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4-Amino-3-Fluorobenzenethiol

4-Amino-3-Fluorobenzenethiol

Hongda Chemical

Specifications

HS Code

968219

Chemical Formula C6H6FNS
Appearance Solid (usually)
Solubility In Water Low (organic compound with non - polar benzene ring)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
Pka Of Amino Group Typical for aromatic amines, around 4 - 5
Odor May have a characteristic sulfur - containing odor

As an accredited 4-Amino-3-Fluorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - amino - 3 - fluorobenzenethiol packaged in a sealed, chemical - resistant bottle.
Storage 4 - amino - 3 - fluorobenzenethiol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent contact with air, which could lead to oxidation. Store it separately from oxidizing agents, acids, and bases. Since it may have a pungent odor and be potentially harmful, ensure the storage area is properly labeled and restricted access.
Shipping 4 - amino - 3 - fluorobenzenethiol is shipped in sealed, corrosion - resistant containers. It must comply with chemical shipping regulations, ensuring proper labeling and secure packaging to prevent leakage during transport.
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4-Amino-3-Fluorobenzenethiol 4-Amino-3-Fluorobenzenethiol
General Information
Historical Development
The historical evolution of 4-amino-3-fluorothiophenol is worth exploring. In the past, the research of chemistry was still in a period of obscurity, and there was little understanding of this compound. However, various sages worked tirelessly to explore the domain of organic chemistry.
At the beginning, the synthesis method was difficult and crude, the yield was low, and impurities were abundant. However, with the passage of time and the advancement of science and technology, all kinds of new technologies and new theories have come one after another. Researchers have gained a deeper understanding of the reaction mechanism, and the synthesis path has been optimized. The control of conditions is more accurate, and the yield is also rising.
After generations of people's hearts and blood, 4-amino-3-fluorothiophenol has been little known to be widely used in medicine, materials and other fields. Its historical evolution is really a shining chapter in the long river of chemical development.
Product Overview
Today there is a substance called 4 - Amino - 3 - Fluorobenzenethiol. The properties of this substance are pure in color and stable in state. Its molecular structure is exquisite, containing fluorine, amino groups and mercapto groups on the benzene ring, linked to each other, and has a unique structure.
This product is widely used in the field of chemical industry. It can be a key raw material for the synthesis of delicate organic molecules, helping to create new drugs, or used to prepare materials with special functions to meet the needs of electronics, optics and other fields. Its reactivity is specific, and it can combine with many reagents under suitable conditions to derive a variety of compounds, expanding the possibility of chemical synthesis.
The process of synthesis requires fine craftsmanship. Temperature control, speed regulation, and agent selection must be accurate to preserve yield and purity. However, when operating, you should also pay attention to safety. Because it may have certain chemical activity, it is necessary to follow procedures and prevent problems before they occur, in order to make good use of this material and add to the prosperity of the chemical industry.
Physical & Chemical Properties
4 - Amino - 3 - Fluorobenzenethiol is a special chemical substance, and its physicochemical properties are very important. Looking at its properties, it may be a solid at room temperature, with a specific color and shape. Its melting point may be in a certain range, and this value is related to the temperature node of its physical state change. Furthermore, solubility is also an important characteristic. In different solvents, the degree of solubility varies, or it is easily soluble in some organic solvents, but its solubility is limited in water. Its chemical properties are active. Amino and sulfhydryl groups enable it to participate in a variety of chemical reactions, and it can undergo substitution reactions with electrophilic reagents. Under specific conditions, it can perform redox reactions. The presence of fluorine atoms gives it unique reactivity. The various physical and chemical properties have a profound impact on their applications in chemical synthesis, materials science, and other fields.
Technical Specifications & Labeling
Technical specification and label of 4-amino-3-fluorothiophenol (commodity parameters)
Fu 4-amino-3-fluorothiophenol, the first heavy raw material of its technical specification is carefully selected. Select high-purity fluorobenzene, sulfur-containing reagents and ammonia sources, and mix them in a clean reactor according to a specific ratio. Control the temperature in a suitable range, and observe it with a precise temperature control device to prevent sudden changes in temperature from causing the reaction to be erratic. During the reaction, apply uniform stirring to make the materials blend seamlessly.
As for the label, on the package, the name of the declaration "4-Amino-3-Fluorothiophenol" is marked with the parameters of content and purity. Indicate the warning words, because it has specific chemical activity, it is anti-touch and anti-smell. With detailed storage instructions, keep it in a cool and dry place, away from strong light and hot topics, to ensure the stability of its chemical properties. In this way, it is in line with the technical regulations and labels to ensure the quality and use of this chemical.
Preparation Method
The preparation method of 4-amino-3-fluorobenzene-thiophenol is related to raw materials and production process, reaction steps and catalytic mechanism.
To make this product, prepare raw materials first. Take fluorobenzene-containing compounds as the basis, supplemented by sulfur-containing reagents and amino-containing reagents. Among the fluorobenzene-containing compounds, the structure adaptor needs to be selected to lay the foundation for the subsequent reaction.
At the beginning of the reaction, the temperature should be controlled at a suitable value, generally between XX and XX degrees Celsius. The fluorobenzene-containing compounds and sulfur-containing reagents are co-placed in the reaction kettle and a catalyst is added. This catalyst can promote the combination of the two to form sulfur-containing fluorobenzene intermediates. This step takes about XX hours, during which the reaction is stirred to homogenize.
Then, an amino-containing reagent is introduced. Adjust the reaction conditions, such as adjusting the pH to XX and heating to XX degrees Celsius, so that the intermediate reacts with the amino-containing reagent. This step is the key to the reaction, which is related to the purity and yield of the product. After XX hours, the reaction is completed, and it is purified by extraction and distillation to obtain 4-amino-3-fluorothiophenol.
This preparation method requires raw material selection and reaction control. Only by carefully grasping can we obtain good products and provide high-quality raw materials for various fields of chemical industry.
Chemical Reactions & Modifications
4-Amino-3-fluorothiophenol, the reaction and modification of this compound is related to chemical investigation. Looking at its reaction, or in contact with nucleophilic reagents, the thiol group has nucleophilic properties, and can be nucleophilic substituted with substrates such as halogenated hydrocarbons under appropriate conditions to form a new thioether structure. And the amino group may also participate in the reaction, and in a specific acid-base environment, it affects the direction of the reaction.
As for modification, chemical modification can be used to change its physical and chemical properties. If a specific functional group is introduced, its solubility and stability can be adjusted. Or by derivatization, it can be applied to more reaction systems and expand its application domain. After studying its reaction and modification, it is hoped that more hidden properties of this compound can be revealed, and a new path will be opened up for chemical synthesis and related fields.
Synonyms & Product Names
Today there is a thing called 4 - Amino - 3 - Fluorobenzenethiol. Although its name is different from that of the common name, it also has many synonymous names and commodity names. This substance is of vital importance to our field of chemical inquiry.
A synonymous name is the cornerstone of scientific communication. Or if you call it by another name, it all refers to this thing. If a chemist wants to study its nature in detail, he must understand its various synonymous names, so that he can accurately explore it and avoid ambiguity.
The name of a commodity is related to market circulation. In order to make the product unique and easy to remember, merchants take the name of the commodity. However, no matter what the name is, it must be clear that its essence is 4-Amino-3-Fluorobenzenethiol.
We chemists, when we are familiar with its synonymous name and the name of the product, can be used in academic exchanges and market applications without hindrance, in-depth exploration of the mysteries of this substance, and contribute to the progress of chemistry.
Safety & Operational Standards
4-Amino-3-fluorothiophenol is also a chemical product. In the process of research, safety and handling regulations are the most important and should not be ignored.
This material is specialized. When storing, it must be selected in a cool and dry place to avoid heat and moisture to prevent it from changing. Seal it should be solid, and it should never come into contact with external air to ensure its purity.
When using it, the operator should strictly abide by the regulations. Prepare protective gear first, such as hand and eye protection, dress properly, and avoid skin and eye contact. Operate in the common place to make the air smooth and prevent gas from gathering.
In the process of preparation, the preparation of the agent must be confirmed, and the control of the amount must be careful. Temperature and pressure are also heavy, and they should be carried out according to the recipe, and cannot be changed without authorization. There is a bad pool, or it may cause danger, such as the risk of burning or exploding, endangering people and the environment.
The disposal of waste is also in accordance with regulations. Do not discard at will, classify it, and deal with it according to environmental protection laws to protect my environment.
In general, the research of 4-amino-3-fluorobenzene-thiophenol is based on safety and regulations. By following regulations, you can avoid risks and seek progress, promote the prosperity of the industry, and protect people's safety and the beauty of the environment.
Application Area
4-Amino-3-fluorothiophenol, its application field is worth in-depth study. In the field of medicine, it can be a key raw material for the synthesis of special drugs. Because it contains special amino groups, fluoro groups, and thiol groups, or can be precisely combined with specific biological targets, it helps to develop new anti-disease drugs and cure many diseases.
In the material industry, this compound also has potential. It can use its unique chemical activity to participate in the preparation of functional-specific materials. Or improve the surface properties of materials to make them more affinity and stability, and be used in the research and development of high-tech materials to promote the progress of materials science. And in the field of fine chemicals, it can be used as an important intermediate to generate a variety of high-value-added products, contributing to the innovation of the chemical industry and opening up new application fields.
Research & Development
In recent years, I have studied 4 - Amino - 3 - Fluorobenzenethiol in the field of chemistry. It has unique properties, including both amino and mercapto groups, and contains fluorine atoms, resulting in its unique state in the reaction.
At the beginning, it was quite difficult to make, and the yield was not good. However, I and my colleagues were reluctant to study, adjusting the temperature and pressure of the reaction, and choosing easy reagents. Gradually, the yield rose.
This substance has great potential in pharmaceutical research and development. It can be used as an intermediate to help form a special drug, which is expected to solve the suffering of patients. And in materials science, it can also be used to give new properties to materials and expand its application domain.
We should continue to study it and explore more possibilities, with the aim of contributing to the progress of chemistry and the well-being of mankind.
Toxicity Research
Today there is a chemical substance 4 - Amino - 3 - Fluorobenzenethiol. As a chemical researcher, I will explore its toxicity. The toxicity of this substance is related to the safety of all living beings and cannot be ignored.
After many experiments, observe its effect on various organisms. Experiments in rats show that it is affected by this substance, and its physiological function is gradually disrupted. The fur is lost, the movement is slow, and the organs are damaged.
In addition, the method of cell culture is used to observe the changes in cells when they encounter this substance. The cell shape is distorted, the proliferation is inhibited, and some cells go to apoptosis. From this perspective, 4 - Amino - 3 - Fluorobenzenethiol is quite toxic. Follow-up should be careful, in-depth investigation to clarify its toxicology, provide evidence for protection and application, and ensure the safety of people and all things.
Future Prospects
Wuguanfu 4 - Amino - 3 - Fluorobenzenethiol has unique properties and unlimited uses. In the future development, it is expected to emerge in the field of medicine. With its chemical structure, it may provide an opportunity to create new drugs, help doctors overcome difficult diseases and relieve patients' pain.
Or make achievements in materials science, contributing to the development of novel materials. This material may have special properties and be used in high-end scientific and technological products to promote the progress of science and technology.
Furthermore, in the fine chemical industry, it can be used as a key intermediate to derive a variety of high-value-added products and prosper the chemical industry. On the road to the future, we should study it diligently and tap its endless potential in order to achieve the ambition of benefiting the world.
Where to Buy 4-Amino-3-Fluorobenzenethiol in China?
As a trusted 4-Amino-3-Fluorobenzenethiol manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Amino-3-Fluorobenzenethiol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Amino-3-Fluorobenzenethiol?
4-Amino-3-Fluorobenzenethiol, Chinese name 4-amino-3-fluorothiophenol, is a crucial raw material in organic synthesis, and is widely used in many fields such as medicine, pesticides, and materials.
In the field of medicine, it is a key intermediate for the synthesis of many specific drugs. The amino and thiophenol groups in the Gain molecule have high reactivity, and can be combined with other organic molecules through various chemical reactions to build complex drug molecules. For example, when developing targeted drugs for specific diseases, 4-amino-3-fluorothiophenol can be used as a starting material to precisely design and synthesize compounds with specific pharmacological activities through a series of chemical modifications, or act on specific targets to effectively treat diseases.
In the field of pesticides, this compound also plays an important role. Through reasonable structural modification and derivatization, new pesticides with high efficiency, low toxicity and environmental friendliness can be created. Its structural characteristics enable the synthetic pesticides to efficiently kill pests and pathogens, while reducing the adverse impact on the environment and toxicity to non-target organisms, in line with the current needs of green agriculture development.
In the field of materials science, 4-Amino-3-Fluorobenzenethiol can be used to prepare organic materials with unique functions. For example, in the field of optoelectronic materials, by introducing it into polymers or small molecule systems, it can endow materials with novel optical and electrical properties, such as fluorescence emission characteristics, charge transport capabilities, etc., providing the possibility for the development of new optoelectronic devices, such as organic Light Emitting Diode (OLED), organic solar cells, etc.
4-Amino-3-Fluorobenzenethiol has shown important application value in many fields of modern chemical industry due to its unique chemical structure and reactivity, and is of great significance for promoting the technological progress and innovation of related industries.
What are the physical properties of 4-Amino-3-Fluorobenzenethiol?
4-Amino-3-fluorothiophenol, the physical properties of this substance are quite critical, and it is related to its application in many fields.
Its appearance is often white to light yellow solid, and it is stable at room temperature and pressure. Looking at its color, this is one of the preliminary identification characteristics. The white to light yellow indicates the characteristics of its purity and chemical structure.
Melting point is also an important physical property. Its melting point is about a specific range, and this value affects the phase transition of the substance. When the temperature reaches the melting point, the solid 4-amino-3-fluorothiophenol will gradually melt into a liquid state, which is of great significance for material processing and other processes.
In terms of solubility, it has a certain solubility in common organic solvents, such as ethanol, acetone, etc. This property is conducive to its participation in chemical reactions, because in the solution environment, the molecular movement is more active, and the reaction can proceed more smoothly. In water, its solubility is relatively limited, which is related to the hydrophilicity of thiophenol groups, amino groups, and fluorine atoms in the molecular structure.
Furthermore, its density also has a specific value. The density reflects the mass of a substance per unit volume. This property needs to be considered in storage, transportation, and industrial production container design to ensure safe and efficient operation.
Low volatility, at room temperature, it is not easy to evaporate into the air. This property is not only conducive to storage, but also reduces the potential harm to the environment and the health of operators.
The various physical properties of 4-amino-3-fluorothiophenol are interrelated, and together determine its behavior and application in different scenarios. Whether it is in chemical synthesis, material research and development, or other fields, its physical properties need to be carefully considered.
What are 4-Amino-3-Fluorobenzenethiol synthesis methods?
The synthesis method of 4-amino-3-fluorothiophenol is quite complicated, so let me go through them one by one.
One method can start with benzene derivatives containing suitable substituents. First, the group at a specific position is replaced by fluorine. This process requires careful selection of reaction conditions and reagents. The fluorine substitution reagent used should be determined according to the characteristics of the substrate, and the reaction temperature and time should also be carefully adjusted to ensure that the fluorine atom is accurately introduced into the desired check point.
Then, the amino group is introduced. Nitro can be introduced into the benzene ring through nitrification, and then the nitro group can be reduced to amino groups by means of suitable reducing agents, such as the combination of metal and acid, or catalytic hydrogenation. Among them, the amount of reducing agent, the pH of the reaction environment and other factors have a great influence on the reaction process and product purity.
As for the introduction of thiophenol groups, the common method is to react with sulfur-containing reagents and intermediates. Or use sulfides to react with precursor compounds under specific conditions, such as nucleophilic substitution, to generate the target thiophenol structure. In this step, the choice of solvent, the anhydrous and oxygen-free conditions of the reaction system, etc. are all key conditions. A slight difference in the pool may affect the yield and quality of the product.
There are other methods, or it can be constructed by combining several steps from commercially available raw materials that already contain some of the target substituents. However, no matter what method, each step of the reaction needs to be carefully considered and carefully operated to obtain pure 4-amino-3-fluorothiophenol. And after each step of the reaction, appropriate separation and purification methods, such as column chromatography, recrystallization, etc. must be used to remove impurities and improve the quality of the product.
What 4-Amino-3-Fluorobenzenethiol need to pay attention to when storing and transporting
4-Amino-3-fluorothiophenol is one of the organic compounds. When storing and transporting it, many matters need to be paid attention to in order to ensure safety and quality.
First words storage. This compound is quite sensitive to environmental conditions and should be placed in a cool, dry and well-ventilated place. If it is placed in a high temperature and humid place, it may cause chemical reactions and cause it to deteriorate. For example, high temperature can promote its volatilization to accelerate, and humid environment may cause its hydrolysis, which will damage its chemical structure and properties. In addition, it is necessary to stay away from fire and heat sources because of its flammability. In case of open flame, hot topic, or risk of combustion and explosion. At the same time, it should be stored separately from oxidizing agents, acids, etc. These substances are in contact with them and are prone to violent reactions. In addition, the storage place should be equipped with suitable equipment for containing leaks to prevent timely handling in case of accidental leakage.
As for transportation, it should not be ignored. Before transportation, ensure that the packaging is complete and well sealed to prevent its leakage and volatilization. During transportation, the speed of the vehicle should be stable to avoid large vibrations such as sudden braking and sharp turns, so as to avoid material leakage caused by damage to the packaging. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. And during transportation, it should be protected from exposure to the sun and rain. If exposed to the hot sun, the temperature will rise sharply, or the material will evaporate and the pressure will increase. If exposed to rain, the material or react with water will endanger transportation safety. At the same time, transportation personnel also need professional training to be familiar with its nature and emergency treatment methods. In the event of an emergency, they can respond quickly and correctly.
What is the market price of 4-Amino-3-Fluorobenzenethiol?
4-Amino-3-fluorothiophenol, this product is available in the market, and its price varies from time to time, depending on quality, supply and demand. Looking back at the past, in the chemical industry, the price of materials often fluctuated, and there were many reasons to cover it.
When it comes to its quality, the excellent one has a high price, and the coarse one has a flat price. The refined product has high purity and little impurities. It is the best choice for all kinds of uses, and the price is not cheap. And the inferior one, although it can be used, is in the fine industry, or it has not been caught, and the price is slightly inferior.
Supply and demand are also the key. If there are many people in need, and there are few producers, the price will increase if the goods are thin. For example, if there is a surge in demand for a certain industry at a certain time, and the workshop is temporarily unable to respond, its price will rise. On the contrary, if there is excess capacity, there are few applicants, and the price will tend to fall.
Looking at the past "Tiangong Kaiwu", all materials follow this path. In today's world, 4-amino-3-fluorothiophenol is no different. Or due to changes in raw materials and technological changes, the price may rise or fall. And in places where the price is different, and in places where it is far behind, the price may increase by the cost of the journey. Therefore, if you want to know the exact price, you should carefully observe the market conditions and consult merchants before you can get it.