4-Bromo-2,3-difluorophenylboronic acid is a valuable reagent in organic synthesis. Its main use is to participate in the Suzuki coupling reaction. This reaction is a classic method for building carbon-carbon bonds and is widely used in pharmaceutical chemistry, materials science, and total synthesis of natural products.
In the field of medicinal chemistry, 4-bromo-2,3-difluorophenylboronic acid can be coupled with various halogenated aromatics or olefins to create compounds with diverse structures. The synthesis of many new drug molecules often relies on this reaction to build a key carbon-carbon skeleton, and then introduce specific functional groups to meet the requirements of drug activity and selectivity.
In the field of materials science, this reagent can be used to prepare organic materials with special photoelectric properties. Through Suzuki coupling reaction, it is connected to compounds containing conjugated structures to synthesize polymers or small molecule materials with unique optical and electrical properties, such as organic Light Emitting Diode (OLED) materials, solar cell materials, etc.
In the field of total synthesis of natural products, 4-bromo-2,3-difluorophenylboronic acid also plays an important role. Natural products have complex structures and are difficult to synthesize. Suzuki coupling reaction provides an effective means for the accurate construction of the carbon skeleton of natural products, and 4-bromo-2,3-difluorophenylboronic acid, as a key reagent, helps chemists to realize the total synthesis of complex natural products, and then in-depth study of their biological activities and pharmacological effects.
In summary, 4-bromo-2,3-difluorophenylboronic acid has shown indispensable value in many scientific fields due to its important position in Suzuki coupling reaction, promoting the continuous development and progress of organic synthetic chemistry.

The synthesis method of 4-bromo-2,3-difluorobenzene-boronic acid is the key content of attention in the field of organic synthesis. The synthesis routes are rich and diverse, and the common ones are as follows.
One is to react with metal reagents by halogenated aromatics, and then undergo subsequent conversion with borate esters. Specifically, 4-bromo-2,3-difluorobenzene is used as the starting material, and magnesium chips are first reacted in anhydrous ether or tetrahydrofuran in an inert solvent to prepare Grignard reagent. This reaction needs to be carried out under harsh conditions without water and oxygen to prevent Grignard reagent from decomposing in contact with water or oxygen. The prepared Grignard reagent is then reacted with boric acid esters such as trimethyl borate or triethyl borate at low temperature, and after hydrolysis steps, 4-bromo-2,3-difluorophenylboronic acid can be obtained.
Second, palladium-catalyzed cross-coupling reaction can be achieved. Using 4-bromo-2,3-difluorobromobenzene and difluorobenzene as reactants, in the presence of palladium catalysts such as tetra (triphenylphosphine) palladium (0), etc., an appropriate amount of bases such as potassium carbonate, sodium carbonate, etc. are added to heat the reaction in suitable organic solvents such as dioxane and toluene. This reaction condition is relatively mild and has high selectivity, which can effectively synthesize the target product. In the reaction process, palladium catalyst is crucial for the smooth progress of the reaction, and its catalytic activity and stability affect the rate and yield of the reaction.
Third, 4-bromo-2,3-difluoroaniline can also be prepared from 4-bromo-2,3-difluoroaniline by diazotization and boracation. 4-bromo-2,3-difluoroaniline is first reacted with sodium nitrite under acidic conditions to form a diazosalt. Subsequently, the diazosalt reacts with boric acid or its derivatives under specific conditions to convert into 4-bromo-2,3-difluorophenylboronic acid. This method requires precise control of the reaction conditions, especially the diazotization reaction. The control of temperature and acidity is extremely critical, otherwise it is easy to cause side reactions and affect the purity and yield of the product.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable synthesis path should be selected according to the availability of raw materials, the difficulty of controlling the reaction conditions, the purity and yield of the product.

4-Bromo-2,3-difluorophenylboronic acid, which is an important reagent in organic synthesis. Its physical properties are unique and related to its performance in various reactions.
In terms of properties, under room temperature, it is mostly white to white solid powder. This form is conducive to storage and use, because it is relatively stable and not easy to evaporate. Looking at its melting point, it is about 120-125 ° C. The exact value of the melting point is of great significance when identifying and purifying this substance. It can be used to determine the purity of the compound. If impurities exist, the melting point is often deviated, or decreased, or the melting range is widened.
In terms of solubility, 4-bromo-2,3-difluorophenylboronic acid exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), and tetrahydrofuran (THF). In dichloromethane, it can be rapidly dissolved to form a uniform solution, providing a convenient reaction environment for many organic reactions. In water, its solubility is poor. This difference in solubility provides ideas for separation and purification, and can be effectively separated from the mixture by solvent extraction.
Furthermore, the density of this substance is about 1.88 g/cm ³. Density, as one of the physical constants, is extremely critical in experimental operations, such as when it involves the conversion of liquid volume and mass. Knowing its density, you can accurately measure the required amount to ensure the smooth progress of the reaction.
In addition, 4-bromo-2,3-difluorophenylboronic acid is quite sensitive to air and humidity. Exposed to air for too long, or in a high humidity environment, it is easy to react and deteriorate. Therefore, when storing, be sure to store it in a dry and sealed container, usually in a cool, dry place, avoid light and humidity, to prevent its physical properties and chemical activities from changing and affecting the subsequent use effect.

The market price of 4-bromo-2,3-difluorophenylboronic acid is difficult to determine. Because the price of chemical products is often influenced by many factors.
First, the price of raw materials is the key end. If the price of bromide, fluoride and boron sources required for the synthesis of this compound fluctuates due to market supply and demand, the distance of origin, and the abundance of resources, the price of 4-bromo-2,3-difluorophenylboronic acid also fluctuates.
Second, the complexity and cost of the production process also have a significant impact. If exquisite and complex processes are required, such as special reaction conditions, high-end equipment, and strict purification processes, the production cost will increase greatly, and the market price will also be high.
Third, the market demand situation should not be underestimated. If this product is in strong demand in the fields of medicine, materials, etc., but the supply is limited, the price will rise; conversely, if the demand is light and the supply is abundant, the price will decline.
Fourth, the brand and scale of the manufacturer are also related to the price. Well-known large factories, with their stable quality and excellent reputation, produce high prices; and under the economy of scale, large factories may be able to reduce costs due to mass production, and the price may be competitive.
Furthermore, regional differences also affect prices. Prices vary from place to place due to differences in transportation costs, tax policies, and market competition.
In summary, in order to determine the exact market price of 4-bromo-2,3-difluorophenylboronic acid, it is necessary to carefully observe the raw material market, production process, market supply and demand, manufacturer status, and regional factors, and to pay attention to the dynamic changes of the chemical market in real time in order to have a more accurate judgment.

For 4-bromo-2,3-difluorophenylboronic acid, all precautions must be paid attention to during storage and transportation.
Its chemical properties are active, and when storing, make sure that the environment is dry and cool. This substance is prone to chemical reactions in case of moisture, causing it to deteriorate, so moisture protection is the first thing. Choose a well-sealed container to avoid contact with water vapor in the air. And excessive temperature will also affect its stability. It should be stored at a low temperature to prevent its decomposition or other adverse changes.
During transportation, stability is essential. Because it may have certain chemical hazards, it must be properly packaged in accordance with relevant regulations. Packaging materials must be able to withstand vibration and collisions to avoid damage to the container due to bumps in the road and leakage. And transportation vehicles should also be kept dry and at a suitable temperature, away from fire and heat sources to prevent accidents. At the same time, transportation personnel must be familiar with the characteristics of this chemical and emergency treatment methods. In the event of leakage, effective measures can be taken quickly to reduce the harm. In this way, the quality and safety of 4-bromo-2,3-difluorobenzene-boronic acid can be ensured during the storage and transportation of 4-bromo-2,3-difluorobenzene-boronic acid.