As a leading 4-[[5-Amino-1-(2,6-Difluorobenzoyl)-1H-1,2,4-Triazol-3-Yl]Amino]Benzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4- [[5-amino-1- (2,6-difluorobenzoyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide
4 - [ [ 5-Amino-1- (2,6-difluorobenzyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide, which is a key intermediate in the field of medicinal chemistry. Its main uses are as follows.
The first is to create antibacterial drugs. In the process of antibacterial drug development, this compound can be combined with other active groups through specific chemical reactions to construct a new compound with high antibacterial activity. It can act on specific bacterial targets and interfere with the normal physiological metabolism of bacteria, such as cell wall synthesis, protein synthesis, etc., to achieve the purpose of inhibiting or killing bacteria, and to add a sharp weapon to human resistance to bacterial infection.
The second is the development of anti-tumor drugs. Studies have shown that some compounds containing such structures have a certain inhibitory effect on tumor cells. Or because it can affect the signaling pathway of tumor cells, block the proliferation of tumor cells, and induce apoptosis of tumor cells, in the exploration of anti-tumor drugs, 4 - [ [ 5-amino-1- (2,6-difluorobenzyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide is a key starting material, which provides an important direction and possibility for the innovation and development of anti-tumor drugs.
Furthermore, it also has potential in the creation of pesticides in the agricultural field. It can be modified by structure to develop efficient pesticides against crop diseases and insect pests. It can specifically target pests or pathogens, ensure the healthy growth of crops, improve crop yield and quality, and contribute to sustainable agricultural development.
What are the chemical properties of 4- [[5-amino-1- (2,6-difluorobenzoyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide
4 - [ [ 5 - amino - 1 - (2,6 - difluorobenzyl) - 1H - 1,2,4 - triazole - 3 - yl] amino] benzylbenzamide, this is an organic compound. Its chemical properties are rich and diverse:
1. ** Acidic and basic **: Because of the amino group, it has a certain alkalinity, and the amino nitrogen atom has lone pair electrons, which can bind protons and react with acids to form corresponding salts.
2. ** Nucleophilicity **: The nitrogen atom on the amino group and the triazole ring is rich in solitary pair electrons, with good nucleophilicity. It is easy to attack the electrophilic reagents and participate in nucleophilic substitution or addition reactions, such as nucleophilic substitution with halogenated hydrocarbons to generate new nitrogen-containing derivatives.
3. ** Aromatics **: The compound contains multiple benzene rings and triazole rings. These cyclic structures meet the Shocker rule, have aromaticity, good stability, and are not prone to addition reactions. It is more inclined to electrophilic substitution reactions. Under appropriate conditions, benzene rings can undergo electrophilic substitution such as halogenation, nitration, and sulfonation.
4. ** Hydrogen bonding **: Amino-hydrogen atoms can be used as hydrogen bond donors, nitrogen atoms can be used as hydrogen bond receptors, and can form hydrogen bonds with molecules or groups containing electronegative atoms (such as oxygen, nitrogen, fluorine), which has a great impact on their physical properties (such as melting point, boiling point, solubility) and biological activity. In water, it can interact with water molecules through hydrogen bonds to affect its own solubility.
5. ** Conjugation effect **: Benzene ring, triazole ring and connecting group form a conjugated system, electron cloud delocalization enhances molecular stability, and at the same time affects molecular spectral properties. It has specific absorption peaks in the ultraviolet-visible spectrum, which can be used for qualitative and quantitative analysis.
What is the production process of 4- [[5-amino-1- (2,6-difluorobenzoyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide
The preparation process of 4 - [ [ 5-amino-1- (2,6-difluorobenzyl) -1H-1,2,4-triazole-3-yl] amino] benzyl] sulfonamide is a crucial skill in the field of fine chemical synthesis. The preparation process is complicated and requires rigorous operation, and there is no room for error.
When starting, use carefully selected raw materials as the base. Select 2,6-difluorobenzyl halides with high purity. This halogen needs to be tested repeatedly to ensure that the impurity content is minimal before it can be used for subsequent reactions. The match is 5-amino-1H-1,2,4-triazole-3-amine with extremely high purity. The quality of this raw material will directly affect the quality of the product.
Then, the two meet in a suitable reaction environment. The choice of reaction solvent is extremely critical, and polar organic solvents such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO) are usually selected, which can effectively promote the dissolution and interaction of the reactants. The reaction temperature also needs to be precisely controlled. Generally, it is maintained in a moderate temperature range, between about 50 ° C and 80 ° C. If the temperature is too high or too low, the reaction may deviate from the expected track, or generate by-products, or the reaction rate may be too slow.
In this process, in order to accelerate the reaction process, a catalyst is often introduced. A suitable catalyst can significantly reduce the activation energy of the reaction and promote the efficient progress of the reaction. During the reaction, the reaction system needs to be continuously stirred to ensure that the reactants are fully mixed and the reaction occurs uniformly.
After the first step of the reaction is completed, the obtained intermediate product needs to be carefully separated and purified. In this step, classical separation methods such as extraction and column chromatography are used to remove unreacted raw materials, by-products and impurities to obtain high-purity intermediates.
Then, this intermediate product is reacted with a specific sulfur-containing reagent under another suitable condition to generate the target product 4 - [ [ 5 -amino-1- (2,6 -difluorobenzyl) -1H-1,2,4 -triazole-3 -yl] amino] benzenesulfonic acid. The final product is also subject to rigorous analytical testing, such as high performance liquid chromatography (HPLC), mass spectrometry (MS) and other means to determine its purity and structure, to ensure compliance with established Quality Standards.
How competitive is 4- [[5-Amino-1- (2,6-difluorobenzoyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide in the market?
Today, there are 4- [[5-amino-1- (2,6-difluorobenzyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide. How competitive is this product in the market? I will say it in ancient Chinese.
Looking at this drug, its structure is exquisite, it fuses several chemical groups, or it has a unique pharmacology. In the field of medical science, the competitiveness of the drug lies in its efficacy. If this drug is targeted at a specific disease, it can show miraculous effects, remove diseases and make patients recover, it will be favored by doctors and patients.
In addition, safety is also the key. Even if the drug is effective, if there are many adverse reactions that endanger the health of patients, it is difficult to have a foothold. This 4- [5-amino-1- (2,6-difluorobenzyl) -1H-1,2,4-triazole-3-yl] amino] benzyl sulfonamide can increase its competitiveness if it can ensure safety.
Cost and price also affect its situation in the market. If the manufacturing cost is controllable, the price is close to the people, and it has a price advantage among the same drugs, it can be widely sold. On the contrary, if the cost is high and the price is not cheap, the audience may be small.
In addition, marketing activities and publicity cannot be ignored. Good publicity of its advantages, so that the medical community and the public know its effectiveness, can get more attention and application.
In summary, the competitiveness of 4- [5-amino-1- (2,6-difluorobenzyl) -1H-1,2,4-triazole-3-yl] amino] benzyl sulfonamide is related to curative effect, safety, cost price and promotion. All links complement each other, and it is expected to stand out in the market.
What is the safety of 4- [[5-amino-1- (2,6-difluorobenzoyl) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide
4- [[5-amino-1- (2,6-diethylanilino) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide, which is a complex chemical substance. To observe its safety, it needs to be analyzed on multiple sides.
In terms of chemical structure, this substance contains amino, triazole and other groups. The amino group has certain reactivity, or can bind with biological macromolecules in the body such as proteins, nucleic acids, etc. by hydrogen bonds or other weak interactions, interfering with normal physiological processes. Triazole ring is common in many drugs and bioactive molecules, but its specific substituents and connection methods may make the substance exhibit unique biological activity and toxicity.
As for its potential toxicity, it is difficult to accurately determine without sufficient experimental data. However, compounds with similar analogical structures may pose risks such as hepatotoxicity and nephrotoxicity. For example, some phenylamine-containing derivatives are metabolically activated in vivo to generate electrophilic metabolites, which can covalently bind with proteins and nucleic acids in hepatocytes, causing hepatocyte damage and hepatotoxicity; compounds containing triazole structures may affect the function of the nervous system and cause neurotoxic symptoms.
In terms of environmental safety, if the substance is released into the environment, its chemical stability and biodegradability are the key considerations. Contains benzene ring and complex heterocyclic structure, or makes it more difficult to biodegrade, persists in the environment, is transmitted and enriched through the food chain, and threatens the ecosystem.
In summary, the safety of 4- [[5-amino-1- (2,6-diethylaniline) -1H-1,2,4-triazole-3-yl] amino] benzenesulfonamide requires rigorous toxicological experiments and environmental behavior studies to fully and accurately evaluate.