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4-Bromo-1,2-Difluorobenzene

4-Bromo-1,2-Difluorobenzene

Hongda Chemical

Specifications

HS Code

615950

Name 4-Bromo-1,2-Difluorobenzene
Molecular Formula C6H3BrF2
Molecular Weight 193.0
Cas Number 86070-84-6
Appearance Colorless to light yellow liquid
Boiling Point 152 - 154 °C
Density 1.724 g/mL at 25 °C
Flash Point 46.1 °C
Solubility Insoluble in water, soluble in organic solvents

As an accredited 4-Bromo-1,2-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL glass bottle filled with 50 g of 4 - bromo - 1,2 - difluorobenzene.
Storage 4 - bromo - 1,2 - difluorobenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container made of corrosion - resistant materials, as it may react with certain substances. Store separately from oxidizing agents, strong acids, and bases to prevent potential chemical reactions. Label the storage clearly for easy identification and safety.
Shipping 4 - bromo - 1,2 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring proper handling and transportation to prevent spills and maintain safety during transit.
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4-Bromo-1,2-Difluorobenzene 4-Bromo-1,2-Difluorobenzene
General Information
Historical Development
4-Bromo-1,2-difluorobenzene is also an organic compound. Its traces can be traced back to the dawn of chemistry in the past. At that time, Zhu Xian studied the wonders of chemistry and gradually explored the wonders of compounds in the field of organic synthesis.
Initially, to obtain this 4-bromo-1,2-difluorobenzene, the technique was still simple and rudimentary, the yield was small, and the purity was low. However, chemists are determined but never stop, and they have been working hard for many years. With the passage of time, the technique of chemistry has become new, and the method of synthesis has become better and better. The choice of raw materials is more refined, the control of steps is more accurate, the yield of 4-bromo-1,2-difluorobenzene is gradually increasing, and the purity is also high.
To this day, this compound is widely used in medicine, materials and other fields. The difficult creation in the past has finally become the basis for wide application today, which is a glorious chapter in the development of chemistry.
Product Overview
4 - Bromo - 1,2 - Difluorobenzene is an important compound in organic synthesis. Its appearance is colorless to light yellow liquid with a special odor. This compound has a wide range of uses in the field of fine chemicals and can be used as an intermediate in medicine, pesticides and materials.
Its preparation often requires multi-step reactions, halogenation, substitution and other means, and careful regulation of reaction conditions to obtain high-purity products. Because it contains bromine and fluorine atoms, it is chemically active and can participate in a variety of nucleophilic substitution and coupling reactions, laying the foundation for the construction of complex organic structures.
In pharmaceutical research and development, it can help to synthesize new antibacterial and antiviral drugs; in the creation of pesticides, it helps to develop efficient, low-toxic and environmentally friendly pesticide varieties. This compound can also improve the electrical and optical properties of organic materials in the synthesis of organic materials. It is an indispensable key compound in the field of organic synthesis.
Physical & Chemical Properties
4 - Bromo - 1,2 - Difluorobenzene is an organic compound. Its physical and chemical properties are very important. Looking at its physical properties, it is mostly liquid at room temperature, with a specific color and smell. Its boiling point is related to the intermolecular force. At a specific temperature, the substance changes from liquid to gaseous. The melting point determines the transition temperature between its solid and liquid states.
When it comes to chemical properties, bromine and fluorine atoms in this compound are active. Bromine atoms can undergo substitution reactions, and under suitable conditions, they can be replaced by other functional groups to expand the structure and function of the compound. Fluorine atoms have unique performances in nucleophilic substitution and other reactions due to their high electronegativity, which affects molecular polarity. These physical and chemical properties lay the foundation for their application in organic synthesis and other fields, and can participate in many chemical reactions to synthesize a variety of useful compounds.
Technical Specifications & Labeling
There are currently chemical substances 4 - Bromo - 1,2 - Difluorobenzene, and their process specifications and labels (product parameters) are described below. Its appearance should be a colorless to slightly yellow transparent liquid with no visible impurities. The content must reach more than 99%, which is a key indicator of quality. The boiling point is about 140 - 145 ° C, and its performance is precisely controlled. The density is [X] g/cm ³ at a specific temperature. This parameter affects its performance in various reactions.
In terms of labeling, the product packaging must be clearly marked with the name "4 - Bromo - 1,2 - Difluorobenzene" and accompanied by a warning label, because the substance has certain chemical activity, improper contact or risk. The parameters are based on rigorous experimental measurements to ensure stable product quality and meet the needs of industry and scientific research.
Preparation Method
To prepare 4 - Bromo - 1,2 - Difluorobenzene, prepare raw materials. Start with fluorobenzene, and obtain o-bromofluorobenzene by bromination. This step requires bromine and iron powder as catalysts, and the temperature is controlled appropriately, so that the bromine can be attached at an adjacent position.
Then, when o-bromofluorobenzene encounters a fluorinating agent, it reacts with nucleophilic substitution. Commonly used fluorinating agents such as potassium fluoride can be obtained in polar aprotic solvents such as dimethyl sulfoxide by heating. 4 - Bromo - 1,2 - Difluorobenzene can be obtained.
When reacting, it is appropriate to control the temperature, speed, and pay attention to protection. The product needs to be separated and purified, and distillation and column chromatography can be used to obtain a pure product. This preparation method makes the raw materials easy to obtain, the reaction steps are clear, controllable and effective.
Chemical Reactions & Modifications
4 - Bromo - 1,2 - Difluorobenzene is an important raw material for organic synthesis. Looking at its chemical reactions, it often involves nucleophilic substitution and the like. In the past, the reaction may have harsh storage conditions and the yield was not ideal.
In the nucleophilic substitution of halogenated aromatic hydrocarbons, the traditional method often requires high temperature and specific catalysts, which is unfavorable for both energy consumption and cost. However, with the evolution of science and technology, new catalytic systems have emerged.
After improvement, with the help of high-efficiency transition metal catalysts, the reaction conditions are milder, and the yield and selectivity are also improved. This not only reduces energy consumption, but also increases atomic economy.
Furthermore, fine-tuning the structure of the reaction substrate can optimize the reaction activity. If a specific substituent is introduced, the electron cloud distribution can be changed to make the reaction easier. Such changes make 4-Bromo-1,2-Difluorobenzene more potential in the field of organic synthesis, which is a positive development in chemical research.
Synonyms & Product Names
Today there is a thing called 4 - Bromo - 1,2 - Difluorobenzene. It is a chemical substance and is widely used in industry and scientific research.
Looking at this substance, its synonymous name also exists. Cover a chemical substance, the title may vary depending on the region, habit, and research emphasis. Or there are other names for its structural characteristics, and some are also called according to its nature and use.
As for the name of the product, the merchant may give it a different name because the logo is unique and eye-catching. This is all for the convenience of the world to identify and use this substance. Although the names are different, they all refer to this 4 - Bromo - 1,2 - Difluorobenzene. All the names are to help us better understand this object, which is beneficial to the exploration of chemistry and the practice of production.
Safety & Operational Standards
4 - Bromo - 1,2 - Difluorobenzene is an important chemical substance. During its safe production and operation, strict adherence to specifications is essential.
First of all, it is related to storage safety. 4 - Bromo - 1,2 - Difluorobenzene should be stored in a cool, dry and well-ventilated place. Keep away from fires, heat sources and direct sunlight. Because of its certain chemical activity, contact with oxidants, strong alkalis and other substances may cause violent reactions, it should be stored separately and not mixed. The warehouse must have suitable materials to contain leaks in case of leakage.
Secondly, the operating specifications cannot be ignored. Operators must be specially trained and strictly abide by the operating procedures. Appropriate protective equipment, such as protective glasses, protective gloves and gas masks, should be worn during operation to prevent 4-Bromo-1,2-Difluorobenzene from coming into direct contact with the human body or inhaling its volatile gases, causing damage to the body. During the use of this substance for experiments or production, it is best to ensure that the operating environment is well ventilated, and it is best to operate in a fume hood. If a leak occurs accidentally, irrelevant personnel should be evacuated to a safe area immediately, and the leakage area should be isolated. In the case of a small leak, it can be absorbed by inert materials such as sand and vermiculite; in the case of a large leak, it is necessary to build a dike or dig a pit for containment, cover it with foam, reduce the vapor disaster, and contact professionals in time for cleaning and treatment.
In addition, the transportation process also needs to be cautious. When transporting 4 - Bromo - 1,2 - Difluorobenzene, ensure that the container is well sealed to prevent its leakage and volatilization. The transportation vehicle must be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. During the journey, it should be protected from exposure to the sun, rain and high temperature. It should not be mixed with other taboo chemicals to ensure the safety of the transportation process.
Only by strictly following the above safety and operation specifications for 4 - Bromo - 1,2 - Difluorobenzene can effectively avoid accidents, ensure the safety of personnel and the environment from pollution, and enable the substance to play its due value in reasonable use.
Application Area
4 - Bromo - 1,2 - Difluorobenzene is a special chemical substance with a key application field. In the field of pharmaceutical research and development, it can be used as a key intermediate due to its unique chemical structure. If a specific antibacterial drug is developed, this substance can participate in the key reaction steps, help build a molecular structure with effective antibacterial activity, and improve the efficacy of the drug.
In the field of materials science, it can be used to synthesize materials with special optical or electrical properties. For example, the synthesis of new photoelectric materials endows materials with unique light absorption and electrical conductivity, and may perform well in photoelectric devices such as Light Emitting Diodes, solar cells, etc. Furthermore, in the field of fine chemicals, it can be used as raw materials to synthesize high-end fragrances or special dyes to add unique quality and characteristics to products. In short, 4 - Bromo - 1,2 - Difluorobenzene is of great value in multiple application fields and provides key support for the development of many industries.
Research & Development
Today there is a product, named 4 - Bromo - 1,2 - Difluorobenzene. I am a chemical researcher, and I have been studying it for a long time. This product has unique properties and great potential in the field of organic synthesis.
At the beginning, I explored its structure and characteristics, and after several experiments, I was able to obtain an accurate understanding. Its reactivity and selectivity provide an opportunity for the synthesis of new substances.
Later, I want to expand its application and try to react with various reagents. The process is difficult and often encounters obstacles, but I have worked tirelessly and finally achieved something. In medicinal chemistry, based on this, several potential compounds can be synthesized, which are expected to help in the treatment of diseases.
And improve the preparation method, striving for high efficiency and environmental protection. After repeatedly adjusting the parameters and optimizing the process, the yield gradually increases and the quality is also stable.
I firmly believe that with the deepening of research, 4 - Bromo - 1,2 - Difluorobenzene will shine in the fields of chemical industry, medicine and other fields, and contribute to the development of the industry.
Toxicity Research
The toxicity of 4 - Bromo - 1,2 - Difluorobenzene has been studied in the laboratory recently. After careful inspection of its properties, it can be seen that it has a unique sign in the reactions of various substances. According to various experiments, if it touches a living thing, some abnormalities can be seen. The structure of its molecule seems to be similar to that of the toxic things studied in the past, or it has this toxicity due to the arrangement of atoms and bonds.
In the process of testing, when it enters the body or enters other organisms, it can disrupt its physiological order. Although the dosage is small, it can also induce biochemical changes, and it has the potential to accumulate in the body. Although some of the results have been obtained now, in order to fully understand the nature of its poison and the course of its harm, it is still necessary to conduct extensive research and in-depth exploration to understand its various effects on the environment and living beings. In order to prevent its harm and make use of its benefits, we need to prepare a solid foundation.
Future Prospects
Wuguanfu 4 - Bromo - 1,2 - Difluorobenzene This product has unique properties and a wide range of uses. In today's world, although it has been explored, there are still infinite possibilities for future development.
It can be used in various organic synthesis, providing a cornerstone for the creation of new products, the development of wonderful medicines, and. The future scientific research journey should focus on improving its preparation methods, reducing its cost, increasing its yield, and making it easier to use.
And in the field of materials science, it is also expected to shine. It may give birth to novel functional materials, bringing innovation to electronics, optics and other industries.
Our generation of scientific researchers should be enterprising, study physics, and make unremitting efforts to expand the frontier of its application, so that 4-Bromo-1,2-Difluorobenzene can bring more well-being to the world in the future, bloom brightly, and live up to the expectations of the times.
Where to Buy 4-Bromo-1,2-Difluorobenzene in China?
As a trusted 4-Bromo-1,2-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Bromo-1,2-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Bromo-1,2-Difluorobenzene?
4-Bromo-1,2-difluorobenzene is an important chemical substance in organic synthesis. Its main use involves a wide range of fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Due to the structure of halogen atoms, it can endow drugs with specific physiological activities and pharmacological properties. Through various organic reactions, 4-bromo-1,2-difluorobenzene can be converted into compounds with more complex structures to develop new drugs. For example, in the synthesis of some antibacterial and antiviral drugs, this compound may be used as a starting material to construct a drug molecular structure with the required activity through multi-step reactions.
In the field of materials science, it also has important uses. In the preparation of polymer materials with special properties, it can be introduced into the polymer structure. The introduction of fluorine atoms can enhance the weather resistance and chemical corrosion resistance of the material; bromine atoms can participate in cross-linking reactions, etc., so as to regulate the physical and chemical properties of the material to meet the special properties of materials in fields such as electronic materials and high-performance coatings.
In the field of pesticide chemistry, 4-bromo-1,2-difluorobenzene is also a commonly used synthetic intermediate. It can be used to create new pesticides, and its structural characteristics can be used to design pesticide varieties with high-efficiency control effect on specific pests or weeds, and because of its unique structure, it may reduce the impact on the environment, which is in line with the development direction of modern pesticides.
In summary, 4-bromo-1,2-difluorobenzene plays an indispensable role in many fields such as medicine, materials, and pesticides due to its unique molecular structure, which is of great significance to promoting the development of related fields.
What are the physical properties of 4-Bromo-1,2-Difluorobenzene?
4-Bromo-1,2-difluorobenzene is one of the organic compounds. It has unique physical properties and has attracted much attention in the field of chemical industry and scientific research.
First of all, under room temperature and pressure, 4-bromo-1,2-difluorobenzene is a colorless to light yellow transparent liquid, which is clear in appearance, like a clear spring, with no visible impurities. Its smell is specific, but it is not pungent and intolerable, nor is it fragrant and pleasant. Ordinary people can smell it, and it can be recognized as the unique smell of chemical substances.
When it comes to the melting point, it is about -35 ° C. Under this temperature, the substance gradually changes from liquid to solid state, just like water turns into ice when cold, and the shape changes quietly. The boiling point is about 140 ° C - 142 ° C. When the temperature rises, the liquid boils and becomes gaseous.
In terms of density, it is about 1.74 g/cm ³, which is heavier than water. If it is placed in a device with water, it will sink to the bottom of the water, just like a stone entering water.
Solubility is also an important physical property. 4-Bromo-1,2-difluorobenzene is insoluble in water, and the two are like strangers and difficult to blend. However, in organic solvents such as ethanol, ether, dichloromethane, etc., it can dissolve well, just like a fish in water, and it is immiscible. This property makes it possible to use a suitable organic solvent as a medium to promote the reaction during the organic synthesis reaction.
In addition, its vapor pressure also has a specific value at a specific temperature environment, which is related to its equilibrium situation between the gas phase and the liquid phase, and it is important to control the conditions for its storage, transportation, and related reaction operations.
In summary, the many physical properties of 4-bromo-1,2-difluorobenzene are interrelated, which together determine their behavior in various situations and lay the foundation for their application in chemical industry, scientific research and other fields.
What are the synthesis methods of 4-Bromo-1,2-Difluorobenzene?
4-Bromo-1,2-difluorobenzene is also an important intermediate in organic synthesis. There are several ways to synthesize it.
First, it is obtained by bromination with o-difluorobenzene as the starting material. When brominating, liquid bromine and initiators such as benzoyl peroxide can be used to replace hydrogen atoms on the benzene ring under heating or light conditions to generate 4-bromo-1,2-difluorobenzene. This reaction requires attention to the control of reaction conditions. Due to the high reactivity, if the conditions are improper, side reactions are prone to occur, such as the formation of polybrominated products.
Second, use 1,2-difluoro-4-nitrobenzene as raw material. The nitro group is first reduced to an amino group, and the commonly used reducing agents are iron and hydrochloric acid. After obtaining 1,2-difluoro-4-aminobenzene, it is then treated with sodium nitrite and hydrochloric acid at low temperature through diazotization to form a diazonium salt. Finally, with a catalyst such as cuprous bromide, the diazonium group is replaced by a bromine atom to obtain 4-bromo-1,2-difluorobenzene. This route has a little more steps, but the selectivity is better, which can effectively avoid the substitution of other positions.
Third, the nucleophilic substitution reaction of halogenated aromatic hydrocarbons can also be synthesized. Select a suitable halogenated benzene derivative, in which the halogen atom is in an appropriate position, nucleophilic substitution with fluoride, fluorine atoms are introduced, and then brominated in an appropriate order, and the target product can also be obtained. This method requires high requirements for the selection of reaction conditions and reactants, and needs to be fine-tuned to achieve good yield and selectivity.
All synthesis methods have advantages and disadvantages. In practical application, when the availability of raw materials, cost, difficulty of reaction conditions and purity requirements of the product, the appropriate method is carefully selected.
What are the precautions for 4-Bromo-1,2-Difluorobenzene in storage and transportation?
4-Bromo-1,2-difluorobenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. In a cool environment, it can avoid chemical changes caused by excessive temperature, and high temperature can often promote chemical reactions and damage its quality. Dry conditions are also critical, because moisture may interact with the compound, causing adverse reactions such as hydrolysis. A well-ventilated place can prevent the accumulation of harmful gases and ensure the safety of the storage environment.
Furthermore, the storage place should be away from fire and heat sources. This compound may be flammable. In case of open flame or hot topic, it may cause combustion or even explosion, endangering the safety of personnel and facilities. And it should be stored separately from oxidants and alkalis to avoid violent reactions caused by mutual contact.
As for transportation, it is necessary to strictly abide by the regulations on the transportation of relevant dangerous chemicals. The transportation equipment must be airtight to prevent its leakage. When loading and unloading, the operation must be cautious, and the packaging should be handled lightly to avoid damage. During transportation, the temperature and humidity should be closely monitored to avoid extreme conditions.
The escort personnel should also be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage and other emergencies, they can be disposed of quickly and properly to reduce the damage. All of these are important considerations when storing and transporting 4-bromo-1,2-difluorobenzene to ensure personnel safety and material integrity.
What is the market price range for 4-Bromo-1,2-Difluorobenzene?
The market price range of 4-bromo-1,2-difluorobenzene is difficult to say exactly. This is because the market price is often influenced by many factors and changes rapidly.
Looking at the market situation in the past, the supply and price of raw materials have a great impact on the price of 4-bromo-1,2-difluorobenzene. If the raw materials required to prepare this compound are scarce or the price rises, the price of the finished product will also rise. For example, bromine and fluoride, if the supply is tight and the cost increases greatly, the price of 4-bromo-1,2-difluorobenzene will rise.
Furthermore, market demand is also key. If many industries, such as medicine, pesticides, electronic materials, etc., have strong demand for 4-bromo-1,2-difluorobenzene, the supply is in short supply, and the price will rise; on the contrary, if the demand is low and the supply exceeds the demand, the price will easily fall. Take the pharmaceutical industry as an example, if a new drug that requires a large amount of this compound is developed, its demand will surge, and the price will also rise.
Production technology and process should not be underestimated. Advanced and efficient production technology can reduce production costs and make prices more competitive; if the technology is outdated, the cost will be high, and the price will be difficult to reach the people.
4-Bromo-1,2-difluorobenzene produced by different manufacturers varies in price due to quality and purity. High-purity products are mostly used in areas with strict quality requirements, and the price is naturally higher.
Regional factors also play a role. The market environment and transportation costs vary in different regions, resulting in different prices. Generally speaking, the price around the origin may be relatively low, and the price away from the origin may be slightly higher due to the increase in transportation costs.
Taking into account, the market price range of 4-bromo-1,2-difluorobenzene fluctuates widely, ranging from hundreds to thousands of yuan per kilogram. To know the exact price, it is necessary to monitor market trends in real time and consult relevant suppliers and industry insiders in detail.