by them, which will remain high.
Looking at the data of past market transactions, the price of 4-bromo-2-fluorothiophenol may range from a few yuan to several hundred yuan per gram. However, this is only a rough range, and the actual price may change from time to time due to the above factors, which is difficult to describe. Therefore, in order to know the exact market price, it is necessary to carefully observe the specific situation of the current market and inquire from multiple parties to obtain accurate price information.