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3-(Trifluoromethyl)Benzeneboronic Acid

3-(Trifluoromethyl)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    683925

    Chemical Formula C7H6BF3O2
    Molecular Weight 189.93
    Appearance White to off - white solid
    Cas Number 1150114-37-5
    Melting Point 125 - 129 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
    Acidity Weakly acidic due to the boronic acid group
    Pka Value Around 8 - 9 (approximate value for boronic acid group)
    Stability Stable under normal conditions, but moisture - sensitive

    As an accredited 3-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3-(trifluoromethyl)benzeneboronic acid packaged in a sealed plastic bottle.
    Storage 3-(Trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place, away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption, as boronic acids can react with water. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions that could lead to decomposition or hazards.
    Shipping 3-(Trifluoromethyl)benzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations to prevent leakage, ensuring safe transport due to its chemical nature.
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    3-(Trifluoromethyl)Benzeneboronic Acid 3-(Trifluoromethyl)Benzeneboronic Acid
    General Information
    Historical Development
    Wenfu 3- (Trifluoromethyl) Benzeneboronic Acid This object has its origin and can be traced back to the past. At the beginning, the sages dedicated themselves to the field of chemistry, hoping to explore the secrets of matter.
    At that time, the road of experimentation was full of thorns, and all attempts were repeatedly frustrated. However, everyone was determined to find its laws in thousands of changes. After long-term efforts, it was possible to obtain a method of synthesis, and the shape of this compound began to emerge.
    Over the years, with the improvement of skills, the understanding of it gradually deepened. Many scholars have devoted themselves to exploring its properties and uses. From basic theory to practical application, they have all pioneered.
    From this perspective, the development of 3- (Trifluoromethyl) Benzeneboronic Acid was gathered by scholars of all dynasties, adding a brilliant chapter to the process of chemistry, exploring new paths for future generations and opening up endless possibilities.
    Product Overview
    Today, there is a compound called 3- (Trifluoromethyl) Benzeneboronic Acid (3- (Trifluoromethyl) Benzeneboronic Acid). This compound often appears as a white to light yellow crystalline powder. It is stable and exhibits unique chemical activity under specific reaction conditions.
    In the field of organic synthesis, 3- (trifluoromethyl) phenylboronic acid is a key reagent. Due to the characteristics of trifluoromethyl and phenylboronic acid in its structure, it can participate in many coupling reactions, such as the Suzuki reaction. Through this reaction, a rich variety of carbon-carbon bonds can be formed, laying the foundation for the synthesis of complex organic molecules. And its introduction of trifluoromethyl gives the product unique physical and chemical properties, such as enhancing lipophilicity and improving metabolic stability, which are widely used in pharmaceutical chemistry, materials science and other fields. It is an indispensable and important material in organic synthetic chemistry.
    Physical & Chemical Properties
    The physical and chemical properties of 3 - (trifluoromethyl) phenylboronic acid can be studied. Looking at its shape, it is usually white to off-white powder, fine and uniform in quality. Its melting point is about a specific temperature range, which is one of the characteristics of its purity. In terms of solubility, it may have a certain solubility in some organic solvents, but in water, its solubility is different. Its chemical activity is also interesting. The existence of boron atoms gives it unique reactivity. It can participate in a variety of organic synthesis reactions, such as coupling reactions. It is an indispensable raw material in the field of organic synthesis. Its stability is also related to the application. Under suitable storage conditions, its properties can be maintained constant. In case of uncomfortable temperature and humidity, light or contact with specific substances, its properties may change. All these physical and chemical properties should be carefully observed by those who use and study this material.
    Technical Specifications & Labeling
    Nowadays, there is a product called 3 - (trifluoromethyl) phenylboronic acid, which is very important in the field of chemical products. Its technical specifications and identification (product parameters) are the key.
    Looking at this 3 - (trifluoromethyl) phenylboronic acid, its purity needs to reach a very high standard, and the impurity content should be minimal. The color should be pure and free of variegated stains. The properties must be stable and do not change easily under conventional conditions.
    In terms of identification, the name of the product should be clear and correct, with its chemical name, common name, etc. The parameters of its composition and content should also be accurately detailed for the user to understand. The standards involved in technical specifications, such as production process standards, should be strictly followed to ensure consistent quality. In this way, this product can be used to the best of the chemical industry and live up to expectations.
    Preparation Method
    There is a method of preparing 3 - (trifluoromethyl) phenylboronic acid, which is described in detail below. The first raw materials are trifluoromethylbenzene, n-butyl lithium, trimethyl borate, etc. The trifluoromethylbenzene is placed in a low temperature environment, and n-butyl lithium is slowly added to initiate the reaction to form an intermediate. This step requires precise temperature control and does not overheat. Next, trimethyl borate is added, and then the reaction is heated up. After the reaction is completed, the product is purified through post-processing steps such as extraction, washing, distillation, etc. During extraction, a suitable solvent is selected to fully dissolve the product. Wash to remove impurities and distillate to obtain a pure product. This preparation method follows the reaction mechanism and controls the conditions of each step to obtain high-purity 3- (trifluoromethyl) phenylboronic acid.
    Chemical Reactions & Modifications
    There is a chemical substance today, named 3- (trifluoromethyl) phenylboronic acid. In chemical reactions, its performance and characteristics are related to the direction of chemical change.
    The reaction of this substance is often found in various chemical synthesis paths. However, the initial reaction, or the survival efficiency is not ideal, and the purity of the product needs to be improved. In order to improve, many methods of change have come into being.
    Researchers have changed the reaction conditions, adjusting the temperature and pressure, hoping to increase its activity and promote the reaction to the expected path. There are also detailed studies from the proportion of reactants to make the ratio subtle to obtain better output. Or add special catalysts to use their power to lead the reaction to move quickly and accurately.
    Through these various changes, 3- (trifluoromethyl) phenylboronic acid has gradually become more efficient and pure in chemical reactions, adding to the chemical synthesis industry and becoming an indispensable key link.
    Synonyms & Product Names
    Today there is a substance called 3- (trifluoromethyl) phenylboronic acid, which is widely used in the field of chemical industry. There are also many synonymous names. This substance, or trifluoromethylphenylboronic acid, is named from its structural essence.
    Because of its boron properties, it is related to boric acid, or it is called trifluoromethyl-containing phenylboronic acid. Among the trade names, there are also different names based on their characteristics and uses, but they all refer to the same thing.
    In the course of our investigation of this chemical, we know that although its synonymous name is complex, it refers to the only one. This will help us to accurately understand and avoid confusion during research and application, so as to clarify its nature, make good use of its capabilities, and contribute to the progress of chemical industry and scientific research.
    Safety & Operational Standards
    Safety and Handling Specifications for 3- (Trifluoromethyl) Phenylboronic Acid
    Fu3- (Trifluoromethyl) Phenylboronic Acid is an important material in chemical research. When using and operating it, be sure to know the safety and operation specifications to ensure that everything goes smoothly and is not dangerous.
    In terms of safety, this compound has certain characteristics and should be contacted with caution. It may be irritating to the skin and eyes, so when operating, be prepared with protective gear. It is advisable to wear experimental clothes to prevent it from being contaminated with clothing and spreading to the skin. Goggles are also indispensable to prevent them from accidentally splashing into the eyes and causing damage to the eyes. If the skin touches it, rinse it with plenty of water quickly. If you feel unwell, seek medical attention. If it enters the eye, it needs to be rinsed with flowing water for a long time immediately, and it is urgent to seek medical attention.
    In terms of operating specifications, the first priority is the suitability of the environment. The place where the experiment is located should be well ventilated to prevent the accumulation of volatile gas and the concentration in the air from being too high. When weighing, use a precise instrument and take the amount according to the experimental requirements, not more or less. After taking it, seal the container to prevent it from being in too much contact with the air and causing changes in properties. During the reaction process, strictly control the temperature and control, and operate according to the established procedures, and do not change it without authorization. And operations such as stirring also need to be stable and orderly to promote a uniform and complete reaction.
    After use, the disposal of its waste cannot be ignored. It should not be discarded at will. It should be collected in accordance with the method of chemical waste disposal and handed over to professional treatment to avoid polluting the environment and harming the nature.
    In short, in the use of 3- (trifluoromethyl) phenylboronic acid, safety and operating standards are essential. From then on, research can be achieved, and violators may cause all kinds of disasters. All things should be cautious.
    Application Area
    3 - (trifluoromethyl) phenylboronic acid is also a chemical compound. The field of its application is very important. In the synthesis of chemical compounds, it is often necessary to replace aromatic compounds, alkenyl compounds, etc., in order to catalyze the coupling of aromatic compounds, aryl-aryl, aryl-alkenyl compounds, to form a variety of chemical compounds, especially in the research and development of chemical compounds.


    <, in order to create special active chemical molecules. Because of the properties of trifluoromethyl groups, it can change the molecular properties, fat solubility, increase the bioavailability of chemical compounds, or reduce the binding mode of their susceptibility.
    It is used to create high-efficiency and low-toxicity new products, help to improve productivity, ensure the prosperity of crops, and eliminate diseases.
    It is also in the field of materials, the system of functional materials, the novelty of materials, and the scene of development and use. It has an extraordinary watch in the field, and promotes science and technology.
    Research & Development
    I have been dedicated to the study of tri (trifluoromethyl) phenylboronic acid for a long time. This compound has unique properties and a wide range of uses, which is of great value in the field of organic synthesis.
    At the beginning, I explored its synthesis path, but after many attempts, I encountered many difficulties. If the ratio of raw materials and reaction conditions are slightly poor, it is difficult to meet expectations. However, I persevered and tried repeatedly, and finally obtained an optimization method to improve the yield and purity.
    Then study its reactivity, react with a variety of compounds, and explore the best reaction conditions and applicable range. During this process, I have gained a deeper understanding of its chemical properties and discovered many new reaction possibilities.
    Today, we are thinking about expanding its application field, hoping to widely apply this research results, promote the development of related industries, and contribute to the progress of the chemical field.
    Toxicity Research
    The study of this substance today is called 3- (trifluoromethyl) phenylboronic acid. The study of its toxicity is crucial. Looking at its structure, it contains trifluoromethyl, or has special toxicity.
    Initial test in mice to observe its physiological changes. When given an appropriate amount of this substance, it is seen that the diet and activities of mice are gradually abnormal. Then analyze its organs, liver and kidneys. The state is slightly different, or it shows toxic invasion.
    Repeat with cells to observe the damage to cells. Cell morphology changes, proliferation is also slow, and the toxicity is clear. However, the depth of toxicity still needs to be widely studied. Exploring many ways to understand its toxicology is to avoid disasters for those who use this substance, and to protect the safety of the environment. I hope to gain detailed knowledge, so that this thing can be used for good without serious harm.
    Future Prospects
    Today there is a thing called "3- (trifluoromethyl) phenylboronic acid", which has great potential in the field of our chemical research, and has a lot to show for the future. This compound has a unique structure, contains trifluoromethyl and boroxy groups, and has strange properties.
    Looking at its future, it is expected to become a key building block in the process of organic synthesis. With its activity check point, it may be able to accurately construct multiple complex organic molecules and promote drug research and development. The process of new drug creation, with its help, may open up a way to solve the drug dilemma of many difficult diseases.
    In the field of materials science, there are also opportunities. Or it can improve the properties of materials, endow materials with special electrical and optical properties, and apply them to high-tech products, such as advanced display and high-efficiency energy storage materials. In this way, its future development will surely shine, opening up a new world for our scientific research.
    Where to Buy 3-(Trifluoromethyl)Benzeneboronic Acid in China?
    As a trusted 3-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3- (trifluoromethyl) phenylboronic acid?
    The main application of tri (ethyl) boroxalic acid is important in the field of engineering and technology. It is commonly used in the synthesis of chemical methods.
    First, in the catalytic reaction, tri (ethyl) boroxalic acid can be used as a catalyst or catalytic aid. It can promote the reaction of many kinds of molecules, such as the polymerization of alkenes, which can make the reaction parts more harmonious and improve the reaction rate. It makes the alkenes efficiently polymerize to form the required polymers at a low degree of force in the phase, which is very important for polymer materials.
    Second, in the synthesis of boron compounds, this is an important factor. It can be made from the reaction of many kinds of compounds, and the reaction of boron-containing molecules can be made. However, boron-containing compounds are widely used in research and development, and can be used to synthesize compounds with specific biological activities, such as some antibacterial and anti-cancer molecules.
    Third, in the field of materials, tri (ethyl) boroxalic acid can be used in materials with special properties. For example, it can be incorporated into polymer materials to improve the optical and mechanical properties of materials. Or in ceramic materials, it can reverse the effect and improve the crystal phase of ceramics, improve their mechanical properties and resistance.
    Fourth, in the field of chemical analysis, it also has its application. It can be used for the evaluation of specific substances, based on the transformation of certain physical properties, to determine or quantitatively analyze the phase, and to play a role in the research and work of analytical transformation.
    What are the synthesis methods of 3- (trifluoromethyl) phenylboronic acid?
    The synthesis of tri (triethyl) boron oxalic acid is an important topic in the field of organic synthesis. There are many methods, each has its own advantages and disadvantages, and the choice of method depends on the actual situation.
    First, boron compounds and raw materials containing oxalic acid groups are synthesized by condensation reaction. Take an appropriate amount of boric acid, and the active oxalate ester, add a suitable catalyst to a specific organic solvent, and heat it at a controlled temperature. The boric acid activity check point interacts with the oxalate functional group, and according to the condensation reaction mechanism, a carbon-boron bond is formed to obtain tri (triethyl) boron oxalic acid. Temperature, catalyst type and dosage are all critical in this process. Low temperature, slow and incomplete reaction; high temperature, side reactions are raw, and product purity is reduced. The catalyst is also heavy, and different catalysts affect the reaction rate and selectivity.
    Second, the Grignard reagent method is used. The ethyl Grignard reagent is first prepared, and it is reacted with the raw material containing boron and oxalic acid structure. The Grignard reagent has high activity and is combined with a specific check point of boron compounds. After subsequent treatment, the oxalic acid part is introduced to obtain the target product. This process is necessary in an anhydrous and oxygen-free environment, otherwise the Grignard reagent is easy to decompose and cause the reaction to fail. When preparing Grignard reagent, the ratio of halogenated hydrocarbons to magnesium, the reaction temperature and time all affect the formation of the product.
    Third, the organometallic catalysis method can be used. Specific organometallic catalysts, such as transition metal complexes, are selected to catalyze the reaction of boron-containing precursors with oxalic acid derivatives. Organometallic catalysts have a unique electronic structure and spatial configuration, which can effectively activate the substrate and promote the reaction. By precisely designing the catalyst structure, the selectivity and efficiency of the reaction can be improved. However, such catalysts are often expensive, and the cost needs to be considered, and the post-reaction treatment needs to remove the catalyst to avoid affecting the quality of the product.
    What are the physical properties of 3- (trifluoromethyl) phenylboronic acid?
    Tri (ethyl) borate is a member of organic boron compounds. Its physical properties are as follows:
    Under normal temperature and pressure, tri (ethyl) borate is a colorless and transparent liquid, clear and free of impurities, just like a clear spring, without the slightest sense of turbidity, transparent to light, and pure.
    Smell it, it has a weak and special smell, not pungent and unpleasant, but also has its own unique smell, like a subtle fragrance hidden in the depths, which can only be detected by smelling.
    Its boiling point is about 117-118 ° C. At this temperature, tri (ethyl) borate is like a smart spirit, transforming from liquid to gaseous, and rising. This boiling point value, among many organic compounds, belongs to a specific mark, making it exhibit a unique physical transformation under specific conditions.
    The melting point is about -84.5 ° C. When the temperature drops to this temperature, it is like a sleeping ice crystal, gradually solidifying from a flowing state to a solid state. This low temperature melting point shows its physical properties in a low temperature environment, and its easy solidification state is also one of its physical properties.
    Furthermore, its density is about 0.864 g/mL. This density value reveals that the amount of substances contained in a unit volume is slightly lighter than the density of water, just like a light feather, which has a different kind of ups and downs in the liquid world.
    In addition, tri (ethyl) borate is slightly soluble in water. Water is the source of life, and many substances have different blending characteristics with it. The blending of tri (ethyl) borate and water is not intimate, only slightly soluble in it, as if it maintains a subtle distance from water, but is related to each other to a certain extent. This solubility is also one of its important physical properties.
    What should be paid attention to when storing and transporting 3- (trifluoromethyl) phenylboronic acid?
    When storing and transporting tri (ethyl) boric acid, there are many key points to pay attention to.
    When storing, the first environment should be placed in a cool, dry and well-ventilated place. Because tri (ethyl) boric acid is easy to decompose in case of moisture, humid environment will cause it to deteriorate and affect quality. And the temperature is too high, or it may cause its chemical reaction, so a cool environment is necessary. The warehouse should be kept away from fire and heat sources to prevent direct sunlight, because light may also affect its stability.
    Furthermore, storage should be carefully isolated from other substances. Do not mix with oxidants, acids, bases, etc. Because of its active chemical properties, contact with these substances, or react violently, and even cause serious accidents such as fires and explosions.
    When transporting, the packaging must be tight. Packaging materials that meet relevant standards should be selected to ensure that no leakage occurs during transportation. Because tri (ethyl) boric acid is toxic and corrosive to a certain extent, once leaked, it will not only pollute the environment, but also endanger the safety of transporters and surrounding people.
    The transportation process should be smooth and avoid violent vibration and impact. Violent vibration or damage to the packaging, causing material leakage. And the transportation vehicle should be equipped with corresponding fire equipment and leakage emergency treatment equipment, just in case. Transportation personnel should also be professionally trained and familiar with the characteristics of tri (ethyl) boric acid and emergency treatment methods to ensure safe transportation.
    What is the market price of 3- (trifluoromethyl) phenylboronic acid?
    At present, the price of trimethylolpropanesulfonic acid in the market often changes due to various reasons. Its price is related to the price of raw materials, the situation of supply and demand, the entry of technology, the direction of politics, etc.
    First talk about the price of raw materials. For the production of trimethylolpropanesulfonic acid, specific materials are often required. If the price of these materials rises, the cost of its production will increase, and the market price will also rise accordingly. If the production of raw materials is due to weather conditions, geopolitical conditions, etc., the supply is less and the demand is more, the price must rise, and the price of trimethylolpropanesulfonic acid will also be affected by it.
    The second discussion on the situation of supply and demand. If there is a demand for trimethylolpropanesulfonic acid in the market, but the supply is insufficient, its price will rise; conversely, if there is a demand for less and more supply, the factory will often reduce its price in order to sell goods. If an industry is booming and needs the help of this product, the demand will increase sharply, and the price will rise; if the business is weak, the demand will drop sharply, and the price may fall.
    Furthermore, the entry of technology also has an impact. If new technologies are developed, the efficiency of trimethylolpropanesulfonic acid production will increase, the cost will decrease, and the market supply will increase or the price will decrease. However, if new technologies are introduced, the demand will increase, and the price may change differently.
    The orientation of government is also critical. If the government promotes the development of this industry, or grants or tax deductions, the factory's cost of production will decrease, and the price will decrease; if the government sets strict regulations, the factory is in compliance, the cost of production will increase, and the price will increase.
    Overall, the market price of trimethylolpropanesulfonic acid is not constant today, and it often rises and falls due to the above reasons. To know the real-time price, when you observe the market situation and observe the industry news, you can get the exact number.