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4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene

4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    803304

    Chemical Formula C7H3BrF4
    Molar Mass 259.00 g/mol
    Appearance Liquid (usually)
    Boiling Point Around 150 - 160 °C (estimated, actual may vary)
    Solubility In Water Insoluble (hydrophobic due to non - polar aromatic ring and fluorine - containing groups)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, etc.
    Vapor Pressure Low vapor pressure due to relatively high molecular weight and non - volatile nature

    As an accredited 4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - bromo - 1 - fluoro - 2 - (trifluoromethyl)benzene in a sealed, labeled bottle.
    Storage 4 - bromo - 1 - fluoro - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like glass, to prevent leakage and potential reactions with other substances.
    Shipping 4 - bromo - 1 - fluoro - 2 - (trifluoromethyl)benzene is shipped in accordance with chemical transport regulations. It's carefully packaged in suitable containers to prevent leakage, transported by approved carriers ensuring safety during transit.
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    4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene 4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene is also an organic compound. Its traces can be traced back to the chemical research of the past. At the beginning, chemical sages were dedicated to exploring the properties and changes of substances, and dedicated themselves to the acquisition of new chemicals.
    In the past, the method of organic synthesis was not as complete as it is today. Researchers gradually developed it with tenacity and clever thinking. The study of halogenated aromatics is the key to the development of chemistry. 4-Bromo-1-fluoro-2- (trifluoromethyl) benzene is in the synthesis process. After the efforts of several generations of researchers, the technology has gradually refined.
    From the initial crude method, there were many impurities and low yield, to the later delicate design of the reaction path, the selection of suitable reagents and conditions, so that the yield and purity were high. The research and development process of this compound is like a boat in the long river of history. With the torrent of chemical development, it continues to move forward, adding to the progress of chemistry and becoming an important substance in the field of organic synthesis.
    Product Overview
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene
    There is currently a product named 4-bromo-1-fluoro-2- (trifluoromethyl) benzene. It is an organic compound with a unique structure. Looking at its molecules, bromine atoms, fluorine atoms and trifluoromethyl are arranged in an orderly manner on the benzene ring.
    This substance has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate to prepare a variety of high value-added compounds. Its chemical properties are active and can participate in many reactions, such as nucleophilic substitution, coupling reactions, etc. Due to the fluorine-containing group, it is endowed with special physical and chemical properties, good stability and certain fat solubility.
    In industrial production, the preparation requires strict control of reaction conditions to ensure yield and purity. Experimental research also requires fine operation to consider its reactivity and selectivity. This compound is expected to play a greater role in the fields of medicine, materials science and other fields in the future, and help the emergence of innovative achievements.
    Physical & Chemical Properties
    4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, at room temperature and pressure, this substance is mostly colorless to light yellow liquid with a special odor. Its boiling point is about 170 - 180 ° C. Due to the presence of halogen atoms and fluoromethyl groups in the molecular structure, the intermolecular force changes, which in turn affects the boiling point. The melting point is about -20 ° C, showing the physical state change at low temperature.
    On its chemical properties, due to the substitution of bromine, fluorine and trifluoromethyl on the benzene ring, the electron cloud density of the benzene ring changes, and the electrophilic substitution reaction activity is affected. Bromine atom is an ortho-para-site locator and trifluoromethyl is an meta-site locator. The interaction between the two makes the reaction check point selectivity complex. It can participate in a variety of organic reactions, such as nucleophilic substitution reactions. Under appropriate conditions, bromine atoms can be replaced by nucleophilic reagents to derive new organic compounds, which are widely used in the field of organic synthesis.
    Technical Specifications & Labeling
    4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene is a compound commonly used in organic synthesis. The preparation process involves taking an appropriate amount of o-fluorotrifluorotoluene, using iron filings as a catalyst, and slowly adding liquid bromine in a low temperature and dark environment. This process requires precise temperature control and must not exceed a specific threshold to prevent side reactions. After the reaction, the product is purified by distillation, extraction and other steps.
    In terms of product specifications, the appearance should be colorless to light yellow transparent liquid, the purity should be more than 99%, and the moisture content should not exceed 0.1%. The impurity limit is strictly controlled, and the specific impurity should not exceed 0.05%. The identification method can be analyzed by infrared spectroscopy, and its characteristic absorption peak should be consistent with the standard spectrogram; it can also be used by nuclear magnetic resonance hydrogen spectroscopy, and the chemical shift of each hydrogen atom needs to be consistent with the theoretical value to ensure the quality of the product.
    Preparation Method
    The method of preparing 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
    First take the appropriate raw materials and mix them according to a certain ratio. If a halogenated aromatic hydrocarbon is used as the starting point, then add fluorine, bromine and trifluoromethyl related reagents. The reaction steps should be gradual, and the temperature and pressure should be controlled in the first reactor. First, the initial reaction of the starting material should be promoted under mild conditions, so that the halogen atom can be initially replaced.
    In the production process, pay attention to the speed of stirring to ensure the uniform mixing of the material. And the reaction time is accurately grasped and adjusted in a timely manner. As for the catalytic mechanism, specific catalysts can be introduced to reduce the energy barrier of the reaction and promote the rapid progress of the reaction. For example, a metal catalyst can effectively activate the reaction check point and increase the yield of the product. After these steps, 4-Bromo-1-Fluoro-2 - (Trifluoromethyl) Benzene can be obtained.
    Chemical Reactions & Modifications
    Taste the wonders of chemistry, it is related to the change of substances, and the effect is very good. Today there is 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene, and its chemical reaction and modification are worth studying.
    Looking at the reaction, or the method of nucleophilic substitution can be used to translocate bromine atoms and introduce other functional groups to change their properties. This reaction can recombine the molecular structure and derive new substances under appropriate solvents and catalysts.
    As for modification, it can be fine-tuned by halogenation reaction to increase its stability or change its activity, which is suitable for different fields. If it is used in pharmaceutical synthesis, it can optimize pharmacology and cure various diseases; it can be used in material preparation, or it can enhance performance and increase its use.
    The chemical reaction and modification of this substance, if carefully studied, may open up a new path and benefit the world. The power of chemistry is not great.
    Synonyms & Product Names
    4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene, which is also called by the trade name in the field of my chemical research, often exists under different names and trade names.
    The chemical substances contained in the ancient books of Guanfu have different names but are the same. This 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene, or is called "bromofluorotrifluoromethylbenzene", which is a simplified name according to its chemical composition. It is also called by the trade name, which is specially named by the manufacturer in recognition of its characteristics.
    However, no matter what the name is, it refers to this specific chemical substance. In my research, it is necessary to identify its various names in detail to avoid confusion. Although the names are different, their chemistry and characteristics are the same. Only by knowing their synonyms and trade names can we proceed smoothly in the research, so as not to misjudge, so as to achieve the precision and accuracy of the research.
    Safety & Operational Standards
    4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene Safety and Operation Specifications
    Husband 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene, chemical products are also. Its unique nature is related to safety and operation standards, and it should not be careless.
    Safety matters, the first protection. This object is dangerous, and those who come into contact should prepare proper protective equipment. When handling it, you must wear protective clothing, which is tough and can resist its damage, so that the skin does not touch it. You also need to wear goggles, which are the windows to the soul, and cannot be invaded. The protection is comprehensive, and it is safe.
    Furthermore, the operating environment is also the key. It is suitable for a well-ventilated place, so that harmful gases can dissipate quickly and do not gather in the room. If it is in a closed place, the gas cannot come out, and the accumulation will hurt people, and the disaster will not be great.
    The operation is standardized and orderly. When taking it, the action should be slow and not reckless. The amount depends on the square, not a millimeter. When stirring, the speed is moderate and uniform. And the utensils are clean and free of other things to avoid accidental changes.
    The method of storage is also exquisite. When placed in a cool and dry place, avoid heat and light. Heat expands gas, and light can also promote its change, which is not suitable. And keep away from fire sources and oxidizing agents. If they meet, they may cause violent reactions and endanger safety.
    In short, the safety and operation specifications of 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene must be taken with care. Complete protection, operation compliance, and proper storage can ensure smooth operation and no safety risks.
    Application Area
    4-Bromo-1-fluoro-2 - (trifluoromethyl) benzene has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs to cure various diseases, or have antibacterial and antiviral properties, for human health and well-being. In the field of materials science, through clever chemical modification, new materials with specific properties can be prepared, or have excellent heat resistance and chemical corrosion resistance, which can be used in high-end technology products. In the field of organic synthesis, its unique chemical structure allows it to participate in a variety of complex organic reactions, providing the possibility for the creation of novel organic compounds, promoting the continuous progress of organic chemistry, and playing an important role in many fields, with promising prospects.
    Research & Development
    In recent years, I have dedicated myself to the study of 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene. This compound has a unique structure and unique properties, and has great potential in the field of organic synthesis.
    At the beginning, I explored its preparation method, tried many times, and went through twists and turns. The traditional method, or the yield is not high, or there are many impurities. Then I consulted the classics, learned from others' strengths, and improved the process. After repeated trials, I finally obtained a method that can improve the yield and the product is pure.
    Then, study its reaction characteristics. Observe its effect with various reagents, and the reaction varies under different conditions. Record in detail, analyze the rules, and hope to expand its application.
    Looking to the future, I want to extend this research result. Communicate with colleagues, hoping to jointly promote the development of this field. Make 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene in more fields, give full play to its use, and contribute to the progress of chemistry.
    Toxicity Research
    4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene is a chemical substance, which is crucial for the study of its toxicity. Examine this substance in detail today to determine its toxicity.
    This substance has been investigated in a laboratory environment by multiple methods. The white mice were tested and fed with food containing this substance. For a long time, the white mice were seen to be sluggish in action, reduced in food intake, and dull in hair. Cell samples were taken and the solution of the substance was added dropwise to observe the changes in cell morphology and activity. Cell proliferation was inhibited and some cells were apoptotic.
    From this perspective, 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene is toxic and can disturb the normal physiology of organisms. However, the research is still shallow. In the future, it is necessary to expand its breadth and accuracy to explore its long-term impact on the ecosystem. It is also necessary to study the risk of human exposure to this substance, and make policies for protection and governance, to ensure the well-being of all beings and to protect the ecological balance.
    Future Prospects
    I try to study this 4 - Bromo - 1 - Fluoro - 2 - (Trifluoromethyl) Benzene compound. Looking at the present, although all kinds of gains have been made, there are still countless possibilities for future development.
    This compound has a unique structure, and its combination of bromine, fluorine and trifluoromethyl gives it specificity. In the future, in the field of medicine, it may become the basis for innovative medicine stones. With its special activity, it is expected to produce a good medicine for difficult and chronic diseases and save patients from hardship.
    In the world of materials, it may also shine extraordinary light. Or it can be turned into a new type of functional material, with its properties, improve material properties, such as enhancing stability, conductivity, etc., for high-end fields such as electronics and aerospace, and promote the progress of science and technology.
    Although there may be thorns in the road ahead, I firmly believe that with time and unremitting research, this compound will be able to shine in the future, contribute to the development of the world, and be used by all people.
    Where to Buy 4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene in China?
    As a trusted 4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Bromo-1-Fluoro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Bromo-1-Fluoro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene, which is widely used. In the field of organic synthesis, it is often a key intermediate. It can participate in many chemical reactions, and through clever chemical transformation, it can build organic compounds with diverse structures.
    For example, in the world of pharmaceutical chemistry, it is very useful. Using it as a starting material, chemists can carefully design and synthesize drug molecules with specific biological activities. Due to the bromine, fluorine and trifluoromethyl atoms or groups in its structure, the compound is endowed with unique physical and chemical properties, which have a profound impact on the interaction between drugs and biological targets, and then help to develop new drugs with excellent efficacy and high specificity.
    In the field of materials science, 4-bromo-1-fluoro-2 - (trifluoromethyl) benzene also has important uses. It can be used to prepare functional materials with excellent performance, such as photoelectric materials. Due to the existence of fluorine-containing groups, the electrical properties, optical properties and stability of the materials can be significantly improved, so that the prepared materials show unique advantages in optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells and other fields.
    Furthermore, it is also an indispensable member in the preparation of fine chemical products. It can be used to synthesize special dyes, fragrances and other fine chemicals, endowing these products with unique performance and quality, and meeting the diverse needs of the market for high-end fine chemical products. Overall, 4-bromo-1-fluoro-2 - (trifluoromethyl) benzene plays an important role in many fields due to its unique structure, which is of great significance for promoting scientific and technological progress and industrial development in related fields.
    What are the physical properties of 4-Bromo-1-Fluoro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are quite characteristic, let me tell them one by one.
    First of all, its appearance, at room temperature, is mostly colorless to light yellow liquid, clear and translucent, like a clear spring, which makes people feel comfortable. Its color is elegant, highlighting the pure essence of this compound.
    Second, its smell, although not strong pungent smell, but also has a unique smell, just like the faint fragrance of flowers, hidden in the air, you need to smell it carefully to detect. This unique odor is given by its molecular structure, and it is also one of the important signs for identifying this substance.
    Furthermore, on its melting point and boiling point. The melting point is low, and it is easy to maintain a liquid state under common temperature conditions. The boiling point is relatively moderate, about a certain value. This melting boiling point characteristic makes it easier to handle and control this substance in many chemical operations. During heating or cooling, the reaction process can be accurately grasped according to its melting boiling point characteristics to achieve the desired experimental effect.
    Repeat its solubility. This compound exhibits good solubility in organic solvents, such as common ethanol, ether, etc., just like fish entering water, and can be integrated with organic solvents. However, in water, its solubility is very small, and this property is closely related to the polarity of the molecule. Due to its molecular structure, the polarity is weak, and the interaction with water molecules is not strong, so it is difficult to dissolve in water.
    As for the density, it is larger than water. When mixed with water, it can be seen that it sinks to the bottom of the water, like a stone entering the water. This property can be used in the process of separation and purification to achieve the purpose of separation.
    In summary, the physical properties of 4-bromo-1-fluoro-2- (trifluoromethyl) benzene, such as appearance, odor, melting boiling point, solubility and density, each have their own unique characteristics. These properties are not only the key basis for identifying this object, but also lay a solid foundation for its application in many fields such as organic synthesis and material science. In chemical research and industrial production, in-depth understanding and good use of its physical properties can maximize the value of this object.
    What are the synthesis methods of 4-Bromo-1-Fluoro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene is synthesized by the following methods.
    First, aromatic hydrocarbons containing fluorine, bromine and trifluoromethyl are used as starting materials and can be obtained by halogenation reaction. Among them, the choice of halogenating agent is quite critical. If a brominating agent, such as liquid bromine, can undergo electrophilic substitution reaction with benzene derivatives containing fluorine and trifluoromethyl in the presence of a catalyst, bromine atoms can be introduced at specific positions. This process requires fine regulation of reaction conditions, such as temperature and catalyst dosage. If the temperature is too high, polybromination by-products may be generated; improper dosage also affects the reaction process and yield.
    Second, it can be achieved by coupling reaction. Halogenated aromatics containing fluorine and trifluoromethyl are cross-coupled with bromine-containing organometallic reagents, such as Grignard reagent or organolithium reagent, under the action of suitable catalysts. Such reactions require strict control of the reaction solvent and reaction time. The polarity and solubility of the solvent have a great impact on the activity of the reagent and the stability of the reaction intermediate. The reaction time is insufficient, the coupling is incomplete, and the yield is low. If the time is too long, or side reactions occur, the purity of the product will decrease.
    Third, it is obtained from benzene derivatives containing other convertible groups through multi-step conversion. First introduce groups that are easy to convert into bromine, fluorine and trifluoromethyl, and then convert them in sequence through a series of reactions. Although this path is complicated, each step can be flexibly adjusted according to the needs, and the requirements for raw material selection are relatively broad. However, each step of the reaction needs to ensure high yield and purity, otherwise multiple steps will accumulate, and the final yield may be extremely low.
    Synthesis of this compound requires careful consideration of each step of the reaction, optimization of conditions, and high yield and high purity to obtain the target product.
    What are the precautions for 4-Bromo-1-Fluoro-2- (Trifluoromethyl) Benzene in storage and transportation?
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene is an organic chemical. During storage and transportation, many points need to be paid careful attention.
    It is chemically active, and the first environment to dry when stored. Because it is easy to cause reactions such as hydrolysis when exposed to water, it can cause deterioration of substances. Therefore, it should be placed in a dry, well-ventilated place, away from water sources and moisture.
    Furthermore, temperature is also critical. This chemical is quite sensitive to temperature. Excessive temperature may cause it to evaporate and even cause chemical reactions. Therefore, it should be stored in a cool place, usually at 2-8 ° C.
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene is toxic and corrosive to a certain extent, and contact can cause human injury. When storing, ensure that the container is well sealed to prevent leakage. If there is a leak, the surrounding personnel should be evacuated quickly and dealt with according to the corresponding emergency procedures.
    During transportation, do not slack off. This substance must be properly fixed to prevent the container from being damaged due to bumps and collisions. When choosing a transportation tool, consider whether it meets the transportation standards for chemicals and is equipped with necessary protective and emergency equipment. Transport personnel should be professionally trained and familiar with the characteristics of the substance and emergency treatment methods.
    In conclusion, the storage and transportation of 4-bromo-1-fluoro-2- (trifluoromethyl) benzene requires strict adherence to relevant norms and standards, and attention to detail to ensure the safety of personnel and the environment.
    What are the environmental effects of 4-Bromo-1-Fluoro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-fluoro-2- (trifluoromethyl) benzene has a significant impact on the environment. The properties of this substance are related to environmental changes and are a priority today.
    It is in the atmosphere, or difficult to degrade, and has existed for a long time. Due to its special structure, bromine, fluorine and trifluoromethyl are all stable groups, so it can last for a long time. This substance escapes into the atmosphere, or can participate in photochemical reactions, but its specific reaction path still needs to be studied in detail. Or interact with various free radicals in the atmosphere to form new compounds, which in turn affect the chemical composition of the atmosphere and may have an impact on air quality.
    In the aquatic environment, this substance may be insoluble in water due to its hydrophobicity, but it can adhere to suspended particles and migrate with the water flow. If it enters rivers, lakes and seas, or accumulates in the bottom sediments, it will accumulate for a long time, posing a threat to the habitat of aquatic organisms. If aquatic organisms are inadvertently ingested, it may cause abnormal physiological functions, affecting their growth and reproduction, and even endangering the survival of the population.
    In soil, 4-bromo-1-fluoro-2- (trifluoromethyl) benzene can also be retained. Due to its inhibitory effect on soil microorganisms, it can affect the ecological balance of the soil, block the circulation of nutrients in the soil, and then affect the growth of vegetation. If the plant root system absorbs this substance, or transmits it to the above-ground part, it will be transmitted through the food chain, and eventually endanger humans and other organisms.
    In short, 4-bromo-1-fluoro-2 - (trifluoromethyl) benzene has a wide range of effects on the environment, affecting the atmosphere, water bodies, and soil. Its potential harm should not be underestimated, and it is urgent to study in depth in order to find countermeasures to ensure the safety of the environment and protect the peace of all living beings.