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What are the main uses of 4- (3-chloropropoxy) -4-fluorobenzene?
The main uses of 4- (3-hydroxyethylamino) -4-methoxybenzene lie in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate. Through specific chemical reactions, it can be introduced into the molecular structure of drugs, giving drugs unique pharmacological activity. For example, when developing anti-tumor drugs with specific targeting properties, the compound can be used as a key fragment of structural modification, cleverly spliced with other active groups, accurately acting on specific targets of tumor cells, improving drug efficacy and reducing damage to normal cells.
In the field of materials science, this compound can be used to prepare functional polymer materials due to its special chemical structure. If it is connected to the main chain or side chain of the polymer, the electrical and optical properties of the material can be changed. For example, when preparing organic Light Emitting Diode (OLED) materials, its introduction may optimize the luminous efficiency and stability of the material, thereby improving the display quality and service life of the OLED display.
In the field of dye chemistry, it can be used as an important raw material for the synthesis of new dyes. With the amino and methoxy groups in its structure, dyes with unique colors and dyeing properties can be constructed by connecting with different chromophores. These dyes may emerge in the textile printing and dyeing industry, achieving efficient and firm dyeing of various fiber materials, and have good light resistance and washable fastness, meeting people's needs for long-lasting and beautiful textiles.
In addition, in the production of fine chemical products, it is also one of the commonly used raw materials. It can be used to synthesize fine chemicals such as special surfactants and fragrance fixing agents, giving these products unique performance and quality, enhancing product added value and market competitiveness.
What are the physical properties of 4- (3-chloropropoxy) -4-fluorobenzene?
The physical properties of 4- (3-hydroxyethylamino) -4-methoxybenzene are as follows:
This substance is mostly in solid form at room temperature. Because its molecular structure contains specific groups, there is a certain interaction force between molecules, which prompts it to form a solid structure.
In terms of solubility, it exhibits good solubility in some organic solvents. This is because the polar part of its molecular structure can form interactions such as hydrogen bonds and van der Waals forces between organic solvent molecules, which helps it to disperse in organic solvents. For example, in polar organic solvents such as ethanol, a certain degree of dissolution can be achieved by virtue of the interaction between polar groups contained in the molecule and ethanol molecules. However, the solubility in water is relatively limited, because the hydrophobic part of the molecule as a whole affects the interaction with water molecules, making it difficult to disperse in water in large quantities.
Its melting point is of great significance for judging the purity and stability of the substance. The specific melting point value depends on the precise composition and interaction of the molecular structure. Interactions between different groups in the molecule, such as hydrogen bonding, electrostatic interaction, etc., jointly determine the energy required to transform the solid state into a liquid state, that is, the melting point.
In terms of density, it has a specific value compared to the density of water, which reflects the degree of tight packing of its molecules and the distribution of atomic mass. The density is closely related to the molecular structure, and the mass of different atoms and the arrangement in space ultimately determine the mass of the substance per unit volume.
These physical properties are of great significance in practical applications. In the field of organic synthesis, the characteristics of solubility help to select the appropriate reaction solvent to ensure the smooth progress of the reaction; the accurate knowledge of the melting point helps to control the reaction temperature and the purification process of the product; and properties such as density provide important reference in the separation, purification and preparation of substances, and help to optimize and design related processes.
Is 4- (3-chloropropoxy) -4-fluorobenzene chemically stable?
The chemical properties of 4- (3-hydroxyethylamino) -4-methoxybenzene are quite stable. Looking at the structure of this compound, it contains specific functional groups, which has a great influence on its chemical stability.
3-hydroxyethyl amino part, hydroxyethyl is hydrophilic, and amino groups can participate in many chemical reactions. However, in this compound, it interacts with surrounding groups to regulate the activity of amino groups. There are lone pair electrons in the nitrogen atom of the amino group, which can theoretically be used as nucleophilic reagents. However, due to the distribution of the overall electron cloud of the molecule, its nucleophilic activity does not reach a very high degree. At the same time, the hydroxyethyl group is connected to the amino group, which restricts the reactivity of the amino group through electronic and spatial effects, and then stabilizes the molecular structure.
4-methoxybenzene moiety, methoxy group is the electron donor group, which can increase the electron cloud density of the benzene ring. This electronic effect makes the benzene ring more prone to electrophilic substitution reaction, and it also interacts with the surrounding groups to form a conjugated system, etc., to improve the stability of the benzene ring. The oxygen atom of the methoxy group forms a p-π conjugate with the benzene ring, which delocalizes the electron cloud and reduces the degree of imbalance in the electron cloud density on the benzene ring. Therefore, the benzene ring part is not susceptible to oxidation, ring opening and other damage reactions,
Furthermore, the bond length and bond angle between the atoms in the whole molecular structure are in a relatively stable state, and the steric hindrance also affects the progress of the chemical reaction. The synergistic effect between the groups makes 4- (3-hydroxyethylamino) -4-methoxybenzene under common conditions, the chemical properties are relatively stable, and it is not easy to spontaneously decompose and isomerize. When encountering extreme conditions such as specific strong oxidizing agents, strong acids, and strong bases, its stable structure may be damaged, triggering corresponding chemical reactions.
What are the preparation methods of 4- (3-chloropropoxy) -4-fluorobenzene?
To prepare 4- (3-methoxyphenyl) -4-phenylbutanol, the method is as follows:
First take 3-methoxybenzaldehyde and phenylmagnesium halide, the method of Iger's reaction, in anhydrous ethyl ether or tetrahydrofuran and other inert solvents, under low temperature and nitrogen protection, slowly add the solution of phenylmagnesium halide to the solution of 3-methoxybenzaldehyde. To be added dropwise, reflux at high temperature, so that the reaction can be fully carried out to obtain 3-methoxy - α - hydroxybenzylbenzene. The key to this step of the reaction lies in the absence of water in the solvent, and the control of the reaction temperature and the drip rate, otherwise it is easy to cause side reactions.
Then, the obtained 3-methoxy - α - hydroxybenzylbenzene is treated with a suitable reducing agent, such as sodium borohydride or lithium aluminum hydride. If sodium borohydride is used, it can be reacted in an alcohol solvent at room temperature. Sodium borohydride can selectively reduce the carbonyl group to a hydroxyl group without affecting other groups such as methoxy. If lithium aluminum hydride is used, it needs to be reacted at low temperature in a solvent such as anhydrous ethyl ether, and the post-reaction treatment needs to be careful to prevent violent reaction in contact with water. After this reduction step, the crude product of 4- (3-methoxyphenyl) -4-phenylbutanol can be obtained.
Finally, the crude product is separated and purified. The extraction method can be used first, and the product can be enriched in the organic phase by multiple extractions with suitable organic solvents and aqueous phases. After column chromatography, the appropriate silica gel and eluent are selected. According to the polarity of the product and the impurity, the product is separated from the impurity. The eluent containing the pure product is collected, and the solvent is removed by vacuum distillation to obtain pure 4- (3-methoxyphenyl) -4-phenylbutanol.
What is the price range of 4- (3-chloropropoxy) -4-fluorobenzene in the market?
The price range of 4- (3-hydroxyethylamino) -4-methoxybenzene in the market will be affected by many factors, and it is difficult to determine with certainty.
In the market of chemical materials, the price of these compounds may vary due to purity, supply and demand, and origin. If its purity is very high, the process is excellent, and it is required for a specific high-end industry, its price may be high; conversely, if the purity is slightly lower and the supply is abundant, it is used in common fields, and the price may be low.
If the origin is far away from the place of demand, the transportation cost will also be added to the selling price. And the state of market supply and demand, if there are many seekers and few suppliers, the price will rise; if the supply exceeds the demand, the price will decline.
However, I do not have the exact data, it is difficult to specify the specific price range. If you want to know the details, you can get a more accurate price range by consulting chemical product suppliers, market survey agencies, or relevant chemical trading platforms.
