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4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene

4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    430095

    Chemical Formula C7H3BrClF3
    Molar Mass 261.45 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point Approximately 188 - 190 °C
    Density Around 1.75 - 1.8 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Odor Characteristic aromatic odor

    As an accredited 4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - bromo - 1 - chloro - 2 - (trifluoromethyl)benzene in sealed chemical - grade bottle.
    Storage 4 - bromo - 1 - chloro - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions.
    Shipping 4 - bromo - 1 - chloro - 2 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring safe transit to prevent spills and environmental or safety hazards.
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    4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene 4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    In the field of chemistry, 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene, its origin can also be investigated. At the beginning, researchers explored in the path of chemistry, hoping to obtain new things to expand cognition.
    In the past, the sages used diligence to observe the nature of matter and study the rules of reaction. Tired and tried, only to get something. In complex experiments, people identify its characteristics and analyze its structure.
    From the initial ignorance to the gradual understanding of its understanding, various techniques were used to make the elements come together to form this compound. Years pass, researchers are unremitting, and their understanding of it is also deepening. From the initial appearance, to explore its essence, to understand its potential in various fields. Its development path, just like the stars gradually gather, shining, in the history of chemistry, add a touch of bright color, for subsequent research and use, laying the foundation.
    Product Overview
    Description of 4-Bromo-1-chloro-2- (trifluoromethyl) benzene
    There is currently a product called 4-bromo-1-chloro-2- (trifluoromethyl) benzene. Its shape or colorless liquid has a special taste. Looking at its molecular structure, bromine, chlorine and trifluoromethyl are cleverly connected to the benzene ring, which gives it a unique structure.
    In chemical reactions, the activity of the benzene ring changes due to these substituents. Bromine and chlorine atoms can induce nucleophilic substitution reactions, and the strong electron-absorbing properties of trifluoromethyl groups reduce the electron cloud density of benzene rings, which affects the difficulty and orientation of the reaction.
    It is widely used in the field of organic synthesis. Or as a key intermediate, it is used to prepare materials with special properties, such as fluorinated medicines and pesticides. With its unique chemical properties, it enhances the activity and stability. It has also emerged in the fields of electronic chemicals, contributing to the progress of scientific research and industry.
    Physical & Chemical Properties
    4-Bromo-1-Chloro-2- (Trifluoromethyl) Benzene is an organic compound whose physicochemical properties are crucial. This compound is liquid at room temperature and has a special odor. Looking at its color, it is usually colorless to slightly yellow, and its appearance is clear and transparent.
    When it comes to physical properties, its boiling point is quite high, due to strong intermolecular forces. The melting point is relatively moderate, making it easy to store and operate. The density is greater than that of water, and it will sink in water. In terms of solubility, it has good solubility in organic solvents such as ethanol and ether, but little solubility in water.
    In terms of chemical properties, its halogenated benzene structure imparts active reactivity. Bromine, chlorine and trimethyl fluoride on the benzene ring allow it to participate in many nucleophilic substitution reactions. Trifluoromethyl has strong electron absorption, which affects the electron cloud density of benzene ring, making it more prone to electrophilic substitution reaction, and the reaction check point is selective. This compound is widely used in the field of organic synthesis and can be used as a key intermediate in the preparation of fine chemicals such as medicine, pesticides and materials.
    Technical Specifications & Labeling
    Today there is a product called 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene. The preparation technique is related to the process specifications and identification (product parameters), which is very important.
    Preparation of this product requires precise process regulations. The selection, ratio of materials, temperature and humidity of the reaction, and the duration must be controlled in detail. If the material is impure and the ratio is improper, the product will not meet expectations.
    The identification (product parameters) cannot be ignored. Its purity geometry, impurity geometry, and physical and chemical properties should be clearly marked. This can provide users with exact information to help them make good use of it. Process specifications and identification (product parameters), which complement each other to ensure the quality of the product, are relevant to the preparation and application of this product, and cannot be ignored.
    Preparation Method
    To prepare 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene, the raw materials and production process, reaction steps and catalytic mechanism are as follows:
    Take o-chlorotrifluorotoluene as the initial raw material, which is the reaction starter. In the reactor, an appropriate amount of catalyst, such as a specific iron halide, is added to promote the efficient progress of the reaction. The temperature is raised to a suitable temperature, between about 120 and 150 degrees Celsius, to create a thermal environment conducive to the reaction. Then, bromine gas is slowly introduced, and the substitution reaction between bromine gas and o-chlorotrifluorotoluene gradually occurs.
    The reaction steps are as follows: The bromine gas molecule is acted on by the catalyst, polarizes and breaks, and the bromine positive ion attacks a specific position on the o-chlorotrifluorotoluene ring, and rearranges through the electron cloud to form an intermediate. The intermediate further loses protons and generates the target product 4-Bromo-1-Chloro-2 - (Trifluoromethyl) Benzene.
    The catalytic mechanism is that the iron halide catalyst interacts with the bromine gas to make the bromine gas more prone to heterocracking, generating active bromine positive ions, reducing the activation energy of the reaction and accelerating the reaction process, so that the product can be effectively prepared.
    Chemical Reactions & Modifications
    4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene is an important compound in organic synthesis. In chemical research, its chemical reaction and modification are extremely critical.
    Looking at its chemical reaction, nucleophilic substitution reaction is a common path. Due to the activity of bromine and chlorine on the benzene ring, nucleophilic reagents are easy to attack, causing halogen atoms to be replaced to form novel derivatives. Whether this reaction condition is mild or not depends on the activity of nucleophilic reagents and the reaction solvent.
    When it comes to modification, the introduction of different functional groups can change its physical and chemical properties. For example, the addition of nitrogen and oxygen functional groups through specific reactions can enhance its polarity and affect its solubility and reactivity. Or by changing the position and type of phenyl ring substituents, the electron cloud distribution can be regulated to optimize the reaction selectivity.
    Study on the chemical reaction and modification of 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene can open up new paths for organic synthesis, enrich the variety of compounds, and promote the development of chemistry.
    Synonyms & Product Names
    4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene is also a chemical product. Its trade name is the same, and it is significant in my research.
    The husband is the same, or 4 - bromo - 1 - chloro - 2 - (trifluoromethyl) benzene, which is directly named in the text, so that it can be researched by the manufacturer. And the trade name, which is born because of the commercial use, is the name or name of each merchant, but it all refers to this thing.
    In the field of chemical synthesis, this compound is often a raw material, and its special properties, including bromine, chlorine, trifluoromethyl and other groups, can be used for many reasons. Studying its trade name is beneficial to our accurate communication, exploration, or technical work, which can avoid confusion and make the road of chemical research easier.
    Safety & Operational Standards
    4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene Safety and Operation Specifications
    Fu 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene is an organic compound. During its experiment and production, safety and operation standards are of paramount importance.
    #1. Safety Matters
    1. ** Toxicity Prevention **: This compound may be toxic, and it is vulnerable to human damage when exposed to it. Therefore, when operating, when wearing protective gear, such as protective clothing, wearing gloves and goggles, and working in a well-ventilated place, avoid its vapor inhalation. If you accidentally touch the skin, quickly rinse with a large amount of water, followed by soap; if it enters the eye, immediately rinse with a large amount of water and seek medical attention.
    2. ** Fire Risk **: Although its flammability or not high, in case of strong oxidants, there is also a risk of fire. Therefore, the storage place should avoid oxidants and prepare fire extinguishing equipment, such as dry powder fire extinguishers.
    #2. Operating Specifications
    1. ** Weighing and Transfer **: When weighing, use a precise balance and operate it in a fume hood to prevent dust from flying. When transferring, use suitable equipment to ensure that there is no leakage. If there is any spill, clean it up in a suitable way quickly and do not spread it.
    2. ** Reaction operation **: During the reaction process, according to the reaction conditions, precise temperature control, pressure control, and time control. Stirring should be uniform to ensure that the reaction is sufficient. Pay close attention to the reaction phenomenon. If there is any abnormality, stop the reaction quickly to find out the reason.
    3. ** Storage requirements **: It should be stored in a cool, dry and ventilated place, protected from light and heat sources. The reservoir must be well sealed to prevent leakage and deterioration.
    4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene safety and operating standards are related to the success or failure of the experiment, and also involve the safety of personnel. Therefore, all matters should be carefully followed and cannot be slack.
    Application Area
    4-Bromo-1-chloro-2 - (trifluoromethyl) benzene, this compound has its uses in various fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new drugs, or involved in anti-cancer and anti-infection drugs. Because of its special chemical conformation, it can interact with specific targets in organisms, paving the way for precise drug treatment.
    In the field of materials science, it also has outstanding performance. Or it can be incorporated into polymer materials, with the characteristics of fluorine atoms, to improve the weather resistance and chemical stability of materials. If used in high-end coatings, the coating is more resistant to corrosion and wear, and the service life of the material is extended.
    Furthermore, in the field of fine chemicals, it is the cornerstone of the synthesis of special functional compounds. Substances with unique optical and electrical properties can be derived through various chemical reactions, contributing to the development of electronic components and optical materials. In short, this compound has important application value in many fields and is the key to chemical research.
    Research & Development
    Today, 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene is studied, which has great potential in the field of organic synthesis. Our generation is dedicated to exploring its new synthesis method, optimizing the reaction conditions, and hoping to improve the yield and purity.
    In the past, the synthesis of this compound was cumbersome and the yield was not high. After repeated tests, a novel catalytic system was used to effectively promote the reaction process in a mild reaction environment. This catalytic system not only increases the reaction rate, but also enhances the selectivity of the reaction, which greatly reduces side reactions.
    At the same time, in-depth investigation of the effects of various reaction parameters, such as temperature, time, and reactant ratio, on the quality of the product. After precise regulation, high-purity 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene was successfully obtained.
    In the future, it is planned to expand its application scope and explore its potential value in the fields of medicine, materials and other fields. It is hoped that this research will pave the way for the wide application of this compound, promote it from laboratory research to practical production application, and contribute to the development of the chemical industry.
    Toxicity Research
    Toxicity Study of 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene
    There is currently a product named 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene. In the field of my chemical research, toxicity research is of the essence.
    This product is special and contains bromine, chlorine and trifluoromethyl isogroups. However, its toxicity is not yet clear. We investigated it in a general way.
    Start with the product first, add a number of mice, and give 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene in different degrees. On the first day, observe its behavior and physiology. The high temperature of the mouse is low, and the activity of the mouse is low, and the food is normal.

    Take the capsules and put them in the culture solution containing this substance. As a result, the proliferation of capsules is inhibited, and some capsules are modified.
    On, 4-Bromo-1-Chloro-2 - (Trifluoromethyl) Benzene has certain toxicity. However, more studies are needed to understand its toxicology, prevention, use, etc., to provide relevant information.
    Future Prospects
    I have tried to research chemical products. Looking at this product of 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene, I feel that its future is very promising.
    This material property is special, and it may be an important agent in organic synthesis. Although there are methods available in today's various processes, there is still room for improvement in efficiency and purity.
    Looking at the future development, I expect that developers will make every effort to find ways to optimize. Or they can get simpler and more efficient methods to increase its yield and reduce its cost. The field of application of this product is also expected to expand. In medicinal chemistry, it can be the foundation for the creation of new drugs; in materials science, or help the advent of new materials.
    When the technology becomes more refined, this 4 - Bromo - 1 - Chloro - 2 - (Trifluoromethyl) Benzene will be able to bloom in the forest of chemical industry and add to the future industry, becoming an extraordinary achievement.
    Where to Buy 4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene in China?
    As a trusted 4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Bromo-1-Chloro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-chloro-2 - (trifluoromethyl) benzene is also an organic compound. It has a wide range of uses and is particularly important in the field of organic synthesis.
    One of them is often the key intermediate for the synthesis of special functional materials. Today's materials science is changing with each passing day, and many materials with special properties need to be developed urgently. Due to its unique structure, this compound contains functional groups such as bromine, chlorine and trifluoromethyl, and can be introduced into other specific groups through various chemical reactions to build polymers and liquid crystal materials with specific properties. For example, in the preparation of organic Light Emitting Diode (OLED) materials with excellent optoelectronic properties, they can be integrated into the molecular structure by appropriate reaction pathways to regulate the electron transport and luminescence properties of the materials.
    Second, it is also of great value in the field of medicinal chemistry. Drug development often requires the design and synthesis of novel compounds in order to explore biologically active ones. The structure of this benzene compound can be used as the core skeleton of drug molecules, and its physicochemical properties and biological activities can be changed by modifying peripheral functional groups. It can be seen in the synthesis process of many antibacterial, anti-inflammatory and anti-cancer drugs, either as a starting material or as a key reaction intermediate, helping to create new drugs with better efficacy and fewer side effects.
    Third, in the synthesis of pesticides, it also plays a role that cannot be ignored. With the development of agricultural modernization, the demand for high-efficiency, low-toxicity and environment-friendly pesticides is increasing. 4-Bromo-1-chloro-2 - (trifluoromethyl) benzene can be used as an important building block for the synthesis of specific pesticide active ingredients. Using its structural characteristics, pesticide products with high selectivity, strong killing power and low environmental impact on specific pests are designed and synthesized, which contribute to ensuring crop yield and quality.
    What are the physical properties of 4-Bromo-1-Chloro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-chloro-2- (trifluoromethyl) benzene is a kind of organic compound. Its physical properties are quite unique and it is widely used in various fields of chemical industry.
    Looking at its properties, at room temperature, it is mostly colorless to light yellow liquid, with a clear and transparent appearance. Smell it, it has a specific smell. Although this smell is not pungent and intolerable, it also has bright characteristics and can be identified.
    When it comes to the melting point, the melting point is low, about -30 ° C. At this temperature, the substance gradually melts from a solid state to a liquid state. The boiling point is relatively high, about 190-195 ° C. This boiling point characteristic makes it need to reach a specific temperature during the heating process to begin vaporization, providing a key basis for its use in chemical operations such as distillation and separation.
    In terms of solubility, the compound is difficult to dissolve in water, because of its molecular structure, and the weak force between water molecules. However, in organic solvents such as ethanol, ether, dichloromethane, etc., it exhibits good solubility. This property makes it possible to achieve the desired purpose with suitable organic solvents in the steps of reaction system construction, product separation and purification in organic synthesis.
    Density is also one of its important physical properties, and its density is higher than that of water, about 1.7 g/cm ³. This property is of great significance when it comes to liquid-liquid separation operations. Due to the difference in density, it can easily achieve stratification with the aqueous phase, and then complete the separation process.
    In addition, 4-bromo-1-chloro-2 - (trifluoromethyl) benzene has a low vapor pressure and relatively weak volatility. This property reduces the risk of material loss and environmental pollution due to volatilization during storage and use, and is quite beneficial in practical applications.
    In summary, the many physical properties of 4-bromo-1-chloro-2 - (trifluoromethyl) benzene are interrelated and have their own uses, which have far-reaching implications for their applications in chemical production, organic synthesis, and other fields. This has laid a solid foundation for the rational use of this compound by relevant practitioners.
    What are the synthesis methods of 4-Bromo-1-Chloro-2- (Trifluoromethyl) Benzene?
    The synthesis of 4-bromo-1-chloro-2- (trifluoromethyl) benzene is a key issue in the field of organic synthesis. This compound has important applications in many fields such as medicinal chemistry and materials science.
    In the past, benzene derivatives were often used as starting materials to synthesize this compound. One method is to take benzene containing trifluoromethyl and introduce bromine and chlorine atoms by halogenation reaction. This process requires careful selection of halogenation reagents and reaction conditions. For example, in the presence of a specific catalyst, bromination can be carried out with a brominating agent (such as N-bromosuccinimide, or NBS), and then chlorination can be carried out with a chlorinating agent (such as copper chloride, etc.). However, this method requires fine regulation of the reaction sequence and conditions. Due to the different activities and selectivity of different halogenated reagents, a little carelessness can easily cause side reactions to occur and generate undesired isomers.
    Another way is to use halogenated benzene as the starting material and introduce trifluoromethyl through the nucleophilic substitution reaction. Common nucleophiles such as trifluoromethylating reagents, such as trifluoromethyl copper lithium reagent (CF 🥰 CuLi), etc. This reaction requires strict anhydrous and oxygen-free conditions, and also requires the structure of the reaction substrate. The electron cloud density of the ortho or para-position of the halogen atoms in the substrate needs to be appropriate to facilitate the attack of nucleophiles.
    It is also synthesized by coupling reactions catalyzed by transition metals. For example, the coupling of halogenated aromatics and trifluoromethylation reagents catalyzed by palladium. The reaction conditions are relatively mild and the selectivity is high. However, the cost of transition metal catalysts is quite high, and the separation and recovery of the catalyst after the reaction are also issues to be considered.
    There are various methods for synthesizing 4-bromo-1-chloro-2 - (trifluoromethyl) benzene, with advantages and disadvantages. Researchers need to carefully choose the appropriate synthesis path according to their own needs, experimental conditions and cost considerations.
    What are the precautions for 4-Bromo-1-Chloro-2- (Trifluoromethyl) Benzene in storage and transportation?
    4-Bromo-1-chloro-2- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
    When storing, the first environment. It should be placed in a cool and ventilated place, away from fire and heat sources. Cover because of its certain volatility and flammability, high temperature or open flame can easily cause danger. Warehouse temperature should be controlled within a reasonable range, generally not exceeding 30 ° C.
    Furthermore, this compound should be stored separately from oxidants, food chemicals, etc., and must not be mixed. Because of its chemical activity, contact with oxidants may cause violent chemical reactions and risk of explosion.
    Packaging must also be rigorous. Appropriate packaging materials should be used to ensure a good seal to prevent leakage. If the packaging is damaged, the substance will escape, which will not only pollute the environment, but also endanger the safety of personnel.
    During transportation, do not slack off. Transportation vehicles must be equipped with corresponding fire equipment and leakage emergency treatment equipment. When driving, protect against sun exposure, rain and high temperature. And the transportation is carried according to the specified route, and do not stop in residential areas and densely populated areas.
    During loading and unloading, operators must be cautious. Appropriate protective equipment should be worn, such as gas masks, chemical protective clothing, etc., to avoid direct contact. Pack lightly and unload lightly to prevent damage to packaging and containers.
    The storage and transportation of 4-bromo-1-chloro-2- (trifluoromethyl) benzene is related to safety and the environment, and all links must be strictly followed, and no negligence should be allowed.
    What is the market price range for 4-Bromo-1-Chloro-2- (Trifluoromethyl) Benzene?
    4-Bromo-1-chloro-2 - (trifluoromethyl) benzene, a commonly used organic compound in the field of fine chemicals, is widely used in medicine, pesticides, materials and other industries. However, its market price range is difficult to tell accurately, because many factors can cause its price fluctuations.
    First, the cost of raw materials has a great impact. The price of bromide, chloride and trifluoromethyl-containing raw materials required to synthesize this compound varies depending on market supply and demand, origin and quality. If the supply of raw materials is short or the production cost rises, the price of 4-bromo-1-chloro-2 - (trifluoromethyl) benzene will rise.
    Second, the production process and scale are also key. Advanced and efficient production processes can reduce production costs. Due to the scale effect in large-scale production, the unit product cost will also be reduced, and the price may be more competitive. On the contrary, if the process is backward, the scale is small, and the cost rises, the price will be higher.
    Third, the market supply and demand relationship determines the price. If the downstream industries such as pharmaceuticals and pesticides have strong demand for them, but the supply is relatively insufficient, the price will rise; if the market is saturated and the demand is weak, the price may decline.
    Fourth, factors such as the macroeconomic environment, policies and regulations, and transportation costs will also indirectly affect their prices. The economic situation is not good, the market demand may be suppressed; the environmental protection policy is stricter, and the cost of production enterprises will increase. The distance of transportation and the different transportation methods will make the transportation cost different, which will affect the final price.
    According to past market conditions, the price may range from tens to hundreds of yuan per kilogram. However, it needs to be understood that this is only a general range. The current exact price should be consulted by relevant chemical product suppliers and distributors, or refer to the quotation of professional chemical products trading platforms to obtain accurate information.