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What is the chemical structure of 4- [3- (difluoromethyl) -5- (3-fluoro-4-methoxyphenyl) -1H-pyrazole-1-yl] benzenesulfonamide?
I look at your words, but it is a question of chemical structure. The description of this structure is slightly complicated, but it can be analyzed according to the theory of chemical nomenclature and structure.
The first sentence "4 - [3 - (diethylamino) - 5 - (3 - ethyl - 4 - acetoxybenzyl) - 1H - pyrrole - 1 - yl] benzoic acid" is the nomenclature of organic compounds, which follows the chemical nomenclature. "Benzoic acid" is the parent nucleus, and the "4 -" epitope is attached to the No. 4 position of the benzene ring.
"[3- (diethylamino) -5- (3-ethyl-4-acetoxybenzyl) -1H-pyrrole-1-yl]" is a complex substituent attached to the phenyl ring at position 4. Among them, "1H-pyrrole-1-yl" is a pyrrole ring, which is connected to other places at position 1. "3- (diethylamino) " means that the pyrrole ring is connected to diethylamino at position 3, that is, two ethyl groups are connected to amino groups. " 5- (3-ethyl-4-acetoxybenzyl) "Epirrole ring No. 5 is connected to benzyl. The benzyl ring of this benzyl group has ethyl at No. 3 and acetoxy at No. 4.
As depicted in the figure, the benzene ring of benzoic acid is the group, and the 4 position is connected to a chain containing a pyrrole ring. The pyrrole ring at No. 3 is stretched diethylamino, which is shaped like a branch; the 5 position is connected to benzyl, and the benzyl ring of benzyl has ethyl at No. 3 and acetoxy at No. 4. The analysis of the chemical structure of
needs to clarify the naming rules and the configuration by name. Although the structure of this compound is complex, it can be solved in sequence to obtain its shape.
What are the main physical properties of 4- [3- (difluoromethyl) -5- (3-fluoro-4-methoxyphenyl) -1H-pyrazole-1-yl] benzenesulfonamide?
4- [3- (diethylamino) -5- (3-ethyl-4-ethoxybenzyl) -1H-pyrazole-1-yl] benzyloxybenzaldehyde, this compound has a variety of important physical properties.
In terms of solubility, due to the presence of a variety of polar and non-polar groups, it can have a certain solubility in polar organic solvents such as ethanol and acetone. Polar groups such as hydroxyl groups and ethoxy groups can form hydrogen bonds with polar solvents; while in non-polar solvents such as n-hexane, the solubility is low, because the molecule as a whole is not highly non-polar.
At the melting point and boiling point, there are interactions such as van der Waals force and hydrogen bond between molecules. Many groups make the structure rigid, the intermolecular force is strong, and the melting point is relatively high. The boiling point is also affected by the intermolecular force. The larger molecular weight and complex structure increase the energy required for the molecule to leave the liquid state, and the boiling point is higher.
In terms of stability, the benzene ring is structurally stable, while some groups such as ethoxy and pyrazolyl can react under specific conditions. Pyrazole ring nitrogen atom has a certain alkaline and may be protonated under acidic conditions; ethoxy groups may react such as hydrolysis when they are in strong acids or strong bases and at high temperatures, which affects the stability of compounds.
The refractive index and density depend on the molecular structure and electron cloud distribution. The complex structure and the type and number of atoms determine that the refractive index has a unique value. The close packing of molecules and the distribution of atomic weight make the density in the corresponding range. These physical properties play a key role in its application in organic synthesis, drug development and other fields, helping to understand its behavior in different environments and guide its rational use and preparation.
What are the applications of 4- [3- (difluoromethyl) -5- (3-fluoro-4-methoxyphenyl) -1H-pyrazole-1-yl] benzenesulfonamide in the field of medicine?
4- [3- (diethylamino) -5 - (3-ethyl-4-ethoxybenzyl) -1H-indole-1-yl] indolo [2,3-b] quinoline, this compound is widely used in the field of medicine.
Looking at its structure, it contains key structural units such as indole and quinoline, which endow it with unique chemical and biological activities. In drug development, it often exhibits a variety of pharmacological activities due to structural characteristics.
First, in the field of anti-tumor, it may inhibit tumor cell proliferation and induce apoptosis by means of specific mechanisms of action. For example, many drugs containing indole and quinoline structures can target key signaling pathway proteins or enzymes in tumor cells, block tumor cell growth and diffusion signaling, and then inhibit tumor development.
Second, in neurological diseases, it may have a positive effect on neurotransmitter regulation and nerve cell protection. Like some compounds with similar structures, it can regulate the release and uptake of neurotransmitters, improve neurotransmission function, and bring hope for the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
Third, in the field of anti-inflammatory, it may show anti-inflammatory effect by inhibiting the release of inflammation-related mediators and regulating inflammation signaling pathways. Some contain similar structural drugs, which can inhibit the production and release of inflammatory cytokines and reduce the inflammatory response, and are used to treat inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Fourth, antibacterial and antiviral aspects, or due to binding to specific targets of pathogens, interfere with their metabolism or replication process, showing antibacterial and antiviral activity. For example, some structural drugs containing this type can act on bacterial cell wall synthase or virus replication key protein to exert antibacterial and antiviral effects. In conclusion, 4- [3- (diethylamino) -5 - (3-ethyl-4-ethoxybenzyl) -1H-indole-1-yl] indolo [2,3-b] quinoline has great potential application value in the field of medicine due to its unique chemical structure. It is expected that innovative drugs for the treatment of various diseases will be developed through in-depth research.
What are the synthesis methods of 4- [3- (difluoromethyl) -5- (3-fluoro-4-methoxyphenyl) -1H-pyrazole-1-yl] benzenesulfonamide?
To prepare 4- [3- (diethylamino) -5 - (3-ethyl-4-ethoxybenzyl) -1H-indole-1-yl] benzoic acid, there are many synthesis methods, and the main ones are selected.
The classic nucleophilic substitution method is first introduced. The halogenated aromatics and nitrogen-containing nucleophiles containing the corresponding substituents are used in appropriate bases and solvents to form carbon-nitrogen bonds through nucleophilic substitution reactions, and then diethylamino groups are introduced. This process requires careful selection of reaction conditions, such as temperature and base strength, to ensure reaction selectivity and yield.
Palladium-catalyzed coupling reactions are also commonly used. For example, Suzuki coupling, Stille coupling, etc., using halogenated aromatics or borates as raw materials, under the action of palladium catalysts and ligands, carbon-carbon bonds are formed, and each substituent is precisely connected to construct the basic skeleton of the target molecule. However, palladium catalysts are expensive, and the reaction conditions are relatively harsh, which requires high requirements for anhydrous and anaerobic environments.
In addition, it can also be achieved through the construction and modification of indole rings. Using suitable aniline derivatives and alaldehyde as the starting materials, the indole ring is formed through cyclization reaction, and then the desired substituent is introduced at a specific position of the indole ring, and the final product is synthesized through multi-step reaction. This strategy requires in-depth understanding and control of the reactivity and regioselectivity of the indole ring.
Or use the idea of reverse synthesis analysis to disassemble the target molecule into several simple fragments, and then select the appropriate reaction to connect in sequence according to the characteristics of each fragment to realize the synthesis path from simple to complex.
During the synthesis process, the purity of the raw material, the fine regulation of the reaction conditions, and the separation and purification of the intermediate are all related to the quality and yield of the final product. Each synthesis method has its own advantages and disadvantages, and the optimal synthesis strategy should be weighed and selected according to the actual situation, such as raw material availability, cost consideration, reaction operability and other factors.
What are the market prospects for 4- [3- (difluoromethyl) -5- (3-fluoro-4-methoxyphenyl) -1H-pyrazole-1-yl] benzenesulfonamide?
I look at this formula, although it is complicated and difficult to understand, but if you think about it carefully, it may be able to promote its market prospects. The chemical structure involved in this formula is complex and contains many special groups, such as diethyl, ethoxybenzoyl, etc.
In the current market, such complex organic compounds may have promising prospects if they are used in the field of medicine. Nowadays, there is a growing demand for compounds with unique structures in pharmaceutical research and development, hoping that they can exhibit novel biological activities to overcome difficult diseases. If this compound is experimentally verified, has good pharmacological activity, can accurately act on specific targets, and has good safety and stability, it will surely be favored by pharmaceutical companies and emerge in the development of anti-tumor, anti-infection and other drugs.
If it is used in the field of materials science, it may give materials special properties. If this structure is introduced into polymer materials, it may improve the thermal stability, mechanical properties, optical properties, etc. With the development of science and technology, the demand for high-end materials has surged. If this compound can meet the needs of material performance improvement, it must have a broad application in frontier fields such as aerospace and electronic information.
However, its marketing activities also have challenges. Complex structures make synthesis difficult and costly. If the synthesis process cannot be optimized and the cost is reduced, it may be difficult to produce and apply on a large scale. And the market competition is fierce, and it needs to compete with similar or alternative products. Only by highlighting unique advantages, such as excellent performance and lower cost, can we gain a firm foothold in the market.