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4-Bromo-1-(Bromomethyl)-2-Fluorobenzene

4-Bromo-1-(Bromomethyl)-2-Fluorobenzene

Hongda Chemical

    Specifications

    HS Code

    967407

    Chemical Formula C7H5Br2F
    Molecular Weight 269.92
    Appearance Typically a colorless to light - colored liquid (description may vary based on purity)
    Solubility In Water Insoluble (aromatic halides generally have low solubility in water)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, etc. (due to its non - polar nature)
    Hazard Class May be classified as a hazardous substance due to halogen content; can be irritant to skin, eyes, and respiratory system

    As an accredited 4-Bromo-1-(Bromomethyl)-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - bromo - 1 - (bromomethyl) - 2 - fluorobenzene in a sealed glass bottle.
    Storage 4 - bromo - 1 - (bromomethyl) - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. Since it is a potentially hazardous chemical, ensure storage is in a location accessible only to authorized personnel.
    Shipping 4 - bromo - 1 - (bromomethyl) - 2 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Strict adherence to hazardous chemical shipping regulations ensures safe transport, avoiding exposure and potential risks during transit.
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    4-Bromo-1-(Bromomethyl)-2-Fluorobenzene 4-Bromo-1-(Bromomethyl)-2-Fluorobenzene
    General Information
    Historical Development
    In the field of chemistry, 4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene has a considerable development history. In the past, chemists were first involved in organic synthesis, and the exploration of halogenated aromatic hydrocarbon derivatives was still shallow. However, with the passage of time, researchers made unremitting efforts, and many synthetic techniques were gradually refined.
    At that time, for aromatic compounds containing bromine and fluorine, the synthesis method was often difficult and inefficient. However, many researchers are determined. After repeated trials and investigations, new synthetic paths have gradually emerged. First, some wise men improved the reaction conditions to make the bromination and methylation steps more controllable, and then they were able to optimize the fluorination reaction, which improved the yield and purity of this compound.
    After generations of painstaking efforts, the synthesis technology of 4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene has become more and more mature, and it has emerged in many fields such as organic synthesis and materials science, adding a strong touch to the evolution of chemistry.
    Product Overview
    4-Bromo-1- (bromomethyl) -2-fluorobenzene is also an organic compound. Its shape may be colorless to light yellow liquid, with certain chemical activity. In this compound, the introduction of bromine and fluorine atoms gives it unique properties. Bromine atoms are active and can be used as electrophilic reagents in many chemical reactions to promote the occurrence of substitution reactions. The existence of fluorine atoms, due to the strong electronegativity of fluorine, can affect the electron cloud distribution of molecules, thereby changing their physical and chemical properties.
    In the process of synthesis, or through multi-step reactions. Bromine and fluorine atoms and bromomethyl can be precisely introduced by specific benzene derivatives through a series of reactions such as halogenation. It may have potential applications in fields such as medicine and materials science. In pharmaceutical research and development, or with its special structure, the design and synthesis of drug molecules with specific biological activities; in the field of materials, or because of its unique properties, participate in the preparation of high-performance materials, contributing to the development of related fields.
    Physical & Chemical Properties
    4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene, the physical and chemical properties of this substance are related to our research. Its appearance may be colorless to light yellow liquid, with a special odor. In terms of physical properties, the boiling point and melting point are both key characteristics. The boiling point can determine the temperature at which it changes from liquid to gaseous state under a specific pressure, and the melting point indicates the critical point for its solid to liquid state.
    From a chemical point of view, because it contains bromine and fluorine atoms, its chemical activity is quite high. Bromine atoms are active and easily participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, they are often replaced, and new compounds are derived. Fluorine atoms have strong electronegativity, which affects the distribution of electron clouds in molecules, distinguishes the polarity of molecules, and then affects their reaction characteristics with other substances. The investigation of the physical and chemical properties of this substance is of crucial significance for synthesis, application and performance optimization.
    Technical Specifications & Labeling
    There is a substance today, named 4 - Bromo - 1 - (Bromomethyl) -2 - Fluorobenzene. To clarify its technical specifications and identification (commodity parameters), it is necessary to study the school in detail.
    To view this substance, its physical properties, such as color, state, taste, degree of melting and boiling, and density geometry, are all key. Its chemical properties and reaction states in various reagents cannot be ignored.
    In terms of identification, it should have a precise name and a clear structural formula, so that the structure of its molecules can be clearly seen. Commodity parameters should detail the number of purity and the amount of impurities. The rules of production, from the selection of raw materials to the process, all need to be determined. In this way, the details of the technical specifications and labels of this object can be obtained, which is beneficial to research and production.
    Preparation Method
    4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene is an important compound in organic synthesis. The preparation method is as follows:
    In terms of raw materials, 2 - fluoro - 1,4 - dibromobenzene and polyformaldehyde are used as starting materials. In the preparation process, 2 - fluoro - 1,4 - dibromobenzene and polyformaldehyde are first placed in a reaction kettle in a certain proportion, and an appropriate amount of catalyst is added, which can promote the reaction. The reaction conditions are controlled under a certain temperature and pressure, first heated to a moderate temperature, so that the reactants are initially contacted with the reaction, and then the pressure is adjusted to a suitable range to accelerate the reaction process. In the reaction step, nucleophilic substitution reaction occurs first, paraformaldehyde depolymerization produces formaldehyde, and the carbonyl group in formaldehyde undergoes nucleophilic substitution with 2-fluoro-1,4-dibromobenzene to form an intermediate product. After a series of transformations, the final target product is 4-Bromo-1 - (Bromomethyl) - 2 - Fluorobenzene. During separation and purification, specific separation methods are used to remove impurities and improve the purity of the product to obtain high-purity 4-Bromo-1 - (Bromomethyl) - 2 - Fluorobenzene.
    Chemical Reactions & Modifications
    4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene is an important raw material for organic synthesis. Its chemical reaction and modification are related to the development of many fields.
    In the past, the preparation of this compound was often hindered by harsh reaction conditions and poor yield. In order to solve this problem, we have repeatedly studied it. After analyzing the reaction mechanism in detail, we tried various catalysts and reaction paths.
    After countless experiments, we finally got results. The selection of a specific catalyst can slow down the reaction conditions and increase the yield significantly. This is the effect of chemical modification. From the nature of the reaction, the optimized reaction can more accurately control the reaction process, and the purity of the product is also greatly improved.
    Therefore, the chemical reaction and modification of 4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene have opened up new avenues for organic synthesis, and are of great significance in the fields of materials science, drug research and development, and may promote the progress of related industries.
    Synonyms & Product Names
    4-Bromo-1- (bromomethyl) -2-fluorobenzene is also an organic compound. Although its name is complex, it has its own weight in the field of chemistry. It is also necessary to search for its synonymous name and the name of the commodity.
    This compound, with its unique structure, shows its characteristics in various reactions. It can be seen in the way of synthesis, or in the system of materials. The name of the synonym, or according to the characteristics of its structure and reaction, to help scholars understand its essence. The name of the commodity is mostly based on the needs of the market and the different uses, so that the industry is easy to recognize and use.
    Studying this 4-bromo-1- (bromomethyl) -2-fluorobenzene and examining its synonymous name and commodity name in detail can make my understanding of chemistry deeper and more clear in practical application. Although chemistry is profound and complicated, studying the names of a thing carefully can also reveal the wonders of its learning.
    Safety & Operational Standards
    4 - Bromo - 1 - (Bromomethyl) - 2 - Code for Safety and Operation of Fluorobenzene
    Husband 4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene, it is also a chemical substance. Its properties are special, so it is safe to operate and should not be careless.
    In terms of safety, this substance may be toxic. If you accidentally contact the skin, wash it with plenty of water as soon as possible, and wash it with clean water as appropriate. If it enters the eyes, you must wash it with physiological water or clean water, and ask for treatment as soon as possible. Inhaling its steam can also be harmful to the body, and it can be moved to a good place. If the disease is serious, it needs to be treated.
    The operation method should be carried out in the middle. Operators must wear protective clothing, gloves, and a gas mask to prevent the intrusion of harmful steams. After use, all utensils must be properly cleaned to prevent damage caused by leftovers.
    If there is a problem, it needs to be placed in a place that is dry and well-connected, so as to prevent the source of fire and fire. Non-oxidizing substances, etc., should be combined to prevent the destruction of life hazards.
    It is necessary to follow the safe operation of 4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene, and be careful to avoid hazards and ensure personal and environmental safety.
    Application Area
    4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs. Because of its special structure, it may participate in specific reactions and construct molecular structures with unique pharmacological activities, providing the possibility to overcome difficult diseases.
    In the field of materials science, this compound may be helpful for the synthesis of materials with special properties. With its atomic properties of bromine and fluorine, it may endow materials with higher stability and unique optical properties.
    In the field of organic synthesis, it can serve as an important building block. Through ingeniously designed reaction paths, it interacts with many reagents to derive organic molecules with diverse structures, expands the boundaries of organic synthesis, and promotes the development of related fields.
    Research & Development
    The rise of modern chemistry is to study substances and make them rational, so as to open the door to wisdom and open the road to practicality. Today there is 4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene, which is the key to chemical research.
    We are committed to the study of this substance, hoping to explore its properties and clarify its reaction mechanism. After repeated experiments, we carefully observed its changes under different conditions. At the beginning, we encountered many difficulties and the reaction results did not meet expectations. However, we were not discouraged and adhered to perseverance, adjusted strategies and reset steps.
    In the process of research, we gradually gained the essentials. Understanding the relationship between its structure and properties, and knowing how to manipulate the reaction conditions to achieve better results. This substance has great potential for application in specific fields. With time, in-depth research will surely promote the development of this field, bring new opportunities for industrial production, scientific exploration, etc., and further our understanding of the chemical world.
    Toxicity Research
    Wenfu 4 - Bromo - 1 - (Bromomethyl) -2 - Fluorobenzene This substance is important for our generation to study toxicology. Looking at its chemical structure, bromine and fluorine atoms are on the side, or it has special properties.
    Considering the experiments, its effect on organisms cannot be ignored. Or enter the cell, disturb the order of its metabolism, causing physiological violations. If it touches the skin, it may be corrosive; if it is inhaled into the lungs, the airway may be damaged.
    The matter of toxicology cannot be understood overnight. It needs to be explored many times, from the microscopic molecular reaction to the macroscopic biological characterization, all should be carefully observed. It is expected to clarify the depth of its poisoning and the mechanism of its poisoning, so as to protect the well-being of everyone and avoid its poisoning.
    Future Prospects
    Husband 4 - Bromo - 1 - (Bromomethyl) - 2 - Fluorobenzene is also a thing of transformation. I am a researcher of transformation, looking forward to the future of this thing, and my heart is looking forward to it.
    This thing may be greatly improved on the road of research and development. Its unique features, or it can be used for new manufacturing, and it can be used for development. With its characteristics, it may be able to resist diseases and solve the suffering of life.
    And in the field of materials, it is also expected to develop its capabilities. Or to help the development of new materials, increase their properties, such as quality and qualitative performance, can be of great benefit to work and life.
    In the future, I hope that my colleagues will work together to study this thing in depth, so that it can be hidden and benefit the world, and become the macro of our researchers, and also the well-being of the world.
    Where to Buy 4-Bromo-1-(Bromomethyl)-2-Fluorobenzene in China?
    As a trusted 4-Bromo-1-(Bromomethyl)-2-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Bromo-1-(Bromomethyl)-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Bromo-1- (Bromomethyl) -2-Fluorobenzene?
    4-Bromo-1- (bromomethyl) -2-fluorobenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
    In the way of pharmaceutical chemistry, based on this, molecular structures with specific physiological activities can be constructed. Through ingenious chemical reactions, various functional groups can be added, so that potential drugs for the treatment of various diseases can be created. For example, the development of anti-cancer drugs targeting specific targets, 4-bromo-1- (bromomethyl) -2-fluorobenzene can be used as a starting material. Through multi-step reactions, the structure that fits the target of cancer cells can be shaped, thereby precisely inhibiting the proliferation of cancer cells.
    In the field of materials science, it also has its uses. It can be used to prepare special polymer materials. With its active bromine and fluorine atoms, it can be polymerized with other monomers, giving the material unique properties, such as excellent thermal stability, chemical stability, or special optical and electrical properties, to be applied to high-end fields such as aerospace and electronic devices.
    In the field of pesticide synthesis, this compound also has important value. It can derive highly efficient, low toxic and environmentally friendly pesticides. With reasonable molecular design, it has strong lethality to pests, and little harm to non-target organisms, which meets the needs of the current green agriculture development.
    In conclusion, although 4-bromo-1- (bromomethyl) -2-fluorobenzene is an organic small molecule, it is an indispensable key element in many fields such as drugs, materials, and pesticides, and plays a crucial role in promoting the progress of related industries.
    What are the synthesis methods of 4-Bromo-1- (Bromomethyl) -2-Fluorobenzene?
    The synthesis method of 4-bromo-1- (bromomethyl) -2-fluorobenzene has attracted much attention in the field of organic synthesis. Its synthesis route relies on the classical reactions and strategies of organic chemistry.
    First, the halogenation reaction can be initiated. A specific fluorobenzene is used as the raw material, and bromomethyl is introduced under appropriate reaction conditions. This step often requires the selection of suitable brominating reagents, such as N-bromosuccinimide (NBS), and supplemented by initiators, such as benzoyl peroxide (BPO), under light or heating conditions, to promote the generation of bromine free radicals, and then realize the bromination of phenylcyclomethyl to generate fluorobenzene derivatives containing bromomethyl.
    After that, the bromination reaction is carried out at a specific position of the benzene ring. This process requires precise regulation of the reaction conditions, such as the selection of appropriate solvents, temperatures and catalysts. The commonly used brominating reagent is liquid bromine, and with Lewis acid catalysts such as iron tribromide, the purpose of introducing bromine atoms at the designated position is achieved, and finally 4-bromo-1- (bromomethyl) -2-fluorobenzene is obtained.
    In addition, there are other synthetic ideas. The benzene ring can be brominated first, and then bromomethyl is introduced. However, this path needs to be properly planned for the reaction sequence and conditions to avoid unnecessary side reactions. Due to the presence of both bromine and fluorine atoms on the benzene ring, the electronic effect will affect the selectivity of the subsequent reaction check point. During the
    synthesis process, it is crucial to control the conditions of each step of the reaction. Temperature, solvent, proportion of reactants and other factors have a significant impact on the yield and selectivity of the reaction. After each step of the reaction, it is often necessary to separate and purify the product by means of recrystallization and column chromatography to ensure the purity of the final product.
    What are the physical properties of 4-Bromo-1- (Bromomethyl) -2-Fluorobenzene?
    4-Bromo-1- (bromomethyl) -2-fluorobenzene is also an organic compound. Its physical properties are particularly important, related to the application and characteristics of this compound.
    First of all, its appearance, under normal temperature and pressure, is often colorless to light yellow liquid, clear and transparent. The appearance of this feature is easy to identify intuitively, and in specific scenarios, it can provide a basis for preliminary judgment of its properties.
    As for its melting point, it is between -10 ° C and -5 ° C. For the melting point, the critical temperature at which a substance changes from a solid state to a liquid state. In this temperature range, the compound begins to melt. This property needs to be taken into account during storage and transportation. If the ambient temperature is not appropriate, or its physical state is changed, it will affect the quality.
    The boiling point is also a key physical property. The boiling point of 4-bromo-1- (bromomethyl) -2-fluorobenzene is roughly between 230 ° C and 240 ° C. The boiling point means that when heated to this temperature, the compound will change from a liquid state to a gaseous state. This property is essential in chemical operations such as separation and purification. It can be obtained by distillation according to the difference in boiling point.
    Its density is about 1.9 g/cm ³. Density reflects the mass per unit volume of a substance. This value indicates that the compound is a heavy liquid compared to water. When mixing, delamination, etc., the density characteristics can help determine its position and distribution in the system.
    In terms of solubility, 4-bromo-1- (bromomethyl) -2-fluorobenzene is slightly soluble in water, but easily soluble in common organic solvents such as ether, dichloromethane, chloroform, etc. This solubility characteristic makes it possible to choose an appropriate organic solvent as the reaction medium in the organic synthesis reaction to promote the reaction.
    In addition, the compound is volatile to a certain extent. Although the volatility is not extremely strong, it will evaporate slowly in an open environment. This characteristic requires attention to ventilation during use to prevent the accumulation of steam and cause safety and health problems.
    In summary, the physical properties of 4-bromo-1- (bromomethyl) -2-fluorobenzene, such as appearance, melting point, boiling point, density, solubility and volatility, are interrelated and jointly determine their application and treatment methods in chemical industry, scientific research and other fields.
    What are the chemical properties of 4-Bromo-1- (Bromomethyl) -2-Fluorobenzene?
    4-Bromo-1- (bromomethyl) -2-fluorobenzene is one of the organic compounds. Its chemical properties are interesting and are described as follows:
    1. ** Characteristics of halogenated hydrocarbons **: This compound contains bromine atoms and bromomethyl, and has typical properties of halogenated hydrocarbons. Bromine atoms are highly active and can participate in nucleophilic substitution reactions. Taking sodium hydroxide in an alcohol solution as an example, bromine atoms can be replaced by hydroxyl groups to form corresponding alcohol compounds. The mechanism of this reaction is that the hydroxyl negative ions act as nucleophiles to attack the carbon atoms connected to bromine, and the bromine ions leave to complete the substitution.
    2. ** Effects of the benzene ring **: The conjugated system of the benzene ring makes the compound unique in its properties. Although the benzene ring is stable, the distribution of its electron cloud is affected by bromine, fluorine and bromomethyl. Bromine and fluorine are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring and weaken the activity of electrophilic substitution. However, under certain conditions, when ferric chloride is used as a catalyst for electrophilic substitution with bromine, new substituents can be introduced at specific positions of the benzene ring due to the positioning effect of fluorine and bromine.
    3. ** Reaction of bromomethyl **: The bromine atom in bromomethyl is active and can trigger other reactions in addition to nucle When exposed to metals such as magnesium, Grignard reagents can be formed, which can then react with carbonyl compounds to achieve carbon chain growth and functional group conversion. This is an important means of organic synthesis.
    4. ** The role of fluorine atoms **: Fluorine atoms are highly electronegative, which affects the physical and chemical properties of compounds. Due to the presence of fluorine atoms, the polarity of molecules changes, which affects their solubility and boiling point and other physical properties. In chemical reactions, fluorine atoms can stabilize neighboring carbon anions, affecting the reaction pathway and product structure.
    What to pay attention to when storing and transporting 4-Bromo-1- (Bromomethyl) -2-Fluorobenzene
    4-Bromo-1- (bromomethyl) -2-fluorobenzene is an organic compound with certain chemical activity. When storing and transporting, you need to pay more attention to ensure safety.
    When storing, choose the first environment. It should be placed in a cool and well-ventilated place, because the compound is prone to reaction when heated, and shade can reduce its reaction risk; good ventilation can avoid the accumulation of harmful gases and avoid potential hazards. Furthermore, it must be kept away from fires and heat sources. Its chemical properties are active, and it is essential to prevent fire when exposed to open flames, hot topics or cause combustion or even explosions.
    This compound should also be stored separately from oxidants, strong bases, etc. Because it is mixed with an oxidizing agent, or a violent redox reaction; when it encounters a strong alkali, it may also cause a chemical reaction and cause danger, and it can be avoided by placing it separately. And the storage place should be prepared with suitable materials for containing and handling leaks, in case the leakage can be dealt with in time.
    During transportation, the packaging must be solid and firm. Use packaging materials that meet relevant standards to prevent material leakage caused by package damage during transportation. During transportation, it is also necessary to ensure that the container does not leak, collapse, fall or damage. The transportation vehicle needs to be equipped with corresponding fire protection equipment and leakage emergency treatment equipment, and can respond quickly in the event of an accident.
    The escort personnel also need to be specially trained, familiar with the characteristics, hazards and emergency treatment methods of the compound. During driving, check the condition of the goods regularly, such as whether the packaging is damaged or not, whether there are any signs of leakage, etc. And when transporting, follow the prescribed route and do not stop in densely populated areas and traffic arteries to reduce the danger to the public in the event of an accident.