4-Amino-Trifluoromethoxybenzene

Hongda Chemical

Specifications

HS Code	540650
Chemical Formula	C7H6F3NO
Molecular Weight	177.12
Appearance	Colorless to light yellow liquid or solid
Boiling Point	Around 190 - 195 °C
Density	Data may vary, but generally around 1.3 - 1.4 g/cm³
Solubility	Soluble in common organic solvents like dichloromethane, chloroform
Flash Point	Relatively high, as it is an organic compound with a certain stability
Purity	Can be produced with high purity, e.g., 98%+ in commercial products
Odor	May have a characteristic, slightly pungent odor typical of aromatic fluorinated compounds

As an accredited 4-Amino-Trifluoromethoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 4 - amino - trifluoromethoxybenzene packaged in a sealed, chemical - resistant bottle.
Storage	4 - amino - trifluoromethoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly closed container to prevent moisture and air exposure, which could potentially lead to degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions.
Shipping	4 - amino - trifluoromethoxybenzene is shipped in well - sealed containers, compliant with chemical transportation regulations. Special care is taken to prevent leakage, with proper labeling indicating its nature for safe and proper handling during transit.

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General Information

Historical Development

4-Aminotrifluoromethoxylbenzene is also a product of chemical industry. Although its origin is difficult to study in detail, there are traces to follow in the evolution of various chemical industries. In the past, chemical industry was at the beginning of its rise, and the path of exploration was bumpy, and the research on such compounds was still shallow. In modern times, science and technology were new, and chemical industry was advanced. Chemists worked hard to study its synthesis methods and properties. Beginning to gradually understand its rationale, optimize the production method, and improve its yield and quality. As a result, 4-aminotrifluoromethoxylbenzene has emerged in the fields of medicine and materials, and its use has become wider and wider. It has added to the development of chemical industry, and has become more and more important in the progress of the times.

Product Overview

4-Amino-trifluoromethoxylbenzene is also a chemical we have studied. It is a white to off-white crystalline powder with specific chemical properties.
This product has a wide range of uses in the field of organic synthesis and is often a key intermediate for the preparation of many high-value-added compounds. Due to its special structure containing trifluoromethoxy and amino groups, the prepared compounds are endowed with unique physical, chemical and biological activities.
After repeated experiments, fine-tuning the reaction conditions, optimizing the synthesis path, and striving to improve its purity and yield. Through unremitting efforts, we have achieved satisfactory results, laying a solid foundation for the development of related industries. I hope this achievement can be applied in more fields and promote the progress of the chemical industry.

Physical & Chemical Properties

4 - Amino - Trifluoromethoxybenzene is a unique compound. Its physical properties, the appearance is often white to light yellow crystalline powder, which is quite stable at room temperature and pressure. The melting point is in a specific range, which is related to its phase transition and has a profound impact on subsequent applications.
In terms of its chemical properties, the amino group endows it with a certain alkalinity, which can neutralize with acids to construct new chemical structures. The presence of trifluoromethoxy group greatly enhances the lipophilicity of the molecule, making the compound exhibit unique reactivity in the field of organic synthesis. In many chemical reactions, the two cooperate, either participating in nucleophilic substitution or involving coupling reactions, laying the foundation for the creation of novel organic materials and drugs, which are key substances that cannot be ignored in chemical research and industrial production.

Technical Specifications & Labeling

Today there is a thing called 4 - Amino - Trifluoromethoxybenzene. Its production method should be based on a certain technical specification. First take the materials and weigh them accurately. The material parameters are related to the quality of the product and must not be ignored. Place the material in a clean vessel, control it at a suitable temperature, observe its changes, and abide by technical regulations, such as heat and duration, which are all fixed.
After it is made, it is necessary to carry out the service of identification. Specify the product parameters, such as purity geometry and composition ratio, so that the viewer can understand its quality. In this way, according to the technical specifications and identification (commodity parameters), a good product can be made for all uses and live up to the intention of research and development.

Preparation Method

To prepare 4 - Amino - Trifluoromethoxybenzene, the raw materials and production process are very critical. First, an appropriate amount of p-nitrochlorobenzene is taken as the initial raw material, and anhydrous potassium carbonate is used as the acid binding agent. In N, N - dimethylformamide solvent, it is co-heated with the trifluoromethoxylation reagent to undergo nucleophilic substitution reaction. In this step, the temperature needs to be controlled in a suitable range. When the reaction is sufficient, p-nitrotrifluoromethoxylbenzene is obtained.
Then, the p-nitrotrifluoromethoxylbenzene is used as a catalyst in an ethanol solvent to carry out the reduction reaction with hydrogen gas. Pay close attention to the hydrogen pressure and temperature during the reaction, so that the nitro group is gradually converted into an amino group, and the final 4 - Amino - Throughout the preparation process, the conditions of each reaction step need to be precisely controlled to ensure the purity and yield of the product.

Chemical Reactions & Modifications

Today there is a chemical substance, named 4 - Amino - Trifluoromethoxybenzene. In chemical reactions and modifications, this is a topic to be studied. To observe the reaction, the conditions must be carefully examined, and temperature, pressure, and catalyst are all important. Changes in temperature can change the speed of the reaction. If it is high, it will increase rapidly, and if it is low, it will decrease rapidly. The same is true for pressure, which can promote the progress of the reaction. Catalysts can lower the energy barrier of the reaction and make the reaction easier.
As for modification, if you want to increase its activity or adjust its characteristics, you can use the method of substitution. In the position of benzene ring, introduce other groups to observe its properties. Or increase its stability, or change its solubility. Through various attempts, the law of its reaction is expected to be clarified, and the method of its modification is improved, so as to expand the use of this substance in various fields and contribute to chemistry.

Synonyms & Product Names

Today there is a thing called 4 - Amino - Trifluoromethoxybenzene. This thing has a wide range of uses in the field of chemical industry. Its synonyms, or other names, all refer to the same substance. The name of the trade name also varies with the habits of the industry and the different places.
We study this thing, search the classics in detail, and go through all aspects. Knowing what its synonyms indicate, it is inseparable from the nature of this chemical ontology. The establishment of the trade name is mostly because it is easy to market and attracts attention. Although the names are different, their essence is the same.
In the process of studying this thing, it is crucial to distinguish the relationship between synonyms and trade names. This can help us to accurately understand and not confuse. It is also the basis for the mutual communication and refinement of various chemical industry operators. It is of great benefit to study synonyms and trade names in 4-Amino-Trifluoromethoxybenzene.

Safety & Operational Standards

4-Amino-trifluoromethoxybenzene is an important raw material in the chemical industry. It often plays a key role in the synthesis of many fine chemicals. However, this substance also has certain dangers, so the safety and operation norms cannot be ignored.
In terms of its physical properties, 4-amino-trifluoromethoxybenzene is a solid, or has a special odor. Its chemical properties are active, under specific conditions, or react violently with other substances.
As for safety, the first protection. When operating, it is necessary to wear appropriate protective clothing, such as protective clothing and protective gloves, to prevent skin contact. And wear protective glasses to protect your eyes from damage. If you accidentally touch the skin, you should quickly rinse with plenty of water, followed by soap. If it enters the eyes, you need to rinse with plenty of water immediately and seek medical attention as soon as possible.
Furthermore, this substance may be toxic. Keep well ventilated during operation to prevent inhalation of its volatile gas. If you inhale and feel unwell, you should also go to a place with fresh air and seek medical treatment.
Operating instructions are also required. When taking 4-amino-trifluoromethoxy benzene, clean and suitable utensils must be used to prevent contamination. When weighing, when operating accurately, take it according to the amount required for the experiment. When mixing, it should be added slowly and stirred continuously to control the reaction rate.
For storage, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. When storing different batches of materials separately, mark them clearly for traceability.
In short, when using 4-amino-trifluoromethoxy benzene, strictly observe safety and operating standards to ensure the smooth operation of the experiment, protect the safety of personnel, and avoid accidents.

Application Area

4-Aminotrifluoromethoxybenzene, this compound is useful in many fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new drugs. Due to the special structure of trifluoromethoxy and amino groups, it endows drugs with unique physical and biological activities, or it can enhance the affinity of drugs to specific targets and improve the efficacy.
In the field of materials science, it also has potential. With its special chemical structure, it can participate in the synthesis of functional materials with special properties, such as for the preparation of sensor materials that are highly sensitive to specific substances, and use its structure to interact specifically with the target to achieve accurate detection.
In the field of pesticides, after rational design, it may become an important component of high-efficiency and low-toxicity pesticides. With its structural characteristics, it exhibits strong toxicity to pests and reduces adverse effects on the environment. This is also the field where 4-aminotrifluoromethoxybenzene can be applied.

Research & Development

4-Amino-trifluoromethoxybenzene is also a new chemical substance. We have been studying it for years. At the beginning, we analyzed its structure, explored its characteristics, and wanted to understand its effect in various reactions.
Study its synthesis method, try various paths, and after many adjustments, get a feasible method. The compatibility of raw materials, the temperature and time of the reaction are all carefully considered.
Looking at its application field, it can be used as an intermediate in the pharmaceutical and chemical industry, and can help the preparation of new drugs, hoping to add a new path to the treatment of diseases.
Although there are gains, the road ahead is still long. Optimizing the synthesis method, reducing its cost, and increasing its yield are all our follow-up tasks. And expand its application, explore its possibilities in other fields, and hope that this new material can shine, which will greatly contribute to the development of chemistry and the well-being of mankind.

Toxicity Research

4-Amino-trifluoromethoxybenzene is needed in today's chemical industry. The study of its toxicity is crucial.
Although this substance is a chemical raw material, the study of toxicity should not be ignored. Past research is mostly concerned with its synthesis and properties, but the study of toxicity is still lacking.
Now it is time to carefully observe its role in living bodies and its impact on the environment. Or you can try it with experimental animals first to observe its physiological changes and observe the damage to its organs. It is also necessary to test its decomposition state in the natural environment, and whether the resulting things have secondary harm.
The study of toxicity is related to people's livelihood and the environment. Hope to be able to study carefully, understand the depth of its toxicity, for those who use it, for those who live in this environment, to ensure its well-being and protect its environment, in order to live up to the responsibility of scientific research.

Future Prospects

4-Amino-trifluoromethoxybenzene is also a new research chemical. Looking at its properties, it has unique properties, or shows extraordinary potential in various fields.
Looking to its future, in the field of medicine, or the basis for making special new drugs, treating difficult diseases and saving patients from pain. In the chemical industry, it can be used as an excellent raw material to help create high-end materials and promote the progress of the industry.
Although the current research is not complete, the future is shining. With time and unremitting research, it will be able to solve its secrets and expand its use. Our researchers should explore the unknown with enthusiasm and determination, and go all out for its future expansion, hoping to benefit the world, lead the new path of science and technology, and show the grand future.

Where to Buy 4-Amino-Trifluoromethoxybenzene in China?

As a trusted 4-Amino-Trifluoromethoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Amino-Trifluoromethoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Amino-Trifluoromethoxybenzene?

4-Amino-trifluoromethoxybenzene, this substance has a wide range of uses and is involved in various fields of chemical industry.
First, it is often a key intermediate in the synthesis of medicine. Because of the structure of trifluoromethoxy, it can significantly affect its fat solubility, metabolic stability and biological activity in drug molecules. Based on this substance, a variety of specific drugs can be derived. For example, some anti-tumor drugs, with their unique structure, can precisely act on specific targets of tumor cells, interfere with the proliferation and survival of tumor cells, and contribute to the fight against cancer; for example, some neurological disease treatment drugs, with 4-amino-trifluoromethoxylbenzene intermediates, can optimize the affinity of drugs to neurotransmitter receptors and improve the therapeutic effect.
Second, in the industry of pesticide creation, it also plays an important role. The synthetic pesticides have outstanding control effects on pests and pathogens. The introduction of trifluoromethoxyl can enhance the effect of pesticide molecules on specific enzymes or receptors in target organisms, thereby improving the selectivity and activity of pesticides. Some new insecticides, using them as raw materials, can precisely attack specific pests, and are environmentally friendly, have low residues, and have little harm to non-target organisms, which is in line with the current trend of green pesticide development.
Third, in the field of materials science, it also has extraordinary performance. Used to synthesize special functional materials, such as photoelectric materials. Materials containing 4-amino-trifluoromethoxy benzene structure have unique advantages in photoelectric conversion efficiency and stability. In organic Light Emitting Diode (OLED) materials, it can optimize the luminous performance of the device, improve the brightness and color purity, and contribute to the improvement of display technology; in solar cell materials, it can enhance the absorption of light and charge transport capacity, improve the photoelectric conversion efficiency of the battery, and promote the development of renewable energy technology.
In summary, 4-amino-trifluoromethoxy benzene is an indispensable key substance in the fields of medicine, pesticides, materials science, etc., which is of great significance to promote the progress of various industries.

What are the physical properties of 4-Amino-Trifluoromethoxybenzene?

4-Amino-Trifluoromethoxybenzene, or 4-amino-trifluoromethoxybenzene, is an important compound in organic chemistry. This substance has unique physical properties, which has a great impact on its application in chemical, pharmaceutical and other fields.
Looking at its properties, it is mostly white to light yellow crystalline powder at room temperature. This form makes it relatively stable during storage and transportation, and it is not easy to lose or deteriorate due to morphological changes. Its melting point is in a specific range, generally around [X] ° C. The melting point characteristic is of great significance in the separation, purification and identification of compounds. By means of melting point determination, its purity can be judged. If the melting point is consistent with the standard value and the melting range is narrow, it indicates that the purity is quite high.
Furthermore, 4-amino-trifluoromethoxylbenzene also has characteristics of solubility. In common organic solvents such as ethanol and acetone, there is a certain solubility, but the solubility in water is very small. This difference in solubility provides a basis for the choice of reaction medium in organic synthesis. In organic reaction systems, organic solvents can dissolve the compound, promoting the reaction to proceed fully.
Its density is about [X] g/cm ³, which is a physical parameter that is crucial when chemical production involves material measurement and ratio. Only by accurately grasping the density can the reactants be accurately measured according to the reaction requirements, ensuring that the reaction is carried out according to the expected stoichiometric ratio, thereby improving the yield and quality of the product.
In addition, 4-amino-trifluoromethoxybenzene is also volatile, but the volatility is weak. Although it evaporates slowly at room temperature and pressure, long-term exposure in a poorly ventilated environment may still affect the human body. Therefore, when using this compound, it is necessary to take ventilation protection measures.

4-Amino-Trifluoromethoxybenzene chemical synthesis methods

There are several common methods for the synthesis of 4-amino-trifluoromethoxybenzene.
First, trifluoromethoxybenzene is used as the starting material. First, the trifluoromethoxybenzene is nitrified. This step requires careful operation and selection of suitable nitrifying reagents, such as mixed acid (mixture of concentrated sulfuric acid and concentrated nitric acid). Under appropriate reaction conditions, such as temperature control and reaction time, nitro groups are introduced into the benzene ring to obtain trifluoromethoxynitrobenzene. Subsequently, the resulting trifluoromethoxy nitrobenzene is subjected to a reduction reaction, and a suitable reducing agent can be selected, such as iron and hydrochloric acid system, hydrogen under the action of a catalyst (such as palladium carbon), etc., to reduce the nitro group to an amino group, and then 4-amino-trifluoromethoxy benzene is obtained.
Second, a halogenated aromatic hydrocarbon containing trifluoromethyl groups is used as a raw material. First, the halogenated aromatic hydrocarbon containing trifluoromethyl groups is reacted with alkoxides such as sodium methoxide under suitable conditions to form a trifluoromethoxy substituted aromatic hydrocarbon. After that, an amino group is introduced into the benzene ring through nitrification and reduction steps similar to the above to complete the synthesis of 4-amino-trifluoromethoxy ben It is necessary to pay attention to the control of the reaction conditions, the activity of halogenated aromatics, the choice of reaction solvent, etc., all of which have important effects on the reaction process and yield.
Third, trifluoromethoxyaniline is used as raw material, through diazotization reaction, and then substitution reaction to prepare. First, trifluoromethoxyaniline and sodium nitrite are diazotized under acidic conditions to form diazonium salts. Then, through a suitable substitution reaction, the desired substituent is introduced, and finally converted into 4-amino-trifluoromethoxylbenzene. In this process, the control of diazotization conditions is very critical, and factors such as temperature and acid concentration are all related to the stability and reaction selectivity of diazonium salts.

4-Amino-Trifluoromethoxybenzene What are the precautions during storage and transportation?

4-Amino-trifluoromethoxybenzene is an organic compound. When storing and transporting, many things must be paid attention to.
One is the storage environment. This substance should be stored in a cool, dry and well-ventilated place. If the environment is humid, or it may be damp and deteriorated, it will affect the quality and performance. And the temperature is too high, or it may cause a chemical reaction, so it needs to be kept away from heat and fire sources to ensure safety.
The second is about packaging. The packaging must be tight to prevent leakage. Because the compound may be toxic and irritating, leakage may endanger people and the environment. It is commonly packaged in sealed containers, and the packaging material must be compatible with the compound and not react with it.
The third is the transportation requirement. During transportation, severe vibrations and collisions should be avoided to avoid package damage. The means of transportation should also be clean, dry, and free of other substances that may react with them. Transportation personnel must be professionally trained and familiar with the characteristics of the compound and emergency treatment methods.
Fourth, the label is clear. Storage containers and transportation packages should be clearly marked, containing information such as the name, nature, and hazard warnings of the compound, so that contacts can see at a glance, so that appropriate protective measures can be taken.
Storage and transportation of 4-amino-trifluoromethoxy benzene require careful treatment of the environment, packaging, transportation, and labeling to ensure its safety and stability and avoid accidents.

What are the potential market application fields of 4-Amino-Trifluoromethoxybenzene?

4-Amino-trifluoromethoxybenzene, this substance is widely used in the field of chemical industry and scientific research.
In the field of pharmaceutical creation, it is a key synthetic block. Due to its unique chemical structure, it can introduce drug molecules and endow them with special physical, chemical and biological activities. For example, through clever design and reaction, it can produce drugs with high efficiency, low toxicity and strong specificity. It plays an indispensable role in the development process of anti-cancer, anti-infection and other drugs.
It is also of great value in the development of pesticides. Using it as a starting material and through a series of reactions, new pesticides can be obtained. Due to the special electronic and spatial effects of trifluoromethoxy, such pesticides may have excellent insecticidal, bactericidal and herbicidal activities, and have relatively little impact on the environment, which is in line with the current trend of green pesticide development.
Furthermore, in the field of materials science, 4-amino-trifluoromethoxylbenzene can participate in the synthesis of high-performance materials. Such as the preparation of special engineering plastics, functional polymer materials, etc. The introduction of this structural unit can improve the thermal stability, chemical stability and mechanical properties of the material, making it useful in high-end fields such as aerospace, electronics and electrical appliances.
In summary, 4-amino-trifluoromethoxybenzene has shown significant application potential in many fields such as medicine, pesticides, and materials science, and has contributed significantly to promoting technological innovation and progress in related industries.