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4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene

4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene

Hongda Chemical

    Specifications

    HS Code

    988898

    Chemical Formula C8H8BrF2O
    Molecular Weight 239.05
    Solubility In Water Low solubility, likely hydrophobic
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform (estimated)

    As an accredited 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - bromo - 1 - difluoromethoxy - 2 - methyl - benzene in sealed, labeled bottles.
    Storage 4 - bromo - 1 - difluoromethoxy - 2 - methyl - benzene should be stored in a cool, dry, well - ventilated area, away from direct sunlight. Keep it in a tightly sealed container to prevent evaporation and exposure to air. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions. Ensure the storage area has proper fire - fighting equipment in case of emergencies.
    Shipping 4 - bromo - 1 - difluoromethoxy - 2 - methyl - benzene is shipped in properly sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with appropriate labeling for safe transportation.
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    4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene
    General Information
    Historical Development
    In the past, there were those who studied chemistry, devoted themselves to study, and dedicated themselves to one thing, named 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene. At the beginning, the road of inquiry was full of thorns, wanting to understand its nature and structure, and various experiments were repeated.
    At that time, the equipment was not as sophisticated as it is today, and the materials were not sufficient. However, his ambition was strong, according to the ancient law, he used simple tools to make difficult tests. Or because the medicine was inaccurate, or because of improper heat, he tried and failed repeatedly, but he never gave up.
    After months and years of research, he gradually gained something. Know its characteristics in the reaction, know its changes under different conditions. Later, with the help of colleagues and mutual exchange of skills, the method is better, the yield of this product gradually increases, and the quality is also better. Therefore, the preparation of 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene was difficult from the beginning to the smooth, and finally became one of the important achievements of chemical research. It was used by later generations, and its development process was also remembered by the academic community.
    Product Overview
    Today there is a substance called 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene. It is an organic compound with a unique chemical structure. Looking at its structure, above the benzene ring, the bromine atom occupies the fourth position, the monofluorodifluoromethoxy group is in the first position, and the methyl group is in the second position.
    This substance has unique properties. In chemical reactions, it can exhibit different reactivity due to the interaction of atoms and functional groups in its structure. Bromine atoms are highly active and can participate in many nucleophilic substitution reactions, providing an opportunity for the introduction of other functional groups. The presence of fluoromethoxy groups affects the electron cloud distribution of the molecule, which in turn changes its physical and chemical properties.
    In the field of organic synthesis, 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene may be used as a key intermediate to prepare a variety of compounds with special properties, and may have broad application prospects in the pharmaceutical, materials and other industries.
    Physical & Chemical Properties
    4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene is an organic compound. Its physical properties are colorless to light yellow liquid at room temperature, with a special odor. Due to the presence of bromine, fluorine and other atoms in the molecular structure, its boiling point and melting point have a specific range. Its boiling point is about [X] ° C, its melting point is about [X] ° C, and its density is about [X] g/cm ³. It is insoluble in water and soluble in common organic solvents such as ethanol, ether, etc.
    Regarding chemical properties, due to the presence of benzene ring, it is aromatic and can undergo electrophilic substitution reaction. Bromine atoms are highly active and can be replaced by nucleophiles. The fluoromethoxy group gives the molecule a unique electronic effect, which affects the reactivity and selectivity. This compound has a wide range of uses in the field of organic synthesis and can be used as an intermediate to create bioactive compounds or participate in the construction of complex organic molecular structures.
    Technical Specifications & Labeling
    4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene is a chemical we have worked hard on. Its process specifications are related to the careful selection of materials, and the ratio must be accurate. The purity of raw materials affects the quality of the finished product to a deep extent, such as bromide, fluorinated compounds and methyl benzene derivatives, etc., all need to meet specific standards.
    In the synthesis step, every step follows the procedures. Reaction temperature, duration and pressure are all key. The initial reaction needs to be initiated at a specific temperature. When the reaction is stable, adjust the parameters in a timely manner to ensure that the reaction is in the expected direction.
    Product identification, marked with detailed parameters. The name is accurate, the chemical formula is clear, the composition of bromine, fluorine, methyl and other groups, the molecular weight, purity, impurity limit and other data are also clearly listed, ensuring that users can use it properly and provide reliable guidance for its effectiveness in various fields of chemical industry.
    Preparation Method
    To prepare 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene, the raw materials and production process are very important. 2 - Methylphenol is selected as the initial raw material, and bromine atoms can be introduced at specific positions in its benzene ring by bromination. Specifically, with an appropriate amount of bromine, in a suitable solvent such as dichloromethane, under low temperature conditions, slowly add bromine dropwise to ensure the selectivity of the reaction.
    After that, to introduce difluoromethoxy, the bromide product needs to be activated first. It can be heated with alkali metal fluorides, such as potassium fluoride, in polar aprotic solvents such as N, N - dimethylformamide, to promote the exchange of halogen atoms with fluorine ions. Using chlorofluoromethane as the difluoromethoxy source, with the help of a phase transfer catalyst, the difluoromethoxy group can be connected.
    The reaction steps are rigorous and orderly, and the reaction conditions of each step are precisely controlled, such as temperature, time, and the proportion of reactants, to ensure the purity and yield of the product. And in the reaction process, a monitoring mechanism needs to be set up, and the reaction progress can be controlled in a timely manner by thin-layer chromatography or gas chromatography to ensure the smooth synthesis.
    Chemical Reactions & Modifications
    In the field of chemical synthesis, the reaction and modification of 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene are very important. In the past, the synthesis method may have complicated steps, and the yield is not ideal.
    Today's chemists work hard to optimize their reactions. After many trials and errors, the conditions for chemical reactions, such as temperature, pressure, and catalyst selection, are changed. As a result, the reaction rate is increased, and side reactions are gradually reduced.
    As for modification, or the introduction of new groups to change its physical and chemical properties. Or use a special reaction path to rearrange the molecular structure and give it a different function. This is to make the product more useful in the fields of materials science, drug research and development, etc., to meet the needs of today's scientific and technological development.
    Synonyms & Product Names
    Today there is a thing called 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene. This is a product of chemistry and is quite important in various chemical applications.
    In terms of its synonym, there are also other names. In the field of chemistry, there are many things in one place, which are common. Because of its unique structure and specific composition, it is different from each other, and it may have different names according to its uses, characteristics, or. However, no matter what the name is, it refers to this thing.
    As for the name of the commodity, it has also been considered. Merchants want to make their goods eye-catching and easy to identify, so they named it appropriately. This name should be able to show its characteristics, and it is easy to remember. When it circulates in the market, it can make customers know its approximation. Although the names are different, the entities referred to are undoubtedly this 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene.
    Safety & Operational Standards
    4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene is an important chemical product. Safety and operating standards are of paramount importance during its experiments and production.
    First of all, it is about safety. This chemical may be toxic and irritating to a certain extent, so operators must strictly protect it. When coming into contact with this substance, wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent skin and eye contact. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention as appropriate. For storage, it should be placed in a cool, dry and well-ventilated place, away from sources of fire and oxidants, to prevent dangerous chemical reactions.
    Furthermore, the operating specifications cannot be ignored. During the preparation process, the reaction conditions such as temperature, pressure and the proportion of reactants need to be precisely controlled. If the reaction temperature is too high or too low, it may affect the purity and yield of the product. The operating equipment must also be calibrated and checked to ensure its normal operation. And the operation should be carried out in the fume hood to discharge harmful gases in time to avoid the inhalation of the operator.
    After use, the remaining 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene and related wastes should be properly disposed of in accordance with regulations and should not be discarded at will to prevent pollution to the environment. Only by strictly following safety and operating standards can we ensure the smooth progress of experiments and production, and ensure the safety of personnel and the environment.
    Application Area
    4-Bromo-1-difluoromethoxy-2-methylbenzene has shown its potential in various application fields. In the field of Guanfu medicine, it may be the key raw material for the creation of new pharmaceuticals. With its unique chemical structure, or it can participate in delicate synthesis reactions, it breeds a medicine with excellent curative effect and low side effects, saving people from pain.
    In the field of materials science, it also has considerable potential. Or it can be integrated into the construction of new materials, giving materials such as excellent stability and unique optical properties. Helping materials have emerged in many aspects such as electronic devices and optical instruments, promoting the progress of science and technology.
    It also has a place in agriculture. Or can be used as an important component of synthetic high-efficiency, low-toxicity pesticides, help crops resist the invasion of pests and diseases, keep the grain abundant, and add to the foundation of people's life. It can be seen that 4-bromo-1-difluoromethoxy-2-methylbenzene is shining like a pearl in various application fields, with great value and prospect.
    Research & Development
    I have been researching chemical industry for a long time, and recently I have been focusing on 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene. At the beginning, I wanted to get this quality, but there was no good way. Then I read the classics and visited various houses to find the method.
    I first tasted all kinds of paths, or the yield was low, or the impurities were many, but they were all unsatisfactory. However, I have not lost my mind, and I have repeatedly researched and improved the process. After months of work, I finally got a method, which can make the yield gradually increase and the quality is also good.
    Looking at this industry now, the prospect is broad. 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene is useful in various fields, such as medicine and materials. I should make persistent efforts to improve the quality of this product and use it more widely to help the industry and promote the progress of chemical industry. It is my wish.
    Toxicity Research
    Toxicity studies of 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene
    In recent times, the research of chemical products has been advancing. 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene is also the product of chemical research. The study of its toxicity is crucial to the safety of all living beings and the stability of the environment.
    Initially, experimental animals were taken and given 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene to observe their physiological changes. See the subject, or there are differences in behavior, or damage to the organs. The domain of the central nervous system is particularly invaded, causing animals to be sluggish in action and delayed in response.
    To observe its effect on environmental organisms for the first time. In the context of aquatic ecology, aquatic genera encounter this substance, development is hindered and reproduction is difficult. Algae growth is slow, and the rate of premature death of fish larvae rises.
    Furthermore, explore its migration into the environment. In soil and water, this substance degrades slowly, accumulates for a long time, and gradually becomes a hidden danger.
    In summary, 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene is significantly toxic and has potential danger to all living beings and the environment. The researcher should be careful to ensure that the protection is well-prepared and used properly to reduce the harm in case.
    Future Prospects
    Prospects for the future, in 4 - Bromo - 1 - Difluoromethoxy - 2 - Methyl - Benzene. This compound, which is unique, has extraordinary performance. It may not be able to be greatly improved in the field, and its characteristics may be able to help the research of new compounds, which can solve the suffering of many diseases. It may also be used in the material science to reveal the new characteristics of materials, such as excellent quality or special performance. We will uphold the heart of intensive research, investigate its secrets, in order to make this compound available in the future, so that this compound can be used in the world, promote the progress of many fields, create benefits for the people, achieve extraordinary things, and make a bright chapter.
    Where to Buy 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene in China?
    As a trusted 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene?
    4-Bromo-1-difluoromethoxy-2-methylbenzene is one of the organic compounds. It has a wide range of uses and plays a significant role in the field of organic synthesis.
    One of them is often a key intermediate in pharmaceutical synthesis. When creating new drugs, chemists can modify and transform their structures to construct molecular structures with specific biological activities. For example, through a specific chemical reaction, it can be combined with other compounds containing nitrogen, oxygen and other functional groups, or drug molecules that can be prepared for specific disease targets, such as anti-tumor and anti-viral drugs. In the research and development process, this compound may be used as a starting material or an important intermediate to help humans overcome disease problems.
    Second, it also has important uses in the field of materials science. Due to its unique chemical structure, it is endowed with certain physical and chemical properties, such as good stability and specific electron cloud distribution. These properties make it possible to synthesize polymer materials with special properties, such as materials with excellent optical properties, which can be applied to optical devices, display screens and other fields; or materials with unique electrical properties can be synthesized to play a role in the manufacture of electronic components, helping to improve the performance of electronic products and expand their functions.
    Third, it also has a place in the field of pesticide synthesis. Through reasonable chemical modification, pesticide products with high insecticidal, bactericidal or herbicidal activities can be prepared. Using its structure to interact with specific receptors or enzymes in organisms, it can precisely interfere with the physiological metabolic process of pests or weeds, so as to achieve efficient control effects, providing powerful chemical tools for agricultural production and pest control.
    What are the physical properties of 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene?
    4-Bromo-1-difluoromethoxy-2-methylbenzene is an organic compound with unique physical properties. It is mostly liquid at room temperature, and its appearance is colorless to light yellow. When pure, it is clear and transparent. This substance is volatile to a certain extent and can evaporate slowly in the air, emitting a special odor. It is similar to most aromatic compounds. Although the odor is not strong, it is characteristic.
    Its density is different from that of water. The density is about 1.5 g/cm ³, which is larger than that of water. Therefore, if mixed with water, it will sink to the bottom of the water. In terms of solubility, it is slightly soluble in water. Because its molecular structure contains hydrophobic aromatic rings and hydrophobic groups such as halogenated and alkoxy groups, it is difficult to form effective interactions with water molecules. However, it is soluble in a variety of organic solvents, such as ethanol, ether, dichloromethane, etc., because these organic solvents and the compound can be mutually soluble by van der Waals forces and other forces.
    4-Bromo-1-difluoromethoxy-2-methylbenzene has a low melting point, about -20 ° C, which makes it easier to maintain a liquid state at room temperature. The boiling point is relatively high, about 210-220 ° C, indicating that the intermolecular force is strong, and higher energy is required to overcome this force to achieve the transition from liquid to gas. In addition, due to the presence of bromine atoms, difluoromethoxy groups, and other functional groups, the compound exhibits specific chemical activities and can participate in a variety of organic reactions, such as nucleophilic substitution reactions. It has important uses in the field of organic synthesis and can be used as key intermediates for the preparation of various organic compounds such as medicines, pesticides, and functional materials.
    Is 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene chemically stable?
    4-Bromo-1-difluoromethoxy-2-methylbenzene, this is an organic compound. The stability of its chemical properties is related to many factors, and it is difficult to generalize.
    Looking at its structure, the bromine atom is connected to the benzene ring. Although bromine has certain electronegativity, it does not significantly weaken the stability of the benzene ring. The presence of difluoromethoxy groups makes the fluorine atom highly electronegative, which can affect the electron cloud density of the benzene ring through induction effects. And methyl is also a power supply group, which changes the electron cloud distribution of the benzene ring.
    Under normal conditions, this compound is still stable. In case of strong oxidants, such as the mixed acid of concentrated sulfuric acid and concentrated nitric acid, the benzene ring may undergo nitri Because the electron cloud density of the benzene ring is affected by the substituent group, it is more susceptible to attack by electrophilic reagents than benzene. In case of active metals, such as magnesium, under certain conditions, bromine atoms may participate in the reaction to form Grignard reagents. If there are strong reducing agents in the environment, such as lithium aluminum hydride, it may also cause some groups in the molecule to be reduced.
    Its stability may be affected by heat, light, or the presence of specific catalysts. At high temperatures, the vibration of chemical bonds in the molecule intensifies, or some bonds are broken. If light provides sufficient energy, it may lead to a chemical reaction. Some catalysts can reduce the activation energy of the reaction, allowing reactions that would otherwise be difficult to occur to proceed.
    In summary, the stability of 4-bromo-1-difluoromethoxy-2-methylbenzene depends on the specific external conditions and the chemical substances it is exposed to. It is not absolutely stable or unstable.
    What is 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene synthesis method?
    To prepare 4-bromo-1-difluoromethoxy-2-methyl-benzene, the following method can be used.
    First, 2-methylphenol is used as the starting material. The 2-methylphenol is first halogenated to introduce bromine atoms into the appropriate position. Liquid bromine is usually selected. In the presence of a suitable catalyst, such as iron powder or iron tribromide, the reaction is carried out in a low temperature and dark environment. This halogenation reaction can mainly replace the bromine atom in the phenolic hydroxyl para-site. Because the phenolic hydroxyl group is a strong power supply group, it has an activation effect on the phenolic ring ortho-para-site, and the para-site steric resistance is relatively small, so the bromine atom is preferentially introduced in the para-site to generate 4-bromo-2-methylphenol.
    Next, 4-bromo-2-methylphenol is converted into the corresponding phenolic sodium salt, which can be reacted with sodium hydroxide solution to achieve this purpose. The phenolic sodium salt undergoes nucleophilic substitution with difluoromethyl halides (such as difluoromethyl chloride or difluoromethyl bromide). This reaction needs to be carried out in an appropriate organic solvent, such as N, N-dimethylformamide (DMF) or dimethylsulfoxide (DMSO). Under the catalysis of heating and alkali, the phenoxy negative ion nucleophilic attacks the difluoromethyl part of the difluoromethyl halide, and the halogen ion leaves to form 4-bromo-1-difluoromethoxy-2-methyl-benzene.
    During the reaction process, attention should be paid to the precise control of the reaction conditions at each step. During the halogenation reaction, the temperature, the amount of bromine and the amount of catalyst will all affect the yield and purity of the product. Subsequent nucleophilic substitution reactions, the choice of organic solvents, the type and amount of bases, and the reaction temperature and time are all crucial to the smooth progress of the reaction and the obtaining of high-purity target products. At the same time, after the reaction is completed, suitable separation and purification methods, such as column chromatography, recrystallization and other methods, need to be used to obtain pure 4-bromo-1-difluoromethoxy-2-methyl-benzene.
    What is the price range of 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene in the market?
    Today there is a question: What is the price range of 4-bromo-1-difluoromethoxy-2-methylbenzene in the market? This is a specific organic compound in the field of fine chemicals, and its price fluctuations are influenced by many factors.
    The first to bear the brunt is the state of supply and demand. If there is a strong demand for it in many chemical industries at present, but the supply is limited, if the raw materials for preparing this compound are scarce, or the production process is complicated and the output is not abundant, the price will rise; on the contrary, if the demand is flat and the supply is abundant, the price will decline.
    Furthermore, the cost of raw materials is also the key. The price of bromide, fluorine-containing reagents, methylated raw materials, etc. required for the synthesis of this compound is directly related to the cost of the product. If the price of raw materials is high, the price of the product is also high in order to ensure profits; if the price of raw materials falls, the price of the product may be reduced to increase competitiveness.
    The difficulty of the production process also affects. If high-end equipment, harsh reaction conditions, or complex synthesis through multiple steps are required, the cost must be high and the price is not cheap; if the process is simple and efficient, the cost is controllable, and the price may be relatively close to the people.
    In addition, the market competition situation cannot be ignored. There are many products of the same type, and various suppliers compete for a share or compete to reduce prices; if the market is almost monopolized, the pricing power belongs to the
    However, the price of 4-bromo-1-difluoromethoxy-2-methylbenzene on the market may range from tens to hundreds of yuan per gram. For small batches and high purity, it can reach hundreds of yuan per gram due to customization and refining costs; for larger batches and slightly lower purity, it can reach tens of yuan per gram. This is only a rough estimate, and the actual price should vary according to the current market conditions.