4-Bromo-2-Fluoro-1-Nitrobenzene

Hongda Chemical

Specifications

HS Code	172209
Chemical Formula	C6H3BrFNO2
Molar Mass	220.00 g/mol
Appearance	Yellow - solid
Boiling Point	246 - 248 °C
Melting Point	40 - 42 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, dichloromethane
Purity Typical	95%+ (check product spec)

As an accredited 4-Bromo-2-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 4 - bromo - 2 - fluoro - 1 - nitrobenzene in sealed glass bottle packaging.
Storage	4 - bromo - 2 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and bases, as it may react with them. Follow proper safety regulations for storing hazardous chemicals.
Shipping	4 - bromo - 2 - fluoro - 1 - nitrobenzene is shipped in sealed, corrosion - resistant containers. It's labeled as a hazardous chemical. Shipment follows strict regulations to ensure safe transport, avoiding exposure and environmental risks.

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General Information

Historical Development

It is also to learn from the goodness of ancient times, to observe the changes of all things, and to study the details of things. In chemical things, there is also a lack of its source and its progress. Today's words 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene This thing, the progress of its history, is also interesting.
At the beginning, the sages of chemistry studied the nature of matter and explored the method of chemical integration. At that time, the technology was not refined, and it was not easy to obtain this 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene. However, the masters were unremitting, and they went through countless experiments. With wisdom and diligence, they gradually learned the art of synthesis.
The years go by, and science and technology are new. The refinement of the instrument and the goodness of the theory all contribute to the research of this substance. The method of synthesis is more convenient and accurate, and the yield is also gradually increasing. From the difficult search in the past, it is easier to obtain today. It depends on the efforts of the ancestors and the progress of chemistry. It can be seen in this thing.

Product Overview

4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene is also an organic compound. Its shape is either crystalline, and its color is yellowish. In this compound, bromine (Bromo), fluorine (Fluoro) and nitro (Nitro) are co-attached to the benzene ring. The characteristics of bromine and fluorine atoms, coupled with the activity of nitro groups, give the compound unique chemical properties.
In the field of organic synthesis, 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene is often an important raw material. Due to the localization effect of bromine and fluorine atoms, as well as the electron-absorbing properties of nitro groups, it can guide the progress of many chemical reactions, such as nucleophilic substitution reactions. It has potential applications in drug synthesis, materials science, etc., and can provide key structural units for creating new drugs and optimizing material properties.

Physical & Chemical Properties

4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene is an organic compound, and its physicochemical properties are particularly important. Looking at its properties, it is mostly solid at room temperature and has a specific melting point. The melting point depends on the intermolecular force. In terms of chemical properties, because it contains functional groups such as bromine, fluorine, and nitro, the chemical activity is quite high. Bromine atoms can undergo substitution reactions, and fluorine atoms change the electron cloud density of the benzene ring, which affects its reactivity. Nitro has strong electron absorption, which makes this compound exhibit a unique localization effect in electrophilic substitution reactions. In addition, its solubility is different from that of organic solvents, due to the interaction between molecular polarity and solvent polarity. The investigation of the physicochemical properties of this compound is of great significance for its application in organic synthesis, materials science and other fields.

Technical Specifications & Labeling

4-Bromo-2-fluoro-1-nitrobenzene is an important compound in organic synthesis. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, the raw materials synthesized must be pure, and the reaction conditions should be precisely controlled. Temperature, pressure, and catalyst dosage are all related to the purity and yield of the product.
In terms of identification, the name and chemical formula must be clearly marked, and its physical and chemical properties, such as melting point, boiling point, solubility, etc., must be explained in detail. Product parameters should cover purity indicators, such as purity must reach a very high level, and impurity content must be very low. In addition, the storage conditions should also be clearly stated, and it should be placed in a cool, dry and ventilated place to prevent deterioration, so as to ensure the effectiveness and safety of the product in various fields.

Preparation Method

Now to prepare 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene, the method is as follows: Prepare the raw materials first, select the appropriate bromide, fluoride and nitro agent. The preparation process is to mix bromide and fluoride in an appropriate reaction vessel according to a specific ratio. Control the temperature and pressure to make the two slowly react. This is the initial step.
After the initial reaction is completed, add the nitro agent, and continue to adjust the reaction conditions to ensure the successful introduction of nitro groups. This process requires fine control of the rhythm of the reaction to ensure the purity of the product.
As for the catalytic mechanism, a specific catalyst can be selected, which can reduce the activation energy of the reaction and promote the reaction rate. The amount and activity of the catalyst need to be precisely regulated to achieve the best preparation effect. In this way, according to these steps, it is expected to efficiently prepare 4-Bromo-2-Fluoro-1-Nitrobenzene.

Chemical Reactions & Modifications

There is now a product named 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene. In the field of chemistry, its reaction and modification are important for our research.
Looking at its structure, bromine, fluorine and nitro are attached to the benzene ring. This structure makes it have unique chemical properties. As far as the reaction is concerned, the electron cloud distribution of the benzene ring is changed due to various substituents, resulting in its electrophilic substitution reactivity different from that of benzene. Bromine and fluorine are ortho-para-sites and nitro are meta-sites. The interaction of the three makes the selection of the reaction check point complicated.
To modify this product, the reaction can be designed according to its characteristics. For example, using the electron-withdrawing properties of nitro groups, or being able to introduce new groups under suitable conditions, change their physical and chemical properties to suit a variety of applications, such as the synthesis of special drugs, materials, etc. All of this requires detailed investigation of reaction conditions, temperature control, catalyst selection, etc., in order to obtain the ideal product and increase the use of this chemical.

Synonyms & Product Names

4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene is also a chemical thing. Although its name is fixed, it is also synonymous with the name of the commodity in the world. Ancient chemistry, which has not been clearly analyzed today, but those who study this thing also have other names.
Looking at its synonymous name, or depending on the region and time wind, it has a different name. Or according to its shape, or according to its origin, it has a similar meaning. And the name of the commodity, the merchant is to recognize its special, and it is also called ingenious.
As in the past, everyone studied this thing, and its naming was different. From its essence, or depending on its use, although the names are different, they all refer to this 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene. Therefore, the names of synonyms and commodities are also interesting in the study of chemistry, which can help us know the traces of its past changes.

Safety & Operational Standards

4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene Code of Safety and Operation
Husband 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene, also a chemical substance. Regarding its safety and operation standards, do not be careless.
This substance is dangerous to a certain extent. It is an organic halide and contains nitro groups, or it is toxic or irritating. During operation, the first protection. The operator, in front of suitable protective clothing, wears gloves and goggles to prevent skin and eye contact. If you accidentally touch it, rinse it with plenty of water quickly and seek medical attention if necessary.
Furthermore, the operation should be in a well-ventilated place. Because the substance or volatile harmful gases, good ventilation can reduce its concentration in the air and avoid the harm of inhalation. If operating in a laboratory, a fume hood is a must to ensure that the gas is discharged in time.
When storing, keep it in a cool, dry and ventilated place. Keep away from fires and heat sources to prevent danger. It should be stored separately from oxidants and reducing agents to avoid mutual reactions.
In terms of waste disposal, it must not be discarded at will. When collected in accordance with relevant regulations, it should be sorted and handed over to professional institutions for treatment to ensure environmental safety.
In short, the operation of 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene must strictly abide by safety and operating standards to protect the safety of people and the environment, so that scientific research can be smooth and safe.

Application Area

4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene is an important organic compound. Its application field is quite wide. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. With this compound, molecular structures with specific pharmacological activities can be constructed through ingenious chemical reactions, and then effective therapeutic drugs for specific diseases can be developed.
In the field of materials science, 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene also has its uses. It can participate in the synthesis of new functional materials, such as materials with special optoelectronic properties, which can be used in optoelectronic devices, such as Light Emitting Diode, solar cells, etc., or can demonstrate excellent performance and promote the development and progress of related technologies.
In addition, in the field of organic synthetic chemistry, as an important starting material, it can build complex organic molecular structures through various reaction paths, providing rich materials and effective ways for the development of organic synthetic chemistry.

Research & Development

In the research and development of chemical products, I always have the heart to study. Recently, the product I studied is 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene. This product has unique properties and has great potential in the field of organic synthesis.
At the beginning, I explored the preparation method, and after many attempts, adjusted the ratio of raw materials, reaction temperature and time. During this time, many problems emerged, such as the reaction yield is not high and impurities are difficult to remove. However, I did not give up. I searched the classics, referred to the methods of predecessors, and combined with my own experience, and tried repeatedly.
Finally, a better method was obtained, the yield was improved, and the product purity was also as expected. And after research, it was found that this product can play a key role in the synthesis of pharmaceutical intermediates. In the future, when in-depth research, expand its application field, it is expected to contribute to the development of chemistry and make achievements.

Toxicity Research

The toxicity of 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene was studied today. Looking at its structure, bromine, fluorine and nitro groups are all chemically active. Bromine can cause protein denaturation and affect the normal metabolism of cells. Fluoride can often interfere with the activity of enzymes and disrupt biochemical reactions in organisms. Nitro groups are easily reduced to form intermediates with strong oxidative properties, which damage cellular DNA and proteins.
After various experiments, it has been observed that this compound can damage liver and kidney functions in organisms. In animal experiments, the tested animals found abnormal liver function indexes, and alanine aminotransferase and aspartate aminotransferase were increased, indicating liver cell damage. Renal tubular damage is seen in the kidneys, and creatinine and urea nitrogen levels rise. And this substance may be mutagenic, which can change the genetic sequence of cells and increase the risk of cancer. Therefore, the study of its toxicity is crucial for protection and safe use, and must not be ignored.

Future Prospects

Husband 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene, it is also a thing of transformation. In today's world, the research and development of these things is also deepening.
It may be used in new systems before it has been developed. It may be special, or it can lead to the transformation and reaction of new materials, so as to make special effects and solve the disease of birth.
Or it may be useful in the material science. With new technologies, it can be integrated into new materials, and the material can be special, such as increasing its quality, changing its quality, etc.
Furthermore, it may also have its uses in the sub-field. It can assist in the research of high-performance sub-components and promote the next step of sub-technology.
In this case, 4 - Bromo - 2 - Fluoro - 1 - Nitrobenzene is currently or is a unified product. However, it has not been developed yet, and there is a limited possibility. It is up to us to diligently explore the research and development to reveal it, use it in the world, and benefit people.

Where to Buy 4-Bromo-2-Fluoro-1-Nitrobenzene in China?

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Frequently Asked Questions

As a leading 4-Bromo-2-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Bromo-2-Fluoro-1-Nitrobenzene?

4-Bromo-2-fluoro-1-nitrobenzene is a crucial intermediate in organic synthesis. It has a wide range of uses and is often a key starting material for the creation of new drugs in the field of medicinal chemistry. The presence of halogen atoms and nitro groups on the phenyl ring gives this compound unique reactivity. It can introduce various functional groups through various chemical reactions, such as nucleophilic substitution reactions, to build complex drug molecular structures.
In the field of materials science, it also has important functions. By chemically modifying it, materials with special properties can be prepared. For example, by reacting with specific organic ligands, materials with unique optical or electrical properties can be synthesized and used in electronic devices such as organic Light Emitting Diodes (OLEDs) and field-effect transistors.
Furthermore, in pesticide chemistry, 4-bromo-2-fluoro-1-nitrobenzene can be used as an important raw material for the synthesis of high-efficiency pesticides. Due to its structural characteristics, the derived pesticides may have good biological activity and selectivity, and play a key role in the control of crop diseases and pests. It can participate in a series of reactions to construct compound structures with insecticidal, bactericidal or herbicidal activities, providing strong protection for agricultural production. In conclusion, 4-bromo-2-fluoro-1-nitrobenzene has shown indispensable value in many important fields due to its unique chemical structure.

What are the physical properties of 4-Bromo-2-Fluoro-1-Nitrobenzene?

4-Bromo-2-fluoro-1-nitrobenzene is one of the organic compounds. Its physical properties are quite unique, let me tell you one by one.
First of all, its appearance, under room temperature, this compound is often light yellow to brown crystalline powder. This color and shape can be one of the aids for those who know it.
Second, its melting point. The melting point is about 44-48 ° C. When the temperature gradually rises to the melting point, the solid 4-bromo-2-fluoro-1-nitrobenzene melts into a liquid state. As for the boiling point, it is about 244 ° C. At this temperature, the liquid substance turns into a gaseous state, which is very important in chemical operations such as separation and purification.
Furthermore, solubility is also an important physical property. 4-Bromo-2-fluoro-1-nitrobenzene is insoluble in water, but it has good solubility in organic solvents such as ethanol, ether, and dichloromethane. This is because the molecular structure of the compound is more compatible with the intermolecular forces of organic solvents than the intermolecular forces of water molecules.
In addition, its density cannot be ignored. The density is about 1.82 g/cm ³, which is heavier than water. This property is used in processes involving liquid-liquid separation, etc., and can be separated by density differences.
Because its structure contains functional groups such as bromine, fluorine, and nitro, it has a certain polarity. This polarity also affects its physical properties, such as its solubility in different solvents and intermolecular interactions.
In summary, the physical properties of 4-bromo-2-fluoro-1-nitrobenzene, such as appearance, melting boiling point, solubility, density, and polarity, are of great significance in many fields such as organic synthesis and chemical production, and can be used as the basis and basis for related operations.

What are 4-Bromo-2-Fluoro-1-Nitrobenzene synthesis methods?

There are several common methods for the synthesis of 4-bromo-2-fluoro-1-nitrobenzene.
First, the o-fluorobrobenzene is used as the starting material. First, the o-fluorobrobenzene is nitrified and the nitro group is introduced. This reaction needs to be carried out under suitable nitrifying reagents and reaction conditions, such as using mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) as the nitrifying reagent, and controlling the appropriate temperature and reaction time to cause the nitro group to replace the hydrogen atom at a specific position on the benzene ring, thereby generating the target product 4-bromo-2-fluoro-1-nitrobenzene. During the reaction, it is necessary to pay attention to the proportion of mixed acids and temperature control to prevent side reactions, such as the formation of polynitro substitution products.
Second, 2-fluoro-1-nitroaniline can be started. First, 2-fluoro-1-nitroaniline is reacted with sodium nitrite and inorganic acids (such as hydrochloric acid) at low temperature to form diazonium salts. Subsequently, under the action of cuprous bromide and other catalysts, the diazo group is replaced by bromine atoms to achieve the synthesis of 4-bromo-2-fluoro-1-nitrobenzene. In this route, the temperature of the diazotization reaction needs to be strictly controlled in the low temperature range to prevent the decomposition of diazonium salts, and the amount and activity of the catalyst have a great influence on the reaction yield.
Third, 4-bromo-2-fluorobenzoic acid is used as the raw material. First, it is converted into the corresponding acid chloride, and thionyl chloride and other reagents are commonly used. Then, through the Huffman degradation reaction, the acid chloride is converted into amine, and then through the steps of diazotization and bromination, 4-bromo-2-fluoro-1-nitrobenzene is finally obtained. There are relatively many steps in this method, and the reaction conditions of each step need to be carefully controlled to ensure the feasibility and high yield of the overall synthesis route.
All synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be selected based on factors such as raw material availability, cost, reaction conditions and product purity requirements.

4-Bromo-2-Fluoro-1-Nitrobenzene What are the precautions in storage and transportation?

4-Bromo-2-fluoro-1-nitrobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First storage, because it has a certain chemical activity, it should be stored in a cool and ventilated warehouse. The temperature of the warehouse should not be too high to prevent it from changing its chemical properties due to heat or triggering dangerous reactions. And it should be kept away from fires and heat sources, which are prone to increase in temperature and endanger safety. It needs to be stored separately from oxidizing agents, reducing agents, alkalis, etc., because it is easy to react chemically with various substances, and mixing may lead to accidents. The storage area should be equipped with suitable materials to contain leaks, in case of leakage, and can be dealt with in time to prevent its spread from causing greater harm.
As for transportation, there are also many important rules. Before transportation, the packaging must be tight to ensure that there is no risk of leakage. Packaging materials need to be able to resist its chemical erosion and have good sealing. During transportation, the speed of the vehicle should not be too fast, and the driving should be stable to avoid damage to the package due to bumps and vibrations. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In case of emergencies, they can respond in time. At the same time, transportation personnel should be familiar with their chemical properties and emergency treatment methods. If there is any abnormality, they can properly handle it.
The storage and transportation of 4-bromo-2-fluoro-1-nitrobenzene should be handled with caution and in accordance with regulations to ensure safety.

4-Bromo-2-Fluoro-1-Nitrobenzene impact on the environment and human health

4-Bromo-2-fluoro-1-nitrobenzene is also an organic compound. The impact on the environment and human health cannot be underestimated.
For the environment, if this substance is released in nature, it may pose many hazards. Because of its certain chemical stability, it is difficult to decompose rapidly in the environment. Inflow into water bodies can cause water pollution and harm aquatic organisms. After ingestion by aquatic organisms, or accumulation in the body, it is transmitted through the food chain, affecting organisms at all levels. If it enters the soil, or changes the chemical properties of the soil, it will hinder plant growth and affect ecological balance.
As for human health, 4-bromo-2-fluoro-1-nitrobenzene can enter the body through breathing, skin contact or accidental ingestion. Its nitro and halogen atoms may be toxic and irritating. After entering the body, it may damage human organs and systems. Or irritate the respiratory tract, causing cough, asthma and other diseases; contact with the skin can cause skin problems such as allergies, redness and swelling. Long-term exposure may affect the nervous system, causing headaches, dizziness, fatigue, and even damage the function of important organs such as liver and kidney. And this substance may be potentially carcinogenic, long-term exposure increases the risk of cancer. Therefore, in the production, use and disposal of 4-bromo-2-fluoro-1-nitrobenzene, great care should be taken to prevent it from polluting the environment and harming human health.