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4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene

4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene

Hongda Chemical

    Specifications

    HS Code

    188820

    Chemical Formula C7H4BrF3O
    Molecular Weight 241.005 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point Approx. 178 - 180 °C
    Density Data may vary, typically in range of halogenated aromatic ethers
    Solubility Soluble in common organic solvents like dichloromethane, toluene
    Vapor Pressure Low vapor pressure at room temperature
    Flash Point Data may vary, but potentially flammable in presence of ignition source
    Stability Stable under normal conditions, but reactive with strong oxidizing agents

    As an accredited 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - bromo - 1 - difluoromethoxy - 2 - fluorobenzene in sealed chemical - grade bottle.
    Storage Store 4 - bromo - 1 - difluoromethoxy - 2 - fluorobenzene in a cool, dry, well - ventilated area away from sources of ignition and heat. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Avoid storing it near oxidizing agents or reactive chemicals. Ensure storage conditions maintain the chemical's stability and prevent leakage or contamination.
    Shipping 4 - bromo - 1 - difluoromethoxy - 2 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring safe transport to prevent leakage and environmental risks.
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    4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene
    General Information
    Historical Development
    4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene is a unique compound. Looking back at its historical development, when chemical research was first emerging in the past, scholars continued to study in the field of organic synthesis. At that time, although the synthesis technology was still in its infancy, all the sages were enthusiastic and determined to discover new substances.
    At first, the ancestors noticed the potential properties of this compound and tried various reaction paths through countless experiments. Early experimental conditions were simple and the purity of the reagent was also poor, so the synthesis of this compound often encountered obstacles. However, with the perseverance of the ancestors, the synthesis method was gradually improved. With the passage of time, science and technology advanced, the instruments became more and more sophisticated, and the understanding of the reaction mechanism became more and more profound. The discovery of new catalysts and the precise regulation of reaction conditions have greatly improved the synthesis efficiency and purity of 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene, laying the foundation for more related research and applications in the future.
    Product Overview
    4-Bromo-1-difluoromethoxy-2-fluorobenzene is a new chemical product developed by us. It is a colorless and transparent liquid with unique chemical properties. The molecular structure of this product is exquisite, and bromine atoms, difluoromethoxy groups and fluorine atoms interact according to their positions, resulting in unique chemical activities.
    In the field of organic synthesis, it can be a key intermediary. Due to its activity, bromine can trigger many nucleophilic substitution reactions, allowing it to be cleverly combined with various reagents to expand the variety of compounds. The introduction of difluoromethoxy and fluorine atoms also significantly changes the polarity and stability of molecules, and may have extraordinary applications in the fields of medicinal chemistry and materials science.
    After repeated experiments and fine analysis, we have clarified its physical and chemical properties, laying a solid foundation for subsequent application research. We hope to use this product as a basis to open up new frontiers in chemical research and benefit the world.
    Physical & Chemical Properties
    4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene is a unique chemical substance. Its physical properties, under normal temperature, or a colorless and transparent liquid, have a special smell, its taste is strong, and the smell is pungent. Its boiling point is moderate, and under a certain pressure, it can reach a specific temperature, which is the key to maintaining its gas-liquid balance. The melting point is relatively low, and its solidified state can be seen in low temperature environments.
    In terms of chemical properties, bromine atoms in this substance are active and easily participate in nucleophilic substitution reactions. Under suitable reaction conditions, they can be replaced by other nucleophilic reagents. The fluorine-containing group endows it with unique chemical activity, which makes it exhibit special properties in many chemical reactions. Its fluorine atom has high electronegativity, which affects the distribution of molecular electron clouds, which makes the substance have potential application value in the field of organic synthesis. It can be used as a key intermediate to participate in the construction of complex organic compounds.
    Technical Specifications & Labeling
    Today there is a product called 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene. The technical specifications and labels (commodity parameters) of its production are related to the quality of this product and its wide range of uses.
    To clarify its technical specifications, it is necessary to carefully consider the coarseness of the raw materials, the proportion of whether it is appropriate, and the preparation process, from the initial combination, to the transformation in the middle, and finally to the extraction of the finished product. The conditions of each step of the reaction, such as temperature, pressure, and the selection of catalysts, need to be precisely controlled to obtain the best product.
    As for the identification (commodity parameters), the physical and chemical characteristics of this product should be detailed, such as color, taste, state, melting point, solubility, etc., so that the user can see at a glance. It should also be clear about its purity geometry and what impurities it contains, so as to be practical. In this way, it is a complete technical specification and identification (commodity parameters), which is of great benefit to those who use this product.
    Preparation Method
    To prepare 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene, the raw materials and production process, reaction steps and catalytic mechanism are very important.
    First take an appropriate amount of fluorobenzene derivatives as the base material, add a specific proportion of brominating reagents, and promote the bromination reaction at a moderate temperature and catalytic environment. At the beginning of the reaction, the temperature and stirring rate need to be strictly controlled to make the reaction proceed uniformly. After the bromination step is completed, the product is separated and purified to obtain a bromine-containing intermediate.
    Then, the intermediate is mixed with the difluoromethoxylation reagent, supplemented by a suitable catalyst, and the reaction conditions are adjusted to make the difluoromethoxy group integrate smoothly. In this step, the control of catalyst activity and reaction time is of paramount importance, which is related to the purity and yield of the product.
    The entire preparation process, the precise regulation of each reaction step, the appropriate proportion of raw materials, and the rational use of the catalytic mechanism are all the keys to the preparation of high purity 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene, and careful operation is required.
    Chemical Reactions & Modifications
    4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene, it is also a matter of transformation. Its transformation and reverse modification are the key to our research.
    If you want to obtain this thing, you often use the method of general transformation. Or the appropriate raw materials, the method of addition and substitution, can be obtained in the long run. However, in the middle of the reaction, the quality of the product is the best. The level of the degree, the rate of reflection. If the degree is high, or the side reaction is caused to grow, the quality of the product is guaranteed; if the degree is low, the reaction is slow, and it lasts for a long time.
    As for the modification, other groups can be introduced to improve its properties. Or increase its quality, or change its solubility, to make it more suitable for use. For example, by replacing the atom at a specific position with a certain group, it can be made to have different chemical activities. Therefore, study the chemical and reverse modification of this material, and observe all factors, and strive to achieve perfection, so as to help with chemical engineering and multi-domain.
    Synonyms & Product Names
    I have heard that there is a thing named 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene. Its similar name is also due to our generation. The same name of this thing is related to the change of its title, and it also involves the customary name of the industry.
    Throughout the ages, the name of a thing has often changed according to time, place and use. The same thing was called this at that time, and it was called that at this time. In Siye, or because of the characteristics of its chemical structure, or because of the field of its application, it has a different name. The same name is not only a change in the title, but also the evolution of industry cognition and the circulation of technology application.
    As chemical researchers, we should carefully examine the same name and clarify its ins and outs, so that we can be accurate and not confused when researching and applying it. Knowing the wonder of the same name of this thing can also contribute to the chemical industry and help it prosper.
    Safety & Operational Standards
    4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene Safety and Operating Specifications
    If you want to make 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene products, the first priority is safety, follow the operating specifications, and you will be safe.
    This product has certain chemical activity, which is related to the safety of people and the environment. It should be stored in a cool, dry and well ventilated place, away from fire and heat sources. Avoid direct sunlight to prevent its properties from changing. The reservoir must be tightly closed to avoid contact with air, moisture, etc.
    When handling, all kinds of protection should not be ignored. Wear appropriate protective clothing, protective gloves and goggles to prevent it from touching the body and entering the eyes. If it is not well ventilated, it is even more necessary to prepare respiratory protective equipment.
    When preparing, follow precise steps. Control the reaction temperature and rate, and keep an eye on the reaction process. Do not mix the reactants suddenly and cause overreaction. Use the finished utensils and wash them immediately to prevent the residual matter from changing.
    If you accidentally touch them, rinse them with plenty of water as soon as possible. Those who enter the eyes should be rinsed thoroughly and seek medical attention immediately. If aspiration, move to a fresh air place and apply artificial respiration if necessary. If eaten by mistake, do not induce vomiting, and seek medical treatment immediately.
    Waste should not be discarded at will. According to relevant regulations, collect it by classification and dispose of it properly to ensure a clean environment and ecological safety. All of these are essential for the safety and operation of 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene. Practitioners must not ignore and always abide by the norms to ensure that everything goes smoothly and without worry.
    Application Area
    4-Bromo-1-difluoromethoxy-2-fluorobenzene, the application field of this substance is very important. In the field of pharmaceutical synthesis, it can be a key intermediate and help to create new anti-disease drugs. With its unique chemical structure, it can participate in various reactions and accurately construct specific pharmacoactive groups, providing strong support for the drug research to overcome difficult diseases.
    In the field of materials science, it also plays a role. Or can be used to synthesize functional materials with special properties, such as photoelectric materials. Due to its fluorine and bromine-containing properties, it may endow materials with excellent optical and electrical properties, and play an important role in the fields of electronic displays, optoelectronic devices, etc., promoting the progress and innovation of related technologies.
    Research & Development
    Today there is a product named 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene. I am a chemical researcher and have been studying it for many years.
    The research of this compound is related to many aspects. Its structure is unique, the atomic arrangement is orderly, and the elements such as bromine and fluorine are ingeniously combined, giving it special characteristics.
    During the research and development process, we investigated its reaction mechanism in detail. After repeated experiments, we explored the changes under different conditions. Tried a variety of synthetic paths, striving for efficient and pure production.
    Although encountering many obstacles, such as low reaction yield and difficult removal of impurities, etc. However, we worked tirelessly to adjust the plan and finally achieved something.
    This compound may be of great use in materials science, drug development and other fields. Hope to further explore and expand its applications in the future to promote scientific progress and be used by the world.
    Toxicity Research
    Today there is a substance called 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene. I am a chemical researcher, specializing in the study of toxicants.
    The toxicity of this substance cannot be ignored. Explore in detail to clarify its properties. Its molecular structure is unique, or it may cause various abnormalities in organisms. After repeated experiments, observe its impact on various organisms, and observe the changes in cells and physiological differences.
    Although the mechanism of its toxicity is not fully understood, there are clues. Or due to interaction with biological macromolecules, it disrupts the normal biochemical path. It spreads in the environment, and it also harms the ecology. Or it is absorbed by soil and water sources, and then harms living things. Therefore, the study of the toxicity of this substance should be persevered in order to know its details in order to prevent problems before they occur and ensure the safety of all things.
    Future Prospects
    I try to research 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene. This product is unique and has a wide range of uses. Although the research is not complete at present, I am looking forward to the future.
    In the future, the research of this product will definitely be refined. Or it can find another way in the synthesis method to make the yield higher and the cost lower. And it is expected to shine in the fields of medicine and materials. Or it can be a key raw material for the development of new drugs, help the progress of medicine, and solve the diseases of everyone; or it can be the cornerstone of new materials, promote material innovation, and meet the needs of many parties.
    I firmly believe that in time, 4 - Bromo - 1 - Difluoromethoxy - 2 - Fluoro - Benzene will be able to shine and benefit the world. This is my future vision.
    Where to Buy 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene in China?
    As a trusted 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene?
    4-Bromo-1-difluoromethoxy-2-fluorobenzene, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
    In the field of medicinal chemistry, with its unique chemical structure, it can be used to create new drugs. Because of its specific functional groups, it can interact with targets in organisms, thus helping to develop compounds with specific pharmacological activities, or used in the development of antibacterial, antiviral, anti-tumor and other drugs.
    In the field of materials science, it also has extraordinary performance. It can be used as a starting material for the synthesis of materials with special properties. Through chemical modification and polymerization, materials with special optical, electrical or thermal properties can be prepared, such as in the fields of optoelectronic materials, polymer materials, etc., to meet specific industrial and scientific research needs.
    In terms of pesticide chemistry, its structural characteristics make it potential to become a synthetic component of high-efficiency pesticides. By designing and synthesizing compounds containing this structure, or by developing pesticides with high selectivity and efficiency for specific pests, it can contribute to the control of pests and diseases in agricultural production. Due to its unique combination of bromine, fluorine, and difluoromethoxy functional groups, this compound has shown important application value in many fields such as organic synthesis, medicine, materials, and pesticides, promoting technological innovation and development in various fields.
    What are the physical properties of 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene?
    4-Bromo-1-difluoromethoxy-2-fluorobenzene is one of the organic compounds. Its physical properties are primarily related to the state of matter. At room temperature, it is often liquid, clear in appearance, no significant color, colorless and transparent, and pure and uniform in texture.
    When it comes to smell, it has a special aromatic smell, but this smell is not pleasant, but slightly irritating, and it is easy to feel uncomfortable when smelled. It is caused by the combined action of halogen atoms and methoxy groups in its structure.
    Furthermore, it is related to its density. Compared with water, this compound has a higher density. If mixed with water, it will sink to the bottom of the water. Due to the relatively large mass of bromine atoms in the molecule, the overall density increases.
    In terms of boiling point, the boiling point of this substance is quite high, about a certain temperature range. Due to the interaction between molecules such as van der Waals forces, coupled with the structure formed by halogen atoms and methoxy groups, the force between molecules is enhanced, so a higher temperature is required to make the molecules break free from each other and boil.
    Solubility is also an important physical property. In organic solvents, such as common ethanol, ether, etc., its solubility is good, and it can be miscible with organic solvents in a certain proportion. This is due to the principle of "similar miscibility", and its molecular structure is similar to that of organic solvent molecules. In water, its solubility is poor, almost insoluble, and it is difficult to form an effective interaction to achieve dissolution due to the large difference between molecular polarity and water molecular polarity.
    What is the chemical synthesis method of 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene?
    To prepare 4-bromo-1-difluoromethoxy-2-fluorobenzene, the following method can be used.
    Starting material, 2-fluoro-4-bromophenol and difluorobromomethane can be selected. The reaction of the two can obtain the target product.
    First dissolve 2-fluoro-4-bromophenol in a suitable organic solvent such as N, N-dimethylformamide (DMF). The system needs to be protected by low temperature and inert gas, and a strong base such as sodium hydride is added. Sodium hydride reacts with the phenolic hydroxyl group of 2-fluoro-4-bromophenol to form phenoxy anion.
    At this moment, difluorobromomethane is slowly added dropwise. The phenoxy anion nucleophilic attacks the carbon atom of difluorobromomethane, and the bromine ion leaves, thus forming 4-bromo-1-difluoromethoxy-2-fluorobenzene.
    After the reaction is completed, pour the reaction solution into ice water, and adjust the pH to weak acidity with dilute acid, such as hydrochloric acid. The product can be extracted with an organic solvent, such as ethyl acetate, or in the organic phase. The extract was dried by anhydrous sodium sulfate, the solvent was removed by rotary evaporation, and then separated and purified by column chromatography to obtain pure 4-bromo-1-difluoromethoxy-2-fluorobenzene.
    Another way, 2-fluoro-4-bromoanisole can also be used as the starting material. First, it is reacted with a fluorine reagent under suitable conditions to introduce fluorine atoms. Then, under specific conditions, the methoxy group is converted to difluoromethoxy. The methoxy group can be activated with a strong oxidizing agent, such as trifluoromethanesulfonic anhydride, and then reacted with a difluoromethylating agent, such as difluoromethyltrimethylsilane, to obtain 4-bromo-1-difluoromethoxy-2-fluorobenzene. The post-reaction treatment is similar to the above method, and the pure product can be obtained by separation and purification.
    What do 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene need to pay attention to when storing and transporting?
    4-Bromo-1-difluoromethoxy-2-fluorobenzene is an organic chemical, and its storage and transportation should be handled with caution.
    Let's talk about storage first. This chemical is more active and sensitive to environmental factors. First, it must be placed in a cool place to avoid heat. Due to heat, the molecular movement will intensify, or chemical reactions will occur unprovoked, impairing its purity, and even causing danger. Second, a dry place is indispensable. If water vapor in the air comes into contact with it, it may react such as hydrolysis. For example, some halogenated hydrocarbon-containing structures are prone to hydrolysis in contact with water, changing their chemical structure. Third, it must be sealed and stored. One is to prevent it from evaporating, escaping from polluting the environment and endangering personnel; the other is to prevent it from reacting with oxygen and other components in the air. If phenolic substances are easily oxidized and discolored when exposed to the air, this compound may also have a similar risk.
    As for transportation, the first thing to ensure is that the packaging is solid. In a special container, the material must be able to withstand the corrosion of this chemical, and it must be well sealed to prevent leakage. During transportation, it is advisable to control the temperature. When it is extremely hot, cooling measures may need to be taken. If it is cold in winter, it is also necessary to prevent the low temperature from changing its physical state and affecting its properties. At the same time, the transportation personnel should be familiar with its characteristics and emergency response methods. In case of leakage, etc., effective measures can be taken quickly, such as evacuating the crowd, isolating the
    In conclusion, the storage and transportation of 4-bromo-1-difluoromethoxy-2-fluorobenzene requires strict regulations and thorough consideration to ensure safety.
    What are the effects of 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene on the environment and human health?
    4-Bromo-1-difluoromethoxy-2-fluorobenzene is one of the organic compounds. The impact of this compound on the environment and human health is of great concern to many people.
    Looking at the situation of various substances in the environment in the past, many organic compounds may be difficult to degrade and can be retained in the environment for a long time. 4-Bromo-1-difluoromethoxy-2-fluorobenzene is also the same, which is difficult to eliminate in soil, water, or over a long period of time. And because its structure contains halogen atoms, or migrates and transforms between environmental media, its distribution is gradually widening and there are many places to be affected.
    As for the impact on human health, it is impossible to ignore. From past experience, such halogenated organic compounds may enter the human body through respiration, diet, skin contact, etc. After entering the body, they may interfere with the normal physiological functions of the human body. Or affect the endocrine system, cause hormone imbalance, such as the secretion and regulation of thyroid hormones, or cause disorders, which in turn affect metabolism, growth and development and many other physiological processes. Or damage the nervous system, causing dizziness, fatigue, memory loss, etc., and even cause organic neuropathy. It may be harmful to the reproductive system, or damage reproductive cells, affect fertility, and even cause abnormal fetal development, with the risk of deformity.
    Furthermore, this compound may form new derivatives in the environment or through complex reactions, and its toxicity may be more than that of the original, which increases the threat to the environment and human health. Therefore, the use and emission of 4-bromo-1-difluoromethoxy-2-fluorobenzene should be handled with caution to prevent it from causing serious harm to the environment and human health.