4-(2,2,2-Trifluoroethoxy)Benzeneboronic Acid

Hongda Chemical

Specifications

HS Code	941775
Chemical Formula	C8H8BF3O3
Molecular Weight	220.956
Appearance	Solid
Melting Point	115 - 119 °C
Solubility	Soluble in organic solvents like dichloromethane, less soluble in water
Purity	Typically high purity, e.g., 97%+ in commercial products
Stability	Stable under normal conditions, avoid strong oxidizing agents

As an accredited 4-(2,2,2-Trifluoroethoxy)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 4-(2,2,2 -trifluoroethoxy)benzeneboronic Acid in sealed chemical - grade packaging.
Storage	4-(2,2,2 - trifluoroethoxy)benzeneboronic acid should be stored in a cool, dry place away from heat and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can be sensitive to hydrolysis. Store separately from incompatible substances, like strong oxidizing agents, to avoid potential reactions.
Shipping	4-(2,2,2 - trifluoroethoxy)benzeneboronic acid is shipped in properly sealed containers, compliant with chemical transport regulations. Packing ensures protection from moisture and damage during transit to maintain its integrity.

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4-(2,2,2-Trifluoroethoxy)Benzeneboronic Acid

General Information

Historical Development

4- (2,2,2-trifluoroethoxy) phenylboronic acid has a long history of development. In the past, at the beginning of chemical research, the exploration of fluorinated organoboronic acid compounds was still unknown. At that time, researchers struggled to develop in the field of complex chemical synthesis.
With the passage of time and the gradual development of science and technology, many researchers have devoted themselves to research. For 4- (2,2,2-trifluoroethoxy) phenylboronic acid, we have unremitting attempts at new synthesis paths. From the initial simple method, the yield was low and there were many impurities, to the later continuous improvement, optimization of reaction conditions, and selection of suitable catalysts, so that the synthesis process gradually matured.
Today, 4- (2,2,2-trifluoroethoxy) phenylboronic acid has made its mark in the fields of medicine, materials science, etc. Its historical development has witnessed the progress of chemical research, from ignorance to precise control, paving the way for more related substance research in the future.

Product Overview

4- (2,2,2-trifluoroethoxy) phenylboronic acid, this compound, its shape is white crystalline powder. Looking at it, it is pure and delicate, shimmering under light. The synthesis method is through multiple fine steps. First take a specific benzene raw material, supplemented by a fluorine-containing reagent, at a suitable temperature and under the action of a catalyst, through a substitution reaction, trifluoroethoxy is introduced. Then, through a boronation reaction, the product is finally obtained.
It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis. With its unique structure, it can couple and react with many organic compounds to build a complex molecular structure. In drug research and development, it also has potential value, or can participate in the construction of active molecules to help create new drugs. Its chemical properties are stable, but under specific conditions, it also exhibits active reactivity, making it an important material for chemical research and production.

Physical & Chemical Properties

The physical and chemical properties of Guanfu 4- (2,2,2-trifluoroethoxy) phenylboronic acid are worth exploring. Its shape may be in the state of powder, color or white, and it is relatively stable at room temperature. In terms of solubility, it may be soluble in some organic solvents, but its solubility in water may be limited. Its melting point, boiling point and other physical constants also have specific values, which are all related to the conditions of practical application. From the perspective of chemical properties, the characteristics of boron atoms give it a certain reactivity and can participate in many organic synthesis reactions, such as coupling reactions. With this property, it may play an important role in the field of organic synthesis and provide assistance for the creation of new compounds.

Technical Specifications & Labeling

Today there is a product named 4- (2,2,2-trifluoroethoxy) phenylboronic acid. In my chemical research, its process specification and identification (commodity parameters) are the key. To make this product, you should first clarify the ratio of its raw materials, control the temperature and timing of the reaction, just like the ancient method of keeping the heat. When the raw materials meet, they should be started in the kettle. The temperature is measured by degree, and the time is measured by the quantity, so that the reaction is complete and pure.
To be prepared, test its quality, observe its color and state, measure its degree of melting and boiling, and analyze its spectral characteristics. The marker, with its name, sex, purity and use, so that the knower can see it at a glance, just like the ancient inscription, remember it. Craft specifications and logos are the discipline of making this thing, and follow them to become good products. In the way of research, take it step by step, and dare not ignore it.

Preparation Method

The method of preparing 4- (2,2,2-trifluoroethoxy) phenylboronic acid is related to the raw material and production process, reaction steps and catalytic mechanism.
The selection of raw materials is crucial, and the compound containing a specific group is the starting point. In the production process, the reaction conditions need to be carefully controlled. First, the raw materials are mixed in a certain ratio and placed in a special reactor. At the beginning of the reaction step, the temperature is adjusted to a suitable range to allow the raw materials to initially blend. Then, a specific catalyst is added, which can significantly change the chemical reaction rate and build an efficient catalytic mechanism. With the action of the catalyst, the activity of the raw material molecules is greatly increased, the probability of collision increases, and the reaction process is accelerated. As the reaction advances, closely monitor the degree of reaction, and adjust the temperature and pressure in a timely manner. After the reaction is complete, the pure 4- (2,2,2-trifluoroethoxy) phenylboronic acid product can be obtained by a series of separation and purification methods. This method is delicate and orderly to achieve the purpose of high-quality production.

Chemical Reactions & Modifications

The chemical substance 4- (2,2,2-trifluoroethoxy) phenylboronic acid has been studied. In the process of chemical synthesis, reaction and modification are crucial. In order to make this substance, it is necessary to study its chemical reaction and make the raw materials interact according to the appropriate method.
To observe the reaction, various conditions, such as temperature, pressure and catalyst dosage, need to be controlled, which are all related to the purity and yield of the product. If the temperature is inappropriate, or the reaction may be too fast and by-products may occur, or the reaction may be delayed as expected.
In terms of modification, it is hoped to adjust its chemical properties and increase its stability or activity. Or introduce other groups to change its molecular structure to make it more effective in specific fields, such as medicine, material synthesis, etc. In this way, by studying the reaction and modification of this chemical substance, it can be widely used in various industries and gain in the world.

Synonyms & Product Names

4- (2,2,2-trifluoroethoxy) phenylboronic acid is quite important in my chemical research. Its synonyms and trade names are really the key to our discussion.
Looking back at the past, all kinds of chemical substances have their own names. In today's world, science is prosperous, but the names of the same substance are also diverse. 4- (2,2,2-trifluoroethoxy) phenylboronic acid, or has aliases to meet different uses.
Trade names are made by merchants to mark their uniqueness and sell widely. And synonyms are derived from academic exchanges, different regional habits, or different research focuses. Although the names are different, they all refer to this 4- (2,2,2-trifluoroethoxy) phenylboronic acid. We chemical researchers need to study various names in detail in order to make good use of their properties and move forward steadily in the path of chemical exploration.

Safety & Operational Standards

4 - (2,2,2 - trifluoroethoxy) phenylboronic acid is a chemical product that we have painstakingly studied. In its experimental and production process, safety and operating standards are of paramount importance, which is related to personnel safety and product quality.
In terms of safety, it is first necessary to clarify the characteristics of this substance. 4 - (2,2,2 - trifluoroethoxy) phenylboronic acid Although it has specific chemical activity, its stability is acceptable under suitable conditions. In case of hot topics, open flames or strong oxidants, there may be latent risks. Therefore, the storage place must be cool, dry and well ventilated, away from fires and heat sources, and avoid mixing with incompatible substances.
Operating specifications cannot be ignored. During the experimental operation, the operator is in front of suitable protective equipment, such as protective gloves, goggles and laboratory clothes, to prevent skin contact and eye splashing. The weighing and transfer process must be precisely operated to avoid environmental pollution caused by powder flying or inhalation of human body. During the reaction process, parameters such as temperature, pressure and reaction time should be strictly controlled, and the operation should be carried out according to the established procedures. If there is an unfortunate leak, do not panic. In the event of a small leak, quickly collect it in a dry, clean, covered container with a clean shovel and dispose of it properly. If there is a large leak, people should be evacuated immediately, and a warning area should be demarcated. Unrelated personnel should be strictly prohibited from approaching. Emergency responders should wear full masks and chemical protective clothing, and use suitable materials to absorb or contain the leak, and then dispose of it according to regulations.
In conclusion, during the research and production of 4- (2,2,2-trifluoroethoxy) phenylboronic acid, strict adherence to safety and operating standards can ensure that everything goes smoothly and meets the expected scientific research and production goals.

Application Area

4- (2,2,2-trifluoroethoxy) phenylboronic acid This compound is quite useful in many application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new special drugs. Due to the unique electronic properties of trifluoroethoxy, it can improve the physical and chemical properties of drug molecules, such as improving lipophilic properties, enhancing cell membrane penetration, and then enhancing drug efficacy.
In the field of materials science, functional materials made from this raw material may have special optical and electrical properties. For example, it can be used to prepare organic optoelectronic materials, which can be used in Light Emitting Diodes, solar cells and other devices to optimize the charge transfer and luminous efficiency of materials with their structural properties. Furthermore, in the field of organic synthetic chemistry, as an important boron reagent, it can participate in many boration reactions, build complex organic molecular structures, and provide a variety of options for the design of organic synthesis routes, expand the synthesis path of new organic compounds, and promote the development of organic chemistry.

Research & Development

In recent years, Yu has dedicated himself to the research of new chemical products, with particular attention to 4- (2,2,2-Trifluoroethoxy) Benzeneboronic Acid. This product has specific properties and has a wide range of applications in organic synthesis and other fields.
At the beginning, I studied the method of its preparation, went through various attempts to adjust the reaction conditions, tried various raw materials and catalysts, and hoped to obtain an efficient and pure method. In the process, I encountered many problems, such as the low reaction rate and the difficulty of removing impurities. However, I was not discouraged by my colleagues and repeatedly investigated, and finally obtained a better method to improve the yield and purity.
Restudy its properties, explore its reaction in different environments, and understand the mechanism of its interaction with other substances. With a deep understanding of its characteristics, it lays the foundation for the expansion of applications.
Looking to the future, we hope to develop more novel materials and processes based on this product, promote the progress of the chemical field, and bring its brilliance to industrial production, scientific research, etc., to help the development of chemistry.

Toxicity Research

The highly toxic substance under study today is called 4- (2,2,2-trifluoroethoxy) phenylboronic acid. The toxicity of this substance is related to the safety of all living beings and cannot be ignored.
Study its properties and explore its harm. Or enter the body, damage the internal organs, disrupt qi and blood, and cause diseases. The skin touches it, or it is red, swollen and ulcerated; the mouth and nose suck it, or it hurts the lungs and brain.
In order to study its poison, all kinds of experiments are carried out. Observe its effect on life and spirits, and observe its changes in the environment. Anticipate its harm, so as to prevent it before it occurs.
I hope everyone will be vigilant in this thing, use it carefully, keep their health and well-being, and do not let the poison be a disaster to the world.

Future Prospects

Wuguanfu 4- (2,2,2-trifluoroethoxy) phenylboronic acid has unique properties and infinite potential in the field of chemical industry. Although it is not widely known today, its future prospects can be looked forward to.
This compound has an exquisite structure, and the introduction of trifluoroethoxy gives it unique characteristics. In the process of organic synthesis, it can be used as a key building block to build various delicate molecular structures. And its boron-containing base can also trigger a variety of chemical reactions, paving the way for the creation of novel materials, drug precursors, etc.
Although it is currently used or not widely used, the technology is new and the research is deeper. With time, it will be able to emerge in materials science, such as the development of high-performance optoelectronic materials, which will contribute to display technology; in the field of medicine, it may help the birth of new drugs and cure various diseases. The future development is still limited, and it will definitely bloom brightly.

Where to Buy 4-(2,2,2-Trifluoroethoxy)Benzeneboronic Acid in China?

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Frequently Asked Questions

As a leading 4-(2,2,2-Trifluoroethoxy)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4- (2,2,2-trifluoroethoxy) phenylboronic acid?

4 - (2,2,2 -trihydroxyethyl) sucrose sulfate, its main uses are as follows:
This compound is quite wonderful in the printing and dyeing industry. It can be used as a leveling agent to make the dye more evenly distributed on the fabric, making the dyeing effect symmetrical and beautiful, and avoiding the drawbacks of different shades. In the textile dyeing process, fabrics are prone to uneven dye adsorption due to differences in material and structure, and this material can effectively alleviate this problem and help to obtain fabrics with consistent color.
In the leather industry, it also has important functions. It can be used as a fat additive to give leather a soft, plump feeling, and improve leather flexibility and durability. Leather through its treatment, the lubrication between fibers is enhanced, friction damage is reduced, the service life of leather products is extended, and the leather products feel better and the quality is improved.
In the field of paper industry, it can be used as a paper softener. It can improve the softness of paper and make the paper feel comfortable to the touch, while having little effect on the strength of the paper. In the production of household paper, through its treatment, the paper is soft and skin-friendly, meeting people's needs for the experience of using paper products.
In the cosmetic industry, it can be used in some skin care product formulations. Because it has certain moisturizing properties, it can help the skin retain moisture, maintain the skin's hydrated state, make the skin delicate and smooth, add efficacy to skin care products, and improve product quality and use effect.
In conclusion, 4- (2,2,2-trihydroxyethyl) sucrose sulfate plays a key role in many industrial fields due to its unique properties, contributing significantly to the improvement of product quality and performance optimization in various industries.

What are the synthesis methods of 4- (2,2,2-trifluoroethoxy) phenylboronic acid?

To prepare 4 - (2,2,2 - trifluoroethoxy) benzoic acid, the following ancient methods can be used.
First, 2 - chlorobenzoic acid is used as the starting material. First, it is heated with potassium hydroxide, and at a suitable temperature and duration, a nucleophilic substitution reaction occurs. At this time, the chlorine atom is replaced by a hydroxyl group to obtain 2 - hydroxybenzoic acid. Subsequently, 2 - hydroxybenzoic acid is co-placed with 2,2,2 - trifluoroethoxyethanol and a dehydrating agent. Under specific conditions, the hydroxyl group is dehydrated and condensed with the hydroxyl group of trifluoroethanol to form an ether bond, and then 4 - (2,2,2 - trifluoroethoxy) benzoic acid is obtained. This process requires attention to the precise control of the reaction conditions. Too high or too low temperature, too long or too short duration may affect the yield and purity.
Second, p-hydroxybenzoic acid is used as the starting material. It is placed in a solution containing an alkali with 2,2,2-trifluoroethyl halide (such as 2,2,2-trifluoroethyl bromide). The alkali can capture the hydrogen of the hydroxyl group of p-hydroxybenzoic acid, and the generated negative ions attack the carbon atom of the 2,2,2-trifluoroethyl halide. The halogen ions leave to form ether bonds, thereby forming the target product. In this step, the type and amount of base and the choice of reaction solvent are very critical. Different bases and solvents have different effects on the reaction rate and product purity.
Third, benzoic acid can be used as a raw material. After nitration, nitro groups are introduced into the benzoic acid benzene ring to obtain nitrobenzoic acid. After reduction, the nitro group is converted into amino groups to obtain aminobenzoic acid. After that, the target product is formed through diazotization and reaction with 2,2,2-trifluoroethanol. This route has a little more steps, but each step has its own subtlety. The diazotization reaction requires low temperature and precise control of the reaction conditions in order to avoid the occurrence of side reactions and ensure the generation of products.
The above methods have their own advantages and disadvantages. In practice, it is necessary to comprehensively consider the availability of raw materials, cost, equipment conditions and other factors, and make careful choices to achieve the high-efficiency synthesis of 4- (2,2,2 -trifluoroethoxy) benzoic acid.

What is the market price of 4- (2,2,2-trifluoroethoxy) phenylboronic acid?

In Guanfu City, there is a lot of trade, and price changes are also of concern to the world. Today there is 4- (2,2,2-triethoxy) benzoxy benzoic acid, and its market price is subject to various factors.
First, the supply and demand of raw materials is also. If the raw materials of this compound are widely sourced and abundant, the price will be equal; if it is scarce and the supply does not continue, the price will rise. And the difficulty of obtaining raw materials and the cost of mining are all related to the cost. Since the cost is high, the market price is also difficult to lower.
Second, the skill of craftsmanship is related to the price. If the production method is fine, it can save material, time, labor, and the yield is also high, the cost can be reduced, and the price is appropriate; if the production process is crude, the cost of materials is time-consuming, the yield is low, and the cost increases, the price will be high.
Third, it has a lot to do with the needs of the city. If this product is needed by a large number of people in the pharmaceutical, chemical and other industries, and the demand exceeds the supply, the merchants will raise the price and the price will be high; if the demand is small and the supply exceeds the demand, the merchants will sell their goods quickly or reduce the price to sell.
Fourth, the trend of competition cannot be ignored. In the market, there are many businesses, and they compete with each other for profits, in order to compete for customers, or they may reduce their prices; if there are few operators in this industry, it is almost monopolized, and its price is in the hands of a few people, and it is easy to become exorbitant.
From this perspective, the market price of 4- (2,2,2-triethoxy) benzoxy benzoic acid cannot be determined immediately, and it is necessary to comprehensively consider raw materials, craftsmanship, demand, competition, etc. to obtain a rough idea. Or there are different prices depending on time, place, or situation.

How is the stability of 4- (2,2,2-trifluoroethoxy) phenylboronic acid?

The stability of 4- (2,2,2-trifluoroethoxy) benzoic acid is related to many physical and chemical properties and environmental conditions.
In this compound, the benzene ring structure provides a certain degree of conjugate stability, making its electron cloud distribution more uniform and less susceptible to easy attack by general chemical reagents. The carboxyl group (-COOH) has a certain degree of acidity and has different stability under different pH environments. In an acidic environment, the carboxyl group exists in the form of protonation and is relatively stable; in an alkaline environment, the carboxyl group is easily dissociated into carboxylate ions, and the stability may change.
Furthermore, the substituent 2,2,2-trifluoroethoxy group, due to the strong electronegativity of fluorine atoms, has a significant electron-withdrawing effect, which can reduce the electron cloud density of the benzene ring, enhance the resistance of the benzene ring to electrophilic reagents, and improve the stability of the whole molecule. At the same time, fluorine-containing groups also make the compound have good thermal stability and chemical stability. Because of its large C-F bond energy, it is not easy to break.
However, the stability of the compound is also restricted by external factors. Under high temperatures, the kinetic energy of the molecule increases, the vibration of chemical bonds intensifies, or some bonds are broken, which decreases the stability. Under light conditions, especially high-energy rays, or luminescent chemical reactions, the molecular structure changes. In addition, in contact with strong oxidizing agents and strong reducing agents, oxidation-reduction reactions may also occur and the molecular structure may be destroyed.
Overall, 4- (2,2,2-trifluoroethoxy) benzoic acid has good stability in a normal temperature, dark, dry environment without strong oxidation and reduction reagents; but under extreme conditions, its stability may be challenged.

In which fields is 4- (2,2,2-trifluoroethoxy) phenylboronic acid used?

4- (2,2,2-trifluoroethoxy) benzoic acid is useful in various fields.
In the field of medicine, it is a key intermediate for the synthesis of many drugs. For example, a certain class of compounds with specific biological activities, with 4- (2,2,2-trifluoroethoxy) benzoic acid participating in the reaction, the required molecular structure can be precisely constructed to regulate human physiology and treat diseases. Due to the unique electronic effect and steric blockage of trifluoroethoxy, it can endow drugs with better lipophilicity, metabolic stability and biological activity, and is often an indispensable raw material in the development of antiviral and anti-tumor drugs.
In the field of pesticides, this compound has also made a name for itself. After ingenious design and synthesis, high-efficiency, low-toxicity and environmentally friendly pesticides can be prepared. Due to its structural characteristics, it can enhance the interaction between pesticides and target organisms, improve drug efficacy, and help reduce pesticide residues, which is in line with the current needs of green agriculture development.
In the field of materials science, 4- (2,2,2-trifluoroethoxy) benzoic acid is also useful. It can be used as a monomer for the synthesis of special functional polymer materials. After polymerization, the material is endowed with characteristics such as excellent thermal stability, chemical stability and weather resistance. In coatings, plastics and other industries, products with excellent performance can be prepared to meet the strict requirements of material properties in different scenarios.
All of these demonstrate the important application value of 4- (2,2,2-trifluoroethoxy) benzoic acid in the fields of medicine, pesticides, materials science, etc. It is a key substance to promote the development of various fields.