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4-Bromo-2,5-Difluorobenzenesulphonyl Chloride

4-Bromo-2,5-Difluorobenzenesulphonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    780120

    Name 4-Bromo-2,5-Difluorobenzenesulphonyl Chloride
    Molecular Formula C6H2BrClF2O2S
    Molecular Weight 307.5
    Appearance Typically a solid or viscous liquid (varies, depends on purity and conditions)
    Reactivity Reactive towards nucleophiles due to the presence of sulphonyl chloride group

    As an accredited 4-Bromo-2,5-Difluorobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - bromo - 2,5 - difluorobenzenesulphonyl Chloride in a sealed glass bottle.
    Storage 4 - bromo - 2,5 - difluorobenzenesulphonyl chloride should be stored in a cool, dry, and well - ventilated area. Keep it away from heat, flames, and moisture as it can react with water. Store it in a tightly sealed container, preferably made of a corrosion - resistant material. Avoid storing near incompatible substances like bases, reducing agents, and reactive metals to prevent chemical reactions.
    Shipping 4 - bromo - 2,5 - difluorobenzenesulphonyl chloride is a chemical. It should be shipped in sealed, corrosion - resistant containers, following hazardous chemical shipping regulations to ensure safety during transit.
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    4-Bromo-2,5-Difluorobenzenesulphonyl Chloride 4-Bromo-2,5-Difluorobenzenesulphonyl Chloride
    General Information
    Historical Development
    4-Bromo-2,5-difluorobenzenesulfonyl chloride is also a chemical material. Trace back to its source, at the beginning, the researchers explored the secrets of the environment, wanting to obtain new things to meet their needs. Every opportunity, explore the traces of this compound. At the beginning, study its properties, make sense, although the road is difficult and not stop. Over the years, all the wise men have made continuous progress in the method of synthesis. Or adjust the temperature, or change the agent, hoping to get the best effect. Over the generations of hard work, its method has gradually improved, and the yield has risen day by day. In use, it gradually shows its ability, involving the fields of medicine and materials, adding bricks and tiles to the progress of the industry. From micro, its achievements in the chemical world cannot be underestimated, and it is a brilliant stroke in the long volume of chemical evolution.
    Product Overview
    4-Bromo-2,5-difluorobenzenesulfonyl chloride is also a chemical material that I studied. Its color is yellowish, like a crystalline powder, with a specific gas.
    This substance is widely used in various fields of chemical industry. In the way of pharmaceutical synthesis, it can be a key intermediate to help create new drugs and cure various diseases. In the context of material science, it can participate in the preparation of special materials to make them have unique properties, such as optimizing the stability and reactivity of the material.
    When preparing, it is necessary to follow a precise process, control the temperature, control the time and pay attention to the material ratio. The reaction environment is also important, and the disturbance of impurities or the impurity of the product is caused.
    However, it is dangerous. When operating, follow safety procedures, wear protective equipment, avoid contact with skin and mucous membranes, and place in a well-ventilated place to prevent harm to people and the environment.
    Physical & Chemical Properties
    4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride is an important chemical substance. Its physical properties are unique. In terms of physical properties, it is often a colorless to slightly yellow crystalline solid, stable at room temperature. Its melting point is moderate, about [specific value]. This characteristic is related to its phase transition and processing during specific process operations.
    Discussing chemical properties, the bromine, fluorine and sulfonyl chloride groups in this substance give it active reactivity. Sulfonyl chloride groups are prone to substitution reactions with nucleophiles, and can introduce various functional groups, which are widely used in the field of organic synthesis. Bromine atoms can also participate in many reactions, such as the classical reaction of halogenated aromatics, to expand the diversity of molecular structures. The presence of fluorine atoms significantly affects the electron cloud distribution and fat solubility of molecules, adding unique chemical properties and potential application value in the fields of medicinal chemistry and materials science.
    Technical Specifications & Labeling
    4-Bromo-2,5-difluorobenzenesulfonyl chloride is one of the substances involved in the research of chemical industry. Its technical specifications and identification (product parameters) are crucial. As far as technical specifications are concerned, it is necessary to clarify its purity geometry, and the type and content of impurities. This is related to product quality and must be carefully measured. If you use precision instruments, carefully observe its molecular structure and chemical properties to ensure that it conforms to the established standards.
    As for the identification (product parameters), its physical properties, such as color, odor, melting point, boiling point, etc., should be listed in detail. Make it clear at a glance who handles it. And on the packaging, clearly marked to prevent misuse. In this way, 4-bromo-2,5-difluorobenzenesulfonyl chloride can be safely applied in the chemical industry to achieve the expected effect.
    Preparation Method
    To prepare 4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride, it is necessary to explain the raw materials and production process, reaction steps and catalytic mechanism.
    The raw material is selected, when the benzene compound containing bromine and fluorine is used as the base, supplemented by a sulfonating agent and a chlorinating agent. For example, 2,5 - difluorobenzene is selected as the starting material, and bromine atoms are introduced through a bromination reaction. The method uses liquid bromine as the bromine source. Under the catalysis of catalysts such as iron powder, the two are mixed and the temperature is controlled to obtain 4 - bromo - 2,5 - difluorobenzene.
    Then sulfonation, with fuming sulfuric acid as sulfonating agent, 4-bromo-2,5-difluorobenzene is co-heated with it, and the sulfonic acid group enters the benzene ring to form 4-bromo-2,5-difluorobenzene sulfonic acid.
    Finally chlorinated, with thionyl chloride as chlorinating agent, it is co-heated with 4-bromo-2,5-difluorobenzene sulfonic acid, and the sulfonic acid group is converted into a sulfonyl chloride group to obtain the target product 4-Bromo-2,5-Difluorobenzenesulphonyl Chloride. Each step of the reaction requires strict control of temperature, time and raw material ratio to achieve yield and purity.
    Chemical Reactions & Modifications
    Taste the wonders of chemistry, with thousands of changes, related to the change of substances and the change of properties. On 4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride, its chemical reaction and modification are quite important.
    In chemical reactions, this compound is often a key agent. Its bromine, fluorine, and sulfonyl chloride groups are all active and can interact with a variety of reagents. In case of nucleophiles, sulfonyl chloride groups are easily replaced to form new derivatives. This reaction can be precisely regulated to achieve the synthesis of specific structures.
    Talking about modification, because it contains halogen atoms, other functional groups can be introduced by chemical means to change their physical and chemical properties. To increase its stability or solubility, it is useful in materials science, drug development and other fields. Through delicate reaction design, the substance can meet different needs and open up new avenues for chemical research and application, which is an indispensable part of chemical exploration.
    Synonyms & Product Names
    Fu Jin has a thing called "4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride". This thing is an important raw material in the field of chemistry. Its synonyms and trade names also have many elegant studies.
    In the academic world, or because of its chemical structure characteristics, there are words with similar meanings. These synonyms are derived from the desire to accurately describe its chemical properties and structural relationships. Looking at its trade name, merchants name it for its characteristics, uses, or from the perspective of its application field and performance advantages.
    If you are looking for synonyms, you need to study chemical principles and consider the characteristics of its atomic combinations and chemical bonds. The formation of a trade name is related to market demand and product positioning. This "4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride", the exploration of its synonyms and trade names, is of great significance in chemical research and industrial applications, and can help scholars and business people better understand its nature and make good use of it.
    Safety & Operational Standards
    4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride Safety and Operation Code
    4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride, the product of transformation. Its nature is different, related to safety and operation, and should not be careless.
    In terms of safety, this product is toxic and corrosive. When touching the skin, it can cause burns, so when handling, it is necessary to wear protective equipment, such as rubber gloves, goggles, protective clothing, etc., to prevent its damage. If you accidentally touch it, rinse it with water quickly, and then seek medical treatment. If it enters the eye, rinse it with plenty of water immediately and seek medical attention immediately.
    If the gas enters the lungs, it is also very harmful, so use it in a well-ventilated place, or use a fume hood to keep the toxic gas from gathering. If you inhale it accidentally, leave the scene quickly and go to a place with fresh air. If you feel unwell, seek medical help.
    As for the operating specifications, when taking it, use a clean and dry appliance to prevent impurities from mixing in and messing with its quality. Weighing must be accurate, according to the amount required by the experiment, do not use too much or too little.
    When mixing, add it slowly, and stir while adding to make the reaction uniform. The reaction temperature and time must strictly abide by the established procedures and cannot be changed. When heating, the temperature control is stable to prevent excessive reaction.
    When storing, it should be stored in a cool, dry and ventilated place, away from fire and heat sources, and sealed to avoid contact with water and active metals, etc., to avoid deterioration or risk.
    In general, those who operate this object must abide by safety and operation regulations to ensure safety, so as to become a scientific research matter.
    Application Area
    4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride, it is also a chemical material. Its use, in the field of research and development, can be an important raw material. With this material, it may be able to help people with biochemical reactions and help treat diseases. In terms of research and development, based on this, it may be possible to develop new technologies to eliminate damage and ensure the health of crops. It is also involved in the material science. It can be used as a starting point for the synthesis of special materials, so that the materials have special properties, such as better quality or performance. In addition, this material has its unavoidable role in the field of multiple uses. We will explore it in depth to develop its more capabilities.
    Research & Development
    I have been studying chemistry for a long time, and recently I focused on the research of 4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride. This compound has unique properties and has great potential in the field of organic synthesis.
    At the beginning, its synthesis path was explored. After several attempts, a method was found to start with a specific halogenated aromatic hydrocarbon and obtain this product through multi-step reaction. However, during the synthesis process, many factors affect the yield and purity, such as reaction temperature, time and reagent ratio. After repeated debugging and optimization of conditions, the yield gradually increases.
    Repeated research on its application found that it has great potential for the preparation of new pharmaceutical intermediates and high-performance materials. Reaction with other compounds can build novel structures and endow materials with unique properties.
    Although research has made progress, there is still a long way to go. The follow-up will explore its reaction mechanism in depth, expand the scope of application, and strive to make it shine in industrial production and scientific research, and promote the development of chemistry.
    Toxicity Research
    I will investigate the toxicity of 4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride. It is a chemical product, and its potential harm must be observed during experimental investigation.
    At the beginning, observe its physical properties, color, taste, etc., all need to be recorded in detail. Then measure it with various experimental methods. Or take a little, put it in a specific environment, observe its reaction with other things, and observe whether there are abnormal changes, such as gas escape, color change, etc.
    Then test it with organisms, select insects, mice, etc., and contact it in an appropriate amount to observe its behavior and physiological changes. If you see insect restlessness and rat convulsion weakness, it is a sign of toxicity.
    After these investigations, the toxicity and mechanism of its action can be known, providing evidence for future use, protection, etc., to ensure the safety of the experimenter and the surrounding environment.
    Future Prospects
    Husband 4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride, it is also a thing of transformation. I have been researching it for years, observing its properties, studying its use, and I have some expectations for it before it is developed.
    This material property is special, or it can be used for new systems. In today's world, there are many diseases, and it is urgent to ask for it, such as the hope of a drought. This compound may be a new way of research, helping to solve the problem of disease.
    And it is also promising in the material department. The new material is the best, and it is recommended to be used. 4 - Bromo - 2,5 - Difluorobenzenesulphonyl Chloride may be able to be used in it, so that the material properties are good, use it.
    I believe that with further research, I will definitely be able to improve my performance. In terms of work, there are great things. This is the period I have not yet completed.
    Where to Buy 4-Bromo-2,5-Difluorobenzenesulphonyl Chloride in China?
    As a trusted 4-Bromo-2,5-Difluorobenzenesulphonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Bromo-2,5-Difluorobenzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 4-bromo-2,5-difluorobenzenesulfonyl chloride?
    4-Bromo-2,5-diethylbenzaldehyde bromide, its physical properties are as follows:
    This substance is mostly liquid at room temperature, and it is clear and transparent when viewed. It is like a quiet water, but its color may vary slightly due to purity. It is often nearly colorless, and occasionally has a slight yellowish tone, just like the light light when the morning light shines.
    Smell its smell, pungent and strong. If placed under the nose, you can instantly feel an impulse reaching the depths of the nasal cavity, making the olfactory nerve sensitive and alert. This smell is pungent and quite irritating, and you will feel uncomfortable if you are not careful.
    In terms of its density, it is heavier than water. If you pour it into the water, it can be seen that it is like a sinking bead falling into the abyss, sinking straight down, and lying quietly at the bottom of the water. The two are clearly defined and do not blend with each other.
    Its boiling point is quite high, and it needs to be under a specific high temperature to transform it from liquid to gas. When heated, watch its state gradually change, and at the boiling point, you can see bubbles churning on the liquid surface, like water boiling, turning into wisps of steam rising.
    The melting point is relatively low, and it is a liquid at room temperature. If it cools down to a specific low temperature, the molecular activities gradually slow down, get close to each other, and finally solidify into a solid state, just like a clear spring that turns into ice when it meets cold. The properties also change between the morphological changes.
    In terms of solubility, it is quite soluble in organic solvents such as ethanol and ether. When the two mix, they can quickly blend to form a uniform phase, just like water and milk. However, in water, the solubility is extremely small, and the two meet, just like oil and water, distinct and difficult to blend.
    What are the chemical properties of 4-bromo-2,5-difluorobenzenesulfonyl chloride?
    4-Bromo-2,5-diethylbenzaldehyde is an organic compound with unique chemical properties and is widely used in the field of organic synthesis.
    It has an aldehyde group, so it has typical aldehyde chemical properties. Oxidation reaction can occur. In case of weak oxidant Torun reagent, the aldehyde group will be oxidized to carboxyl group to form 4-bromo-2,5-diethylbenzoic acid, and silver mirror will be produced at the same time. This reaction can be used to test aldehyde groups; in case of strong oxidants such as potassium permanganate, not only aldehyde groups are oxidized, but alkyl groups may also be oxidized.
    Reduction reaction can occur. Hydrogen is used as the reducing agent. Under the action of suitable catalysts (such as nickel, palladium, etc.), aldehyde groups can be reduced to alcohol hydroxyl groups to generate 4-bromo-2,5-diethylbenzyl alcohol.
    Because it contains a benzene ring and has the properties of aromatic hydrocarbons, an electrophilic substitution reaction can occur. The electron cloud density distribution on the benzene ring is affected by bromine atoms, aldehyde groups and ethyl groups. Bromine is an ortho-para-site group and aldehyde groups are meta-site groups. Under the combined influence, the electrophilic substitution reaction may occur at a specific position in the benzene ring. For example, when a bromine reaction occurs, the bromine atom may mainly replace the hydrogen atom at a specific position
    In addition, aldehyde groups can undergo condensation reactions with compounds containing active hydrogen. If reacted with alcohols under acid catalysis, acetals can be formed. This property is often used to protect aldehyde groups in organic synthesis. After a specific reaction is completed, the aldehyde groups can be restored by hydrolysis.
    4-Bromo-2,5-diethylbenzaldehyde is rich in chemical properties and is an important intermediate in organic synthesis, pharmaceutical chemistry and other fields. It can construct complex organic compounds through various reactions to meet the needs of different fields.
    What is the common synthesis method of 4-bromo-2,5-difluorobenzenesulfonyl chloride?
    The common method for the synthesis of 4-bromo-2,5-diethoxy-benzaldehyde is to take 2,5-diethoxy-phenol, a suitable brominating agent, such as liquid bromine or N-bromosuccinimide (NBS), in a suitable solvent, such as dichloromethane or carbon tetrachloride, at low temperature and in the presence of a catalyst, such as iron powder or iron tribromide, to obtain 4-bromo-2,5-diethoxy-phenol. This step requires careful temperature control and feeding rate to prevent the formation of polybrominated by-products.
    Then, the obtained 4-bromo-2,5-diethoxy phenol is oxidized with a mild oxidizing agent, such as manganese dioxide or chromium trioxide-pyridine complex, in an organic solvent, such as dichloromethane or acetic acid, so that the phenolic hydroxyl group is oxidized to an aldehyde group, and finally 4-bromo-2,5-diethoxy benzaldehyde. This oxidation process requires attention to the choice of reaction conditions to avoid excessive oxidation.
    There is another method, which can first react 2,5-diethoxy benzene with a brominating agent to obtain 4-bromo-2,5-diethoxy benzene. After that, the target product 4-bromo-2,5-diethoxybenzaldehyde can also be obtained by reacting with formylation reagents, such as N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl), at appropriate temperatures, using anhydrous aluminum trichloride as a catalyst. In this process, the amount of catalyst and the reaction temperature have a great influence on the selectivity and yield of the reaction.
    What are the main applications of 4-bromo-2,5-difluorobenzenesulfonyl chloride?
    Sodium 4-bromo-2,5-diethylbenzenesulfonate has important applications in printing and dyeing, medicine, chemical synthesis and other fields.
    In the field of printing and dyeing, it can be used as a dye aid. In the printing and dyeing process, it is crucial to evenly color the dye, otherwise the fabric color is uneven and affects the quality. Sodium 4-bromo-2,5-diethylbenzenesulfonate can enhance the affinity between the dye and the fabric through its own characteristics, so that the dye is evenly attached to the fabric fibers, so that the color of the fabric after printing and dyeing is uniform and bright, and it improves the color fastness, so that the fabric is not easy to fade during daily wear and washing.
    In the field of medicine, it is often an important intermediate. Many drug synthesis requires organic compounds with specific structures as starting materials or reaction intermediates. Sodium 4-bromo-2,5-diethylbenzenesulfonate can participate in a series of chemical reactions due to its unique molecular structure. After ingeniously designed reaction routes, it can be converted into compounds with specific pharmacological activities, thus laying the foundation for the development and production of new drugs.
    In chemical synthesis, this compound also plays a key role. Chemical synthesis often requires the construction of complex organic molecular structures. Sodium 4-bromo-2,5-diethylbenzenesulfonate can be used as a starting material to participate in the construction of carbon-carbon bonds and carbon-heteroatomic bonds. Through the means of organic synthetic chemistry, based on it, polymer materials, surfactants and other chemical products with special properties can be synthesized to meet the needs of different industrial production and life.
    What are the precautions for 4-bromo-2,5-difluorobenzenesulfonyl chloride during storage and transportation?
    4-Hydroxy-2,5-dimethylbenzaldehyde chlorine should be paid attention to many key matters during storage and transportation.
    First safety protection. This substance may be toxic and irritating, and appropriate protective equipment must be worn when contacting it, such as protective clothing, gloves, goggles and gas masks, to prevent it from coming into contact with the skin, eyes and inhaling into the body, causing physical damage.
    Secondary storage conditions. It should be stored in a cool, dry and well ventilated place, away from fire and heat sources. Because it is sensitive to temperature and humidity, high temperature, high humidity environment or cause it to deteriorate. It needs to be stored separately from oxidants, acids, alkalis, etc., to avoid dangerous chemical reactions caused by mixed storage. And the storage place should be set up with clear warning signs to prevent accidental touch and misuse.
    The transportation process should not be ignored. Before transportation, ensure that the packaging is complete and well sealed to prevent leakage. Select compliant transportation tools, and properly load and fix them in accordance with relevant regulations to avoid packaging damage caused by collision and vibration during transportation. Transportation personnel need to be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. In the event of a leak, personnel should be evacuated from the surrounding area quickly, isolate the leakage area, and take corresponding treatment measures according to the leakage amount and site conditions. Small leaks can be absorbed by inert materials such as sand and vermiculite. Large leaks need to be built embankments or excavated for containment, and timely reported to relevant departments.