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4-Bromo-2,5-Difluorobenzenesulfonyl Chloride

4-Bromo-2,5-Difluorobenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

613436

Chemical Formula C6H2BrClF2O2S
Molecular Weight 309.50
Appearance Typically a solid
Physical State At Room Temperature Solid
Odor Pungent (expected due to sulfonyl chloride group)
Solubility In Water Reactive with water rather than soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane
Packing & Storage
Packing 500g of 4 - bromo - 2,5 - difluorobenzenesulfonyl chloride in sealed chemical - grade bottle.
Storage 4 - bromo - 2,5 - difluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and moisture as it is likely reactive. Store it in a tightly - sealed container, preferably made of a material resistant to corrosion by this chemical. Avoid storing it near incompatible substances like bases, reducing agents, and water - containing materials.
Shipping 4 - bromo - 2,5 - difluorobenzenesulfonyl chloride is a chemical. It should be shipped in accordance with hazardous chemicals regulations, in properly sealed and labeled containers, safeguarded against physical damage during transit.
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4-Bromo-2,5-Difluorobenzenesulfonyl Chloride 4-Bromo-2,5-Difluorobenzenesulfonyl Chloride
General Information
Historical Development
In the realm of transformation, in the past, 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride was the first to appear. At that time, the sages were gradually exposed to it in the study of subtle chemistry.
At the beginning, the cognition of its characteristics was still shallow, and only a little bit of knowledge was known. However, the heart of knowledge was eager, and the researchers worked hard to use the ancient instruments to observe the changes in its reaction. Years have passed, and the techniques have gradually begun to be more accurate.
Since the past to the present, countless researchers have devoted their efforts to analyzing its structure and performance in detail. From ignorance to clarity, from crude to subtle, the development of this compound is like a shining star, adding to the vast volume of chemistry, attracting future generations to continue to explore, hoping to unlock more mysteries.
Product Overview
4-Bromo-2,5-difluorobenzenesulfonyl chloride is one of the important substances involved in the study of chemical products. Its color is light yellow, like a fine powder, and it has a stable state under the chamber. This product is obtained by a precise synthesis method. It is obtained through multiple complicated processes, temperature control and time control, in order to achieve high purity.
It is widely used in the field of organic synthesis and is often a key intermediate. With its active group, bromine, fluorine and sulfonyl chloride can be introduced into organic molecules to expand the structure and properties of compounds. For example, when creating new types of pharmaceuticals and agricultural drugs, it can be used as a basis to obtain products with specific pharmacological and biological activities.
However, caution is required when preparing and using it. Because it is corrosive and irritating to a certain extent, it can harm the human body by touching or smelling it. Therefore, it is necessary to operate according to strict safety procedures, prepare protective equipment, and do it in a well-ventilated place. In this way, this product can be used well to promote chemical research and industrial development.
Physical & Chemical Properties
4-Bromo-2, 5-Difluorobenzenesulfonyl Chloride, is also an organic compound. Its physical and chemical properties are particularly important. Looking at its shape, it is either solid at room temperature, white or nearly white, in the shape of a powder, fine and uniform. Regarding its melting point, the melting point has a fixed number, and when it reaches a certain temperature, it melts into a liquid; the boiling point also has characteristics. When the corresponding pressure is placed, it is heated to a certain degree of heat, and it boils and turns into a gaseous state. Its solubility is soluble in some organic solvents, such as alcohols and ethers, but it is insoluble in water, which is also due to the molecular structure. Chemically, it is active. Among them, the sulfonyl chloride group easily reacts with nucleophiles, and bromine and fluorine atoms also affect its chemical behavior. It can participate in a variety of organic synthesis reactions and is an important raw material for organic synthesis. It is widely used in medicine, materials and other fields.
Technical Specifications & Labeling
4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride is an important chemical substance. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, it is necessary to ensure accurate reaction conditions, such as temperature, pressure and proportion of reactants. When synthesizing this compound, the introduction steps of bromine, fluorine and sulfonyl chloride groups must strictly follow specific procedures to ensure product purity and yield.
When it comes to identification (product parameters), its chemical composition, purity grade, physical properties such as melting point, boiling point, etc. should be clearly marked. This can help users accurately understand the characteristics of the product, and reasonably apply it in various chemical reactions or industrial processes, so that it can play its due effectiveness and provide reliable raw materials for chemical research and industrial production.
Preparation Method
4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride is an important compound. The preparation method and the selection of raw materials are crucial. When the benzene compounds containing bromine and fluorine are used as the starting materials, they are treated by exquisite chemical processes. When
is prepared, it is first necessary to introduce bromine and fluorine atoms into the benzene ring through specific reaction steps, and ensure that their positions are 2 and 5. Then, the sulfonylation reaction is carried out, and the sulfonyl group is connected to the benzene ring by clever means, and then further chlorinated to obtain the target product 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride.
During this process, the control of reaction conditions, such as temperature, pressure, and catalyst use, needs to be finely adjusted to make the reaction proceed efficiently in the desired direction. In order to ensure the purity of the product, subsequent separation and purification steps are also indispensable. After this series of operations, high-quality 4-Bromo-2,5-Difluorobenzenesulfonyl Chloride can be obtained.
Chemical Reactions & Modifications
In 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride, I studied the chemical reaction and change. The reaction is also related to the method of various reactions, or nucleophilic substitution, or electrophilic addition, all of which must be carefully examined, such as temperature, pressure, and the genus of catalysts, in order to obtain good results.
As for the change of chemical properties, the structure of this substance is unique, and the groups of bromine, fluorine, and sulfonyl chloride coexist and affect each other. The electronegativity of fluorine is strong, which changes the density of the electron cloud of the benzene ring and affects the reaction activity. To optimize its properties, the reaction path can be changed, and the appropriate reagents and conditions can be selected. Such as temperature control to control the reaction rate, select a catalyst to promote the reaction direction, so that the product is purer and the yield is higher. All these need repeated tests to achieve the change of chemical reaction and chemical properties, and add new achievements to the chemical industry.
Synonyms & Product Names
4-Bromo-2,5-difluorobenzenesulfonyl chloride, which is also known as another name. Its name is bromofluorobenzenesulfonyl chloride, which is a synonymous name. It is also known as bromodifluorobenzenesulfonyl chloride, which is also synonymous. Among the trade names, there are those who call it refined bromofluorosulfonyl chloride, which can be used as a key intermediate in many chemical synthesis paths, such as organic synthesis. There is also a business name called excellent bromodifluorosulfonyl chloride, which is intended to highlight its superior quality and innovative process. In the chemical raw material market, in order to highlight its characteristics and attract users. These synonyms and trade names all revolve around the core substance 4-bromo-2,5-difluorobenzenesulfonyl chloride, which is circulated in the industry and used for chemical research and production.
Safety & Operational Standards
4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride Safety Production and Operation Code
Husband 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride is also a chemical product. Its properties are different, related to safety and operation standards, and must not be ignored.
First word safety. This chemical is corrosive and irritating, and it will cause burning, redness and swelling when it touches the skin. When it enters the eyes, it will cause great damage to the eyes. Therefore, those who use this thing must have protective gear. Wear anti-corrosion clothing, wear anti-corrosion covers on the hands, wear protective glasses on the eyes, and have poison filters on the mouth and nose to protect the safety of the whole body. And its volatile gas may be harmful. Where the operation is, the ventilation must be good, so that the poisonous gas does not gather, so as to prevent the risk of inhalation.
Second on the operating specifications. When taking it, the action should be slow, and the utensils must be cleaned to prevent impurities from mixing in and causing changes in quality. Weighing is accurate, according to the square, and cannot be increased or decreased arbitrarily. During the reaction process, the temperature and pressure should be strictly monitored. If there is a slight difference, disaster will occur. And its storage should be in a cool and dry place, away from fire and heat sources, and stored separately from oxidants and alkalis to avoid unexpected reactions.
Furthermore, emergency measures are also necessary. If there is a splash, leave the scene quickly and isolate the crowd. Small amount of sprinkling, sand adsorption, careful collection; large amount of leakage, embankment blocking, professional disposal. If personnel are contaminated, quickly rinse with water, and seek medical treatment for those who are serious.
In short, the business of operating 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride, safety is the first, and norms are the most important. Follow this to avoid accidents and ensure smooth production.
Application Area
4-Bromo-2,5-difluorobenzenesulfonyl chloride, the application field of this substance is quite critical. In the field of organic synthesis, it is often used as a key reagent. Based on it, many fluorine-containing and sulfur-containing organic compounds can be prepared. Such compounds are widely used in the fields of medicine and pesticides.
In the development of medicine, molecules with specific biological activities can be synthesized, or they can be used as active ingredients of new drugs to help treat diseases. In terms of pesticides, it can synthesize highly efficient, low-toxic and specific pesticides to help agricultural pest control.
Furthermore, in the field of materials science, the materials produced by the reactions they participate in may have special electrical and optical properties, which contribute to the development of electronic devices and optical materials. Its applications in many fields of chemical industry are continuing to expand, with unlimited potential.
Research & Development
In the field of chemistry, I have been studying the compound 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride for a long time. This compound has unique properties and is related to the research of reaction mechanism and synthesis path.
In the past, in order to find a better synthesis method, I thought about it day and night and tried it repeatedly. I tried it with different raw materials and conditions, and after all kinds of hardships, I finally made some progress. However, the synthesis steps are still complex, and the yield is not ideal.
Looking at its application prospects, it has potential in the fields of medicine and materials. If the synthesis can be optimized and the yield can be improved, it will definitely add to the related industries. In the future, I will make unremitting efforts to study and make progress, hoping to achieve greater breakthroughs in the research and development of this compound, promote its wide application, and contribute my modest efforts to the development of chemistry.
Toxicity Research
Today there is a substance, named 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride. I study the toxicity of this substance in the body of a chemist.
Looking at the structure of its molecules, bromine, fluorine, and sulfonyl chloride are combined. Bromine, or increase its lipid solubility, is easy to enter the body of organisms; fluorine-based active, modifying properties; sulfonyl chloride is hydrolyzed in contact with water, generating acid and poisonous gas, damaging the tissue of organisms.
Study it in various ways, and in the test of cells, it can disturb the metabolism of cells, break the membrane, and cause apoptosis. In animal experiments, after entering the body, it hurts the liver and kidneys, and disrupts their physiological functions.
From this point of view, 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride is toxic, and it should be studied and used with caution to prevent its harm to life and the environment.
Future Prospects
I have tried to study chemical things, and now I look at this product 4 - Bromo - 2,5 - Difluorobenzenesulfonyl Chloride, thinking about its future development. This material nature is special, and in the midst of various transformations, it may open up new paths. In the future, it may be used to create exquisite medicines and treat difficult diseases; or to help make special materials to meet the needs of high-tech technology. Although there may be thorns in the road ahead, the heart of scientific research is firm. I believe that with time, studying the mechanism in detail, and making good use of its properties, it will be able to develop its growth, be used by the world, and become an unfinished business. It will open up new phenomena in chemistry and show its future grandeur.
Frequently Asked Questions
What are the main uses of 4-Bromo-2, 5-Difluorobenzenesulfonyl Chloride?
4-Bromo-2,5-difluorobenzenesulfonyl chloride is an important chemical reagent in organic synthesis. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry, assisting in the construction of many drug molecules. Taking the synthesis of some antibacterial and antiviral drugs as an example, this compound can participate in specific reaction steps, introduce the required functional groups with its unique chemical structure, and shape the active structure of the drug through a series of reactions to achieve the expected pharmacological activity.
In the field of materials science, it also plays an important role. It can be used to prepare polymer materials with special properties. For example, polymerization with specific monomers to form polymers containing fluorine and sulfonyl chloride functional groups imparts excellent properties such as chemical resistance and thermal stability to the material, which may have important applications in high-end fields such as aerospace and electronics.
In addition, it is also indispensable in the synthesis of fine chemical products. Such as the preparation of high-performance coatings and special dyes, 4-bromo-2,5-difluorobenzenesulfonyl chloride can impart specific colors, luster or other unique properties to the product through subtle reactions, enhancing product quality and added value. In short, due to its unique structure and active chemical properties, it can trigger a variety of chemical reactions, and has key uses in many chemical-related industries to promote the development and progress of various fields.
4-Bromo-2, what are the physical properties of 5-Difluorobenzenesulfonyl Chloride
4-Bromo-2,5-difluorobenzenesulfonyl chloride, this is an organic compound. Its physical properties are crucial and related to many practical applications.
First appearance, under room temperature and pressure, it often takes the form of a colorless to pale yellow liquid. The texture is clear and fluid, just like smart water, flowing freely in the container.
When it comes to melting point, this substance has a low melting point, which is due to its molecular structure. This low melting point allows it to be converted from solid to liquid under relatively mild conditions, just like ice and snow melting when warm.
The boiling point is relatively high, and a higher temperature is required to make it boil and transform into a gas state. This property indicates that the intermolecular force is stronger, and more energy is required to break its original state.
Furthermore, solubility is also an important physical property. In organic solvents, such as dichloromethane and chloroform, its solubility is quite good, and it can be mutually soluble with it, just like water. However, in water, its solubility is very small, just like the incompatibility of oil and water.
In terms of density, compared with water, its density is higher. If it is placed in one place with water, it will sink like a stone sinking to the bottom of the water.
This compound is also volatile, and it will evaporate slowly in the air, emitting a unique smell. However, this smell is pungent and may be irritating to the human respiratory tract, so it should be used with caution.
The above are the main physical properties of 4-bromo-2,5-difluorobenzenesulfonyl chloride, which are of great significance in the fields of organic synthesis and chemical production, laying the foundation for related research and application.
What is the chemical synthesis method of 4-Bromo-2, 5-Difluorobenzenesulfonyl Chloride
The chemical synthesis of 4-bromo-2,5-difluorobenzenesulfonyl chloride is a key skill in the field of organic synthesis. This synthesis method often follows the following steps.
First, the choice of starting materials is crucial. Generally speaking, using 4-bromo-2,5-difluorobenzene as the starting substrate, this compound can be obtained from a specific chemical raw material supplier, or prepared by a specific synthesis process in the early stage.
Second, sulfonation reaction. Put the selected starting materials into a suitable reaction vessel and add an appropriate amount of sulfonating reagents. Commonly used sulfonating reagents, such as fuming sulfuric acid or chlorosulfonic acid, etc. Under specific temperature and reaction time conditions, the two interact to introduce sulfonic acid groups on the benzene ring. In this step, temperature control is extremely important. If the temperature is too high, it is easy to cause side reactions to occur and generate unnecessary by-products. If the temperature is too low, the reaction rate will be delayed and the yield will be affected.
Furthermore, the chlorination reaction. The product after the sulfonation reaction is further chlorinated. At this time, a suitable chlorination reagent can be selected, such as phosphorus pentachloride or dichlorosulfoxide. The chlorination reagent reacts with the sulfonic acid group to convert the sulfonic acid group into a sulfonyl chloride group, thereby obtaining the target product 4-bromo-2,5-difluorobenzenesulfonyl chloride. This step also requires precise control of reaction conditions, such as reaction temperature, reaction time, and molar ratio of reactants.
During the synthesis process, attention should also be paid to the separation and purification of the reaction. After the reaction, the product is often mixed with impurities such as unreacted raw materials, by-products, and reaction solvents. Commonly used separation and purification methods include distillation, extraction, recrystallization, and column chromatography. Through these methods, impurities can be effectively removed and the purity of the target product can be improved.
In addition, safety factors cannot be ignored. The reagents used, such as fuming sulfuric acid, phosphorus pentachloride, etc., are corrosive, toxic, or irritating. During operation, strict safety procedures must be followed, working in a well-ventilated environment, wearing appropriate protective equipment to ensure the safety of the experimenter and the smooth progress of the experiment. In this way, pure 4-bromo-2,5-difluorobenzenesulfonyl chloride products can be obtained.
4-Bromo-2, 5-Difluorobenzenesulfonyl Chloride What are the precautions in storage and transportation
4-Bromo-2,5-difluorobenzenesulfonyl chloride, when storing and transporting, many matters must be paid attention to.
First of all, storage, because of its active nature, is quite sensitive to environmental conditions. The first storage place must be dry and cool. Because of the humid gas, it is easy to cause its hydrolysis, causing it to deteriorate, and its efficacy is greatly reduced. A cool environment can inhibit its chemical reaction rate and ensure the stability of its chemical properties. And it should be kept away from fire and heat sources. These are all hidden dangers of combustion and explosion. If you are not careful, you will be in trouble.
Furthermore, the storage place should be stored separately from alkalis, alcohols and other substances. When alkali meets it, it is easy to cause violent chemical reactions, and alcohols may also react with it, affecting its quality and even causing danger. Be sure to use a sealed storage container to prevent the intrusion of air and water vapor and maintain its chemical integrity.
As for transportation, it should not be neglected. The transportation equipment must be clean, dry, and free of residual impurities to prevent contamination of this material. During transportation, it is necessary to ensure that the temperature is stable, and there should be no large fluctuations to prevent it from decomposing due to temperature changes. The escort must be familiar with its physical and chemical properties and emergency response methods. In case of emergencies, he can respond quickly and save the danger.
And the transportation process should avoid vibration and impact, because it is subject to violent vibration or impact, or the packaging is damaged, causing leakage. Once leaked, it will not only pollute the environment, but also pose a serious threat to the surrounding people. In short, whether storing or transporting 4-bromo-2,5-difluorobenzenesulfonyl chloride, you must be careful and operate strictly in accordance with regulations to ensure safety.
What are the effects of 4-Bromo-2, 5-Difluorobenzenesulfonyl Chloride on the environment and human health?
4-Bromo-2,5-difluorobenzenesulfonyl chloride is a chemical reagent commonly used in organic synthesis. It is widely used in industry and scientific research, but it also has a certain impact on the environment and human health.
When it comes to the impact on the environment, if this chemical is accidentally released into the environment, it can migrate and diffuse through air, water and soil. It may be difficult to degrade in soil, which can cause soil pollution, affect the balance of soil ecosystems, change the structure and function of soil microbial community, and then affect plant growth. In water bodies, it may have toxic effects on aquatic organisms, interfere with the physiological and biochemical processes of aquatic organisms, and reduce biodiversity. And because of its volatility, it can cause adverse effects on air quality in the atmosphere or participate in photochemical reactions.
As for the impact on human health, 4-bromo-2,5-difluorobenzenesulfonyl chloride is irritating. If the human body is in direct contact, whether it is skin contact or eye contact, it can cause irritation symptoms. Skin contact can cause skin redness, pain, itching, and in severe cases, skin burns. Eye contact can damage the conjunctiva and cornea, causing eye pain, tears, blurred vision and other symptoms. If inhaled, its volatile gas can irritate the respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, and long-term inhalation or chronic damage to the respiratory system, such as decreased lung function and respiratory inflammation. If accidentally ingested, it can burn the mouth, throat and gastrointestinal tract, causing nausea, vomiting, abdominal pain, diarrhea and other digestive system symptoms, and may also cause damage to human organs.
Therefore, when using 4-bromo-2,5-difluorobenzenesulfonyl chloride, strict protective measures must be taken to avoid its harm to the environment and human health. In industrial production and experimental operations, attention should be paid to waste disposal and ventilation should be strengthened to reduce its adverse effects on the environment and human body.