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What are the main uses of 4-Bromo-2-Fluorobenzenethiol?
4-Bromo-2-fluorothiophenol is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the creation of medicine, this compound is of great value. The special chemical properties of the thiophenol group and the halogen atom can participate in various chemical reactions to build a molecular structure with specific biological activities. In this way, new drugs may be developed for the treatment of diseases, such as the development of antibacterial and anti-cancer drugs. Because the specific structure can be precisely combined with the target in the organism, so as to achieve the therapeutic effect.
Second, in the field of materials science, 4-bromo-2-fluorothiophenol is also useful. It can be used to prepare materials with special properties through the reaction it participates in. For example, after polymerization with other monomers, polymer materials with unique electrical and optical properties can be generated for the manufacture of electronic devices and optical components, such as organic Light Emitting Diodes (OLEDs), sensors, etc., to improve the performance of related devices.
Furthermore, it can also be seen in the synthesis of pesticides. Its chemical structure can endow pesticides with specific biological activities, such as insecticidal and weeding effects. Through rational design and modification, new pesticides with high efficiency, low toxicity and environmental friendliness may be created to meet the needs of agricultural production.
In short, 4-bromo-2-fluorothiophenol has shown important application potential in many fields such as medicine, materials, and pesticides due to its unique chemical structure, providing a key material basis and synthetic raw material for the development of various fields.
What are the physical properties of 4-Bromo-2-Fluorobenzenethiol?
4-Bromo-2-fluorothiophenol, is one of the organic compounds. It has the following physical properties:
In terms of normal conditions, it is a colorless to light yellow liquid with a clear texture and is easy to identify visually. This color state characteristic can provide an intuitive basis for preliminary judgment of the state of the substance in chemical production and experimental observation.
Smell, emits a special odor, although difficult to describe accurately, it is different from common odorless substances. This unique odor can be used as a way of sensory identification in actual operation, but because it may be irritating, it needs to be handled with caution.
When talking about the boiling point, it is about a specific temperature range. As an important physical constant of a substance, the boiling point is of great significance when separating and purifying the compound. By controlling the temperature to reach its boiling point, the substance can be vaporized and separated from the mixture, and then pure 4-bromo-2-fluorothiophenol can be obtained.
Its melting point also has corresponding values. The melting point determines the critical temperature for the substance to change from solid to liquid. During storage and transportation, the ambient temperature needs to be controlled according to the melting point to prevent accidental changes in the state of the substance, which affects its quality and performance.
In terms of solubility, 4-bromo-2-fluorothiophenol exhibits a certain solubility in organic solvents such as ethanol and ether. This property is extremely critical in organic synthesis reactions, enabling it to fully contact and mix with other reactants in suitable solvents, promoting the smooth progress of the reaction and improving the reaction efficiency and product purity.
Density is also one of the important physical properties. Its density value is helpful for the measurement and separation of substances in practical operation. For example, in the process of liquid-liquid separation, according to the density difference, the substance can be stratified with other liquids of different densities to achieve the purpose of separation.
In addition, 4-bromo-2-fluorophenylthiophenol has active chemical properties due to its thiophenol group, and is widely used in the field of organic synthesis. It can participate in many reactions and synthesize organic compounds with diverse structures. It plays a key role in many fields such as medicine, pesticides, and materials science.
4-Bromo-2-Fluorobenzenethiol chemical synthesis methods
4-Bromo-2-fluorobenzothiophenol is also an organic compound. The synthesis method is often obtained by starting with bromine and fluorine-containing benzene, supplemented by sulfur source, and after various reactions.
One method is to first take 4-bromo-2-fluorobromobenzene as a substrate and combine it with metal reagents, such as magnesium powder, in anhydrous ether and other inert solvents to form 4-bromo-2-fluorophenyl magnesium bromide. Afterwards, carbon disulfide is introduced to produce 4-bromo-2-fluorophenyl dithiocarboxylate, and then acid-lyzed to obtain 4-bromo-2-fluorophenylthiophenol. In this way, the Grignard reaction needs to be anhydrous and oxygen-free to prevent side reactions.
There are also those who use 4-bromo-2-fluoronitrobenzene as the initial material. First, a reducing agent, such as iron and hydrochloric acid, is nitrogenated to an amino group to obtain 4-bromo-2-fluoroaniline. Then, after co-heating with thiocyanate, through a series of reactions such as diazotization and thiocyanation, the amino group is converted to thiocyanate, and finally the thiocyanate group is reduced by a method such as zinc powder and hydrochloric acid, so that the thiocyanate group is changed to a thiol group, and then 4-bromo-2-fluorothiophenol is obtained. There are many steps in this diameter, so the raw material is easy to obtain.
Another example is to start with 4-bromo-2-fluorophenol. First, the phenolic hydroxyl group is converted into a group that is easy to leave, such as p-toluenesulfonate. Then, it is reacted with sulfur sources such as sodium hydride in an appropriate solvent to replace the leaving group with thiohydrogen to obtain 4-bromo-2-fluorobenzene thiophenol. This method focuses on the activation of phenolic hydroxyl groups to make the reaction smooth.
Synthesis has advantages and disadvantages. Grignard reaction method is simple in steps, but harsh in conditions; nitrobenzene is used as the starting material, and the raw material is easy to obtain and proliferated in steps; the method of starting with phenol requires fine treatment of phenolic hydroxyl groups. When choosing the method, it is determined according to various factors such as the convenience of raw materials, equipment, and cost calculation.
4-Bromo-2-Fluorobenzenethiol What are the precautions in storage and transportation?
4-Bromo-2-fluorothiophenol is an organic compound. During storage and transportation, many key matters need to be paid attention to.
First safety protection. This compound may be irritating, toxic and other hazards, and may damage the human body if it touches the skin, eyes or inhales its volatiles. When storing, be sure to store it in a cool, well-ventilated place, away from fire and heat sources, and must be stored separately from oxidants and acids. Do not mix it to prevent severe chemical reactions. During transportation, operators should wear protective clothing, protective gloves and goggles and other equipment, and handle it carefully to avoid damage to packaging and containers.
Second is the packaging requirement. Packaging must be tight to ensure a good seal to prevent leakage. Commonly used packaging materials should be able to withstand the corrosion of the compound and have a certain strength. They can resist external forces such as vibration and collision during transportation, and prevent material leakage due to package rupture.
Furthermore, pay attention to environmental impact. In the event of leakage, 4-bromo-2-fluorothiophenol may cause pollution to soil, water and other environments. The storage site should be equipped with suitable containment materials so that it can be quickly collected and treated in the event of leakage. During transportation, if there is a leakage, emergency measures should be taken in time to prevent the spread of pollution.
In addition, storage and transportation should strictly follow relevant regulations and standards. Whether it is the storage site conditions, or the transportation vehicles, personnel qualifications, etc., all must comply with the corresponding regulations, and the transportation documents should specify the nature, hazards, and emergency treatment methods of the compound in detail, so that relevant personnel can respond properly when necessary.
What is the market price range for 4-Bromo-2-Fluorobenzenethiol?
The market price range of 4-bromo-2-fluorothiophenol is difficult to determine with certainty. The price of this chemical is often influenced by many factors, just like the changing situation and unpredictable.
First, the cost of raw materials has a deep impact on its price. If the starting materials required for the synthesis of this compound are difficult to obtain, or the price fluctuates greatly due to season, origin, supply and demand, it will directly transmit to the price of 4-bromo-2-fluorothiophenol. For example, if the price of bromine and fluorine-related raw materials soars due to scarcity of resources, the cost of 4-bromo-2-fluorothiophenol will surely rise, and the price will also rise.
Second, the difficulty and complexity of the production process are also key factors. If the production of 4-bromo-2-fluorothiophenol requires many complicated steps, demanding reaction conditions, and special equipment and catalysts, the production cost will inevitably increase significantly, and its market price will also rise accordingly.
Third, the relationship between market supply and demand also affects the fluctuation of prices. If the demand for 4-bromo-2-fluorothiophenol is strong in many industries, but the production supply is difficult to meet, just like the trend of water, the price will rise; on the contrary, if the market demand is low and the supply is excessive, the price will fall.
Fourth, the market competition situation should not be underestimated. If many manufacturers in the market produce 4-bromo-2-fluorothiophenol, the competition is fierce, and the manufacturers compete for shares, or the price will be lowered; if the market is almost monopolized, only a few companies can produce, and the price may be controlled by them, which will remain high.
Looking at the data of past market transactions, the price of 4-bromo-2-fluorothiophenol may range from a few yuan to several hundred yuan per gram. However, this is only a rough range, and the actual price may change from time to time due to the above factors, which is difficult to describe. Therefore, in order to know the exact market price, it is necessary to carefully observe the specific situation of the current market and inquire from multiple parties to obtain accurate price information.