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What is the main use of 4- (2,2,3,3-tetrafluoropropoxy) benzene-1,2-dimethylnitrile?
4- (2,2,3,3-tetrafluoroethoxy) benzene-1,2-diacetic acid, which is an important chemical raw material in the field of organic synthesis. Its main uses are as follows:
First introduced in the field of pharmaceutical synthesis, it is often used as a key intermediate. For example, when creating some drug molecules with specific biological activities, this compound can give specific spatial configuration and chemical properties to drug molecules by virtue of its unique chemical structure, thereby enhancing the affinity and selectivity of drugs to specific targets. Through chemical modification and reaction, complex and biologically active drug frameworks can be constructed, laying the foundation for the development of new drugs.
Furthermore, in the field of materials science, it also plays an important role. It can be used as a monomer for the synthesis of polymer materials with special properties. Due to its fluorine-containing group and benzene ring structure, it can endow polymer materials with characteristics such as excellent chemical corrosion resistance, low surface energy and good thermal stability. These properties make the synthesized polymer materials very useful in high-end fields such as aerospace, electronics and electrical appliances, such as the preparation of high-performance sealing materials required in the aerospace field, or chemical-resistant insulating materials in electronic appliances.
In addition, it is also an indispensable raw material in the synthesis of fine chemical products. It can be used in the preparation of special coatings, pigments and additives. Taking the preparation of special coatings as an example, introducing them into the coating system can improve the film-forming performance, weather resistance and wear resistance of the coatings, making them suitable for protective coatings in extreme environments, such as anti-corrosion coatings for metal structures in marine environments.
4- (2,2,3,3-tetrafluoroethoxy) benzene-1,2-diacetic acid is widely used in the fields of medicine, materials science and fine chemicals due to its unique structure. It is of great significance to promote technological innovation and development in related industries.
What are the physical properties of 4- (2,2,3,3-tetrafluoropropoxy) benzene-1,2-dimethylnitrile
4- (2,2,3,3-tetrafluoropropoxy) naphthalene-1,2-dicarboxylic acid is an organic compound with specific physical properties. Its properties are mostly crystalline solids, which is due to the existence of various forces between molecules, such as van der Waals forces and hydrogen bonds, which promote the regular arrangement of molecules.
In terms of melting point, due to the tight molecular structure and strong interaction force, the lattice is stable, usually has a high melting point, and more energy is required to break the lattice and turn the solid state into a liquid state, about 180-200 ° C.
In terms of solubility, the compound contains groups such as naphthalene ring and ester group. Naphthalene ring is hydrophobic and the polar ester group is limited, so it has low solubility in water, strong water polarity, and weak interaction with the compound. However, it has good solubility in some organic solvents, such as dichloromethane, chloroform, and acetone. These organic solvents can form similar intermolecular forces with this compound, which is conducive to mutual dissolution.
Good stability, under general conditions, the molecular structure is stable, and it is not easy to spontaneously react. The naphthalene ring has a conjugated system to enhance stability; although the ester group is relatively active, it is also relatively stable in the absence of specific conditions, such as strong acid, strong base, and high temperature.
The specific physical properties of this compound make it widely used in the field of organic synthesis. It can be used as an intermediate to synthesize materials with special functions, providing assistance for the development of organic synthesis chemistry.
Is the chemical property of 4- (2,2,3,3-tetrafluoropropoxy) benzene-1,2-dimethylnitrile stable?
4- (2,2,3,3-tetrafluoroethoxy) quinine-1,2-diethyl ester, which is chemically stable. The reason is that from a structural point of view, the fluorine atoms present in the molecule can form stable chemical bonds with neighboring atoms due to their extremely strong electronegativity. This property of fluorine atoms makes the C-F bond energy quite high, which is difficult to be destroyed by general chemical reactions.
Furthermore, the quinoline ring system itself has a certain aromaticity, and this aromatic structure gives the molecule additional stability. The π electron cloud in the aromatic system is highly delocalized, which reduces the molecular energy and enhances the stability.
At the same time, although the ester group has a certain reactivity, under appropriate conditions, its hydrolysis and other reactions can be effectively controlled. Moreover, the interaction between the groups in the compound makes the overall structure tend to be stable. Under common environmental conditions, obvious decomposition, oxidation and other reactions are not easy to occur. Therefore, 4- (2,3,3-tetrafluoroethoxy) quine-1,2-diethyl ester is chemically stable under normal circumstances, and can maintain its own structure and properties relatively stable in many environments.
What are the synthesis methods of 4- (2,2,3,3-tetrafluoropropoxy) benzene-1,2-dimethylnitrile?
To prepare 4- (2,2,3,3-tetrafluoropropoxy) benzyl-1,2-diacetic acid, the following methods can be followed:
First, start with fluoroalcohol and halobenzyl derivatives, and build its carbon-oxygen bond through nucleophilic substitution reaction. Such as 2,2,3,3-tetrafluoropropanol and halobenzyl (such as bromobenzyl or chlorobenzyl chloride), with the help of bases (such as potassium carbonate, sodium hydroxide, etc.), in suitable solvents (such as N, N-dimethylformamide, acetone, etc.). The alkali grabs the hydrogen of the alcohol hydroxyl group to form an alcohol anion, which attacks the halogen atom of halobenzyl to connect to the carbon, and the halogen ion leaves to form a 4- (2,2,3,3-tetrafluoropropoxy) benzyl intermediate. This intermediate is then substituted with acetic anhydride or haloacetic acid under alkali catalysis by nucleophilic substitution, and an acetyl group or carboxymethyl group is introduced at the ortho position of the benzyl group, and then the target product can be obtained by hydrolysis.
Second, starting from the benzyl alcohol derivative, the benzyl alcohol hydroxyl group is first halogenated to obtain halobenzyl alcohol. After that, it reacts with 2,2,3,3-tetrafluoropropanol under alkali catalysis to obtain 4- (2,2,3,3-tetrafluoropropoxy This alcohol is oxidized to aldehyde, which can be used as mild oxidizing agents such as manganese dioxide, PCC (pyridinium chlorochromate salt), etc. The aldehyde is then introduced into the diacetic acid group by Perkin reaction or similar condensation reaction with acetic acid derivatives (such as acetic anhydride, ethyl acetate, etc.) under alkali catalysis. In this case, the alkali activates the α-hydrogen of the acetic acid derivative to generate carboanion, nucleophilic addition to the aldehyde group, and then dehydrates and hydrolyzes to obtain the target product.
Third, using benzene ring derivatives as starting materials, through the electrophilic substitution reaction of aromatic hydrocarbons, (2,2,3,3-tetrafluoropropoxy) benzyl is first introduced, such as under the catalysis of Lewis acid (such as aluminum trichloride, boron trifluoride, etc.), benzene is reacted with (2,2,3,3-tetrafluoropropoxy) benzyl halide. Then the acetyl group is introduced at the ortho-position of the benzene ring, which can be acylated by Friedel-Crafts, with acetic anhydride as the acylating agent and catalyzed by Lewis acid. Subsequent steps such as proper oxidation and hydrolysis of the acetyl group are converted into diacetic acid groups, so as to obtain 4- (2,2,3,3-tetrafluoropropoxy) benzyl-1,2-diacetic acid. Each method has its own advantages and disadvantages, and it needs to be selected according to the availability of raw materials, the ease of control of reaction conditions, and the requirements of product purity.
What is the price range of 4- (2,2,3,3-tetrafluoropropoxy) benzene-1,2-dimethylnitrile in the market?
I think what you are asking is about the price range of (2,2,3,3-tetrafluoropropoxy) benzene-1,2-diacetic acid in the market. However, the price of this chemical substance often changes for many reasons, and it is difficult to determine the fixed price.
First, the price of raw materials, the preparation of this substance requires specific raw materials. If the production of raw materials is affected by the weather, geographical location, supply and demand, and its price fluctuates, the cost of (2,2,3,3-tetrafluoropropoxy) benzene-1,2-diacetic acid also changes, which in turn affects its selling price.
Second, the difficulty of preparation. If the preparation method is complicated, high-end equipment, exquisite skills are required, and the yield is limited, the price will be high; if the preparation is easier, the cost will be reduced, and the price may also drop.
Third, the need of the market. If many industries compete for this product, the demand is greater than the supply, the price will be higher; if the demand is few, the supply exceeds the demand, the price will be lower.
Fourth, the quality is poor. Those with excellent quality, the price may be higher than ordinary products.
Overall, in the market, the price of (2,2,3,3-tetrafluoropropoxy) benzene-1,2-diacetic acid can range from hundreds of yuan per kilogram to thousands of yuan per kilogram. The specific price needs to be asked by the franchisee or the real-time market conditions to obtain an accurate number.