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4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene

4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    778035

    Chemical Formula C7H3BrF3NO2
    Molecular Weight 270.003
    Appearance Solid (Typical)
    Boiling Point 243.9 - 244.9 °C at 760 mmHg
    Melting Point 42 - 46 °C
    Density 1.802 g/cm³
    Flash Point 101.3 °C
    Solubility Soluble in organic solvents like dichloromethane, chloroform
    Vapor Pressure 0.0253 mmHg at 25 °C
    Refractive Index 1.505

    As an accredited 4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - bromo - 1 - nitro - 2 - (trifluoromethyl)benzene packaged in a sealed container.
    Storage 4 - bromo - 1 - nitro - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air and moisture. This helps maintain its chemical stability and safety.
    Shipping 4 - bromo - 1 - nitro - 2 - (trifluoromethyl)benzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transport due to its potentially harmful nature.
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    4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene 4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene is an important product in chemical research today. Looking at its history, the research of this product has been gradual over the years. At the beginning, the sages of chemistry, diligently explored the properties and changes of substances. In the past, with the rise of organic chemistry, scholars devoted themselves to the acquisition of new chemicals.
    When people studied halogenated aromatics, they sought the method of introducing nitro and fluorinated groups. After many trials and errors, with precise methods, 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene was combined. Early methods were complex and ineffective, but scholars did not stop. With the advance of science and technology, the technique of analysis becomes more refined, and the method of synthesis becomes better.
    Today, this product is widely used in the fields of medicine, agrochemistry, etc. The difficulties of exploring in the past have laid the foundation for its wide use today. Looking back at its history, it can be seen that chemical evolution has changed from simple to complex, from difficult to easy, step by step, eventually resulting in the success and use of this product, contributing to human well-being.
    Product Overview
    Overview of the products of 4-bromo-1-nitro-2- (trifluoromethyl) benzene
    4-bromo-1-nitro-2- (trifluoromethyl) benzene is an important compound in the field of organic chemistry. It has a unique chemical structure, and the bromine atom, nitro group and trifluoromethyl are based on the specific position distribution of the benzene ring, which endow the substance with unique physical and chemical properties.
    From the perspective of chemical properties, bromine atoms are active and easily participate in nucleophilic substitution reactions. They can react with many nucleophilic reagents to achieve functional group transformation; nitro groups have strong electron absorption, which affects the electron cloud density of the benzene ring and changes the activity of the electrophilic substitution The introduction of trifluoromethyl greatly enhances the fat solubility of the compound and has a significant impact on its physical properties such as melting point, boiling point and solubility.
    This compound is widely used in the fields of medicine and pesticides. In pharmaceutical research and development, it can be used as a key intermediate to synthesize drug molecules with specific biological activities; in the field of pesticides, with its unique structure and properties, it can prepare pesticide products with high efficiency, low toxicity and good environmental compatibility. In-depth research on it will provide strong support for the development of related fields.
    Physical & Chemical Properties
    4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, it is solid at room temperature, colored or light yellow, with a certain melting point, which can be accurately measured by experiments. As for its chemical properties, above the benzene ring, bromine, nitro and trifluoromethyl are in their respective positions, resulting in unique reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution reactivity. Although the bromine atom is an ortho-para-site group, it is affected by the nitro group, and the reaction check point also changes. Trifluoromethyl has strong electronegativity, which further affects the electron cloud distribution and spatial structure of molecules. It exhibits different chemical behaviors in many organic reactions and is often used as a key intermediate in the field of organic synthesis. It is often used as a key intermediate to produce various organic materials with special properties.
    Technical Specifications & Labeling
    4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene is an important chemical product. Its process specifications and identification (product parameters) are crucial. The preparation of this product requires a specific process. The first raw material is selected and refined, and the bromide, nitro compound and reagent containing trifluoromethyl must be of high purity. During the reaction process, the temperature, pressure and reaction time must be precisely controlled. If the temperature is too high or side reactions occur frequently, if it is too low, the reaction will be delayed. Pressure also affects the reaction rate and product purity. In terms of identification, the product name, chemical formula, purity, molecular weight and other parameters should be clearly indicated. The packaging must be sturdy to prevent damage during transportation. Only in this way can we ensure the quality and application efficiency of this product and play its due role in the chemical industry.
    Preparation Method
    The method of preparing 4-bromo-1-nitro-2- (trifluoromethyl) benzene is as follows: Prepare the raw material with 1-bromo-3-nitro-5- (trifluoromethyl) benzene as the starting material, which is the key thing.
    The process of preparation is to replace the method by electrophilicity. In an appropriate reactor, add an appropriate amount of 1-bromo-3-nitro-5- (trifluoromethyl) benzene, and add a catalyst, such as iron filings or anhydrous ferric trichloride, which can promote the reaction to proceed quickly.
    Then, slowly inject bromine, control the speed of its dropwise addition, and stabilize the temperature of the reaction, about 50 to 60 degrees Celsius, do not make the temperature fluctuate greatly, to avoid side reactions. When the bromine is dripped and stirred for a few more times, the reaction is complete.
    When the reaction is completed, the product is purified by distillation, except for the untreated raw materials and by-products. First, the low boiling point material is heated to escape, and then the 4-bromo-1-nitro-2- (trifluoromethyl) benzene fraction is adjusted to obtain a pure product. In this method, the yield is quite high, and the product is also pure, which can be used for subsequent purposes.
    Chemical Reactions & Modifications
    4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene, in the field of chemistry, the study of its reaction and modification is very important.
    Looking at its chemical reaction, it often involves the genus of electrophilic substitution. Above the benzene ring, the electron cloud density distribution changes due to the presence of nitro and trifluoromethyl. Nitro is a strong electron-absorbing group, and so is trifluoromethyl. The electron cloud density of the benzene ring is reduced, so the electrophilic substitution reaction activity is weakened, and the substitution check point is also affected by its orientation. Although the bromine atom is an ortho-para-localization group, the selectivity of the reaction check point in this structure is also different from that of the conventional one due to the action of nitro and trifluoromethyl.
    As for modification, other functional groups can be introduced through nucleophilic substitution reaction, thereby changing their physical and chemical properties. The reaction and modification of this compound may open up new paths for the research and development of new materials and drug synthesis, and have far-reaching significance and value.
    Synonyms & Product Names
    In the field of chemistry, there is a name 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene. This thing is also its synonymous name, or it is called. In terms of business names, there are also differences.
    The synonymous names are often used by scientific research institutes in recognition of their chemical properties. And the business names are convenient for the market, and they are ordered according to the needs of the time. Although the two refer to the same thing, they are called differently.
    Scientists use synonymous names to seek precision and clarity, so as to facilitate academic exchanges and the advancement of research. Merchants take business names, hoping that they are easy to memorize, attract customers' attention, and increase the sales of goods.
    Look at this 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene, synonymous names and business names, each with its own uses, complement each other, and co-spectrum chemical things in the world.
    Safety & Operational Standards
    4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene is an important chemical. Safety and operating practices are of paramount importance when researching and producing this substance.
    All operations involving this substance must be carried out in a well-ventilated environment. Due to its toxicity and irritation, if operating in a poorly ventilated area, harmful gases will accumulate, which may endanger the health of the operator. During operation, operators must strictly wear professional protective equipment, such as protective gloves, goggles and gas masks. Protective gloves can avoid direct contact with the skin to prevent chemical burns; anti-goggles can effectively protect the eyes from splashes; gas masks can filter harmful gases in the air to ensure safe breathing.
    There are also strict requirements for the storage of substances. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its certain chemical activity, high temperature or open flame environment may cause dangerous chemical reactions and even cause serious consequences such as explosion. At the same time, obvious warning signs should be set in the storage area to remind personnel to pay attention to safety.
    When using the substance, the operation should be precise and standardized. According to the amount required for experiment or production, use appropriate tools to measure. During the use process, avoid spilling and waste. If there is any spilling, it should be cleaned up immediately in accordance with relevant regulations to prevent pollution to the environment and prevent harm caused by accidental contact with personnel.
    For residual substances and waste after use, it must not be discarded at will. It needs to be properly disposed of according to specific treatment procedures. Generally speaking, it should be collected in a special container and handed over to a professionally qualified treatment agency for harmless treatment to ensure that the entire operation process meets safety and environmental protection requirements and avoids potential threats to the environment and human health. In short, strict adherence to safety and operating practices is an indispensable criterion when researching and using 4-Bromo-1-Nitro-2 - (Trifluoromethyl) Benzene.
    Application Area
    4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene is a unique chemical substance. Its application field is quite wide. In the field of medicinal chemistry, this compound may act as a key intermediate to help synthesize drug molecules with specific biological activities. Its unique structure may endow the prepared drug with unique pharmacological properties to deal with specific diseases.
    In the field of materials science, this substance may be used to create new functional materials. With its special chemical groups, the electrical and optical properties of the material can be adjusted to meet the needs of different fields such as electronic devices and optical materials.
    Furthermore, in organic synthesis chemistry, 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene is often regarded as an important starting material. Chemists can modify and expand its structure through various chemical reactions, resulting in the preparation of a series of organic compounds with complex structures and unique properties. The application of this compound in many fields has opened up broad prospects for chemical research and industrial production.
    Research & Development
    In the field of chemical industry, it is very important to study and develop. Today there is 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene, which is the object of our dedicated study.
    We explore its synthesis method and strive to improve. Initially, we tried various paths, or due to harsh conditions, or because the yield did not meet expectations, none of them were ideal. However, everyone was not discouraged, and they repeated their deliberations and improved the steps.
    On the basis of the reaction conditions, carefully control the temperature and pressure, and carefully consider the ratio of the reactants. After countless attempts, we finally got a method that can steadily improve the yield of this product.
    Looking at its application prospects, it has potential in the fields of medicine, materials, etc. We are exploring in depth and hope to expand its use to help the development of related industries. With time, we will be able to study and develop this product and make great achievements, contributing to the progress of chemical industry.
    Toxicity Research
    Of 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene, chemical substances are also. We study the toxicity of this substance, especially.
    At the beginning, bromine, nitro, and trifluoromethyl groups are attached to benzene. Bromine, or chemical activity, and nitro is oxidizing, and trifluoromethyl is also special.
    Seeking it in the first place, take biological substances, such as rats and rats. At different degrees of this compound or contact it. When rats eat it, there is a sign that the food is not good, and the food is not good. When they encounter it, their vitality is low, and their health is also affected.
    It follows from this that 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene is toxic. It has the ability to affect the physiology of living things, or the ability to break cells. We are very careful about it. It is safe to use it and prevent it.
    Future Prospects
    Prospects of the future, in 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene, this product is an important component of the synthesis, and can be derived from many high-value compounds. The application involves the fields of medicine, medicine, and materials.
    It is expected to develop high-efficiency and low-toxicity new products, protect crops, and ensure the harvest of food. In terms of materials, it may promote the generation of novel functional materials, and promote the progress of science and technology.
    We, the researchers, are committed to further studying their properties and synthesis methods, reducing their costs and improving their efficiency. With unremitting efforts, 4 - Bromo - 1 - Nitro - 2 - (Trifluoromethyl) Benzene will be widely used in the future, benefit the world, and become the grand work of our scientific research.
    Where to Buy 4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene in China?
    As a trusted 4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Bromo-1-Nitro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Bromo-1-Nitro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-nitro-2- (trifluoromethyl) benzene, which has a wide range of uses. In the field of organic synthesis, it is a key intermediate. It can introduce other functional groups through specific chemical reactions, and then build complex organic compounds.
    As far as pharmaceutical chemistry is concerned, it can be used as a starting material to participate in the construction of drug molecules. Because of its unique chemical structure, it can endow the synthesized drugs with specific physiological activities and help to develop new drugs.
    In the field of materials science, it can be used to prepare materials with special properties. For example, by chemical reaction, it can be integrated into the structure of polymer materials, or the material can have excellent properties such as chemical corrosion resistance and heat resistance.
    In the field of dye chemistry, there are also potential applications. Dyes synthesized by their participation in reactions, or due to the bromine, nitro and trifluoromethyl groups they contain, exhibit unique color and dyeing properties, improving the quality and application range of dyes.
    In addition, in the preparation of fine chemical products, 4-bromo-1-nitro-2 - (trifluoromethyl) benzene is also often used as an important raw material to assist in the synthesis of a variety of high-value-added fine chemicals.
    What are the physical properties of 4-Bromo-1-Nitro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-nitro-2- (trifluoromethyl) benzene is also an organic compound. It has unique physical properties, which are described in detail today.
    Looking at its morphology, under normal temperature and pressure, it often appears in a solid state, which is due to the intermolecular force. In the molecular structure, the presence of bromine atoms, nitro groups and trifluoromethyl groups causes the polarity of the molecule to change, which in turn affects its aggregation state.
    When it comes to the melting point, due to the presence of polar groups in the molecule, the intermolecular force is enhanced, so its melting point and boiling point are higher than those of benzene compounds with simple structures. However, the exact value needs to be accurately determined according to experiments.
    In terms of solubility, this compound has a certain solubility in organic solvents, such as dichloromethane, chloroform, ether, etc. Due to the characteristics of its organic groups, it can interact with organic solvents through van der Waals forces, etc., so it is mutually soluble. However, in water, its polarity is not enough to overcome the forces such as hydrogen bonds between water molecules, so the solubility is not good.
    In terms of density, it is larger than that of water. This is due to the large relative atomic mass of bromine atoms, trifluoromethyl atoms or groups in the molecule, resulting in an increase in the mass of the substance per unit volume.
    Furthermore, its volatility is low. Because of the strong intermolecular force, the energy required for the molecule to break away from the liquid surface and enter the gas phase is higher, so it is not easy to volatilize.
    The physical properties of 4-bromo-1-nitro-2- (trifluoromethyl) benzene are determined by its molecular structure, which also has an important impact on its application in organic synthesis, materials science and other fields.
    What are the synthesis methods of 4-Bromo-1-Nitro-2- (Trifluoromethyl) Benzene?
    The synthesis methods of 4-bromo-1-nitro-2-trifluoromethyl) benzene are quite various, and the following is described in detail by you.
    First, it can be started from the corresponding aromatic hydrocarbon. Using 2 - (trifluoromethyl) benzene as the substrate, bromine atoms are first introduced through a bromination reaction. Under appropriate reaction conditions, such as bromine as the bromination reagent, in the presence of catalysts such as iron powder or iron tribromide, bromine atoms can selectively replace hydrogen atoms at specific positions on the benzene ring to generate 4-bromo-2 - (trifluoromethyl) benzene. Subsequently, the resulting product is nitrified. In general, using the mixed acid of concentrated nitric acid and concentrated sulfuric acid as the nitrifying agent, controlling the appropriate temperature and reaction time, the nitro group can be introduced into the 1-position of the benzene ring, thereby preparing 4-bromo-1-nitro-2 - (trifluoromethyl) benzene.
    Second, you can also start from compounds containing nitro groups. For example, 1-nitro-2 - (trifluoromethyl) benzene is used as the raw material to introduce bromine atoms through bromination reaction. During this process, attention should be paid to the regulation of the reaction conditions to ensure that bromine atoms can accurately enter the 4-position of the benzene ring. Selecting appropriate brominating reagents and reaction aids, such as N-bromosuccinimide (NBS) and a suitable initiator, and reacting in a specific solvent is expected to achieve the synthesis of the target product.
    Third, there is another way to start with halogenated aromatics. For example, using 2-bromo-1-nitrobenzene as a raw material, the structure of the target molecule is first constructed by introducing trifluoromethyl. Appropriate trifluoromethylation reagents, such as zinc trifluoromethyl halide, can be used to introduce trifluoromethyl under palladium catalysis and other conditions, and then 4-bromo-1-nitro-2 - (trifluoromethyl) benzene can be synthesized.
    All the above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to carefully select the appropriate synthesis path according to the specific needs, the availability of raw materials and the conditions of the reaction, etc., in order to achieve the purpose of efficient synthesis.
    What are the precautions for 4-Bromo-1-Nitro-2- (Trifluoromethyl) Benzene in storage and transportation?
    4-Bromo-1-nitro-2- (trifluoromethyl) benzene organic compounds, when storing and transporting, need to pay attention to many matters.
    First safety protection. This compound has certain toxicity and irritation, and contact may endanger the human body. The storage place should be well ventilated, and fireworks are strictly prohibited. Operators must wear protective clothing, protective gloves and goggles to avoid skin contact and inhalation of its volatile gases.
    Second storage conditions. It should be stored in a cool, dry place, away from fire and heat sources. Because it is sensitive to light and heat, it is easy to decompose or deteriorate due to heat or light, so it should be stored in a brown bottle and protected from light. At the same time, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc. to prevent chemical reactions.
    Another is the transportation requirement. During transportation, ensure that the container is sealed to prevent leakage. Select appropriate transportation tools and follow relevant regulations on the transportation of hazardous chemicals. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In case of leakage, they can respond in time. And during transportation, they should be protected from exposure to the sun, rain, and high temperature.
    In short, the storage and transportation of 4-bromo-1-nitro-2- (trifluoromethyl) benzene must be operated in strict accordance with regulations, and safety management must be strengthened to ensure personnel safety and environmental safety.
    What are the effects of 4-Bromo-1-Nitro-2- (Trifluoromethyl) Benzene on the environment and the human body?
    4-Bromo-1-nitro-2- (trifluoromethyl) benzene is one of the organic compounds. Its effects on the environment and human body should be investigated in detail.
    In the environment, if this compound is released into nature, its fate is quite complicated. Because of its specific chemical structure, it may be difficult to degrade rapidly in the soil, so it can remain for a long time. It may be adsorbed on soil particles, affecting the physical and chemical properties of the soil, thereby interfering with the structure and function of soil microbial communities and destroying the balance of soil ecosystems. In water bodies, it may migrate with water flow and spread to a wider area. Due to its hydrophobicity, or easy accumulation in aquatic organisms, it is transmitted and amplified through the food chain, posing a threat to organisms at all levels of the aquatic ecosystem. For example, it may cause the growth and development of some aquatic organisms to be blocked, their reproductive ability to decline, and even cause changes in population size.
    As for the impact on the human body, it should not be underestimated. This compound may enter the human body through breathing, diet or skin contact. Once in the body, it may interfere with the normal physiological and biochemical processes of the human body because of its functional groups such as bromine, nitro and trifluoromethyl. Nitro can cause changes in the structure and function of biological macromolecules such as proteins and nucleic acids in the body, affecting the normal metabolism and proliferation of cells. Bromine may have adverse effects on the nervous system and endocrine system, causing symptoms such as headache, dizziness, and endocrine disorders. The presence of trifluoromethyl may enhance its fat solubility, making it easier to penetrate biofilms, and then accumulate in the body, causing damage to important organs such as the liver and kidneys, and affecting their normal functions.
    In summary, 4-bromo-1-nitro-2- (trifluoromethyl) benzene has many potential hazards to the environment and the human body. It should be treated with caution, and monitoring and control should be strengthened to reduce its negative effects.