4-Benzyloxy-3-fluorophenylboronic acid is an important organic boron compound commonly used in the field of organic synthesis. It is widely used in the field of medicinal chemistry and is often used as a key intermediate to participate in the construction of drug molecules. Due to the unique electronic properties of boron atoms, it can be efficiently coupled with halogenated aromatics or halogenated olefins through a variety of organic reactions, such as Suzuki-Miyaura coupling reaction, to achieve carbon-carbon bond formation, help build complex drug molecular structures, and provide an effective way for innovative drug research and development.
In the field of materials science, it also has important uses. By means of organic synthesis, it can be introduced into the structure of polymer materials, which can endow materials with special properties. For example, when preparing materials with photoelectric activity, use its participation in the reaction to construct a conjugated structure to improve the photoelectric properties of the material, and apply it to organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices.
In the field of total synthesis of natural products, this compound plays a key role. Natural products have complex structures and are difficult to synthesize. 4-Benzyloxy-3-fluorophenylboronic acid, with its reactivity and selectivity, provides a powerful tool for the accurate construction of carbon skeletons and the introduction of specific functional groups in the total synthesis strategy of natural products. It helps organic chemists complete the total synthesis of many complex natural products, which is of great significance to the chemical research of natural products and the development of related drugs.

The synthesis of 4-benzyloxy-3-fluorophenylboronic acid is an important task in organic synthesis. The method can follow the classical organic synthesis method, using existing organic compounds as starting materials and combining various chemical reactions.
First, when looking for a suitable starting material, benzene derivatives with corresponding substituents can be selected. For example, select benzene compounds containing benzoxy groups and fluorine atoms, which can lay the foundation for the subsequent introduction of boric acid groups.
Later, the commonly used method is to borrow metal-organic chemistry. For example, the reaction of Grignard reagent or lithium reagent with halogenated aromatics first forms a carbon-metal bond. In this process, the reaction conditions, such as temperature, solvent, and reactant ratio, should be carefully controlled. The temperature can significantly affect the reaction rate and selectivity, and the appropriate solvent can promote the reaction and ensure the solubility of the reactants.
Furthermore, the resulting carbon-metal compound is reacted with a borate ester reagent. After the hydrolysis step, the borate ester can be converted into a borate group, and the target product is 4-benzyloxy-3-fluorophenylboronic acid. When hydrolyzing, pay attention to the pH of the reaction medium and the reaction time to prevent excessive hydrolysis or other side reactions.
In addition, during the reaction process, the product of each step should be separated and purified. Methods such as column chromatography and recrystallization can be used to ensure the purity of the product, so that the subsequent reaction can proceed smoothly. And in the entire synthesis process, the safety specifications of chemical experiments must be strictly followed, and various chemical reagents and products must be properly handled to ensure the safety of the experimenter and the harmless environment. In this way, according to the above synthesis path and precautions, 4-benzyloxy-3-fluorophenylboronic acid can be obtained.

4-Benzyloxy-3-fluorophenylboronic acid has unique properties and has attracted much attention in various fields of chemistry. It is a white to off-white solid with a fine powdery appearance and shines slightly in sunlight. The melting point range is about 125-130 ° C, and it gradually melts when heated. This temperature characteristic is of great significance in the planning of chemical synthesis processes and is related to the accuracy of reaction temperature control.
In terms of solubility, it is soluble in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). It is like fish getting water and can interact with organic solvent molecules to form a uniform dispersion system. However, the solubility in water is poor, just like the barrier between oil and water, with only a little solubility. This difference in solubility is a key consideration when separating, purifying and selecting reaction media.
Chemical activity, as a boric acid compound, 4-benzyloxy-3-fluorophenylboronic acid has typical boric acid properties and can chemically react with various functional groups such as hydroxyl groups and amino groups. Especially in the field of organic synthesis, it is often used as a key intermediate, participating in many important reactions such as carbon-carbon bond construction, and is widely used in cutting-edge fields such as drug development and materials science. It is like a cornerstone of building a complex molecular edifice, making great contributions to creating novel compounds and expanding the boundaries of material properties.

4-Benzyloxy-3-fluorophenylboronic acid is in the market, and its price range is difficult to determine. The price of this compound is often influenced by various factors.
First, the price of the raw material, if the starting material required for its preparation is expensive, or it is not easy to obtain, resulting in scarcity of supply, the price of 4-benzyloxy-3-fluorophenylboronic acid will be high. On the contrary, if the raw material is easily available and the price is average, the price of the product may be slightly lower.
Second, the simplicity of the preparation process is also the key. If the synthesis method requires multiple steps of reaction, and the yield of each step is not high, or requires special equipment, harsh reaction conditions, such as high temperature, high pressure, anhydrous and anaerobic, etc., or requires expensive catalysts, the cost will increase greatly, and its market price will also rise. If the process is simple and the yield is quite good, the price may be close to the people.
Third, the market supply and demand conditions also affect the price. If there are many people who want it, but there are few products, and the supply exceeds the demand, the price will rise; if the production is greater than the demand and the market is saturated, the merchant may reduce the price for competitive sale.
Looking at past market conditions, the price of such fine chemicals may range from tens to hundreds of yuan per gram. However, this is only a rough estimate, not an exact number. Market conditions are fickle, and prices fluctuate accordingly. To know its exact price, when consulting chemical raw material suppliers in detail, you can get the current exact quotation.

4-Benzyloxy-3-fluorophenylboronic acid, this is an organic compound. Its storage conditions are very critical, related to its stability and quality. According to the common sense of chemical preservation, it needs to be properly disposed of.
The first weight is moisture-proof. If this compound is exposed to humid air, it is easy to react with water vapor, causing its structure to change, affecting its purity and activity. Therefore, it should be stored in a dry place, such as in a sealed container equipped with a desiccant. The desiccant can be selected as anhydrous calcium chloride or silica gel, which can effectively absorb water vapor and maintain a dry environment.
The second is heat avoidance. High temperature can accelerate chemical reactions or cause the compound to decompose or deteriorate. It should be stored in a cool place, preferably at a temperature of 2-8 ° C. It is commonly found in the refrigerated layer of the refrigerator, which can slow down the movement of molecules, reduce the reaction rate, and prolong the shelf life.
And avoid light. Light or lead to luminescent chemical reactions to destroy the structure of the compound. Store in brown bottles or opaque packaging materials to block light and reduce the impact of light on it.
At the same time, pay attention to isolation. Do not coexist with strong oxidants, strong acids, strong bases and other substances. Because of its chemical properties, it is easy to react with them and damage its own properties. It should be stored separately and marked well to prevent confusion.
Following the above storage conditions, 4-benzyloxy-3-fluorophenylboronic acid can be maintained stable for a long time for subsequent chemical experiments, production and other purposes.