3- [ (trifluoromethyl) -benzene] -boronic acid, which is an important chemical reagent in organic synthesis, has a wide range of uses.
First, it can be used in carbon-carbon bond formation reactions. For example, in the Suzuki-Miyaura coupling reaction, the reagent can efficiently form biphenyls or alkenylated products with halogenated aromatics or olefins under the action of palladium catalysts and bases. This reaction is of great significance in the field of drug synthesis and materials science. In medicinal chemistry, complex molecular frameworks can be constructed to help develop drug molecules with specific biological activities; in materials science, new photoelectric materials can be synthesized, which contributes to the development of organic Light Emitting Diode (OLED) materials.
Second, it is also a good assistant in modifying the structure of aromatic rings. Due to its unique structure, trifluoromethyl has strong electron absorption and can change the electron cloud density of benzene rings. By introducing this boric acid reagent, the physical and chemical properties of aromatic rings can be precisely regulated through a series of reactions. For example, in dye synthesis, the structure of aromatic rings can be modified to adjust the color, stability and solubility of dyes to meet the needs of different fields.
Third, it plays a key role in the construction of fluorine-containing organic compounds. The introduction of fluorine atoms can often significantly change the biological activity, lipophilicity and metabolic stability of compounds. As a fluorine-containing synthesizer, this boric acid reagent provides convenience for the synthesis of organic compounds containing trifluoromethylbenzene structures, and has important applications in pesticides, medicine and other fields. In the field of pesticides, fluorinated compounds often have higher biological activity and environmental adaptability, which can help develop high-efficiency and low-toxicity pesticide products.

The synthesis methods of 3 - [ (trifluoromethyl) -benzene] -boric acid are generally as follows.
One is the halogenated aromatic hydrocarbon method. Take (trifluoromethyl) benzene containing a halogen atom, use a metal complex such as palladium as a catalyst, and react with borate ester reagents under the action of a base. For example, using (trifluoromethyl) bromobenzene as a starting material, in a suitable organic solvent, add tetrakis (triphenylphosphine) palladium as a catalyst, potassium carbonate and other bases, and then mix it with pinacol borate, heat and stir. In this process, the halogen atom is replaced by a borate group, and then hydrolyzed to obtain the target product 3- [ (trifluoromethyl) -benzene] -boric acid. The advantage of this method is that the raw materials are easier to obtain, the reaction conditions are relatively mild, and the catalyst cost may be higher.
The second is the Grignard reagent method. The Grignard reagent is first prepared from (trifluoromethyl) halobenzene, which is usually reacted with magnesium in a solvent such as anhydrous ether or tetrahydrofuran to form the corresponding Grignard reagent. Subsequently, the Grignard reagent is reacted with borate esters, such as trimethyl borate, and then treated with acid hydrolysis. The method has high reactivity and the yield can be observed. Weige's reagent is extremely sensitive to water and air, and the preparation and reaction process need to be strictly anhydrous and oxygen-free.
The third is the lithium reagent method. The lithium intermediate is formed by the action of lithium reagents such as (trifluoromethyl) halobenzene and butyl lithium. This intermediate reacts with borate ester, and then hydrolyzes to obtain the product. This method has strong reactivity and can be used for the synthesis of boric acid with some special structures, but its reaction conditions are harsh, lithium reagents are expensive, and the operation needs to be extra cautious.
All these methods have their own advantages and disadvantages. In actual synthesis, the appropriate method should be carefully selected according to many factors such as the availability of raw materials, cost considerations, and the difficulty of reaction conditions.

3 - [ (trifluoromethyl) -benzene] -boronic acid, this substance is in the state of white to light yellow crystalline powder. Its melting point is in a specific range, about 130-135 ° C. Within this temperature range, the substance gradually changes from solid to liquid. This property is critical in many experiments and industrial processes involving the phase transition of substances.
Its solubility is also an important physical property. In common organic solvents, such as dichloromethane and chloroform, it has a certain solubility and can be dissolved to form a uniform dispersion system. This property is conducive to the use of these organic solvents as a medium to carry out various chemical reactions and facilitate the design of organic synthesis routes. However, in water, its solubility is relatively low, only slightly soluble in water. This property is related to the hydrophobic trifluoromethyl group in the molecular structure, which results in poor affinity for water as a whole.
In addition, the stability of this substance is also worthy of attention. Under normal environmental conditions, it can be properly stored in a dry and cool place to maintain a relatively stable chemical state. However, if exposed to high temperature, high humidity environment, or in contact with specific chemicals such as strong oxidants and strong bases, its structure may change, causing chemical properties to change, which in turn affects its effectiveness in various application scenarios.

3 - [ (trifluoromethyl) -benzene] -boronic acid is a commonly used reagent in organic synthesis. When storing and transporting, there are many key points to be paid attention to.
Bear the brunt, temperature is of paramount importance. This compound is quite sensitive to temperature, and high temperature can easily cause it to decompose and deteriorate. Therefore, when storing, it should be placed in a cool place, and the temperature should be maintained at 2-8 ° C, which can ensure the stability of its chemical properties.
Furthermore, humidity should not be underestimated. Boric acid compounds are prone to moisture absorption, and after moisture absorption, their purity and reactivity may be affected. Therefore, it should be stored in a dry place, sealed and stored on top. Sealed containers or moisture-proof packaging can be used to prevent moisture from invading.
Light is also a factor that cannot be ignored. Long-term exposure to light may cause photochemical reactions of this compound, resulting in structural changes. Therefore, when storing, it should be protected from light, it should be placed in a brown bottle, or stored in a place where light is difficult to reach.
When transporting, safety is of paramount importance. Because it may have certain chemical activity, it is necessary to ensure that the packaging is firm to prevent collision and vibration from causing damage to the package and causing leakage. And during transportation, appropriate temperature and humidity conditions should also be maintained, and relevant chemical transportation norms and requirements should be followed to ensure the safety of the transportation process.
In conclusion, proper storage and safe transportation of 3- [ (trifluoromethyl) -benzene] -boronic acid are related to its quality and performance. Only by paying strict attention to the above items can we avoid losses and risks caused by improper storage and transportation.

3 - [ (trifluoromethyl) -benzene] -boronic acid, its market price range will vary due to a variety of factors. This compound is widely used in the chemical industry and scientific research fields, and its price is mainly affected by the following aspects.
First, purity has a significant impact on price. If the purity is extremely high, such as more than 99%, it is often used in high-end scientific research experiments, and the impurity content is demanding. The preparation process is complicated, and it requires a lot of high-end equipment and fine processes. Therefore, the price is high, and the price per gram may be in the hundreds or even thousands of yuan.
Second, the relationship between market supply and demand is also a key factor. If there is a large increase in demand from many scientific research institutions or chemical companies during a certain period of time, and the supply is limited, the price will naturally rise; on the contrary, if the market demand is flat and the supply is sufficient, the price will drop accordingly.
Third, the price varies between the manufacturer and the place of origin. Well-known large factories rely on advanced technology and strict quality control, the product quality is stable, and the price may be high; although the price of some small factories is relatively low, the quality is uneven.
Fourth, the purchase volume has a significant impact on the price. When purchasing in large quantities, due to the scale effect, the manufacturer often gives a certain discount, and the price per gram may be reduced by tens of yuan; when purchasing in small quantities, the unit price is higher.
Overall, under the common purity and purchase quantity, the price per gram may range from tens to hundreds of yuan. But the specific price also needs to pay attention to the market dynamics of chemical raw materials in real time, and consult relevant suppliers in detail.